• Journal of Haehwa Medicine
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• v.17 no.2
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• pp.185-198
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• 2008

Wished to examine closely effect that Atopy cream-Jawoongo ointment (A-J) used to atopy dermatitis disease patient get in atopy eruption control experimentally. In this research A-J ointment as treatment result to a NC/Nga mouse by BMAC ointment, clinical skin severity score decreased remarkably than control group. Thus, NC/Nga mice suffered from dermatitis very similar to human AD with IgE hyperproduction. Specially, result that measure IgE and IgG1 level in serum decreased remarkably than control group.

• Korean Journal of Human Ecology
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• v.23 no.4
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• pp.733-742
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• 2014

Atopic dermatitis is a chronic relapsing inflammatory skin disease. In the past years, numbers of children with atopic dermatitis has increased all over the world. Objective of this study was to evaluate awareness of students in atopy-friendly elementary schools about environmentally-friendly grown agricultural products and their practice levels for dietary guidelines. This study was conducted by using a questionnaire on 116 students from three atopy-friendly schools in Jin-an, Jeong-eup, and Gwang-ju and 124 students from general elementary schools. According to the results, the numbers of children who suffer from atopic dermatitis between atopy-friendly schools and general schools were not significantly different. Among, students with atopic dermatitis, more students in atopy-friendly school, compared to general school, restricted foods. Since different school feeding services have been provided, students in atopy-friendly schools generally get more information about the environmentally-friendly agricultural products through nutrition education. However, most results did not show differences in knowledge levels and practice levels for dietary guidelines for children between students in atopy-friendly schools and general schools about environmentally-friendly produces. However, students in atopy-friendly schools less frequently eat cookies, soda drinks, or fast foods. In conclusion, appropriate program for nutrition education should be provided to elementary school students with atopic dermatitis.

• Journal of Evidence-Based Herbal Medicine
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• v.1 no.2
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• pp.1-6
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• 2008

The internet is closely related to the lives of modern people in the 21st Century. Exchanging information with others over the internet in any place through is possible nowadays and such exchanging information has been developed at rapid speed also in the areas of medical care. The internet is an important and rapidly-evolving source of health-related information, and many patients with atopy dermatitis attempt to find information from the internet. This study was performed to investigate the current information available in atopy dermatitis on the internet in Korea. We chose three portal sites and two network communities to analyze the information in which the topic of 'atopy' could be found. Among the 2,024 web sites and 5,613 network communities, 98.2% of the web sites and 71.7% of the communities were related products or service advertisements, and some of them provided incorrect of exaggerated information. There were only 42 web sites and 75 available communities with genuine information, and most of these also presented unattested treatment methods, including alternative therapies. It is quite understandable that patients with atopy dermatitis want to seek information related to their disease and the internet has the potential to be a useful source of information. However, there are no regulations to control the accuracy and quality of information on the internet. We should take an active role in identifying the accuracy and evaluating the quality.

• Herbal Formula Science
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• v.15 no.1
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• pp.199-211
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• 2007

Inducible nitric oxide synthase (iNOS) are important inflammation enzyme and severe up-nitric oxide (NO) production by this enzyme has been intricated with pathogenesis of inflammation diseases as atopy dermatitis. The present study was designed in order to determine whether Sopungdojeok-san could inhibit atopy dermatitis through modulation of iNOS mRNA expression and NO production, We found that iNOS mRNA expression and NO production in RAW 264.7 macrophages stimulated with lipopolysaccharide dose-dependantly decreased by Sopungdojeok-san extract treatment (0.4 - 1.0 mg/ml). The distribution of iNOS positive reacted cell in atopy dermatitis elicited skin of mice were remarkably decreased by Sopungdojeok-san administration (2.5 ml/kg/day). The SOD ability of Sopungdojeok-san were dose-dependantly increased from 0.6 mg/ ml than butylated hydroxyanisole. These data likely indicate that Sopungdojeok-san may act as inflammatory regulator for atopy dermatitis may be possible to develop useful agent for chemopreventation of NO-intricate inflammatory diseases.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.5
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• pp.1092-1098
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• 2007

Inducible nitric oxide synthase (iNOS) are important inflammation enzyme and severe up-nitric oxide (NO) production by this enzyme has been intricate with pathogenesis of atopy dermatitis. The present study was designed in order to determine whether Cheonggi-san could inhibit atopy dermatitis through modulation of iNOS mRNA expression and NO production. We found that iNOS mRNA expression and NO production in RAW 264.7 macrophages stimulated with lipopolysaccharide dose-dependantly decreased by Cheonggi-san extract treatment (0.5 - 2.0 mg/ml). The distribution of iNOS positive reacted cell in NC/Nga mice with atopy dermatitis were decreased by Cheonggi-san extract treatment (2.5 ml/kg/day) and apoptosis were increased. These data likely indicate that Cheonggi-san may act as inflammatory regulator for atopy dermatitis and may be possible to develop useful agent for chemoprevention of NO intricate inflammatory diseases.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.2
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• pp.278-283
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• 2010

Inducible nitric oxide synthase (iNOS) are important inflammation enzyme and severe up-nitric oxide (NO) production by this enzyme has been intricate with pathogenesis of atopy dermatitis. The present study was designed in order to determine whether Lonicera japonica could inhibit atopy dermatitis through modulation of iNOS by NF-${\kappa}B$ suppression. We found that IKK mRNA and iNOS mRNA expression in RAW 264.7 macrophages stimulated with lipopolysaccharide dose-dependantly decreased by Lonicera japonica (0.4 - 1.0 mg/$m{\ell}$) and NO production decreased. The distribution of NF-${\kappa}B$ p65 and iNOS positive reacted cell in NC/Nga mice with atopy dermatitis were decreased by Lonicera japonica (45 mg/kg/day) and apoptosis were increased. These data likely indicate that Lonicera japonica may act as inflammatory regulator for atopy dermatitis through iNOS modulation by NF-${\kappa}B$B suppression and may be possible to develop useful agent for chemoprevention of NO intricate inflammatory diseases.

