• 제목/요약/키워드: apoplexy

검색결과 97건 처리시간 0.03초

민간약 등나무의 생약학적 연구 (Pharmacognostical Studies on the Folk Medicine 'DeungNaMu')

  • 배지영;박종희
    • 생약학회지
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    • 제43권2호
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    • pp.98-100
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    • 2012
  • Korean folk medicine 'DeungNaMu' has been used mainly to cure apoplexy, pain of the stapes and tonic for weak man. With regard to the botanical origin of DeungNaMu, it has been considered to be Wisteria species of Leguminosae, but there was no pharmacognostical confirmation on it. To clarify the botanical origin of 'DeungNaMu', the anatomical characteristics of the branches of Wisteria species growing wild in Korea, Wisteria japonica and W. japonica forma. alba were studied. As a result, it was clarified that DeungNaMu was the branches of Wisteria japonica.

단기간 과량의 마늘투여가 HK phenotype 진도견의 혈액상에 미치는 영향 (The Effect of Short-Term Administration of Excessive Amount of Garlic on Hematology in HK Phenotype Jindo-Dog)

  • 진태원;김홍태;장우석;오태호;송재찬;정규식;박승춘;이근우
    • 한국임상수의학회지
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    • 제18권3호
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    • pp.232-236
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    • 2001
  • It has been known that garlic, one of the essential ingredient in korean food, has a hypotensive effect. and it is reported that they lower the level of triglycerides, cholesterol and glucose in blood. Especially, the sulfur containing amine acid and the derivatives of the garlic has the counteracting effect to heavy metals. Nowadays, the garlic is known for its efficiency for the various kinds of cancer, neoplasms, hypertension, arteriosclerosis and apoplexy. But, it is reported that the intake of the excessive amount of garlic causes hemolytic anemia recently. The hemolytic anemia is more severe especially in HK phenotype dogs which has a Na-K-ATPase activity. Therefore, this study was performed to examine the effect on the blood of the HK phenotype Jindo dogs when administered the excessive amount of garlic. HK phenotype group showed the significant decrease on RBC, WBC, PCV, Hb, MCV, MCHC, GSH, Met-Hb but LK phenotype group didn't show the significant decrease.

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상완혈압과 두부혈압의 상관성 분석에 의한 진단요소 추출과 다기능 전자혈압계의 개발 (Diagnosis parameters extraction by correlativity analysis of blood pressure(BP) and head blood pressure(HBP) and Development of multi-function automatic blood pressure monitor)

  • 이용흠;고수복;정동명
    • 전자공학회논문지SC
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    • 제40권6호
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    • pp.58-67
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    • 2003
  • 각종 성인병과 난치성질환인 뇌졸중과 치매, 중풍의 원인으로는 혈액순환장해에 의한 고혈압과 두부혈압의 상승이 주된 요인으로 작용하고 있다. MRI , X-ray 같은 의료장비는 뇌졸중이나 중풍 등의 발병전 예방보다는 발병후의 치료를 위한 목적으로 이용되고 있다. 최근에는 이러한 난치성 질환이 정상인에서도 발생하고 있어서, 상완혈압에 의한 진단보다는 뇌혈류 상태를 반영하는 두부혈압을 진단하는 것이 더 정확한 임상진단을 할 수 있다 그러나 기존 혈압계나 전자혈압계로는 두부혈압을 측정하거나 개선할 수 있는 기능을 수행할 수 없다. 따라서, 본 논문에서는 혈압과 두부혈압을 쉽고 간편하게 측정하고, 상완혈압에 대한 두부 혈압의 상관성을 추출하여 뇌혈류 상태 및 건강상태를 조기 진단/예방할 수 있는 시스템 및 알고리즘을 개발하였다. 임상실험 결과, 기존의 혈압계보다 측정오차가 작고 재현성이 우수하여 신뢰성을 확인하였고 ,두부혈압의 최고압은 상완 최고압의 62%, 최저혈압은 상완 최저혈압의 46%에 해당하는 상관성을 확인하였다. 정상인과 환자간의 상관성에 큰 차이가 있고, 이는 상완혈압 측정에 의존한 진단보다 두부혈압 측정에 의해 더 중요한 진단요소론 추출할 수 있어서 더 정차한 진단을 할 수 있음을 의미한다. 따라서, 뇌혈류에 이상이 있을 때 달라지는 두부혈압을 측정하여 상완혈압과의 상관성을 추출하고, 환자를 대상으로 분석하여 뇌혈류 상태를 진단/개선함으로서 새로운 진단체계를 구축할 수 있는 시스템을 개발하였다.

