• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2941-2946
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• 2007

A model of the cardiovascular system coupling cell, hemodynamics and autonomic nervecontrol function is proposed for analyzing heart mechanics. We developed a comprehensive cardiovascular model with multi-physics and multi-scale characteristics that simulates the physiological events from membrane excitation of a cardiac cell to contraction of the human heart and systemic blood circulation and ultimately to autonomic nerve control. Using this model, we delineatedthe cellular mechanism of heart contractility mediated by nerve control function. To verify the integrated method, we simulated a 10% hemorrhage, which involves cardiac cell mechanics, circulatory hemodynamics, and nerve control function. The computed and experimental results were compared. Using this methodology, the state of cardiac contractility, influenced by diverse properties such as the afterload and nerve control systems, is easily assessed in an integrated manner.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.4
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• pp.1088-1091
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• 2005

This study was designed to research whether Dinamika can yield a suitable diagnosis for Activity of Autonomic Nene System on stroke. The testing of Dinamika was carried out at Oriental Medical Centar of Dong-Eui University with the participation of 27 patients. The results of Dinamika examinations shows as follows : Group A(the rising of a parasympathetic nerve system) is 0 persons. And Group B(the balancing autonomic none system) is 4 persons. Group C(the rising of a sympathetic nerve system) is 23 persons. There are 7 persons that it is difference of more than $20\%$ between B1 (the control ability of autonomic nerve system) and B2(the potential energy to control autonomic nerve system), 11 person that B1 and B2 are less than $10\%$, 1 person that B1 and B2 are balanced about $60\%$, 8 person that it is balanced domain from $10\%\;to\; 60\%$ between B1 and B2. According to this study on activity of autonomic nerve system using Dinamika on Stroke, these results suggest that 27 patients evidence the problem of autonomic none systems.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.5
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• pp.409-415
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• 2015

This study compared the heart rate variability tests of healthy college students and chronic fatigue patients for 2 years. Study subjects were idiopathic chronic fatigue patients who carried out the HRV tests and students conducted HRV test when health screening test. Study subjects were 250 people, 104 people and men (41.6%), women were 146 patients (58.4%). In patient group, the autonomic nervous system activity was decreased, the activity of the sympathetic nerve and the parasympathetic nerve were significantly reduced compared to the control group(Patient:84.17±16.27, Control:98.33±17.28). Regardless of gender, patient group's autonomic nervous system activity was decreased, the activity of the sympathetic nerve and the parasympathetic nerve were significantly reduced, compared to the control group(Patient Female:84.17±16.27, Patient Male:84.07±14.96/Control Female:98.33±17.28, Control Male:96.45±16.92). Even though same ages, patient group's autonomic nervous activity was reduced compared to control group(Patient:89.36±12.43, Control:97.39±16.91). Fatigue patients' activity of the sympathetic nerve and the parasympathetic nerve were significantly reduced, regardless of the fact that activity of the sympathetic nerve is increased and the parasympathetic nerve is decreased in stress state like an impassioned injury(七情傷). Therefore HRV test is useful to diagnose Fatigue from this study.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.4
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• pp.77-82
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• 2016

Purpose: The purpose of this study was to investigate the therapeutic effect of non-invasive vagus nerve stimulation by transcutaneous electrical nerve stimulation application on the autonomic nervous system of human body. Methods: Participants were seventeen healthy adults. Standard deviation of all normal N-N intervals(SDNN), root mean square of successive differences(RMSSD), low frequency(LF), high frequency(HF) were compared in pre and post Mean values after intervention. Data were analyzed in Wilcoxon's signed-ranks test. Results: The results of this study is that sistolic blood pressure and pulse rate decreased mean value after non-invasive vagus nerve stimulation by transcutaneous electrical nerve stimulation. High frequency, low frequency, SDNN, RMSSD increased mean value in heart rate variability after intervention. But that is not significant except for SDNN. Conclusion: Non-invasive vagus stimulation by transcutaneous electrical nerve stimulation effect on parasympathetic nerve stimulation, and then it might be effective method for autonomic nerve balance control.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.17 no.4
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• pp.531-538
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• 2010

Purpose: This study was done to identify the effects of Qi hand reflexology on autonomic nerve activity in patients admitted to hospital. Method: A non-equivalent control group and quasi-experimental research with pre/post test design were used and 59 patients on a medical ward were assigned to either the experimental group (32) or the control group (27). The study variables included vital signs, autonomic nerve activities (ALF (absolute low frequency), AHF (absolute high frequency), nLF (normalized low frequency), nHF (normalized high frequency), SDNN (standard deviation of all normal-normal intervals)) and were evaluated using the QECG-3 system. The experimental group was treated with Qi hand reflexology for 10 minutes per day, for 3days. Results: Skin temperature and systolic blood pressure in the experimental decreased with treatment. ALF, AHF and SDNN for the experimental group increased with regulating proportion (nLF: nHF=6:4) and a significant difference between the groups was observed. Conclusion: The results indicated that application of Qi hand reflexology for patients in the hospital is effective in regulating the autonomic nervous system activation. Implication of finding should be useful for future research.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.12
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• pp.1181-1188
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• 2004

This paper reviews the main aspects of cardiovascular system dynamics with emphasis on modeling hemodynamic characteristics using a lumped parameter approach. Methodological and physiological aspects of the circulation dynamics are summarized with the help of existing mathematical models: The main characteristics of the hemodynamic elements, such as the heart and arterial and venous systems, are first described. Lumped models of micro-circulation and pulmonary circulation are introduced. We also discuss the feedback control of cardiovascular system. The control pathways that participate in feedback mechanisms (baroreceptors and cardiopulmonary receptors) are described to explain the interaction between hemodynamics and autonomic nerve control in the circulation. Based on a set-point model, the computational aspects of reflex control are explained. In final chapter we present the present research trend in this field and discuss the future studies of cardiovascular system modeling.

