• Journal of Chest Surgery
• /
• v.28 no.11
• /
• pp.1058-1062
• /
• 1995

We have experienced one case of hemoptysis which developed from both upper lung fields due to pulmonary aspergilloma combined with pulmonary tuberculosis. A 48 year old female patient was admitted with 10 years history of recurrent hemoptysis. Chest X-ray film revealed moderately advanced active pulmonary tuberculosis lesion on both upper lung fields, and cresentic radiolucent space between cavity wall and round radiopaque lesion on left upper lung field. Bronchial arteriogram showed hypervascularity and extravasation of contrast media in the right lung and it was treated by bronchial artery embolization. Hemoptysis recurred 7 months after embolization and repeat examination revealed greatly increased bronchial vasculature in the left upper lobe and therefore underwent left upper lobectomy. The pathologic result was compatible with aspergillosis, and the postoperative recovery was uneventful.

• Korean Journal of Microbiology
• /
• v.17 no.2
• /
• pp.65-71
• /
• 1979

On studying of microbes and appearance frequency which are floating around dwelling space and life environments in Seoul area, the results are summarized as follows ; 1. 1931 strains of 29 bacteria are isolated in dwelling spaces, Among them, there are Staphylococcus aureus, S. anthracis which are pathogenic to human beings. 2. In fungi, 76 strains of 13 species are isolated. That of highest frequency is confirmed to be Aspergillus which is pathogens of Aspergillosis (one of a group of diseases of animals and human being caused by various species of Aspergillus). The places, where the number of kinds and the frequency of appearances have been observed highest, are coffee shops, lunch counters and office rooms, while factory districts are of far lower level than expected. 3. 0.1% $HgCl_2$, Leasking oil, and Telephone disinfectant were better than any other in fungicidal effect.

• Journal of Chest Surgery
• /
• v.30 no.10
• /
• pp.1032-1035
• /
• 1997

Fungal infection of intracardiac pacing wire is very rare. We experienced a case of patient with functioning transvenous pacemaker lead, inserted 3 years previously, which was completely encased in a large thrombus infected with aspergillus. The lung biopsy also confirmed aspergillus infection.

• Journal of Veterinary Clinics
• /
• v.18 no.2
• /
• pp.174-177
• /
• 2001

A nine-month-old male ostrich (Struthio camelus) exhibited loss of appetite and dyspnea for 10 days, followed by emaciation and death. Grossly, multiple white nodules measuring 1-3 mm in diameter were observed in the surface of and inside of the lung and in the mucosa of the air sac. Microscopically, the granuloma formations were observed in the lung and air sac. The core of granuloma consisted mainly of macrophages and fibroblasts. The thin layer comprising the giant cells and macrophages surrounded the granuloma. By Periodic acid Schiff reaction, mycelia were detected especially in the core of granuloma. From the present results, the causative agent inducing the death of an ostrich was thought to be Aspergillus sp. This is the first report of the occurrence of acute Aspergillus pneumonia (brooder pneumonia) in an adult male ostrich in Korea.

• Journal of Veterinary Clinics
• /
• v.34 no.4
• /
• pp.310-312
• /
• 2017

A five-month-old African grey parrot was presented with alopecia, yellowish diarrhea, depression, and paralysis in the veterinary medical center, Chungbuk National University. The patient died 3 h later after hospitalization. For the accurate diagnosis, necropsy was performed and fungi were detected in the air sac. PCR was done for the viral detection which caused the alopecia, and for the species identification of fungi. Final diagnosis was a multi infection with avian circoviruses that caused psittacine beak and feather disease (PBFD), avian polyomavirus cause budgerigar fledgling disease (BFD), and Aspergillus fumigatus. This is the first report of a multi infection in South Korea.

