• Kidney Research and Clinical Practice
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• 제41권3호
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• pp.298-309
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• 2022

Background Hyponatremia overcorrection can result in irreversible neurologic impairment such as osmotic demyelination syndrome. Few prospective studies have identified patients undergoing hypertonic saline treatment with a high risk of hyponatremia overcorrection. Methods We conducted a post hoc analysis of a multicenter, prospective randomized controlled study, the SALSA trial, in 178 patients aged above 18 years with symptomatic hyponatremia (mean age, 73.1 years; mean serum sodium level, 118.2 mEq/L). Overcorrection was defined as an increase in serum sodium levels by >12 or 18 mEq/L within 24 or 48 hours, respectively. Results Among the 178 patients, 37 experienced hyponatremia overcorrection (20.8%), which was independently associated with initial serum sodium level (≤110, 110-115, 115-120, and 120-125 mEq/L with 7, 4, 2, and 0 points, respectively), chronic alcoholism (7 points), severe symptoms of hyponatremia (3 points), and initial potassium level (<3.0 mEq/L, 3 points). The NASK (hypoNatremia, Alcoholism, Severe symptoms, and hypoKalemia) score was derived from four risk factors for hyponatremia overcorrection and was significantly associated with overcorrection (odds ratio, 1.41; 95% confidence interval, 1.24-1.61; p < 0.01) with good discrimination (area under the receiver-operating characteristic [AUROC] curve, 0.76; 95% CI, 0.66-0.85; p < 0.01). The AUROC curve of the NASK score was statistically better compared with those of each risk factor. Conclusion In treating patients with symptomatic hyponatremia, individuals with high hyponatremia overcorrection risks were predictable using a novel risk score summarizing baseline information.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1873-1880
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• 2015

Background: A recent genome-wide association study (GWAS) on patients with chronic hepatitis C (CHC) treated with peginterferon and ribavirin (pegIFN-${\alpha}$/RBV) identified a single nucleotide polymorphism (SNP) on chromosome 19 (rs12979860) which was strongly associated with a sustained virological response (SVR). The aim of this study was twofold: to study the relationship between IL28B rs12979860 and sustained virological response (SVR) to pegIFN-${\alpha}$/RVB therapy among CHC patients and to detect the rs12979860 polymorphism by high resolution melting curve (HRM) assay as a simple, fast, sensitive, and inexpensive method. Materials and Methods: The study examined outcomes in 100 patients with chronic hepatitis C in 2 provinces of Iran from December 2011 to June 2013. Two methods were applied to detect IL28B polymorphisms: PCR-sequencing as a gold standard method and HRM as a simple, fast, sensitive, and inexpensive method. Results: The frequencies of IL28B rs12979860 CC, CT, and TT alleles in chronic hepatitis C genotype 1a patients were 10% (10/100), 35% (35/100), and 6% (6/100) and in genotype 3a were 13% (13/100), 31% (31/100), and 5% (5/100), respectively. In genotype 3a infected patients, rs12979860 (CC and CT alleles) and in genotype 1a infected patients (CC allele) were significantly associated with a sustained virological response (SVR). The SVR rates for CC, CT and TT (IL28B rs12979860) were 18%, 34% and 4%, respectively. Multiple logistic regression analysis identified two independent factors that were significantly associated with SVR: IL-28B genotype (rs 12979860 CC vs TT and CT; odds ratio [ORs], 7.86 and 4.084, respectively), and HCV subtype 1a (OR, 7.46). In the present study, an association between SVR rates and IL28B polymorphisms was observed. Conclusions: The HRM assay described herein is rapid, inexpensive, sensitive and accurate for detecting rs12979860 alleles in CHC patients. This method can be readily adopted by any molecular diagnostic laboratory with HRM capability and will be clinically beneficial in predicting treatment response in HCV genotype 1 and 3 infected patients. In addition, it was demonstrated that CC and CT alleles in HCV-3a and the CC allele in HCV-1a were significantly associated with response to pegIFN-${\alpha}$/RBV treatment. The present results may help identify subjects for whom the therapy might be successful.

