• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.12 no.2
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• pp.31-42
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• 2017

Objectives : This review aims to assess the effect of Wuqinxi exercise for osteoporosis. Methods : We searched 9 electronic databases(Pubmed, EMBASE, Cochrane Library, CAJ, Oasis, KISS, NDSL, KMBASE, KISTI) and related 2 journals until November 2017. We included randomized controlled trials(RCTs) of testing Wuqinxi exercise for osteoporosis. The methodological quality of RCTs related assessed by the Cochrane risk of bias tool. Results : 12 RCTs were eligible in our inclusion criteria. No statistical differences were found between the Wuqinxi versus no intervention, Wuqinxi plus antiosteoporosis medications versus antiosteo-porosis medications on lumbar spine, femora bone mineral density (BMD). However, Wuqinxi significantly improved lumbar spine BMD compared with antiosteoporosis medications (P < 0.00001). Additionally, the results showed a remarkable effect in improving pain score(VAS) when Wuqinxi or Wuqinxi plus antiosteoporosis medications (P < 0.0005) was used. Conclusions : There is evidence of Wuqinxi exercise for osteoporosis with meta-analysis. However, our systematic review has limited evidence to support Wuqinxi exercise for osteoporosis. because of low quality of original articles and further well-designed RCTs should be encouraged.

• The Journal of Korean Medicine
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• v.19 no.1
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• pp.5-18
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• 1998

The purpose of this study was to determine the effects of aqua-acupuncture of Laennec N HO (Hominis placenta Cervi pontotrichum cornu Carthami semen). on trabecular area and physiological change in ovariectomized osteoporotic rats. This experiment was performed to .investigate an antiosteoporosis. effects of Laennec N HO(Hominis placenta Cervi pontotrichum cornu Carthmi semen) aqua-acupuncture on the osteoporosis induced by both ovariectomy in Rats. So rats were divided into Sham group and OVX group. OVX groups were divided into control group, Exp. I group, Exp II group and Exp III group). The Ratios of trabecular area seen in ephiphysis and diaphysis of tibia and lumbar vertebral body and physiological change were as follows. 1. In the proximal ephiphysis of tibia, Exp I II III groups were significantly increased compared to that in control group (p<0.05). 2. In the diaphysis of tibia, Exp III group were significantly increased compared to that in control group (p<0.05). 3. In the first lumbar vertebral body, Exp II group were significantly increased compared to that in control group. 4. In the cortical thickness index of tibia, Exp III III groups were significantly increased compared to that in control group. 5. Osteoca1cin was increased in the Exp II group than those of other Experiment groups and control group, and Phosphorus was decreased in the Exp I II group than that in control group, But a significant difference was not seen. GOT, GPT and Alkaline phosphatase were decreased in all Experiment groups than that in control group. But a significant difference was not seen. From the above results, it might be suggested that aqua-acupuncture Laennec N HO(Hominis placenta Cervi pontotrichum cornu Carthami semen) prevented the increase in bone turnover and the decrese in bone mass induced by OVX in rats.

• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 2003.04a
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• pp.22-39
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• 2003

Biological activity of phenolic compounds in seeds and leaves of safflower (Carthamu tinctorius L.) were evaluated using several in vitro and in vivo assays. Six phenolic constituents were isolated from the seeds and identified as N-feruloylserotonia, N- (p-coumaroyl)serotonin, matairesinol, 8′-hydroxyarctigenin, acacetin 7-O-$\beta$-D-glucoside (tilianine) and acacetin. Six phenolic compounds exhibited considerable antioxidative activity, and especially two serotonins showed potent DPPH radical scavenging activity and antiperoxidative activity against rat liver microsomal lipid peroxidation induced by the hydroxyl radical generated via a Fenton-type reaction. Additionally, six phenolic compounds possessed comparable cytotoxicity against three cancer cells, Hela cell, MCF-7 and HepG2 cell, and particularly acacetin and its glycosides had the most potent cytotoxicity. Moreover, we found that feeding safflower seeds attenuated bone loss, and lowered levels of plasma and liver lipids in ovariectomized rats. Serotonins, lignans and flavones stimulated proliferation of the osteoblast-like cells in a dose-dependent manner (10$^{-15}$ ~10$^{-6}$ M), as potently as E$_2$ (17$\beta$-estradiol). Particularly, serotonins were mainly responsible for bone-protecting and lipid lowering effects in ovariectomized rats. Meanwhile, eight flavonoids, including a novel quercetin-7-O-(6"-O-acetyl)-$\beta$-D-glucopyranoside and seven kown flavonoids, luteolin quercetin, luteolin 7-O-$\beta$-D-glucopyranoside, luteolin-7-O-(6"-O-acetyl)-$\beta$-D-gluco-pyranoside, quercetin 7-O- -glucopyranoside, acacetin 7-O-$\beta$-D-glucuronide and apigenin-6-C-$\beta$-D-glucopyranosyl-8-C-$\beta$-D-glucopyranoside were first isolated and identified from safflower leaf. Among these flavonoids, luteolin-acetyl-glucoside and $\beta$quercetin- acetyl-glucoside showed potent antioxidative activities against 2-deoxyribose degradation and lipid peroxidation in rat liver microsomes. Luteolin, quercetin and their corresponding glycosides also exhibited strong antioxidative activity, while acacetin glucuronide and apigenin-6, 8-di-C-glucoside were relatively less active. Finally, changes in phenolic compositions were also determined by HPLC in the safflower seed and leaf during growth stages and roasting process to produce standardized supplement powerds. These results suggest that phenolic compounds in the roasted safflower seed and leaf may be useful as potential sources of therapeutic agents against several pathological disorders such as carcinogenesis, atherosclerosis and osteoporosis.