두부혈압 측정 시스템의 설계 및 두부혈압과 상완혈압과의 상관성 추출 (Design of Head Blood Pressure(HBP) Measurement System and Correlativity Extraction of Blood Pressure(BP) and HBP)

  • 이용흠;정석준;장근중;정동영
    • 대한의용생체공학회:의공학회지
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    • 제24권5호
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    • pp.381-389
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    • 2003
  • 상완혈압과 두부혈압의 상승은 혈액순환장애와 함께 각종 성인병과 난치성질환인 뇌졸중과 치매, 중풍의 원인이 되고 있다. 뇌졸중이나 중풍의 조기진단에 있어서, MRI 같은 의료장비는 발병전 진단보다는 발병후의 치료를 위한 목적으로 이용되고 있으며 의료비 부담이 큰 단점이 있다. 또한, 상완혈압이 정상인 사람에서도 중풍이 발생하고 있어서, 상완혈압에 의한 진단보다는 뇌혈류상태를 반영하는 두부혈압을 진단하는 것이 더 정확한 임상진단을 할 수 있다. 그러나 기존 혈압계로는 두부혈압을 측정할 수 없다. 본 논문에서는 상완혈압과 두부혈압을 쉽고 간편하게 측정하고, 상완혈압에 대한 두부 혈압의 상관성을 추출하여 뇌혈류 상태 및 건강상태를 조기 진단/예방할 수 있는 시스템 및 알고리즘을 개발하였다. 시스템의 임상실험 결과, 두부혈압의 최고압은 상완 최고압의 62%, 최저혈압은 상완 최저혈압의 46%에 해당하는 것을 확인하여 상관성을 추출하였다, 상완혈압이 정상, 고혈압 및 뇌졸중 환자를 대상으로 측정한 결과, 두 혈압간 상관성에 큰 차이가 있음을 확인하였다. 이는 상완혈압 측정에 의존한 진단보다 두부혈압 측정에 의해 더 중요한 진단요소를 추출할 수 있어서 더 정확한 진단을 할 수 있음을 의미한다. 따라서, 뇌혈류에 이상이 있을 때 달라지는 두부혈압을 측정하여 상완혈압과의 상관성을 추출하고, 환자를 대상으로 분석하여 뇌혈류 상태를 진단/개선함으로써 새로운 진단체계를 구축할 수 있는 시스템을 개발하였다.

두개내압상승(頭蓋內壓上昇)과 궐의(厥) 상관성(相關性)에 대(對)한 동서의학적(東西醫學的) 고찰(考察) (The Eastern and Western Medical Investigation on the Relation with I.I.C.P and Kwul)