• Journal of environmental and Sanitary engineering
• /
• v.12 no.1
• /
• pp.1-8
• /
• 1997

The microbial distribution on 115 transmitter of telephone in 5 site were studied during the period Mar to May 1996. The result were follows: 1. The public telephone at Kangnam terminal showed highest contamination of total bacteria (1.5 $\times $ 10$^{4}$/cm$^{2}$ and the telephone at home showed lowest contamination at the mean 4.6/cm$^{2}$ 2. The most frequent bacteria was staphylococcus epidermides and staptylococcus aureus which is pathogen of food poison was frequently isolated. 3. The public telephone at Seoul showed the highest contamination of fungi and the telephone at home showed lowest contamination of Fungi 4. In fungi 631 strains of 16 species were isolated that of highest frequency is confirmed to be Asperillus fumigatus which is pathogen of Aspergillosis, Nigar and Penicillium spp. were frequently isolated.

• Journal of Chest Surgery
• /
• v.25 no.6
• /
• pp.611-615
• /
• 1992

Between July 1988 and August 1991, 8 cases of pulmonary resection for pulmonary asp-ergilloma had been performed in the department of thoracic surgery, Korea Cancer Center Hospital. The patients were consisted of 4 males and 4 females and were evenly distributed from fourth decade to sixth decade. Hemoptysis was the most common chief compla int. In chest roentgenogram, patch infiltration was noted in 4 cases[50%] and intracavi-tary fungus ball was noted in only 2 cases[25%]. A. fumigatus was identified pre-operatively in 2 cases by bronchoscopic washing and in 1 case by culture of pleural effusion, Eight pulmonary resections were done by 5 lobectomies, 1 segmentectomy, 1 wedge resection and 1 pneumonectomy, Postoperative pathologic findings showed that 6 cases [75%] were combined with bronchiectasis, 1 case with tuberculosis and 1 case with pneumonia. We experinced 1 case of postoperative pulmonary edema but there was no mortality case.

• Journal of Integrative Natural Science
• /
• v.7 no.4
• /
• pp.234-240
• /
• 2014

C-C chemokine receptor type 4 (CCR4) is a chemokine receptor with seven transmembrane helices and it belongs to the GPCR family. It plays an important role in asthma, lung disease, atopic dermatitis, allergic bronchopulmonary aspergillosis, cancer, inflammatory bowel disease, the mosquito-borne tropical diseases, such as dengue fever and allergic rhinitis. Because of its role in wide spectrum of disease processes, CCR4 is considered to be an important drug target. Three dimensional structure of the protein is essential to determine the functions. In the present study homology modeling of human CCR4 was performed based on crystal structure of CCR5 chemokine receptor. The generated models were validated using various parameters. Among the generated homology models the best one is selected based on validation result. The model can be used for performing further docking studies to identifying the critical interacting residues.

• Imaging Science in Dentistry
• /
• v.48 no.2
• /
• pp.139-145
• /
• 2018

Aspergilloma of the maxillary sinus is considered rare in immunocompetent patients, but a considerable increase has recently been seen in the incidence of reported cases. Dental procedures involving the antral region are thought to predispose individuals to this form of aspergillosis. Because aspergilloma shares similar clinical features with other sinus pathologies, its diagnosis may be delayed. Thus, an early diagnosis confirmed by a histopathological examination plays a crucial role in the adequate management of aspergilloma. This article provides a concise review of the reported cases of aspergilloma associated with dental procedures and reports 2 new cases of aspergilloma in middle-aged female patients, with a presentation of their cone-beam computed tomographic findings.

• Mycobiology
• /
• v.45 no.4
• /
• pp.233-239
• /
• 2017

Drosophila melanogaster is a useful model organism that offers essential insights into developmental and cellular processes shared with humans, which has been adapted for large scale analysis of medically important microbes and to test the toxicity of heavy metals, industrial solvents and other poisonous substances. We here give a brief review of the use of the Drosophila model in medical mycology, discuss the volatile organic compounds (VOCs) produced by the opportunistic human pathogen, Aspergillus fumigatus, and give a brief summary of what is known about the toxicity of some common fungal VOCs. Further, we discuss the use of VOC detection as an indirect indicator of fungal growth, including for early diagnosis of aspergillosis. Finally, we hypothesize that D. melanogaster has promise for investigating the role of VOCs synthesized by A. fumigatus as possible virulence factors.