• 제목/요약/키워드: aurodox group antibiotics

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Isolation, Physico-chemical Properties and Biological Activity of Aurodox Group Antibiotics

  • Kim, Si-Kwan;Yeo, Woon-Hyung;Kim, Sang-Seock
    • Journal of Microbiology and Biotechnology
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    • 제6권4호
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    • pp.265-269
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    • 1996
  • An isolate of Streptomyces rochei synonym was found to produce antibiotics with narrow anti-microbial spectrum against Streptococcus and Xanthomonas sp. Among the antibiotic complex produced by the strain, the main active compound was isolated, and its physico-chemical properties and biological activities were investigated. Molecular weight of the compound was determined to be ${[M+H]}^+$ 797 (FAB-MS). UV, $^1H \;and\;^{13}C$ NMR, and IR spectra suggested that the compound is a kirromycin-like aurodox group antibiotic. However, the anti-microbial spectrum of the main compound was slightly different from that of kirromycin. In addition, it was newly found that kirromycin showed a selective anti-microbial activity against Streptococcus pyogenes and phytopathogenic Xanthomonas sp.

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Identification and Fermentation of a Streptomyces Producing Aurodox Group Antibiotics

  • Kim, Si-Kwan;Yeo, Woon-Hyung;Kim, Sang-Seock
    • Journal of Microbiology and Biotechnology
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    • 제6권4호
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    • pp.260-264
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    • 1996
  • An isolate, 90-GT-129 was found to produce antibiotics with a selective inhibitory activity against Streptococcus pyogenes and Xanthomonas sp. The isolate formed a gray spiral aerial spore mass with smooth surface. Analysis of the cell wall acid hydrolysate of the isolate revealed presence of LL-di-aminopimelic acid, which indicates that the isolate belongs to a cell wall type Ⅰ actinomycetes. Cultural and physiological characteristics of the isolate placed it in Streptomyces rochei synonym cluster. A comparison of the isolate with 26 reference strains of Streptomyces rochei synonym demonstrated differences in physiological and cultural characteristics.

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