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QM/MM-MD Simulation을 통한 수용액 상에서의 Formamide Hydrolysis Mechanism 연구

  • Baek, Yong-Su;Choe, Cheol-Ho
    • Proceeding of EDISON Challenge
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    • 2014.03a
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    • pp.141-155
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    • 2014
  • Peptide bond hydrolysis는 세포 내외의 생화학반응에 있어서 핵심이다. 하지만 amide Hydrolysis Mechanism은 아직 명확하게 규명되지 않았다. pH가 중성인 물에서의 비 촉매 가수분해가 발생하는 몇몇 실험적 증거가 있지만, 해당 반응 매커니즘은 4 가지(non-assisted concerted, non-assisted step-wise, assisted concerted, assisted step-wise)로 여전히 논란이 있다. 이번 연구에서는, Formamide의 가능한 Hydrolysis Mechanism을 자세히 연구해보고자 한다. 먼저, Ab-initio 계산을 통해 4가지 반응 메커니즘의 다시 한번 확인하고, quantum chemical calculations과 quantum mechanical molecular dynamic이 결합된 (QMMD) simulation을 통하여 water solvent에서의 반응 메커니즘의 에너지관계를 규명하였다. 결론적으로 아직 계산이 끝나지 않은 supported concerted mechanism을 제외한 모든 계산에서 non-supported, supported 두 system 모두에서 step-wise가 일어나기 쉬웠고, non-supported 보다 supported mechanism이 선호됨을 보였다. Intermediate인 amino-gem-diol의 수용액 상에서 안정화 또한 나타났다. 이는 Ab-initio 계산만 통해서는 정확하게 산출할 수 없는 엔트로피의 영향을 잘 보여준다.

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Stability criterion and its calculation for sail-assisted ship

  • Hu, Yihuai;Tang, Juanjuan;Xue, Shuye;Liu, Shewen
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.7 no.1
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    • pp.1-9
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    • 2015
  • Stability criterion and its calculation are the crucial issue in the application of sail-assisted ship. However, there is at present no specific criterion and computational methods for the stability of sail-assisted ship. Based on the stability requirements for seagoing ships, the stability criterion of the sail-assisted ships is suggested in this paper. Furthermore, how to calculate the parameters and determine some specific coefficients for the ship stability calculation, as well as how to redraw stability curve are also discussed in this paper. Finally, to give an illustration, the proposed method is applied on a sail assisted-ship model with comments and recommendations for improvement.

The Effect of Dispatcher-assistance on Cardiopulmonary Resuscitation Performance (전화상담원 도움이 심폐소생술 수행에 미치는 효과)

  • Pi, Hye-Young
    • The Korean Journal of Emergency Medical Services
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    • v.14 no.2
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    • pp.5-12
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    • 2010
  • Purpose : The comparative effectiveness of without dispatcher-assisted telephone instruction CPR but received lectured and training(NDCPR) and without received lectured and training CPR but dispatcher-assisted telephone instruction(DCPR) in CPR. Methods : The CPR instruction to 774 students and faculties in universities and colleges. There selected without dispatcher-assisted telephone instruction CPR but received lectured and training(NDCRP) and without received lectured and training CPR but dispatcher-assisted telephone instruction(DCPR). Compare the effectiveness to sills performance of DCPR and NDCPR students and faculties of according to the CPR. Results : 397(51%) students and faculties was DCPR and 377(49%) students and faculties was NDCPR. There was no difference in the compression depth, hand position, adequacy of recoil, volume of ventilation, self-confidence, and willingness to do CPR between the two instructional methods. Conclusion : Under the guide of dispatcher-assisted CPR instruction integrated into mobil phone, novice could perform more effective CPR. This method could be used as a supplement to CPR practice and skill retention.

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Investigation of Trap-Assisted-Tunneling Mechanism in L-Shaped Tunneling Field-Effect-Transistor (L형 터널 트랜지스터의 트랩-보조-터널링 현상 조사)

  • Najam, Faraz;Yu, Yun Seop
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2018.10a
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    • pp.512-513
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    • 2018
  • Trap-assisted-tunneling (TAT) degrades subthreshold slope of real-world tunneling field-effect-transistors (TFET) and it should be considered in the simulation. However, its mechanism is not very well understood in line tunneling type L-shaped TFET (LTFET). This study investigates TAT mechanism in LTFETs using dynamic nonlcoal Schenk model. Both phonon assisted and direct band to trap tunneling events are considered in this study.