• Journal of Environmental Health Sciences
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• v.37 no.3
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• pp.193-200
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• 2011

Objective: The purpose of this study is to compare and analyze the level of exposure to volatile organic compounds for different kinds of households in apartments or houses and analyze the relation between atopy-related symptoms and concentration of volatile organic compounds in order to improve indoor air quality and start to build a process to prevent environmental diseases. Method: From July 2010 to November 2010, TVOC concentration levels were measured and analyzed in 402 general households and 236 weak households, totalling 638 households. Residents were asked to fill out a survey on environmental disease. All resources were analyzed using SPSS 12.0 program. Result: In comparing the differences in concentration levels of volatile organic compounds for different types of households, including existing apartments and houses, the type of housing did not affect the concentration level of volatile organic compounds, but the relevance with skin trouble, diagnosed atopy, and atopy systems all had statistical similarities. Moreover, above-limit volatile organic compounds showed statistical relevance with amount of ventilation, time of construction, skin trouble, diagnosed atopy and atopy symptoms. Conclusion: The study concludes that as the time of construction recedes further into the past and as the amount of ventilation is higher, the exposure level to volatile organic compounds was lower and the group that were suffering from atopy symptoms had higher exposure to volatile organic compounds.

• BioChip Journal
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• v.12 no.4
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• pp.304-308
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• 2018

Atopic disease is caused by a complex combination of environmental factors and genetic factors, and studies on influence of exposure to various environmental factors on atopic diseases are continuously reported. However, the exact cause of atopic dermatitis is not yet known. Our study was conducted to analyse the association of SNPs with the development of atopic disease in a small cohort. Samples were collected from the Mothers' and Children's Environmental Health (MOCEH) study and 192 cord blood DNA samples were used to identify incidence of atopy due to influence of exposure to environmental factors. Genetic elements were analysed using a precision medicine research (PMR) array designed with various SNPs for personalized medicine. Case-control analysis of atopy disease revealed 253 significant variants (p<0.0001) and SNPs on five genes (CARD11, ZNF365, KIF3A, DMRTA1, and SFMBT1) were variants identified in previous atopic studies. These results are important to confirm the genetic mutation that may lead to the onset of foetal atopy due to maternal exposure to harmful environmental factors. Our results also suggest that a small-scale genome-wide association analysis is beneficial to confirm specific variants as direct factors in the development of atopy.

• Environmental Analysis Health and Toxicology
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• v.27
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• pp.6.1-6.8
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• 2012

Objectives: Childhood allergic diseases are a major concern because they lead to a heavy economic burden and poor quality of life. The purpose of this study was to investigate the prevalence of childhood atopic dermatitis, asthma, allergic rhinitis, and the comorbidity of allergic diseases in Seoul, Korea. Methods: We conducted a cross-sectional survey between May and October 2010 to evaluate the prevalence of childhood allergic diseases, including atopic dermatitis, asthma, and allergic rhinitis, using a questionnaire from the International Study of Asthma and Allergies in Childhood group. Each questionnaire was completed by the parent or guardian of a child. Results: In the 31,201 children studied, the prevalence of atopic dermatitis symptoms in the past 12 months was 19.3% in children 0 to 3 years of age, 19.7% in children 4 to 6 years of age, 16.7% in children 7 to 9 years of age, and 14.5% in children 10 to 13 years of age (p for trend < 0.001). The prevalence of asthma in these age groups was 16.5%, 9.8%, 6.5%, and 5.4%, respectively (p for trend < 0.001). The prevalence of allergic rhinitis in these age groups was 28.5%, 38.0%, 38.5%, and 35.9%, respectively (p for trend = 0.043). The percentage of subjects with both atopic dermatitis and asthma, both asthma and allergic rhinitis, or both atopic dermatitis and allergic rhinitis was 2.5%, 4.7%, and 8.7%, respectively. The prevalence of comorbid allergic diseases decreased with age (p for trend < 0.001). Conclusions: Our study revealed that the prevalence of some allergic diseases, such as atopic dermatitis and asthma, was relatively high in very young children and that all of the principal allergic diseases in children often co-exist.

• The Korean Journal of Food And Nutrition
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• v.18 no.4
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• pp.380-384
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• 2005

The aim of this study is to recognize that functional herbal extract is effective to treat the atopy dermatitis patients. The result of general survey of 36 patients who visited the pharmacy and oriental medicine clinic, males had higher ratio of troubling the atopy dermatitis than females had and the atopy suffered patients was higher under 20 age than the other age. The atopy symptom highly appeared on the leg and fleshy inside of the thigh and the patients over the 50 percentage have the part presented over three of atopy symptoms. The results taken functional herbal extract, the patients got better in atopy symptoms than before taken that.