• Proceedings of the Ginseng society Conference
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• 1980.09a
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• pp.87-113
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• 1980

This experiment was carried out to evaluate the effects of Korean ginseng extract on carcinogenesis induced by various chemical carcinogens. Red ginseng extract was used for this study and was administered orally to the experimental animals. Carcinogens that were injected in subscapsular region of ICR newborn mice within 24 hours after birth were 9,10-dimethyl-1,2-benzan-thracene (DMBA), urethane, N-2-fluorenylacetamide(AAF), aflatoxin $B_1$ and tobacco smoke condensate. N -methyl-N -nitroso-N'-nitroguani-dine(MNNG) was injected subcutaneously at the back of wistar rats. Experimental animals were autopsied in immediately after being sacrificed. All major organs were examined grossly and weighted. After fixation histopathological preparations were made for microscopical study. Following results were obtained. In DMBA group sacrificed at the 26th week after the treatment with DMBA, the incidence of lung adenoma was $77\%$ and the average number of the tumor was 17. However, in DMBA combined with red ginseng group, the incidence was $78\%$ and the average number of lung adenoma was 14.1. This indicates that ginseng extract had no effect on the incidence of lung adenoma but decreased the average number of lung adenoma by $17\%.$ In DMBA group sacrificed at the 48th week after the injection of DMBA, the lung adenoma incidence was $88\%.$ The average diameter of the largest lung adenoma was 3.5 cm, the incidence of diffuse pulmonary infiltration was $18\%$ and the average lung weight of male experimental mice was $528.2{\pm}469.1\;gm.$ On the other hand, in DMBA combined with red ginseng group sacrificed at the 48th week, the incidence of lung adenoma was $96\%.$ The average diameter of the largest adenoma was 2.7 cm, the incidence of diffuse pulmonary infiltration was $7\%$ and the average lung weight of male mice was $418.0{\pm}520\;gm.$ These observations show that ginseng extract did not have any inhibitory effect on the incidence of lung adenoma but decreased the average diameter of the largest lung adenoma by $23\%,$ the incidence of duffuse pulmonary infiltration by $63\%$ and the average lung weight of male experimental mice by $21\%.$ From these results we have found that the prolonged administration with ginseng extract showed no inhibitory effect on the incidence of adenoma but it had the inhibitory effect on the proliferation of lung adenomas induced by DMBA. In urethane group sacrificed at the 28th week after the injection of urethane, the incidence of lung adenoma was $94\%$ and the average number of lung adenoma was 8.6. In urethane combined with red ginseng group, the. incidence of lung adenoma was $73\%$ and the average number of adenoma was 6.0. These results indicate that there were $22\%$ decrease of the lung adenoma incidence and $31\%$ decrease of the average number of adenoma in urethane combined with red ginseng group. And in urethane group sacrificed at the 50th week, the incidence of lung adenoma was $98\%$ and the incidence of diffuse pulmonary infiltration was $14\%$. In urethane combined with ginseng group the incidence of lung adenoma was $85\%$ and the incidence of diffuse pulmonary infiltration was $12\%$. Therefore the ginseng administration resulted in $15\%$ decrease of the lung adenoma incidence and $14\%$ decrease of the diffuse pulmonary infiltration incidence. From these results we knew that the prolonged administration with ginseng extract inhibited the incidence and also the proliferation of the lung adenoma induced by urethane. Lung adenoma and hepatoma were induced in the experimental mice sacrificed at the 68th week but not in the experimental mice sacrificed at the 28th week after the injection of AAF. In AAF group sacrificed at the 68th week after the injection of AAF the incidence of lung adenoma was $18\%$ and the incidence of hepatoma was $27\%$. And in AAF combined with ginseng group the lung adenoma incidence was $12\%$ and the hepatoma incidence was $37\%$. So the ginseng seemed to decrease the lung adenoma incidence by AAF, but we were unable to conclude the significant inhibitory effect of the ginseng extract on the incidence of lung adenoma by AAF because the above incidence of lung adenoma were similar to that of control group which was $11\%$. And these experimental data revealed that ginseng extract didn't have any inhibitory effect on the incidence of hepatoma induced by AAF. In aflatoxin $B_1$ group sacrificed at the 56th week, the incidence of lung adenoma was $24\%$ and hepatoma was $11\%$. However in aflatoxin $B_1$ combined with ginseng group the incidence of lung adenoma was $17\%$ and hepatoma was $3\%$ These results indicate that there were $29\%$ decrease of the lung adenoma incidence and $75\%$ decrease of the hepatoma incidence in aflatoxin $B_1$ combined with ginseng group. In tobacco smoke condensate experimental group sacrificed at 67th week, no tumors were induced except just a few lung adenoma. The lung adenoma incidence both in tobacco smoke condensate group and in tobacco smoke condensate combined with ginseng group was $8\%$. And this incidence rate was similar to that of control group. These results indicate that the injection of 320 ug tobacco smoke condensate per ICR newborn mouse was unable to induce lung adenoma in our experiments. In MNNG group sacrificed at the 27th week the tumor incidence was $38.5\%$ and in MNNG combined with ginseng extract group was $37\%$. In MNNG group for investigation of the life span of tumor bearing rats the tumor incidence was $93\%$ and the average life span of tumor bearing rats was 318 days. And in MNNG combined with ginseng extract group the tumor incidence was $96\%$ and the average life span was 337 days. Tumor induced by MNNG was almost sarcoma. This indicates that there was no inhibitory effect of ginseng extract on the tumor incidence, but the extract prolonged the average life span of tumor bearing rats by approximately 19 days.

