• Advances in Traditional Medicine
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• 제4권2호
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• pp.87-90
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• 2004

The efficacy of Arque-Ajeeb (AA), a compound formulation of Unani medicine was investigated for antidiarrhoeal activity against barium sulphate-induced gut motility and castor oil-induced diarrhoea in rats. The control, standard and test groups of experimental animals were administered with distilled water (p.o.), lomotil (p.o.) and AA (0.007 ml and 0.014 ml/100 g, p.o.) respectively. Barium sulphate and castor oil were administered after 15 and 60 min respectively in each group of first and second experiment. The distance traveled by barium sulphate in small intestine was measured after 15 and 30 min of barium sulphate administration and diarrhoea was observed every 30-min for six hour after castor oil administration. Oral administration of AA caused significant reduction in diarrhoea. AA may have the potential to reduce the diarrhoea in rats.

• Advances in Traditional Medicine
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• 제8권3호
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• pp.215-221
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• 2008

In this present study Indian traditional Ayurvedic herbal formulation Amritaristo has been studied to assess the general pharmacological effect on mice. The drug showed no significant activity on the neuropharmacological test models experimented. The increased pentobarbital sleeping time was considered related with hepatic metabolism of pentobarbital. The formulation exhibited a non-significant reduction of gastrointestinal motility, and devoid of any acute diuretic activity. The tested drug revealed antidiarrhoeal activity on castor oil-induced model, whereas on magnesium sulphate-induced model no effect was observed.

• 셀메드
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• 제3권4호
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• pp.28.1-28.7
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• 2013

Careya arborea Roxb. (Lecythidaceae) is a significant medicinal plant known as kumbhi in Ayurveda. Though, most of the plant parts are used in traditional systems of medicine, bark and leaves constitute the important medicinal parts. The present review gives an account of the updated information on its phytochemical and pharmacological properties. The review reveals that numerous phytochemical constituents have been isolated from the plant possessing hepatoprotective, antioxidant, antimicrobial, anticoagulant, analgesic, antidiarrhoeal and various other important activities. Leaves are used in filaria, colic, loose motions and ulcers. Bark is used as an antipyretic, abortifacient, antipruritic and in smallpox, urinary discharges and rheumatic pain. Since last few decades, extensive exploration has been done to establish the biological activities and pharmacology of the extracts and plentiful chemical constituents including flavonoids, tannins, alkaloids, terpenoids and many other have been isolated.

• Advances in Traditional Medicine
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• 제6권3호
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• pp.208-214
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• 2006

In this study the Ayurvedic formulation Dasamularista was studied for its preliminary pharmacological properties using laboratory mice. Dasamularista showed a decrease in food intake and stool formation, while the water content of stool and water intake was higher and the volume of the urine was less. Dasamularista in a slight extent reduced the intestinal motility. This constipating effect was further supported by the significant anti-diarrhoeal property of the formulation in castor oil induced dairrhoea. The tested formulation markedly increased the latent period of diarrhoea and reduced the purging index value. Dasamularista did not alter the acetic acid induced abdominal writhing. Significant reduction on the onset of sleeping time and increased duration of sleep was observed in pentobarbital induced sleeping time test.

• Advances in Traditional Medicine
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• 제9권4호
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• pp.320-325
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• 2009

The pharmacological interest coupled with traditional uses (antidiarrhoeal, antiseptic, analgesic etc) prompted us to test for anti-inflammatory, antinociceptive and diuretic activitities of Trema (T.) orientalis Linn. The crude methanolic leaves extract of T. orientalis was investigated for its possible anti-inflammatory activities using carrageenin induced rat paw edema model and cotton pellet implantation method in mice. Then the extract analyzed for its antinociceptive activities by acetic acid induced writhing model in mice. The extract possessed significant anti-inflammatory activity in both models at the doses of 200 and 400 mg/kg body weight of mice. Moreover, the extract showed significantly reduced the number of acetic acid-induced abdominal constriction in mice of 200 and 400 mg/kg body weight. The extract also showed positive diuretic activity in albino mice.

• Advances in Traditional Medicine
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• 제8권4호
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• pp.395-399
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• 2008

Methanol and aqueous extract of leaves of Trema orientalis Linn. were subjected to the potential antioxidant and antibacterial activities. The pharmacological interest of this plant coupled with traditional use (antidiarrhoeal, antiseptic, analgesic etc) prompted to test for antioxidant and antibacterial activities. The antioxidant potential of the methanolic extract was determined on the basis of their scavenging activity of the stable 1,1-diphenyl-2-picryl hydrazyl free radical. $IC_{50}$ of the methanol extract of T. orientalis was $110.25\;{\mu}g/ml$ which indicated the strong antioxidant activity of the plant. However the aqueous extract showed mild antioxidant activity. In case of antibacterial activities test, the extract was subjected for its effectiveness against both Gram-positive and Gram-negative bacteria in agar diffusion method. The zones of inhibition produced by the crude methanol and aqueous extract against few sensitive strains were measured and compared with those of standard antibiotic Gentamycin. It is evident that both extracts are active against the bacteria at low concentrations. The obtained results provide a support for the use of this plant in traditional medicine and suggest its further advance investigation.

• Advances in Traditional Medicine
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• 제7권3호
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• pp.286-289
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• 2007

Heracleum nepalense D Don. (Umbelliferae) is a small shrub having high glabrescent stem found in stream banks in Sikkim. Various medicinal properties which include antidiarrhoeal, antiseptic, anti-influenzal etc. have been attributed for this plant in the traditional system of medicine in Sikkim. In present investigation the methanol extract of roots of Heracleum nepalense was subjected for its effectiveness against both Gram-positive and Gram-negative bacteria causing diarrhoea. The roots extract was tested for its minimum inhibitory concentration (MIC) against both Gram-positive and Gram-negative organisms causing diarrhoea. Further, the zones of inhibition produced by the crude extract against few sensitive strains was measured and compared with those of standard antibiotic ciprofloxacin. It is evident that the methanol extract is very active against the bacteria causing diarrhoea at low concentrations. The antibacterial efficacy of the root extract was found to decrease in the following order against different tested bacterial strains like Shigella dysenteriae, Escherichia coli, Shigella boydii, Vibrio cholerae, Salmonella typhimurium.