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Performance Analysis of Content Distribution in Peer-Assisted CDN (Peer-Assisted CDN에서 콘텐츠 전송 성능 분석)

  • Son, Sei-Il;Yeom, Jong-Ho;Choi, Hak-soo
    • Proceedings of the Korea Information Processing Society Conference
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    • 2009.04a
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    • pp.968-970
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    • 2009
  • Peer-Assisted CDN은 CDN과 P2P 기술을 상호보완적으로 이용해서 많은 사용자들에게 효율적으로 콘텐츠를 전송한다. 본 논문에서는 Peer-Assisted CDN과 전통적인 CDN, P2P 시스템의 성능 비교를 위한 간단한 성능 분석 모델을 제시한다. 그리고 실재 트레이스를 기초로 트래픽, 전송량, 다운로드 속도 측면에서 Peer-Assisted CDN과 CDN의 성능을 비교 한다. 본 논문의 결과에 따르면, Peer-Assisted CDN이 총 업로드 용량, 다운로드 속도, 확장성 측면에서 일반 CDN 보다 우수하다.

The Effects of Robot-Assisted Rehabilitation on the Gait Ability of Stroke Patients with Hemiplegia: A Mixed Methods Research Study (보행로봇 재활치료가 편마비 뇌졸중 환자의 보행능력에 미치는 효과: 혼합연구설계)

  • Park, Min Gyeong;Ha, Yeong Mi;Cho, Hyung Je;Jeon, Mi Yang
    • Journal of Korean Biological Nursing Science
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    • v.23 no.1
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    • pp.72-82
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    • 2021
  • Purpose: This study used a mixed methods research design in an attempt to verify the effects of robot-assisted rehabilitation on the gait ability of stroke patients with hemiplegia, and thereby further understand the benefits and challenges of stroke patients' experiences relying on robot-assisted rehabilitation. Methods: An exploratory sequential mixed methods study design was used in order to combine both quantitative and qualitative data. For the quantitative data collection, a total of 30 stroke patients with hemiplegia were recruited from one rehabilitation hospital. Qualitative data were collected through individual interviews using semi-structured questionnaires for a group of 15 patients who were currently undergoing robot-assisted rehabilitation. The data were analyzed through qualitative content analysis. Results: As a result of the quantitative analysis, there were significant differences between the two groups in terms of daily living activity patterns, total number of steps, and average walking speed. As a result of the qualitative analysis, the four main themes derived consisted of, 'curiosity about the usage of robot-assisted rehabilitation,' 'pleasure experienced while using the robots,' 'insufficient information about robots,' and 'a lack of education about robot-assisted rehabilitation.' Conclusions: Robot-assisted rehabilitation had a significant effect on the walking ability of stroke patients with hemiplegia. Additionally, stroke patients with hemiplegia experienced difficulty during the course of their robot-assisted rehabilitation, due to a lack of sufficient information on correct usage techniques. These quantitative and qualitative findings could provide the basic foundation for the development of an educational program on robot-assisted rehabilitation.

Systemic Analysis on Laparoscope-Assisted Gastrectomy for Patients with Gastric Cancer

  • Hu, Jun-Hong;Tang, Hong-Na;Ma, Yong-Ping;Wang, Chen-Yu;Yao, Kun-Hou;Zhang, Jun-Jie;Ren, Xue-Qun
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.5
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    • pp.2027-2029
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    • 2015
  • Background: Laparoscope-assisted gastrectomy in treating patients with gastric cancers developed with a background of highly invasive traditional surgery and is being increasingly performed in the Asian Pacific area. This study systemically investigated the technique and clinical results for comparison with traditional radical subtotal gastrectomy for gastric cancers. Methods: Clinical studies evaluating the effectiveness and side effects of laparoscope-assisted gastrectomy in treating patients with gastric cancers were identified using a predefined search strategy. Summary rates of effectiveness and side effects of laparoscope-assisted gastrectomy were calculated. Results: Thirteen clinical studies which including 1,412 patients with gastric cancer treated by laparoscope-assisted gastrectomy were considered eligible for inclusion. Systemic analysis showed that, for all patients, the pooled resection rate was 100%. Major adverse effects were anastomotic stenosis, abdominal abscess, abdominal bleeding, postoperative ileus. Treatment related death occurred in 0. 71% (10/1412). Conclusion: This systemic analysis suggests that laparoscope-assisted gastrectomy in treating patients with gastric cancers is associated with good curative rate and acceptable complications.