• Journal of the Korean Institute of Landscape Architecture International Edition
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• no.2
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• pp.120-129
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• 2004

Urban stream restoration projects can improve water quality, wildlife habitats, urban landscape, outdoor recreation spaces, and urban microclimate. The objectives of this research were to investigate temperature cooling effect of urban streams by using satellite imagery, to evaluate environmental variables related to stream cooling effect, and to estimate the cooling effect of the Cheonggye stream restoration project of Seoul, Korea. Findings of this research can be summarized as follows. First, a method of estimating temperature distribution around urban streams by using satellite imagery was developed. Scatter plots of distance from stream edges and average temperature obtained through multiple buffering were used for the estimation. Second, urban temperature cooling effect of streams was estimated by comparing background temperature and temperature of each buffer zone. Third, environmental factors affecting stream cooling effect were also identified. Fourth, the temperature cooling effect of the restoration project was estimated based on three scenarios. An estimated cooling effect based on the average cooling effect of existing tributaries showed the most significant effect; $2.0^{\circ}C$ lower than the present level at the edge of the renovated stream. It was estimated that the temperature of the same area would be $1.4^{\circ}C$ cooler than the present level if the cooling effect of the Yangjaechun was used as the bench mark But the effect would be $1.2^{\circ}C$ lower than the present level if environmental variables related to the temperature cooling effect of urban streams were used as the bench mark.

• Journal of Korean Society for Atmospheric Environment
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• v.25 no.6
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• pp.571-578
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• 2009

$PM_{2.5}$ black carbon (BC) concentrations were measured to investigate the filter spot loading effect in raw BC data at 5-minute time-based resolution using a single-wavelength aethalometer at a Gwangju site. Also the elemental carbon (EC) concentrations from 24-hr integrated filter-based measurements of $PM_{2.5}$ particles were determined to compare with the loading compensated BC values. Close examination of the time-series BC data showed clearly the "gaps" when the filter tape advances, suggesting the correction of raw BC data. Therefore, we calculated the average BC concentration in each range of attenuation (ATN) to decide if there was (or was not) an effect on the aethalometer data according to the loading of the filter spot. A consistent decrease of average BC concentration was found with increasing ATN values for every month, suggesting there was a consistent "spot loading effect" in the raw BC data. The loading compensated BC concentration according to a simple compensation model with loading effect was 1.01~1.15 times greater than the raw BC data. The 24-hr average concentration of EC observed during summer sampling period was about 3% higher than the original 24-hr average BC value and 2% lower than the loading compensated BC concentration.

