• Title/Summary/Keyword: area under curve

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Poor Treatment Outcome of Neuroblastoma and Other Peripheral Nerve Cell Tumors May be Related to Under Usage of Radiotherapy and Socio-Economic Disparity: A US SEER Data Analysis

  • Cheung, Rex
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.9
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    • pp.4587-4592
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    • 2012
  • Purpose: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) neuroblastoma (NB) and other peripheral nerve cell tumors (PNCT) outcome data. This study found under usage of radiotherapy in these patients. Materials and methods: This study analyzed socio-economic, staging and treatment factors available in the SEER database for NB and other PNCT. For the risk modeling, each factor was fitted by a generalized linear model to predict the outcome (soft tissue specific death, yes/no). The area under the receiver operating characteristic curve (ROC) was computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate the modeling errors. Risk of neuroendocrine (other endocrine including thymus as coded in SEER) death was computed for the predictors. Results: There were 5261 patients diagnosed from 1973 to 2009 were included in this study. The mean follow up time (S.D.) was 83.8 (97.6) months. The mean (SD) age was 18 (25) years. About 30.45% of patients were un-staged. The SEER staging has high ROC (SD) area of 0.58 (0.01) among the factors tested. We simplified the 4-layered risk levels (local, regional, distant, un-staged/others) to a simpler 3-tiered model with comparable ROC area of 0.59 (0.01). Less than 50% of PNCT patients received radiotherapy (RT) including the ones with localized disease. This avoidance of RT use occurred in adults and children. Conclusion: The high under-staging rate may have precented patients from selecting definitive radiotherapy (RT) after surgery. Using RT for, especially, adult PNCT patients is a potential way to improve outcome.

A Study on Sasang Constitutional Classification Methods based on ROC-curve using the personality score (성격점수를 이용한 ROC-curve 기반 사상체질 분류 방법에 대한 연구)

  • Kim, Ho-Seok;Jang, Eun-Su;Kim, Sang-Hyuk;Yoo, Jong-Hyang;Lee, Si-Woo
    • Korean Journal of Oriental Medicine
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    • v.17 no.2
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    • pp.107-113
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    • 2011
  • Objectives : Sasang typology is extensively studied for the Sasang constitution diagnosis objectification with various data, for example, questionaires, reference materials, etc and analyzed with the several statistical methods. In this study, we used ROC-curve (Receiver Operating Characteristic curve) analysis to diagnose Sasang constitution, which is a kind of epidemiologic research methods and is away from traditional statistical methods. Methods : We collected personality questionnaire which consists of 15 items, from 24 oriental medical clinics. We analyzed the sensitivity and specificity using ROC curve method based on the score of personality questionnaire and also investigated classification accuracy and cut-off value of Sasang constitution. Results : The AUC (area under the ROC curve) value was 0.508 (p=.5511) for Taeeumin, 0.629 (p<.0001) for Soeumin and 0.604(p<.0001) for Soyangin, respectively. so the classification accuracy for Soeumin was highest Soeumin for over 30 points and Soyangin for below 28 points respectively. Conclusions : We suggest that Taeeumin is not classified easily in the ROC-curve analysis. We may classify Soeumin and Soyangin but the accuracy of Sasang constitutional diagnosis is still low.

Classification of Middle Aged Women's Breast Shapes Using 3D Body Measurement Data (3차원 인체 측정치들을 이용한 중년 여성의 유방 형태에 따른 유형)

  • Lee, Hyun-Young;Hong, Kyung-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.34 no.3
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    • pp.385-392
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    • 2010
  • The breast types of middle-aged women of 80A (formerly 80B) size were classified through a 3D scanned nude body. Thirty seven measurements including the radius of curvature, surface area, volume, surface length, and breast displacements were used as input variables. We extracted five main factors through the factor analysis of the measurements and classified 36 subjects into 3 clusters through the cluster analysis. As a result of the factor analysis, the size of the breast, breast sag, the curvature of the inner and the outer breast curve, the width of the breast, and the nipple direction were found as the main factors. For the results of the classification of breast types, Cluster 1 was characterized by narrow breast width and unsymmetrical under the breast curve, whereas Cluster 2 was a wide and sagged shape. Cluster 3 was classified into big breast volume and symmetrical under-breast curve. The results are useful to the product development of high quality brassieres which reflect the 3D characteristics of breast types of middle-aged women.

Capillary Bundle Model for the Estimation of Air-water Interfacial Area and the Gas-filled Pore Size Distribution in Unsaturated Soil (모세관 모델을 이용한 불포화토양의 물-가스 접촉면적 및 가스공극 크기분포의 계산 및 검증)

