• 지구물리와물리탐사
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• 제12권1호
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• pp.41-48
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• 2009

자연적인 자기장은 전기 전도도가 높은 물에서는 감쇠한다. 이러한 이유로, 해양 지전류 탐사법에서 장주기(1000 - 100000 초) 자료를 측정하였나. 맨들 구조가 해저 지전류측정의 주된 적용 대상이었다. 반면에 지각구조를 밝히기 위해서, 예를 들어, 메카트러스트 지진지역이나 천연자원조사와 같은 분야에서는 보다 짧은 주기의 전자기장에 대한 자료가 중요하다. 예를 들어 전자의 조사를 위해서는 1000초 보다 자은 주기를 가지는 전자기장 자료가 필요하다. 그러나, 이러한 용도를 위한 적절한 해저 전자력계 (OBEM)가 없기 때문에 높은 샘플링 속도와 조립과 회수 과정을 용이하게 하기 위한 팔-접힘 구조를 가지는 소규모 OBEM과 해저 전위계 (OBE)를 개발하였다. 자기장 측정을 위하여 플럭스게이트 센서를 이용하였다. 개발된 장비의 현장 성능을 평가하기 위한 현장측정이 이루어졌다. 모든 장비는 전자기 측정자료를 획득한 채로 회수되었다. 첫번째 실험의 결과, 개발된 시스템은 동작과 측정 모두 그 기능이 정상적으로 잘 이루어지고 있음을 확인하였다. 돗토리 근해에서의 또 다른 현장실험 결과는 새로운 OBEM과 OBE 시스템으로 획득된 전자기 자료가 탐사 목적에 충분한 양질의 자료라는 주장을 뒷받침해 주었다. 이러한 견과들은 개발된 장비들이 해저면 전자기장 측정에 대한 장비적인 장애를 모두 해결하고 있음을 확증하고 있다.

• 대한인간공학회지
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• 제33권2호
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• pp.109-124
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• 2014

Objective: This study was conducted for one-hand users including hemiplegic clients currently using general folding manual wheelchairs, so as to analyze their specific problems and recommend solutions regarding usage. Background: Traditional manual wheelchairs require considerable use and control of both hands for operation, thus adaptations become necessary for individuals with asymmetrical use of hands. Method: Thirty hemiplegic clients who were admitted to rehabilitation and convalescent hospitals participated as subjects. The research tools were general folding manual wheelchairs commonly used by people with impaired gait, and the Wheelchair Skills Tests (WST) WST-M/WCU 4.1 version was adopted as the assessment tool. All participants were asked to fill out questionnaires on demographics and wheelchair usage characteristics. Assessment procedures were performed with currently used manual wheelchairs and with/without the use of foot to control the wheelchair. Results: When the participants drove folding manual wheelchairs without the use of foot, even the lowest failure rate among the WST items tested recorded 96.7%. On the contrary, with the use of foot in maneuvering the wheelchairs, failure rates dropped noticeably and success rate among the WST items tested was as high as 86.7%. Conclusion: These findings imply that the use of one-arm (hand) propellable (drivable) wheelchair can be an active and effective solution in resolving problems for hemiplegic clients using existing manual wheelchairs. As such, the government should provide institutional support to further develop and distribute this device or technology, and promote relative research in tandem. For now, the supply of commercially available device to hemiplegic clients is deemed urgent and also a mechanism to provide the devices and relevant services. Application: This study offers viable solutions for hemiplegic clients who rely on existing manual wheelchairs to increase their mobility and occupational performance.

• 한국자기공명학회논문지
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• 제12권1호
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• pp.1-13
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• 2008

Acetyl-CoA carboxylase (ACC) catalyzes the first step in fatty acid biosynthesis: the synthesis of malonyl-CoA from acetyl-CoA. As essential regulators of fatty acid biosynthesis and metabolism, ACCs are regarded as therapeutic targets for the treatment of metabolic diseases such as obesity, In ACC, the biotinoyl domain performs a critical function by transferring an activated carboxyl group from the biotin carboxylase domain to the carboxyl transferase domain, followed by carboxyl transfer to malonyl-CoA. Despite the intensive research on this enzyme, only the bacterial and yeast ACC structures are currently available, To explore the mechanism of ACC holoenzyme function, we determined the structure of the biotinoyl domain of human ACC2 and analyze its characteristics using NMR spectroscopy. The 3D structure of the hACC2 biotinoyl domain has a similar folding topology to the previously determined domains from E. coli and P. Shermanii, however, the 'thumb' structure is absent in the hACC2 biotinoyl domain. Observations of the NMR signals upon the biotinylation indicate that the biotin group of hACC2 does not affect the structure of the biotinoyl domain, while the biotin group for E. coli ACC interacts directly with the thumb residues that are not present in the hACC2 structure. These results imply that, in the E. coli ACC reaction, the biotin moiety carrying the carboxyl group from BC to CT can pause at the thumb of the BCCP domain. The human biotinoyl domain, however, lacks the thumb structure and does not have additional non-covalent interactions with the biotin moiety; thus, the flexible motion of the biotinylated lysine residue must underlie the "swinging arm" motion. This study provides insight into the mechanism of ACC holoenzyme function and supports the "swinging arm" model in human ACCs.