• Journal of Korea Water Resources Association
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• v.42 no.5
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• pp.385-396
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• 2009

The spatial distribution of precipitation trends according to urbanization, geographical and topographical conditions have been studied. In this study, precipitation data from 1973 to 2006 were analyzed for 56 climatological stations including the Seoul metropolis in South Korea. In addition to annual average daily precipitation, monthly average daily precipitation in April, July, October and January were analyzed, considering seasonal effect. The geographical and topographical characteristics of these sites were examined using GIS analysis. Land use status of the study area was also examined to estimate the extent of urbanization. The study results indicate that annual average precipitation increased, and monthly average precipitation in April and October decreased, while those in January and July increased. Considering urbanization effect, annual average precipitation and monthly average precipitation in July increased; however, monthly average precipitation in January, April and October decreased. Furthermore, compared with urbanization rate and proximity to coast, average elevation of study area appeared to be the most close correlation with annual and monthly averages of precipitation trends.

• Korean Journal of Agricultural Science
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• v.41 no.4
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• pp.481-485
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• 2014

According to statistical data the past ten years, cultivation area and yield of radish are steadily decreasing. This phenomenon cause instability of radish's supply due to meteorological chage, even if radish's yield per unit area is increasing by cultivation technological development. These problems raise radish's price. So, we conducted study on meteorological factors for accuracy improvement of radish yield estimation. Panel analysis was used with two-way effect model considering group effect and time effect. As the result, we show that mixed effects model (fixed effect: group, random effects: time) was statistical significance. According to the model, a rise of one degree in the average air temperature on August will decrease radish's yield per unit area by $428kg{\cdot}10a^{-1}$ and that in the average air temperature on October will increase radish's yield per unit area by $438kg{\cdot}10a^{-1}$. The reason is that radish's growth will be easily influenced by meteorological condition of a high temperature on August and by meteorological condition of a low temperature on Octoboer.

• Structural Engineering and Mechanics
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• v.54 no.5
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• pp.891-908
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• 2015

For a systematic study on wind-induced vibration characteristics of large hyperbolic cooling towers with different feature sizes, the pressure measurement tests are finished on the rigid body models of three representative cooling towers with the height of 155 m, 177 m and 215 m respectively. Combining the refined frequency-domain algorithm of wind-induced responses, the wind-induced average response, resonant response, background response, coupling response and wind vibration coefficients of large cooling towers with different feature sizes are obtained. Based on the calculating results, the parametric analysis on wind-induced vibration of cooling towers is carried out, e.g. the feature sizes, damping ratio and the interference effect of surrounding buildings. The discussion shows that the increase of feature sizes makes wind-induced average response and fluctuating response larger correspondingly, and the proportion of resonant response also gradually increased, but it has little effect on the wind vibration coefficient. The increase of damping ratio makes resonant response and the wind vibration coefficient decreases obviously, which brings about no effect on average response and background response. The interference effect of surrounding buildings makes the fluctuating response and wind vibration coefficient increased significantly, furthermore, the increase ranges of resonant response is greater than background response.

• International Area Studies Review
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• v.20 no.3
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• pp.123-144
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• 2016

This paper investigates the linkages between returns both in foreign exchange and stock markets, and uncertainties in two markets using daily data for the period of 16 July 2004 to 30 June 2014 in Nepalese economy. Four hypotheses are tested about how uncertainty influences the stock index and exchange rates. From the empirical results, a bivariate EGARCH-M model is the best to explain the volatility in the two markets. There is a negative relationship from the exchange rates return to stock price return. Empirical results do provide strong empirical confirmation that negative effect of stock index uncertainty and positive effect of exchange rates uncertainty on average stock index. GARCH-in-mean variables in AR modeling are significant and shows that there is positive effect of exchange rates uncertainty and negative effect of stock index uncertainty on average exchange rates. Stock index shocks have longer lived effects on uncertainty in the stock market than exchange rates shock have on uncertainly in the foreign exchange market. The effect of the last period's shock, volatility is more sensitive to its own lagged values.

