• Korean Journal of Head & Neck Oncology
• /
• v.37 no.2
• /
• pp.67-69
• /
• 2021

Langerhans cell histiocytosis (LCH) is commonly characterized by abnormal function and differentiation or proliferation of monocytes. In LCH, granulomatous lesions, including langerine-positive histocytes and inflammatory infiltrates, can occur to all tissues, particularly well in the bones, skin, lungs, and pituitary gland. In case of external auditory canal LCH, conductive hearing loss may occur, and the most common symptom is otorrhea. Here we present a case that 49-year-old male with external auditory canal mass. Since no invasive findings were seen in radiologic study, endoscopic transcanal excision was performed and LCH was proven by pathologic report. We present this case of external auditory canal LCH with the review of literature.

• Journal of Society of Preventive Korean Medicine
• /
• v.16 no.2
• /
• pp.95-111
• /
• 2012

Objective : The water extract of Danguiyonghoihwan (DGYHW) has been traditionally used in treatment of tinnitus in Oriental Medicine. However, little is known about the mechanism by which DGYHW rescues auditory neuronal cells from injury damages. Therefore, in this study I effort to elucidate the mechanism of the cytoprotective effect of the DGYHW extract on glutamate-induced auditory sensorineuronal cell death. Methods : I determined the elevated cell viability by DGYHW extract on glutamate-induced auditory sensorineuronal cell death. Glutamate induced neuronal damage in oranotypic explant culture also, glutamate decreased cell viability on VOT-33 cells but pretreatment with DGYHW inhibited cell death. Results : One of the main mediator of glutamate-induced cytotoxicity was known to generation of reactive oxygen species (ROS). Pretreatment with DGYHW inhibited this ROS generation from glutamated-stimulated VOT-33 cells. Also, I identified that the ROS-induced DCF-DA green fluorescence is reduced by DGYHW pretreatment. The critical markers of apoptotic cell death were cleavages of procaspase-3 protease protein. So I checked the expression level and cleavage of procaspase-3 protease protein. Glutamate-treated VOT-33 cells were shown to have cleavage of procaspase-3 protease proteins and following reduction of expression of these proteins. But I found that pre-treatment with DGYHW protects glutamate-induced changes of biochemical marker protein, caspase-3. Conclusion : These findings indicated that DGYHW may prevent cell death from glutamate induced VOT-33 cell death by inhibiting the ROS generation and modulation of protein expressions in procaspase-3, catalase and Bcl-2.

• Journal of Biomedical Engineering Research
• /
• v.28 no.2
• /
• pp.205-211
• /
• 2007

A novel envelope extraction algorithm for speech processor of cochlear implants, called adaptation algorithm, was developed which is based on a adaptation effect of the inner hair cell(IHC)/auditory nerve(AN) synapse. We achieved acoustic simulation and hearing experiments with 12 normal hearing persons to compare this adaptation algorithm with existent standard envelope extraction method. The results shows that speech processing strategy using adaptation algorithm showed significant improvements in speech recognition rate under most channel/noise condition, compared to conventional strategy We verified that the proposed adaptation algorithm may yield better speech perception under considerable amount of noise, compared to the conventional speech processing strategy.

• The Journal of the Acoustical Society of Korea
• /
• v.14 no.5
• /
• pp.51-57
• /
• 1995

In this paper, we study a noise-robust feature extraction method of speech signal based on auditory modeling. The auditory model consists of a basilar membrane, a hair cell model and spectrum output stage. Basilar membrane model describes a response characteristic of membrane according to vibration in speech wave, and is represented as a band-pass filter bank. Hair cell model describes a neural transduction according to displacements of the basilar membrane. It responds adaptively to relative values of input and plays an important role for noise-robustness. Spectrum output stage constructs a mean rate spectrum using the average firing rate of each channel. And we extract feature vectors using a mean rate spectrum. Simulation results show that when auditory-based feature extraction is used, the speech recognition performance in noisy environments is improved compared to other feature extraction methods.

• Korean Journal of Head & Neck Oncology
• /
• v.33 no.1
• /
• pp.15-19
• /
• 2017

Background/Objective: The survival and recurrence pattern of the patients with primary cancer of the external auditory canal was evaluated. Materials & Methods: Seventeen patients with primary cancer of the external auditory canal from 2002 to 2013 was analyzed retrospectively. Overall survival, recurrence free survival, local recurrence free survival and distant metastasis free survival was calculated by Kaplan-Meyer's method. Results: Five year overall survival rate, 5 year recurrence free survival rate, 5 year local recurrence free survival rate and 5 year distant metastasis free survival rate were 49.3% 54.9%, 64.7% and 69.6% respectively. The recurrence pattern is different to the pathologic type, squamous cell carcinoma or adenoid cystic carcinoma. The patients with squamous cell carcinoma showed local recurrence and the patients with adenoid cystic carcinoma showed distant metastasis mainly. Conclusion: Primary cancer of external auditory canal showed different clinical course depend on the pathologic diagnosis.