  • 정승현;박성식;이원철
    • 동국한의학연구소논문집
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    • 제3권
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    • pp.237-267
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    • 1994
  • The purpose of this study is the approach to I.I.C.P. centered on the meaning of consciousness disorder and the pathological aspect of Kwul (Jose consciousness ; faint, fall into a coma). The meaning of consciousness disorder and apoplexy is evidently involved the definition of Kwul. 1. It is found that the etymological interpretation on Kwul which the energy rises back to go through blocked space and the meaning interpretation of regarding Kwul as apoplexy with medical viewpoint, are related with consciousness disorder and motor disturbance in IICP in the aspect of the rise of Kwul and the abnormal rising of vital energy and blood, In addtion, the overall of meaning of Kwul is showed in table <1-1> by reference to doctors of many generations, 2. The pathology of Kwul includes abnormal rising, sthenia-syndrome in the upper part and asthenia in the lower, the origin of Kwul, the lower, looking like Yin by too sthenic Yang and looking like Yang by too sthenic Yin. The headache, vomiting, papilledema, paralysis of nervi craniales, coma, blood pressure rising, tachycardia by I.I.C.P can be regarded as a conception of trouble of vital energy, sthenia-syndrome of Kwul. The pulse pressure, brachycardia, bradypnea can be regarded as the conception of looking like Yin by too sthenic Yang. 3. In the emergency of Kwul, the abnormal ternimal reversion of the Kwulyin channel, Kuyang channel, and three Yins are related with the phenomenon in I.I.C.P. It is considered that the reverse movement of materials, I.I.C.P. can be closely observed by giving meaning on the meridian of Kwul in Somunkwulron. And the content of phrases of Naelyung which includes consciousness disorder refered in the chapter of Kwul, is compared with I.I.C.P. 4. The followings should be considered; examination of optic symptom and abnormal posture in cerebral herniation ; understanding and working out counterplans of factors and symptoms of consciousness disorder by the observation of vital sign, check of general stages, neurologic inverstigation, clinical diagnosis, and subsidiary diagnosis; application of morphological change of opinion; addtion of the conception of demonstration centered on Yunkyung, Samyinkwulruk, asthenia and thenia of healthy energy in oriental medicine. 5. The similarity of Kwul and I.I.C.P. can be found from etiology and pathotenic factor. The similarity is clearly found by investigation of etiology, pathotenic factor, symptoms and thrapy of Kwul, disease symptom ar.d other symptoms.

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현훈(眩暈)의 형상의학적(形象醫學的) 치료(治療) (Treatment of Vertigo in Hyungsang Medicine)

  • 강경화;강덕수;이용태
    • 동의생리병리학회지
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    • 제20권4호
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    • pp.793-798
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    • 2006
  • Vertigo is one of the subjective symptoms which appears commonly in so many diseases that it is often neglected. But it needs active medical care because it can be a forewarning of serious illness like cerebral apoplexy. This thesis makes a study of vertigo in view of Hyungsang medicine. The followings are the conclusion drawn in diagnosis and treatment of Vertigo: Excess in the upper and deficiency in the lower part(上實下虛) is a main cause of male vertigo. Deficiency in the upper and excess in the lower part(下虛上實) is a general cause of female vertigo. Vertigo is also caused by the insufficiency of the kidney water(腎水) or reservoir of marrow(髓海). persons of Jung pe(精科) with large check bones , those of Fish type(魚類) with Dig mouth and thick lips ; and those with large heads are mainly attacked by this cause. A fleshy person's vertigo comes from the deficiency of Ki and damp phlegm(氣虛濕症) so it is cured by reinforcing Ki, removing dampness and dispelling phlegm. A slim person's vertigo comes from the deficiency of blood and dryness heat(血虛有火) so it is treated by tonifying the blood, cleaning heat away the heat. In case of womanly shaped male and manly shaped female, the vertigo is due to the phlegm fire. Wind-heat(風熱) can cause vertigo generally 施 the persons of following types : wind type(風人), running animal type(走類),bird type(烏類), and Yangmyung meridian type (陽明形). Vertigo also comes from consumption. The deficiency of Ki can be a cause of vertigo in case of male; persons with pale complexion; and those with pronounced noses. The deficiency of blood can be a reason of vertigo in the persons of Hyul type(血科) and those with pale eyelids and lips. The hypofunction of the splean and stomach brings on the deficiency of Ki and blood, which can give rise to the vertigo for those with large nose and mouth. The old people's vertigo comes from the hypofunction of Ki, blood, Yin and Yang.