• KSTLE International Journal
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• v.3 no.1
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• pp.7-11
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• 2002

The roughness effects are very important due to the presence of interacting asperities in mixed lubrication regime. An average Reynolds equation using flow factors is useful to determine the effects of surface roughness on mixed lubrication. In this study, the effect of kurtosis on flow factors is investigated using random rough surfaces generated numerically, The results show that flow factors are very sensitive to h/$\sigma$ according to the value of kurtosis in the partial lubrication regime.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.25 no.3
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• pp.56-64
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• 2012

Objectives : This study was performed in order to investigate an immediate improvement effect of nasal obstruction after having patient with chronic rhinitis use nasal spray in nasal cavity after distilling Korean medicine, satisfaction for its fragrance and irritation and its effect continuance time. Methods : A questionnaire was performed for an immediate therapeutic effect of nasal spray 1, 2 and 3 weeks later after using spray by targeting 13 patients who used Korean medicine distillate spray for over 3 weeks among the patients who visited Sangji University Korean Medicine Hospital and whose symptoms were determined as chronic rhinitis and for whom Korean medicine distillate spray was prescribed. 3 weeks later after using spray, a questionnaire was performed for fragrance, irritation and continuance effect of Korean medicine. Immediate therapeutic effect being felt right after spraying was also surveyed and symptom scores was expressed from 10 to 0 and on the assumption that nasal obstruction symptom just before spraying was 10 points, symptom score after spraying was surveyed. In case of evaluation of satisfaction, satisfaction for fragrance and irritation of nasal spray was evaluated by scale based on full score of 5 point from 'very satisfied=5', 'satisfied=4', 'average=3', 'unsatisfactory=2' and 'very unsatisfactory=1', respectively. Effect continuance time after spraying was surveyed by dividing it into within 5 minutes, within 5-10 minutes, within 10-30 minutes and over 30 minutes. All the data was statistically analyzed by Friedman Test that is non-parametric test of Paired t-test and descriptive statistics. Results : Total surveyed patients were 13 persons including 6 males and 7 females and total average age was represented to be $27.1{\pm}17.7$ years old. Score of immediate nasal obstruction improvement effect at 1st week was $6.3{\pm}2.4$ points, at 2nd week $5.7{\pm}2.5$ points and at 3rd week $5.5{\pm}2.5$ points and when comparing 1st week, 2nd week and 3rd week statistically, p value was 0.047<0.05 and from this, it could be seen that the longer spray was used, the more was improvement effect represented with slight significance. In case of fragrance and irritation, both of its score was represented to be high as average $4.0{\pm}1.08 $points and average $4.4{\pm}0.8$ points, respectively. Effect continuance time below 10 minutes was represented in 8 persons who accounted for 61.5%. Conclusions: Immediate improvement effect of nasal obstruction being felt by the patients by using Korean medicine nasal spray could be confirmed and by having the patients use such spray for 3 weeks continuously, it could be realized that such effect was sustained and satisfaction for fragrance or irritation of Korean medicine nasal spray was significant. However, rather short sustained time was considered to be unsatisfactory and this shortcomings is required to be improved in the future.

• Journal of Family Relations
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• v.22 no.4
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• pp.31-52
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• 2018

Objectives: The purpose of this study is to examine whether the maternal and paternal value of children mediates the relationship between the marital relationship satisfaction and the parental sense of competence in the longitudinal dyadic approach. Method: The data were obtained from the Panel Study on Korean Children (PSKC) conducted by the Korea Institute of Child Care and Education. Using the Actor-Partner Interdependence Model（APIM), the author analyzed three waves (from 5th to 7th year) of the data, and the sample size was 1,773. The average age was 34.79 for mothers, and 37.26 for fathers. Their average length of marriage was 95.3 months, and their children were 51.03 months old on average. Results: The marital relationship satisfaction influenced the parental sense of competence with both the actor effect and the partner effect of mothers and fathers. The marital relationship satisfaction also influenced the value of children, with the actor effect from both mothers and fathers and with the partner effect only from mothers. The value of children influenced the parental sense of competence with the actor effect only from mothers and fathers. Also, the value of children mediated the relationship between the marital relationship satisfaction and the parental sense of competence with the actor effect from both mothers and fathers. For the partner effect, only the mediation path from fathers' marital relationship satisfaction to mothers' value of children to mothers' parental sense of competence was significant. Conclusions: These results suggest the importance of highlighting the marital relationship satisfaction and the value of children to improve the parental sense of competence.