  • Kim, Heonki
    • Journal of Soil and Groundwater Environment
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    • v.26 no.1
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    • pp.1-7
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    • 2021
  • Air-water interfacial area is of great importance for the analysis of contaminant mass transfer processes occurring in the soil systems. Capillary bundle model has been proposed to estimate the specific air-water interfacial areas in unsaturated soils. In this study, the measured air-water interfacial areas of a soil (loam) using the gaseous interfacial tracer technique were compared to those from capillary bundle model. The measured values converged to the specific solid surface area (7.6×104 ㎠/㎤) of the soil. However, the simulated air-water interfacial areas based on the capillary bundle model deviated significantly from those measured. The simulated values were substantially over-estimated at low end of the water content range, whereas the model under-estimated the air-water interfacial area for the most of the water content range. This under-estimation is considered to be caused by the nature of the capillary bundle model that replaces the soil pores with a bundle of glass capillaries and thus no surface roughness at the inner surface of the capillaries is taken into account for the estimation of the air-water interfacial area with the capillary bundle model. Subsequently, appropriate correction is necessary for the capillary bundle model to estimate the air-water interfacial area in soils. Since the soil-moisture release curve data is the basis of the capillary bundle model, the model can be of use due to its simplicity, while the gaseous tracer technique requires complicated experimental equipment followed by moment analysis of the breakthrough curves. The size distribution profile of the pores filled with gas estimated by the water retention curve was found to be similar to that of particle size at different size range. The shifted distribution of gas-filled pores toward smaller size side compared to the particle size distribution was also found.

Validity of Ultrasonography in the Diagnosis of Non-alcoholic Fatty Liver Disease in Living Liver Donors (생체 간이식 공여자에서 비알코올성 지방간 질환의 진단에 있어서 초음파검사의 타당도 연구)

  • Kim, Yon-Min;Han, Dong-Kyoon
    • The Journal of the Korea Contents Association
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    • v.11 no.10
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    • pp.342-348
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    • 2011
  • The study aimed to compare the validity between the abdominal ultrasonographic(US) grading system of fatty liver and histologic grading system of fatty liver in living liver donor candidates. As the fatty liver is defined as pathologic total fat >10%, US validity was sensitivity 64.6%, specificity 68%, positive predictive value 76.8%, negative predictive value 54%. As the strict data handling on US grading normal, mild fatty liver are negative, moderate fatty liver is positive, US validity was sensitivity 26.8%, specificity 100%, positive predictive value 100%, negative predictive value 45.5%. ROC curve analysis according to different cut off value of liver-to-kidney brightness ratio was Area under ROC curve=0.859(95% CI=0.795~0.922, state variable= total fat 10%). There were statistically significant difference( p<0.001). Ultrasonography for the fatty diagnosis showed a high validity to predict the result of histology grade of fatty liver.

Exploring the Predictive Factors of Passing the Korean Physical Therapist Licensing Examination (한국 물리치료사 국가 면허시험 합격 여부의 예측요인 탐색)

  • Kim, So-Hyun;Cho, Sung-Hyoun
    • Journal of The Korean Society of Integrative Medicine
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    • v.10 no.3
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    • pp.107-117
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    • 2022
  • Purpose : The purpose of this study was to establish a model of the predictive factors for success or failure of examinees undertaking the Korean physical therapist licensing examination (KPTLE). Additionally, we assessed the pass/fail cut-off point. Methods : We analyzed the results of 10,881 examinees who undertook the KPTLE, using data provided by the Korea Health Personnel Licensing Examination Institute. The target variable was the test result (pass or fail), and the input variables were: sex, age, test subject, and total score. Frequency analysis, chi-square test, descriptive statistics, independent t-test, correlation analysis, binary logistic regression, and receiver operating characteristic (ROC) curve analyses were performed on the data. Results : Sex and age were not significant predictors of attaining a pass (p>.05). The test subjects with the highest probability of passing were, in order, medical regulation (MR) (Odds ratio (OR)=2.91, p<.001), foundations of physical therapy (FPT) (OR=2.86, p<.001), diagnosis and evaluation for physical therapy (DEPT) (OR=2.74, p<.001), physical therapy intervention (PTI) (OR=2.66, p<.001), and practical examination (PE) (OR=1.24, p<.001). The cut-off points for each subject were: FPT, 32.50; DEPT, 29.50; PTI, 44.50; MR, 14.50; and PE, 50.50. The total score (TS) was 164.50. The sensitivity, specificity, and the classification accuracy of the prediction model was 99 %, 98 %, and 99 %, respectively, indicating high accuracy. Area under the curve (AUC) values for each subject were: FPT, .958; DEPT, .968; PTI, .984; MR, .885; PE, .962; and TS, .998, indicating a high degree of fit. Conclusion : In our study, the predictive factors for passing KPTLE were identified, and the optimal cut-off point was calculated for each subject. Logistic regression was adequate to explain the predictive model. These results will provide universities and examinees with useful information for predicting their success or failure in the KPTLE.

