• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.3
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• pp.723-733
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• 2009

The purpose of this study is to evaluate the difference about pathogenesis of normal group and depression group(who' pulmonary function is below expected value). Author used DSOM to investigate oriental pathogenesis. Depression group is consisted of people who's FVC%(forced vital capacity)is below 80% or $FEV_1$/FVC%(Forced Expiratory Volume in 1sec/FVC) is below 70%, and they don't have history of lung disease(Athma, tuberculosis, COPD, suchlike). Normal group is consisted of people who's FVC%(Forced Vital Capacity) is in 80-120% and $FEV_1$/FVC%(Forced Expiratory Volume in 1sec/FVC) is above 70%. they also don't have history of lung disease. Author carried out each group's PFT(pulmonary function test) by ATS(American Thoracic Society) method. DSOM was used for oriental pathogenesis investigation of two groups. There was significant difference between normal group and depression group in Kidney(p<0.05). In depression group comparison of sex, there was significant difference between male and female in stagnation of qi, cold, heat, spleen, phlegm(p<0.05). In Normal group there was significant difference between male and female in stagnation of qi, blood stasis, cold, heat, spleen(p<0.05). In depression group comparison of smoke, there was no significant difference between smoker and non-smoker(p<0.05). In Normal group comparison of smoke, there was significant difference between smoker and non-smoker in heat(p<0.05). This result showed difference of the pathogenesis between Depression group and Normal group.

• Food Science of Animal Resources
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• v.32 no.3
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• pp.364-368
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• 2012

Bovine lactoferrin is well known as biological activator in defense mechanism related some cells. In this study, we was investigated about the immune modulator as a role of lactoferrin through the transcriptional regulation of genes associated with hypersensitivity such as allergy, athma and inflammatory disease. Effects of inflammatory reaction of bovine lactoferrin was carried out by RT-PCR analysis from isolated total RNA treated with lactoferrin 0, 10, 50, 100, 500 ${\mu}g/mL$ and PMA 100 ng/mL. The expression of the TYROBP, PITPNA, IL-10, SLP1, DC-stamp and ICAM-1 mRNA were increased by synergy effect of bovine lactoferrin and PMA. The results of RT-PCR showed that bovine lactoferrin and PMA had an effect of immune modulator by enhancement of TYROBP, PITPNA, SLP1, DC-stamp, IL-10 and ICAM-1 gene transcription in U937, Mutz-3 and NK92 cells, respectively. Bovine lactoferrin showed a potential of biological function which could be used for industrial applications as a material of food and pharmaceutical.

• Journal of the Korea Convergence Society
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• v.8 no.4
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• pp.37-48
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• 2017

The purpose of the study was to identify factors influencing the knowledge and management of allergic disease. Participants were 220 childcare teachers working in childcare facility, date was collected through self-questionnaire. Data was analyzed using SPSS/WIN 23.0. Age(p=0.13), experience of education(0.49) showed significant difference in athma/ allergic rhinitis. Experience of education(p=0.45), necessity of education(p=.034) in asthma/ allergic rhinitis showed significant difference. There is no significant difference in knowledge and management of atopic dermatitis. Allergic disease management and age accounted for 36.2% influencing on knowledge of asthma/allergic rhinitis. Allergic disease knowlege, education experience and necessity of education accounted for 43.1% influencing management of asthma/ allergic rhinitis. Based on the findings of this study, it can be used to educational programs data for childcare teacher.

• Tuberculosis and Respiratory Diseases
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• v.44 no.3
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• pp.559-573
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• 1997

Background : Asthma causes recurrent episodes of wheezing, breathlessness, chest tightness, and cough. These symptoms are usually associated with widespread but variable airflow limitation that is partly reversible either spontaneously or with treatment. The inflammation also causes an associated increase in airway responsiveness to a variety of stimuli. Method : Of the 403 adult bronchial asthma patients enrolled from March 1992 to March 1994 in Allergy Clinics of Severance Hospital in Yonsei University, this study reviewed the 97 cases to evaluate the treatment effects and to analyse prognostic factors. The patients were classified to five groups according to treatment responses ; group 1 (non control group) : patients who were not controlled during following up, group 2 (high step treatment group) : patients who were controlled longer than 3 months by step 3 or 4 treatment of "Global initiative for asthma, Global strategy for asthma management and prevention" (NHLBI/WHO) with PFR(%) larger than 80%, group 3 (short term control group) : patients who were controlled less than 1 year by step 1 or 2 treatment of NHLBI/WHO, group 4 (intermediate term control group) : patients who were controlled for more than 1 year but less than 2 years by step 1 or 2 treatment of NHLBI/WHO, group 5 (long term control group) : patients who were controlled for more than 2 years by step 1 or 2 treatment of NHLBI/WHO. Especially the patients who were controlled more than 1 year with negatively converted methacholine test and no eosinophil in sputum were classified to methacholine negative conversion group. We reviewed patients' history, atopy score, total IgE, specific IgE, methacholine PC20 and peripheral blood eosinophil count, pulmonary function test, steroid doses and aggrevation numbers after treatment. Results : On analysis of 98 patients, 20 cases(20.6%) were classified to group 1, 26 cases(26.8%) to group 2, 23 cases(23.7%) to group 3, 15 cases(15.5%) to group 4, and 13 cases(13.4%) to groups 5. There were no differences of sex, asthma type, family history, smoking history, allergic rhinitis and aspirin allergy among the groups. In long term control group, asthma onset age was younger, symptom duration was shorter, and initial pulmonary function was better. The long term control group required lower amounts of oral steroid. had less aggrevation during first 3months after starting treatment and shorter duration from enrollment to control Atopy, allergic skin test, sputum and blood eosinophil, total IgE, nonspecific bronchial responsiveness was not significantly different among the groups. Seven out of 28 patients who were controlled more than 1 years showed negatively converted methachloine test and no eosinophils in the sputum. The mean control duration was $20.3{\pm}9.7$ months and relapse did not occur. Conclusion : Patients who had asthma of onset age younger, shorter symptom duration, better PFT, lower treatment initial steps, lower amounts of steroid needs and less aggravation numbers after starting treatment were classified in the long term control groups compared to the others.