• Korean Journal of Radiology
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• 제20권5호
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• pp.759-772
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• 2019

Objective: To investigate the value of ultrasound (US) microflow assessment in distinguishing malignant from benign solid breast masses as well as the association between US parameters and histologic microvessel density (MVD). Materials and Methods: Ninety-eight breast masses (57 benign and 41 malignant) were examined using Superb Microvascular Imaging (SMI) and contrast-enhanced US (CEUS) before biopsy. Two radiologists evaluated the quantitative and qualitative vascular parameters on SMI (vascular index, morphology, distribution, and penetration) and CEUS (time-intensity curve analysis and enhancement characteristics). US parameters were compared between benign and malignant masses and the diagnostic performance was compared between SMI and CEUS. Subgroup analysis was performed according to lesion size. The effect of vascular parameters on downgrading Breast Imaging Reporting and Data System (BI-RADS) category 4A masses was evaluated. The association between histologic MVD and US parameters was analyzed. Results: Malignant masses were associated with a higher vascular index (15.1 ± 7.3 vs. 5.9 ± 5.6), complex vessel morphology (82.9% vs. 42.1%), central vascularity (95.1% vs. 59.6%), penetrating vessels (80.5% vs. 31.6%) on SMI (all, p < 0.001), as well as higher peak intensity (37.1 ± 25.7 vs. 17.0 ± 15.8, p < 0.001), slope (10.6 ± 11.2 vs. 3.9 ± 4.2, p = 0.001), area (1035.7 ± 726.9 vs. 458.2 ± 410.2, p < 0.001), hyperenhancement (95.1% vs. 70.2%, p = 0.005), centripetal enhancement (70.7% vs. 45.6%, p = 0.023), penetrating vessels (65.9% vs. 22.8%, p < 0.001), and perfusion defects (31.7% vs. 3.5%, p < 0.001) on CEUS (p ≤ 0.023). The areas under the receiver operating characteristic curve (AUCs) of SMI and CEUS were 0.853 and 0.841, respectively (p = 0.803). In 19 masses measuring < 10 mm, central vascularity on SMI was associated with malignancy (100% vs. 38.5%, p = 0.018). Considering all benign SMI parameters on the BI-RADS assessment, unnecessary biopsies could be avoided in 12 category 4A masses with improved AUCs (0.500 vs. 0.605, p < 0.001). US vascular parameters associated with malignancy showed higher MVD (p ≤ 0.016). MVD was higher in malignant masses than in benign masses, and malignant masses negative for estrogen receptor or positive for Ki67 had higher MVD (p < 0.05). Conclusion: US microflow assessment using SMI and CEUS is valuable in distinguishing malignant from benign solid breast masses, and US vascular parameters are associated with histologic MVD.

• Korean Journal of Radiology
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• 제24권1호
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• pp.39-50
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• 2023