Differences in Clinical Characteristics and Surgical Outcomes of Patients with Ischemic and Hemorrhagic Pituitary Adenomas

  • Jingpeng, Liu;Peng, Huang;Xiaoqing, Zhang;Yong, Chen;Xin, Zheng;Rufei, Shen;Xuefeng, Tang;Hui, Yang;Song, Li
    • Journal of Korean Neurosurgical Society
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    • 제66권1호
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    • pp.72-81
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    • 2023
  • Objective : Ischemia and hemorrhage of pituitary adenomas (PA) caused important clinical syndrome. However, the differences on clinical characteristics and surgical outcomes between these two kinds apoplexy were less reported. Methods : A retrospective analysis was made of patients with pituitary apoplexy between January 2013 and June 2018. Baseline and clinical characteristics before surgery were reviewed. All patients underwent transsphenoidal surgery and were followed up at least 1 year. Results : Total 67 cases (5.8%) among 1147 pituitary tumor patients were enrolled, which consisted of 28 (~2.4%) ischemic PA and 39 (~3.4%) hemorrhagic PA. There were more male patients in the ischemic group compared with hemorrhagic group (78.6% vs 53.8%, p=0.043). However, the mean age, tumor size and functional tumor ratio were significant higher in the hemorrhagic group. Headache was more common in ischemic PA (82.1%) than that of hemorrhagic PA (51.3%, p=0.011). Magnetic resonance imaging findings found that mucosal thickening and enhancement of the sphenoid sinus was observed in 15 ischemic PA patients (n=27, 55.6%), but none in patients with hemorrhagic PA (n=38, p<0.0001). It was worth noting that the rate of pre-surgical hypopituitarism in ischemic PA patients were seemed higher than that in hemorrhagic PA patients, but not significant. The two groups got a total tumor resection rate at 94.1% and 92.9%, independently. No significant difference on the operative time, blood loss in operation and complications in perioperative period was observed in two groups. After operation, cranial nerve symptoms recovered to normal at 81.8% of ischemic PA patients and 82.6% of hemorrhagic PA patients. Importantly, the incidence of postoperative hypopituitarism partially decreased in both groups, among which the rate of hypothyroidism in ischemic PA patients significantly decreased from 46.4% to 18.5% (p=0.044). Conclusion : Patients with ischemic PA presented different clinical characteristics to the hemorrhagic ones. Transsphenoidal surgery should be considered for the patients with neuro-ophthalmic deficits and might benefit for pituitary function recovery of the apoplectic adenoma patients, especially pituitary thyroid axis in ischemic PA patients.

거풍도담탕의 백서의 뇌혈류 변화에 미치는 기전연구 (A Mechanism Study of Geopungdodam-tang on the Change of Cerebral Blood Flow in Rats)

  • 송정석;정현우
    • 동의생리병리학회지
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    • 제16권1호
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    • pp.99-103
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    • 2002
  • Geopungdodam-tang(GDT) have been used in oriental medicine for many centuries as a therapeutic agent of apoplexy. The mechanism of GDT on the cerebral blood flow is not known. The purpose of this Study was to investigate effects of GDT on the pial arterial diameter and action mechanism of GDT-induced increased regional cerebral blood flow(rCBF). The changes of regional cerebral blood f1ow(rCBF) was determinated by Laser-Doppler Flowmetry(LDF), and the changes of pial arterial diametet were determinated by video microscopy methods and video analyzer. The results were as follows ; 1. Pial arterial diameter was significantly increased by GDT in a dose-dependent manner. 2. Pretreatment with L-NNA significantly inhibited GDT induced increased rCBF. 3. Pretreatment with methylene blue significantly inhibited GDT induced increased rCBF. 4. Pretreatment with indomethacin inhibited GDT induced increased rCBF. These results suggest that GDT causes a diverse response of cerebral hemodynamics(rCBF and pial arterial diameter). The cerebral hemodynamics is also mediated by nitric oxide synthase, cyclic GMP(guanylyl cydase) and prostaglandin(cyclooxygenase).