• Korean Journal of Audiology
• /
• v.23 no.1
• /
• pp.59-62
• /
• 2019

Primary tumors arising from the external auditory canal (EAC) are rare. We describe two cases of mass lesions within the EAC causing slowly progressive hearing loss without otorrhea or otalgia. Otoendoscopic examination demonstrated total obstruction of the EAC, and pure tone audiometry revealed conductive hearing loss. Based on the findings of the histopathologic examination, one patient was diagnosed with venous hemangioma that was treated using surgical resection, and the other patient was diagnosed with diffuse large B-cell lymphoma (DLBCL) that was treated using external-beam radiation therapy. Although primary tumors in the EAC are rare, both benign tumors such as venous hemangiomas and malignant lesions such as DLBCL should be considered as possible differential diagnoses of mass lesions in the EAC.

• Journal of Audiology & Otology
• /
• v.23 no.1
• /
• pp.59-62
• /
• 2019

Primary tumors arising from the external auditory canal (EAC) are rare. We describe two cases of mass lesions within the EAC causing slowly progressive hearing loss without otorrhea or otalgia. Otoendoscopic examination demonstrated total obstruction of the EAC, and pure tone audiometry revealed conductive hearing loss. Based on the findings of the histopathologic examination, one patient was diagnosed with venous hemangioma that was treated using surgical resection, and the other patient was diagnosed with diffuse large B-cell lymphoma (DLBCL) that was treated using external-beam radiation therapy. Although primary tumors in the EAC are rare, both benign tumors such as venous hemangiomas and malignant lesions such as DLBCL should be considered as possible differential diagnoses of mass lesions in the EAC.

• Journal of Electrical Engineering and Technology
• /
• v.12 no.6
• /
• pp.2378-2387
• /
• 2017

Violinists learn to make better sounds by hearing and evaluating their own playing though numerous practice. This study proposes a new method of auditory feedback, which mimics this violinists' step and verifies its efficiency using experiments. Making the desired sound quality of a violin is difficult without auditory feedback even though an expert violinist plays. An algorithm for controlling a robot arm of violin playing robot is determined based on correlations with bowing speed, bowing force, and sound point that determine the sound quality of a violin. The bowing speed is estimated by the control command of the robot arm, where the bowing force and the sound point are recognized by using a two-axis load cell and a photo interrupter, respectively. To improve the sound quality of a violin playing robot, the sounds information is obtained by auditory feedback system applied Short Time Fourier Transform (STFT) to the sounds from a violin. This study suggests Gaussian-Harmonic-Quality (GHQ) uses sounds' clarity, accuracy, and harmonic structure in order to decide sound quality, objectively. Through the experiments, the auditory feedback system improved the performance quality by the robot accordingly, changing the bowing speed, bowing force, and sound point and determining the quality of robot sounds by GHQ sound quality evaluation system.

• Journal of rehabilitation welfare engineering & assistive technology
• /
• v.6 no.2
• /
• pp.23-30
• /
• 2012

In this study, we developed a wireless rehabilitation auditory feedback gait training system for symmetrical weight-bearing in patient with CVA. The device consists of an instantaneous shoe equipped with two load-cell sensors. Auditory feedback can be applied according to the weight-bearing. For gait patterns analysis, cadence, walking velocity, stance/swing phase ratio and gait cycle were examined. The clinical test with six healthy volunteers and two hemiplegic patients was performed applying the auditory feedback system. Both normal subjects and hemiplegic patients were increased strength on weight-bearing in affected limb, walking velocity, and cadence after biofeedback device. Also, the stance time with weight-bearing was increased while the swing time was decreased in gait phase. It can be expected that by using the feedback system, the patient with lower limb disorder will be able to reach a better quality of weight-bearing during gait.

• Clinical and Experimental Otorhinolaryngology
• /
• v.11 no.4
• /
• pp.224-232
• /
• 2018

Objectives. Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown. We examined the presence and characteristics of SGN-neural stem cells (NSCs) in mice as a function of age. Methods. The expression of Nestin and Ki67 was examined in sequentially dissected cochlear modiolar tissues from mice of different ages (from postnatal day to 24 weeks) and the sphere-forming populations from the SGNs were isolated and differentiated into different cell types. Results. There were significant decreases in Nestin and Ki67 double-positive mitotic progenitor cells in vivo with increasing mouse age. The SGNs formed spheres exhibiting self-renewing activity and multipotent capacity, which were seen in NSCs and were capable of differentiating into neuron and glial cell types. The SGN spheres derived from mice at an early age (postnatal day or 2 weeks) contained more mitotic stem cells than those from mice at a late age. Conclusion. Our findings showed the presence of self-renewing and proliferative subtypes of SGN-NSCs which might serve as a promising source for the regeneration of auditory neurons even in adult mice.