• Journal of Pharmaceutical Investigation
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• 제28권3호
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• pp.141-149
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• 1998

In order to reduce systemic side effects following administration, flurbiprofen was formulated as O/W microemulsion consisting of the surfactant, oil phase and aqueous phase. Particle size distribution, apparent viscosity, solubility and skin permeation of flurbiprofen in various vehicles and microemulsion were evaluated. The domain of O/W microemulsion s phase diagram had difference between oil types and the area of O/W microemulsion was wide distributed by adding to PG and cosurfactant than that of water alone. As increasing 10, 15 and 20% of Brij 97 content and 1, 2.5, 5% of oil content, the solubility of flurbiprofen in O/W microemulsions and various vehicles was $400{\sim}1,000$ and $10{\sim}500$ times higher than that of control. Also, apparent viscosity of soybean oil microemulsions was higher than that of IPM microemulsions and that of vehicle were increased as increasing vehicle content. Since skin permeation of flurbiprofen decreased as increasing viscosity, in each vehicle, it was not affected 2% ${\beta}-CD$ and decreased as increasing PG content and to 2, 5 and 10% of $HP-{\beta}-CD$. In O/W microemulsion, 5% soybean oil. 20% Brij 97 and 75% water(A-1) with high viscosity showed low skin penetration.

• Journal of Pharmaceutical Investigation
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• 제26권4호
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• pp.263-271
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• 1996

Sulconazole nitrate(SCN), an imidazole derivative which has been effective in the treatment of dermatophytosis, tinea versicolor and candidiasis, was formulated as a gel containing drug, poloxamer 407, ethanol and propylene glycol. The resulting SCN gels were evaluated with respect to their viscosity, drug release rate, skin permeation rate. The apparent viscosity of SCN gel increased in proportion to poloxamer 407, drug and propylene glycol concentration. In case ethanol was added, the apparent viscosity decreased. The drug release rate of SCN gel increased in proportion to temperature and ethanol concentration. But the drug release rate decreased as the concentration of poloxamer 407 increased. The increase of drug concentration induced nonlinear increase of drug release rate. When propylene glycol was added at the level of 10%, the drug release rate increased but from 15% it decreased. The skin permeation rate decreased in high concentration of poloxamer 407. The skin permeation rate of SCN gel containing 15% ethanol increased about twice than that of gel without ethanol. The increase of drug concentration induced nonlinear increase of skin permeation rate. When propylene glycol was added at the level of 10%, the skin permeation rate increased but from 15% it decreased.

• 한국수산과학회지
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• 제28권4호
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• pp.397-400
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• 1995

Chitosan 용액의 물성학적 특성을 조사하기 위하여 chitosan 용액의 점도에 미치는 전단속도, 온도, 농도 및 염의 영향을 조사한 결과, chitosan 용액$(0.5\%)$의 유동곡선은 hysteresis loop가 나타나는 Bingham 유체와 일치하였고, $10^{\circ}C-40^{\circ}C$에서 Arrhenius 온도의존성을 나타내었다$(2\%,\;2.5\%,\;3\%\;chitosan$ 용액). 활성화 에너지는 3.25-8.35(kcal/g mol)로 전단속도가 높을수록 그리고 농도가 높을수록 증가하였다. Chitosan 용액의 겉보기점도는 농도가 증가할수록 지수적으로 증가하였고, 측정 온도가 높을수록 농도의존성은 낮았다. 한편 chitosan용액에 염을 첨가하였을 때 점도감소현상이 나타났으며, 염농도가 높아짐에 따라 점도의 감소폭은 줄어들었다 염의 종류에 따른 점도변화는 없었다

• Food Science and Biotechnology
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• 제15권1호
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• pp.33-38
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• 2006

This study was performed to provide basic rheological data of dandelion root concentrates in order to predict their processing aptitude and usefulness as functional foods material. The hot water and 70% ethanol extracts of dandelion root were concentrated at 5, 20, and 50 Brix, and their static viscosity, dynamic viscosity, and Arrhenius plots were investigated. Almost all hot water concentrates showed the typical flow properties of a pseudoplastic fluid, but evaluation using the power law model indicated that the 70% ethanol concentrates showed a flow behavior close to a Newtonian fluid. The apparent viscosity of hot water and 70% ethanol concentrates decreased with increasing temperature. Yield stresses of hot water and 70% ethanol concentrates by Herschel-Bulkley model application were in the range of 0.026 - 1.368 Pa and 0.022 - 0.238 Pa, respectively. The effect of temperature and concentration on the apparent viscosity was examined by Arrhenius equation. The activation energies of hot water and 70% ethanol concentrates were in the range of $8.762-23.778{\times}10^3\;J/mol{\cdot}kg$ and $3.217-20.384{\times}10^3\;J/mol{\cdot}kg$ with increasing concentration, respectively. Storage (G') and loss (G") moduli were generally increased with increasing frequency. For the 70% ethanol concentrates, G" predominated over G' at all applied frequencies and so they showed the typical flow behavior of a low molecular solution. However, for the hot water concentrates, G' predominated over G" at more than 1.9 rad/sec (cross-over point) and so they showed the typical flow behavior of a macromolecular solution.