"임증지남의안(臨證指南醫案)"권일(卷一) "현운(眩暈)"에 대한 고찰 (Study on ${\ulcorner}$Medical Records as a Guide to Clinical Works${\lrcorner}$ ${\ulcorner}Volume\;1{\lrcorner}$ ${\ulcorner}dizziness{\lrcorner}$)

  • 신순식
    • 제3의학
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    • 제1권2호
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    • pp.31-37
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    • 1996
  • ${\ulcorner}Volume\;1{\lrcorner}$ of ${\ulcorner}$Medical Records as a Guide to Clinical Works${\lrcorner}$, written by Ye Tian Shi, showed some clinical cases of dizziness. In this study, his diagnosis and treatment was studied with 16 clinical cases of dizziness with pathogenic factor, pathogenesis and symptoms of dizziness. Ye Tian Shi thought that phlegm, fire, wind and insufficiency were the causes of dizziness and phlegm-fire, phlegm-fire-wind, wind-phlegm and insufficiencyfire-wind were the causes of dizziness, clinically. Dizziness is caused when the body is in condition of excess in the upper and deciency in the lower. The acompanying clinical symptoms of dizziness are endogenous wind, fire of deficiency type, phlegm wind and phelegm fire. For the treatment of dizziness, Ye Tian Shi used the combination of medicines with some modifications by the cases for phlegm, fire, wind and insufficiency. He also encouraged the mental therapy for the treatment of dizziness. He emphasized the early treatment of dizziness to prevent hemiplegia after apoplexy. It can be postulated from Volume 1 of ${\ulcorner}$Medical Records as a Guide to Clinical Works${\lrcorner}$, diagnosis and treatment of symptoms and illness of Ye Tian Shi was strictly based on actual clinical cases.

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거풍제습탕이 뇌허혈이 유발된 백서의 뇌혈류 변화에 미치는 영향 (Effects of Geopungjeseub-tang(Gufengchushi-tang) on the Changes of Cerebral Blood Flow in Rats)

  • 홍석;전상윤
    • 대한한방내과학회지
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    • 제26권3호
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    • pp.596-604
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    • 2005
  • Objectives : Geopungjeseub-tang(Gufengchushi-tang) has been used in oriental medicine for many centuries as a therapeutic agent for hemiplegia caused by deficiency of qi(氣虛) and damp phlegm(濕痰). This study was performed to evaluate effects of Geopungjeseub-tang extract(GJT) on hemodynamics[regional cerebral blood flow(rCBF), pial arterial diameter(PAD), mean arterial blood pressure(MABP), heart rate(HR)] in normal rats and in rats with cerebral ischemia by middle cerebral artery(MCA) occlusion. Also, effects of adrenergic ${\beta}-receptor$, cyclooxygenase on response to GJT were evaluated. Methods : Laser-doppler flowmetry(LDF) measured changes of rCBF, MABP and HR. Video microscope and width analyzer measured changes in PAD. Results : rCBF and PAD increased after treatment with GJT(10mg/kg, i.v.) during the period of cerebral reperfusion, and pretreatment with indomethacin raised rCBF and PAD increased after treatment with GJT during the same period as above. Pretreatment with propranolol decreased rCBF, but increased after GJT treatment, but raised PAD increased after GJT treatment during this period of reperfusion. Conclusion : CR caused diverse responses were observed in rCBF and PAD after treatment with GJT. ACF action is mediated by adrenergic ${\beta}-receptor$ and cyclooxygenase. Result suggest that GJT has an anti-ischemic effect through the improvement of cerebral hemodynamics and has theraputic potential for cerebral apoplexy.

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