The Effects of Robot-Assisted Gait Training for the Patient With Post Stroke: A Meta-Analysis (뇌졸중 환자에게 적용한 로봇보행 재활훈련의 효과: 메타분석)

  • Park, So-Yeon
    • Physical Therapy Korea
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    • v.22 no.2
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    • pp.30-40
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    • 2015
  • Robot-assisted rehabilitation therapy has been used to increase physical function in post-stroke patients. The aim of this meta-analysis was to identify whether robot-assisted gait training can improve patients' functional abilities. A comprehensive search was performed of PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Physiotherapy Evidence Database (PEDro), Academic Search Premier (ASP), ScienceDirect, Korean Studies Information Service System (KISS), Research Information Sharing Service (RISS), Korea National Library, and the Korean Medical Database up to April, 2014. Fifteen eligible studies researched the effects of robot-assisted gait training to a control group. All outcome measures were classified by International Classification of Functioning, Disability, and Health (ICF) domains (body function and structures, activity, and participation) and were pooled for calculating the effect size. The overall effect size of the robot-assisted gait training was .356 [95% confidence interval (CI): .186~.526]. When the effect was compared by the type of electromechanical robot, Gait Trainer (GT) (.471, 95% CI: .320~.621) showed more effective than Lokomat (.169, 95% CI: .063~.275). In addition, acute stroke patients showed more improvement than others. Although robot-assisted gait training may improve function, but there is no scientific evidence about the appropriate treatment time for one session or the appropriate duration of treatment. Additional researchers are needed to include more well-designed trials in order to resolve these uncertainties.

The Approach of Robot-assisted Gait Therapy for Locomotor Recovery of Chronic Stroke Patients: a Case Report

  • Shin, Hee-Joon;Lee, Ju-Hyeok;Seo, Dong-Kyu;Kim, Hong-Rae;Moon, Ok-Kon;Park, Si-Eun;Park, Joo-Hyun;Kim, Nyeon-Jun;Min, Kyung-Ok
    • Journal of International Academy of Physical Therapy Research
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    • v.2 no.1
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    • pp.207-213
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    • 2011
  • In this case report, we investigated the effects of robot-assisted gait therapy in a chronic stroke patient using motor assessment and gait analysis. A patient who suffered from the right hemiparesis following the left corona radiata and basal ganglia infarction received 30 minutes of robot-assisted gait therapy, 3 times a week for 4 weeks. Outcome was measured using Motoricity index(MI), Fugl-Meyer assessment(FMA), modified motor assessment scale(MMAS), isometric torque, body tissue composition, 10-meter gait speed and gait analysis. After robot-assisted gait therapy, the patient showed improvement in motor functions measured by MI, FMA, MMAS, isometric torque, skeletal muscle mass, 10-meter gait speed. In gait analysis, cadence, single support time, double support time, step length, walking speed improvement in after robot-assisted gait therapy. The results of this study showed that robot-assisted gait therapy is considered to facilitate locomotor recovery of the chronic hemiparetic stroke patient.

Novel Class of Entanglement-Assisted Quantum Codes with Minimal Ebits

  • Dong, Cao;Yaoliang, Song
    • Journal of Communications and Networks
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    • v.15 no.2
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    • pp.217-221
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    • 2013
  • Quantum low-density parity-check (LDPC) codes based on the Calderbank-Shor-Steane construction have low encoding and decoding complexity. The sum-product algorithm(SPA) can be used to decode quantum LDPC codes; however, the decoding performance may be significantly decreased by the many four-cycles required by this type of quantum codes. All four-cycles can be eliminated using the entanglement-assisted formalism with maximally entangled states (ebits). The proposed entanglement-assisted quantum error-correcting code based on Euclidean geometry outperform differently structured quantum codes. However, the large number of ebits required to construct the entanglement-assisted formalism is a substantial obstacle to practical application. In this paper, we propose a novel class of entanglement-assisted quantum LDPC codes constructed using classical Euclidean geometry LDPC codes. Notably, the new codes require one copy of the ebit. Furthermore, we propose a construction scheme for a corresponding zigzag matrix and show that the algebraic structure of the codes could easily be expanded. A large class of quantum codes with various code lengths and code rates can be constructed. Our methods significantly improve the possibility of practical implementation of quantum error-correcting codes. Simulation results show that the entanglement-assisted quantum LDPC codes described in this study perform very well over a depolarizing channel with iterative decoding based on the SPA and that these codes outperform other quantum codes based on Euclidean geometries.