• Korean Circulation Journal
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• v.54 no.5
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• pp.223-232
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• 2024

Trigger and functional substrate are related to the tone of autonomic nervous system, and the role of the autonomic nerve is more significant in paroxysmal atrial fibrillation (AF) compared to non-paroxysmal AF. We have several options for neuromodulation to help to manage patients with AF. Neuromodulation targets can be divided into efferent and afferent pathways. On the efferent side, block would be an intuitive approach. However, permanent block is hard to achieve due to completeness of the procedure and reinnervation issues. Temporary block such as botulinum toxin injection into ganglionated plexi would be a possible option for post-cardiac surgery AF. Low-level subthreshold stimulation could also prevent AF, but the invasiveness of the procedure is the barrier for the general use. On the afferent side, block is also an option. Various renal denervation approaches are currently under investigation. Auditory vagus nerve stimulation is one of the representative low-level afferent stimulation methods. This technique is noninvasive and easy to apply, so it has the potential to be widely utilized if its efficacy is confirmed.

• Journal of Korean Medicine Rehabilitation
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• v.31 no.2
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• pp.81-97
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• 2021

Objectives This study was designed to identify the changes of autonomic nervous system (ANS) which was induced by acupuncture at the field of the auricular branch of the vagus nerve. Methods 30 healthy adults were selected and classified into two groups; experimental group, control group. After providing mental stress, acupuncture was applied at external ear in experimental group and no treatment executed in control group. The evaluation of ANS function was measured by heart rate variability (HRV). We statically analyzed the difference of HRV parameters which include mean heart rate (MHRT), standard deviation of all N-N intervals (SDNN), square root of the mean of the sum of the squares of differences between adjacent N-N intervals (RMSSD), total power (TP), low frequency power (LF), high frequency power (HF), LF/HF ratio. Results All subjects showed significant increase in SDNN, LF after stress stimulation (p<0.05). Immediately after intervention, MHRT was significantly decreased (p<0.001) and RMSSD, HF were significantly increased in experimental group (p<0.05). After the end of intervention, SDNN, HF, RMSSD, TP, LF were significantly increased in experimental group (p<0.01, p<0.05). And when comparing baseline HRV, SDNN, LF were significantly increased in control group (p<0.01) and SDNN, RMSSD, TP, LF were significantly increased in experimental group (p<0.05). In the subgroup analysis, normal balance of ANS group showed significant increase in TP, LF, SDNN, HF (p<0.01, p<0.05). Conclusions We suggested that acupuncture at external ear, region of the vagus nerve distribution could increase parasympathetic activity and cause changes and reregulation of the ANS.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.16 no.3
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• pp.49-58
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• 2012

Objectives: This research was designed to study the characteristics of heart rate variability in acute dyspepsia patients compared with normal group. Methods: The testing of HRV was carried out at Oriental Medical Center of ${\bigcirc}{\bigcirc}$University with the participation of 94 acute dyspepsia patients and 85 control group people. We checked HRV of the 2 groups that were checked on the first visit day and compared HRV index between groups. Results: In the frequency domain analysis, HF, LF, VLF, LF/HF ratio, TP were significantly lower than control group on acute dyspepsia patient group. HF, LF, VLF, LF/HF ratio, TP were not significantly associated with age. Conclusions: According to this study, autonomic nerve system was more decreased on the acute dyspepsia patient group compared with the control group. Though further studies will be needed, the present finding provide us the possibility that stress is a major cause of the acute dyspepsia along with food factor.

• Journal of Acupuncture Research
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• v.22 no.6
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• pp.51-60
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• 2005

Objectives : This study was designed to evaluate the effect of inbalance of autonomic nerve system on peripheral facial palsy patients in comparison of Heart Rate Variability results of healthy control group with that of peripheral facial palsy group. Methods : The peripheral facial palsy patiens who visited the Dongguk university Bundang oriental medicine hospital from April to June in 2005 were tested Heart Rate Variability items which are Mean Heart Rate(MHRT), Standard Deviation of all the Normal RR intervals (SDNN), Root Mean Square of Successive Differences Between The Normal Heart Beats(RMSSD), Total Power(TP), Low Frequency, High Frequency, ratio between the Low Frequency and High Frequency power(LF/HF ratio). The Heart Rate Variability test results of peripheral facial palsy group were compared with the HRV test results of healthy control group who didn't have nervous disease, musculoskeletal disease, heart problem and pain for the past 6 months. Results : 1. MHRT was not significantly different between peripheral facial palsy group and healthy control group(P=0.18). 2. SDNN was not significantly different between peripheral facial palsy group and healthy control group(P=0.41). 3. RMSSD was not significantly different between peripheral facial palsy group and healthy control group(P=0.93). 4. TP was not significantly different between peripheral facial palsy group and healthy control group(P=094). 5. LF and HF were not significantly different between peripheral facial palsy group and healthy control group((P=0.34, 0.30). 6. LF/HF ratio was significantly different between peripheral facial palsy group and healthy control group(P=0.04). Conclusion : LF/HF ratio is generally used as autonomic nerve system evaluation and there was significantly statistical difference between peripheral facial palsy group and healthy control group.