Surveying and Optimizing the Predictors for Ependymoma Specific Survival using SEER Data

  • Cheung, Min Rex
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.2
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    • pp.867-870
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    • 2014
  • Purpose: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) ependymoma data to identify predictive models and potential disparity in outcome. Materials and Methods: This study analyzed socio-economic, staging and treatment factors available in the SEER database for ependymoma. For the risk modeling, each factor was fitted by a Generalized Linear Model to predict the outcome ('brain and other nervous systems' specific death in yes/no). The area under the receiver operating characteristic curve (ROC) was computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate the modeling errors. Risk of ependymoma death was computed for the predictors for comparison. Results: A total of 3,500 patients diagnosed from 1973 to 2009 were included in this study. The mean follow up time (S.D.) was 79.8 (82.3) months. Some 46% of the patients were female. The mean (S.D.) age was 34.4 (22.8) years. Age was the most predictive factor of outcome. Unknown grade demonstrated a 15% risk of cause specific death compared to 9% for grades I and II, and 36% for grades III and IV. A 5-tiered grade model (with a ROC area 0.48) was optimized to a 3-tiered model (with ROC area of 0.53). This ROC area tied for the second with that for surgery. African-American patients had 21.5% risk of death compared with 16.6% for the others. Some 72.7% of patient who did not get RT had cerebellar or spinal ependymoma. Patients undergoing surgery had 16.3% risk of death, as compared to 23.7% among those who did not have surgery. Conclusion: Grading ependymoma may dramatically improve modeling of data. RT is under used for cerebellum and spinal cord ependymoma and it may be a potential way to improve outcome.

Stydy of Pool Boiling under Steady State using Ultrasonic Measurement (초음파 측정법을 이용한 정상상태의 푸울비등 연구)

  • 장길홍
    • Journal of Ocean Engineering and Technology
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    • v.6 no.2
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    • pp.35-40
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    • 1992
  • A recently developed new technique for measuring the fraction of wetted area has applied to pool boiling of water. The basis of the new applied technique of ultrasonic makes use of the reflection of ultrasonic from the vapour surface to measure the fraction of wetted area values. The results are the measured fraction of wetted area values in nucleate and transition boiling and the pool boiling curve for water under steady state conditions. The measurement of this paper shows a fraction of wetted areaf around 0.98 at the critical heat flux for water.

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Diagnostic Performance of Combined Single Photon Emission Computed Tomographic Scintimammography and Ultrasonography Based on Computer-Aided Diagnosis for Breast Cancer (유방 SPECT 및 초음파 컴퓨터진단시스템 결합의 유방암 진단성능)

  • Hwang, Kyung-Hoon;Lee, Jun-Gu;Kim, Jong-Hyo;Lee, Hyung-Ji;Om, Kyong-Sik;Lee, Byeong-Il;Choi, Duck-Joo;Choe, Won-Sick
    • Nuclear Medicine and Molecular Imaging
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    • v.41 no.3
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    • pp.201-208
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    • 2007
  • Purpose: We investigated whether the diagnostic performance of SPECT scintimammography (SMM) can be improved by adding computer-aided diagnosis (CAD) of ultrasonography (US). Materials and methods: We reviewed breast SPECT SMM images and corresponding US images from 40 patients with breast masses (21 malignant and 19 benign tumors). The quantitative data of SPECT SMM were obtained as the uptake ratio of lesion to contralateral normal breast. The morphologic features of the breast lesions on US were extracted and quantitated using the automated CAD software program. The diagnostic performance of SPECT SMM and CAD of US alone was determined using receiver operating characteristic (ROC) curve analysis. The best discriminating parameter (D-value) combining SPECT SMM and the CAD of US was created. The sensitivity, specificity and accuracy of combined two diagnostic modalities were compared to those of a single one. Results: Both SPECT SMM and CAD of US showed a relatively good diagnostic performance (area under curve = 0.846 and 0.831, respectively). Combining the results of SPECT SMM and CAD of US resulted in improved diagnostic performance (area under curve =0.860), but there was no statistical differerence in sensitivity, specificity and accuracy between the combined method and a single modality. Conclusion: It seems that combining the results of SPECT SMM and CAD of breast US do not significantly improve the diagnostic performance for diagnosis of breast cancer, compared with that of SPECT SMM alone. However, SPECT SMM and CAD of US may complement each other in differential diagnosis of breast cancer.

Constitutive Modeling of Confined Concrete under Concentric Loading

  • Lee, Cha-Don;Park, Ki-Bong;Cha, Jun-Sil
    • KCI Concrete Journal
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    • v.13 no.1
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    • pp.69-78
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    • 2001
  • The inelastic behavior of a reinforced concrete columns is influenced by a number of factors : 1) level of axial load, 2) tie spacing, 3) volumetric ratio of lateral steel, 4) concrete strength, 5) distribution of longitudinal steel, 6) strength of lateral steel, 7) cover thickness, 8) configuration of lateral steel, 9) strain gradient, 10) strain rate, 11) the effectively confined concrete core area, and 12) amount of longitudinal steel. A new constitutive model of a confined concrete is suggested in order to investigate the nonlinear behavior of the reinforced concrete columns under concentric loading. The developed constitutive model for the confined concrete takes into account the effects of effectively confined area as well as the horizontal and longitudinal distributions of the confining pressures. None of the existing models incorporated these two main effects at the same time. A total of different six constitutive models for the behavior of the confined concrete under concentric compression were compared with the sixty-one test results reported by different researchers. The superiority of the developed model in its accuracy is demonstrated by evaluating the error function, which compares the weighted averages for the sum of squared relative differences in peak compressive strength and corresponding strain, stress at strain equal to 0.015, and total area under stress-strain curve up to strain equal to 0.015.

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