Objective: To assess the contrast-enhanced CT and ultrasonography (US) findings of intracholecystic papillary neoplasm (ICPN) and determine the imaging features predicting ICPN associated with invasive carcinoma (ICPN-IC). Materials and Methods: In this retrospective study, we enrolled 119 consecutive patients, including 60 male and 59 female, with a mean age ± standard deviation of 63.3 ± 12.1 years, who had pathologically confirmed ICPN (low-grade dysplasia [DP] = 34, high-grade DP = 35, IC = 50) and underwent preoperative CT or US. Two radiologists independently assessed the CT and US findings, focusing on wall and polypoid lesion characteristics. The likelihood of ICPN-IC was graded on a 5-point scale. Univariable and multivariable logistic regression analyses were performed to identify significant predictors of ICPN-IC separately for wall and polypoid lesion findings. The performances of CT and US in distinguishing ICPN-IC from ICPN with DP (ICPN-DP) was evaluated using the area under the receiver operating characteristic curve (AUC). Results: For wall characteristics, the maximum wall thickness (adjusted odds ratio [aOR] = 1.4; 95% confidence interval [CI]: 1.1-1.9) and mucosal discontinuity (aOR = 5.6; 95% CI: 1.3-23.4) on CT were independently associated with ICPN-IC. Among 119 ICPNs, 110 (92.4%) showed polypoid lesions. Regarding polypoid lesion findings, multiplicity (aOR = 4.0; 95% CI: 1.6-10.4), lesion base wall thickening (aOR = 6.0; 95% CI: 2.3-15.8) on CT, and polyp size (aOR = 1.1; 95% CI: 1.0-1.2) on US were independently associated with ICPN-IC. CT showed a higher diagnostic performance than US in predicting ICPN-IC (AUC = 0.793 vs. 0.676; p = 0.002). Conclusion: ICPN showed polypoid lesions and/or wall thickening on CT or US. A thick wall, multiplicity, presence of wall thickening in the polypoid lesion base, and large polyp size are imaging findings independently associated with invasive cancer and may be useful for differentiating ICPN-IC from ICPN-DP.

• 한국제4기학회지
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• 제18권1호통권22호
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• pp.31-39
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• 2004

東北 日本의 후빙기 사면붕괴 이력을 복원하기 위하여 3지역(川통盆地, 茂庭, 高田濕原, 根白石濕原)의 습지 퇴적물의 화분조성과 무기질함량을 대상으로 安定-不安定 曲線 그래프(이하 S-U曲線)와 灼熱減量 曲線 그래프(이하 IL曲線)를 작성하였다. 그 결과, S-U曲線에 의하면 사면붕괴 발생빈도가 높은 시기는 川통盆地에서는 약 5,600~4,670yrB.P.의 1회, 茂庭 $\cdot$ 高田濕原에서는 약 6,390~5,070yrB.P.와 약 4,750~3,800yrB.P.의 2회, 根白石濕原에서는 약 6,630~6,070yrB.P., 약 5,890~5,360yrB.P. 및 약 5,000~4,650yrB.P.의 3회가 확인되었다. 그리고 IL曲線에 의하면 사면붕괴 발생빈도가 높은 시기는 川통盆地에서는 약 5,600~5,140yrB.P.의 1회, 茂庭 $\cdot$ 高田濕原에서는 약 6,390~6,170yrB.P.와 약 4,750~2,840yrB.P.의 2회가 확인되었다. 이와같은 분석결과는 선행연구에서 조사지역의 지형 $\cdot$지질단면도로부터 추정된 결과와 매우 유사한 경향을 나타내는 것으로 판명되었다.

• 화약ㆍ발파
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• 제35권1호
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• pp.1-17
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• 2017

공기를 통해 이동하는 폭발파에 의한 압력 및 압력에 의해 지표 및 지하구조물에 미치는 영향을 이해하는 것은 매우 중요하다. 폭발의 충격이 구조물에 미치는 영향을 컴퓨터 시뮬레이션하기 위해서는 시간과 거리에 따른 압력의 변화를 결정하여야 한다. 기존의 연구를 통해 압력의 변화와 관련되는 인자들을 추정하기 위한 여러 경험식들이 개발되었다. 본 연구에서는 최대압력, 양압지속기간, 임펄스, 최소음압, 음압지속기간, 폭발파 도착시간과 감쇠상수를 예측하는 경험식들을 조사 분석하였으며 가장 널리 사용되고 있는 Kingery 경험식과 다른 경험식에 의한 압력 변화를 비교하였다.