• 한국가정과학회지
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• 제3권1호
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• pp.88-99
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• 2000

옥수수, 감자, 고구마 전분현탁액에 가열 전 $.$후 산을 첨가하여 pH를 4.0∼5.0으로 하였을 때 마밀로그라프에 의한 호화특성과 Brookfield 점도계로 측정한 전도 특성은 다음과 같다. 산 첨가에 따른 옥수수전분, 감자전분. 고구마전분의 아밀로그라프에 의한 특성은 가열전에 산을 첨가하였을때 호화개시온도가 대조군보다 상승되었고, 감자전분의 호화개시온도 상승이 가장 컸다. 각 전분의 점도는 pH가 낮아질수록 감소하였는데 옥수수전분의 경우 가열전 $.$후와는 관계없이 점도변화가 가장 적었다. 가열전 산을 첨가하였을 때 consistency(C-H), setback(C-P)은 증가하였고. breakdown(P-H)은 감소하였다. 가열 후 산을 첨가한 경우는 consistency(C-H), setback(C-P)은 감소하였고, breakdown(P-H)은 증가하여 가열전과 가열후 산첨가의 결과는 다르게 나타났다. 산에 의한 점도의 변화정도는 감자전분, 고구마전분, 옥수수전분 순으로 크게 변화하였다. 가열전 산을 첨가하여 일정온도까지 가열하여 Brookfield 점도계로 점도를 측정한 경우 pH가 낮을수록 점도는 전체적으로 낮게 나타났으나, 가열에 따른 냉각점도는 가열온도가 높을수록 pH의 영향에 따른 냉각점도의 감소가 뚜렷하게 나타났다. 가열 후 산을 첨가하여 냉각점도를 측정한 경우 가열전 산첨가에 비하여 옥수수전분 과 고구마전분은 전반적으로 점도가 높은 경향이었다.

• 한국세라믹학회지
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• 제34권12호
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• pp.1261-1267
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• 1997

Four kids of powder admixtures(A, B, C, D) based on anhydrite were manufactured by mixing at a fixed rate of II-anhydrite, fly ash and active silica as an industrial by-product. Fluidity properties of cement paste such as mini-slump, apparent viscosity with elapsed time, as well as setting time of cement pastes of these admixtures substituted up to 11wt% of cement were compared to those of cement paste(SS) substisuted by marketed high-strength powder admixture(S). Among these powder admixtures, the fluidity of cement pastes(PA, PC) substituted by A and C powder admixtures manufactured from II-anhydrite and fly ash had an excellent property than that of cement paste substituted by marketed powder admixture and also a good fluidity-retention effect with elapsed time by adding of superplasticizer. The setting time of cement paste substituted by powder admixtures based on anhydrite slightly retarded than that of cement paste substituted by marketed powder admixture.

• 한국세라믹학회지
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• 제41권9호
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• pp.647-652
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• 2004

In aqueous tape casting of alumina slurry systems, the relationships between the suspension compositions and the defects of the dried tapes were discussed. The suspensions compositions were controlled with the ratios of the solids, water and organics binder contents. The effects of the thickness of dried tape and kinds of binder system were also examined. In the defect free region, the apparent viscosity showed nearly same value due to the count balancing effect of solid and organic binder content on the apparent viscosity. When water content was constant, increasing solid led to decrease of organic binder content. The defect free region was narrowed with increasing of casting thickness. When linear type acrylic emulsion binders system (D1000 and D 1035) were used, defect free zone formed the belt type in the triangle of solid, water and organic binder content according to the line of constant water contents. However the defect free region was not found in the cross-link type emulsion binder system (D 1050).

• 한국세라믹학회지
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• 제42권1호
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• pp.1-6
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• 2005

In aqueous alumina tape casting, the effects of altering the composition of the suspensions, the binders and the casting thickness were studied. The rheological behavior of the suspensions and the defects of the dried tapes were examined and the relationships between them are discussed. The changes in the defect regions reported in the previous paper were related with the rheological properties with variations of the binder, the composition and the casting thickness. The shear thinning factor increased with the organic content and the solid content (the decrease of water content). The apparent viscosity increased with the shear thinning factor. The relation between the shear thinning factor and the log apparent viscosity was similar for all binder types. In the relation between the defect free region and the rheological properties, the defect free region became narrower with increasing casting thickness. The defect free region is independent of binder type. Therefore, the thicker tape is more difficult to produce in aqueous alumina tape casting. Knowledge of the rheological properties of the suspensions could help Predict the defect type and the possibility of defect free dried tapes.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1995년도 추계학술대회 논문집
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• pp.542-545
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• 1995

This paper provides an investigation of torque converter system using ERF (Electro-Rheological Fluid). The torque converter system using ERP is a new concepting device because we can change an apparent viscosity of ERF by adapting an electric field. The device was designed by using the equations which were proposed by Carlson et al. The devices based on ERF generally assume one two possible forms. One is the parallel plate type in which the device elements are facing circular disks separated by a flat layer of ERF, The other is coaxial cylinder or Couette types in which the ERF file the annular apace between a pair of coaxial cylindrical electrode. The discussion on this study is specifically for coaxial cylinder gemetry and experiment results show that the measured torque was rapidly increased with the increase of the eletric field.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2001년도 춘계학술대회 논문집(한국공작기계학회)
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• pp.66-71
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• 2001

In this work, an ER clutch has been constructed and its characteristics have been evaluated by adapting an electro-rheological fluid(ERF) as an operating medium. ER fluids are suspensions which show an abrupt increase in rheological properties under electric fields. An ER clutch system using ER fluid is a new conception device because an apparent viscosity of ER fluid can be changed by apply an electric field. As a first, Bingham properties of ER fluids are experimentally distilled as a function of electric field. We use the disk type ER clutch in which the ER fluid fills the annular space between a pair of coaxial disk electrodes and experiment results show that the measured revolution per minute was increased with the increase of the electric field. The ER fluid used in the present study consists of weight fraction 35% in zeolite suspended silicone oil.