• 보건의료산업학회지
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• 제11권2호
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• pp.105-115
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• 2017

Objectives : The aim of this study was to suggest the optimal cut off for best, very good, good, slightly bad, and bad grades. Methods : The subjects were recruited from 4 areas of South Korea and 487 questionnaires were analyzed. The nominal and continuous self-rated health questions were used to reveal the optimal cut off and the Short Form-12 Health Survey questionnaire (SF-12) was additionally used. Frequency, Pearson's correlation coefficient, and ROC-curve analysis were used; the significance level was <.05. Results : Subjects assigned 15(3.1%), 90(18.5%), 237(48.7%), 130(26.7%), and 15(3.1%) to best, very good, good, slightly bad and bad groups respectively. The self-rated health score was associated with total Component (r=.563, p<.001), Physical Component (r=.520, p<.001) and Mental Component of SF-12 (r=.303, p<.001). The optimal cut off was 80.5, 70.5, 53.5, and 40.5 for best, very good or more, good or more, and under slightly bad respectively and area under curve was 0.898, 0.908, 0.945, and 0.908 accordingly. Conclusions : This study suggests that the self-rated health score and grade could be integrated with the optimal cut off.

• Structural Engineering and Mechanics
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• 제64권1호
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• pp.11-21
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• 2017

It has been observed in the past that, the reinforced concrete (RC) bridge columns are very often subjected to torsional moment in addition to flexure and shear during seismic vibration. Ignoring torsion in the design can trigger unexpected shear failure of the columns (Farhey et al. 1993). Performance based seismic design is a popular design philosophy which calls for accurate prediction of the hysteresis behavior of structural elements to ensure safe and economical design under earthquake loading. However, very few investigations in the past focused on the development of analytical models to accurately predict the response of RC members under cyclic torsion. Previously developed hysteresis models are not readily applicable for torsional loading owing to significant pinching and stiffness degradation associated with torsion (Wang et al. 2014). The present study proposes an improved polygonal hysteresis model which can accurately predict the hysteretic behavior of RC circular and square columns under torsion. The primary curve is obtained from mechanics based softened truss model for torsion. The proposed model is validated with test data of two circular and two square columns. A good correlation is observed between the predicted and measured torque-twist behavior and dissipated energy.

• Wind and Structures
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• 제8권2호
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• pp.79-88
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• 2005

This paper deals with a unified way for calculating vortex-induced vibrations (Aeolian vibrations in transmission line parlance) of undamped single overhead conductors. The main objective of the paper is to identify reduced parameters which would unify the predicted vibration response to the largest possible extent. This is actually done by means of a simple mathematical transformation resulting, for a given terrain (associated to a given wind turbulence intensity), into a single, unified response curve that is applicable to any single multi-layered aluminium conductor. In order to further validate the above process, the predicted, unified response curve is compared with measured response curves drawn from tests run on a full-scale test line using several aluminium-conductor-steel-reinforced (ACSR), all-alloy-aluminium-conductor (AAAC) and aluminium-conductor-alloy-reinforced (ACAR) conductors strung at different tensions. On account of the expected scatter in the results from such field tests, the agreement is shown to be good. The final results are expressed by means of only four different curves pertaining to four different terrain characteristics. These curves may then be used to assess the vibration response of any undamped single, multi-layer aluminium conductor of any diameter, strung at any practical tension.

• 한국물환경학회지
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• 제28권3호
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• pp.409-417
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• 2012

SWAT model was applied for the Nakdong River Basin to characterize water quality variability and assess the feasibility of using the load duration curve to water quality management. The basin was divided into 67 sub-basins considering various watershed environment, and rainfall runoff and pollutant loading were simulated based on 6 year measurements of meteo-hydrological data, discharge data of treatment plants, and water quality data (SS, T-N and T-P). The results demonstrate that non-point source loads during wet season increase by 80 ~ 95% of total loads. Although the rate of water flow governs the amount of SS that is transported to the main streams, nutrient concentrations are highly elevated during dry season by being concentrated. This phenomenon is more pronounced in the lower basin, receiving large amounts of urban point source discharges such as treated sewages. Also, the load duration curves (LDC) demonstrate dominant source problems based on the load exceedances, showing that SS concentrations are associated with the rainy season and nutrients, such as T-P, may be more concentrated at low flow and more diluted at higher flow. Overall, the LDC method could be used conveniently to assess watershed characteristics and pollutant loads in watershed scale.