• Asian-Australasian Journal of Animal Sciences
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• 제19권3호
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• pp.425-430
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• 2006

Three hundred and sixty sexed 3-day-old broiler chicks were divided randomly into six treatment groups (control, antibiotic and black cumin at four levels) of 60 birds each. Black cumin seeds at 0.5%, 1%, 2% or 3% and avilamycin at 10 mg/kgt were added to the basal diet and their effects determined on feed intake, daily live weight gain, feed conversion ratio and carcass characteristics. There were no significant differences in daily feed intake at 21 and 42 days (p>0.05). Average daily gain was significantly different between the treatments. The birds fed the diet containing 1% black cumin seeds and antibiotic were the highest average daily gain, followed by those the other treatment diets and negative control (p<0.05). From 1 to 42 days of age, feed conversion ratios were improved significantly by supplementation with 1% black cumin seeds and with antibiotic (p<0.05) by approximately 5% compared to the control group. Similarly, the highest cold carcass, thigh, breast, wing, neck and liver weights were observed in the 1% black cumin and antibiotic groups (p<0.05). Accordingly, 1% supplementation of black cumin seeds to diets could be considered as an alternative natural growth promoter for poultry instead of antibiotics.

• Fisheries and Aquatic Sciences
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• 제16권2호
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• pp.79-84
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• 2013

In an effort to discover an alternative antibiotic for treating infections with methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas sp. UJ-6, a marine bacterium that exhibited antibacterial activity against MRSA, was isolated. The culture broth and its ethyl acetate extract exhibited bactericidal activity against MRSA. The extract also exhibited antibacterial activity against gram-negative bacteria, which were not susceptible to vancomycin. The treatment of MRSA with the extract resulted in abnormal cell lysis. The extract retained >95% of its anti-MRSA activity after heat treatment for 15 min at $121^{\circ}C$. Thus, although most antibiotics are unstable under conditions of thermal stress, Pseudomonas sp. UJ-6 produces a heat-stable anti-MRSA substance. The results of this study strongly suggest that Pseudomonas sp. UJ-6 can be used to develop a novel, heat-stable, broad-spectrum antibiotic for the treatment of MRSA infections.

• 한국동물위생학회지
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• 제36권4호
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• pp.283-289
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• 2013

The antibiotic chemotherapy produces sometimes side effects and fails to eliminate bacterial infection. The occurrence of strains resistant to antibiotics would be expected to increase, and it is nowadays important to search for non-antibiotic substances. We are aimed to evaluate the effects of Torilis fructus extracts against enteropathogenic Escherichia coli (E. coli) in Piglets. The piglets were divided with three groups; Negative control group, E. coli-infected positive control group, and the Torilis fructus extracts treated group with E. coli infection. During the study period, we compared clinical signs, weight increase rate, fecal scores, gross findings between the treated group and non treated group. After necropsy, necropsy findings and histopathological findings were conducted with the comparison between the groups. As the results of this study, the Torilis fructus extracts additive showed the effects on the suppression of E. coli-induced lesions. On the basis of this study results, our data suggest that the Torilis fructus extracts additive have the antimicrobial effects. The Torilis fructus extracts additive could be used as the alternative material for antimicrobial feed additives.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권1호
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• pp.60-64
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• 2006

Backgrounds: Though they are considered as reliable devices, titanium plates and screws have limitations due to some potential problems. To overcome these problems, researches on bioabsorbable materials for internal fixation have been continuing. Recently, there are many clinical trials to apply biodegradable internal fixation devices in oral and maxillofacial surgery. The purpose of this study was to evaluate the clinical results of application of bioabsorbable plates and screws in orthognathic surgery. Methods: Fifty-four patients with dentofacial deformity (17 male patients and 37 female patients) were selected in this study. The patients were treated by internal fixation using bioabsorbable plates and 2.4-mm, 2.0-mm pretapped screws (Biosorb FX, Bionix Implants, Inc., Finland). The patients were evaluated for complications during the follow-up period. Results: Five patients (9.3%) experienced complications. All complications in these cases were infection. No other complications related with physical or mechanical properties of bioabsorbable plates were found such as malunion or nonunion, fractures of plates and loosening of screws. All complications were minor and adequately managed with drainage and supportive care with antibiotics coverage. Conclusions: From the results, the use of these fixation systems in orthognathic surgery will provide a promising alternative titanium fixation in appropriate cases.

• 한국동물위생학회지
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• 제32권1호
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• pp.33-41
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• 2009

In order to develop probiotic strain for pigs, Lactobacillus spp. (527 isolates), Streptococcus spp. (95 isolates) and Bifidobacterium spp. (25 isolates) were isolated from the feces of 35 pigs. These isolates were tested through in vitro experiment such as acid tolerance at pH 2.0 (Lactobacillus spp. and Streptococcus spp.) or pH 3.0 (Bifidobacterium spp.), bile tolerance in MRS broth containing 0.3% (w/v) Oxgall, heat resistance at $70^{\circ}C$ and $80^{\circ}C$ for 5 min, antibiotic resistance, antimicrobial activity against pathogenic bacteria and Caco-2 cell adherence assay. Finally ten most superior strain (5 Lactobacillus spp. strain, 3 Bifidobacterium spp. strain and 2 Streptococcus spp. strain) were selected as potential candidate for probiotic use in pig industry. It could be used as an alternative to antibiotics in feed additives.

• 대한소화기학회지
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• 제72권5호
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• pp.237-244
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• 2018

While the prevalence of Helicobacter pylori (H. pylori) infection is decreasing in Korea, the incidence of gastric cancer remains high, emphasizing the importance of H. pylori eradication. A new treatment strategy is needed as the eradication rate with standard triple therapy, which is currently the standard first-line regimen for H. pylori infection, has decreased below the optimum level. The major cause of eradication failure is increased antibiotic resistance. Sequential, concurrent, and hybrid therapies that include clarithromycin produce higher eradication rates than conventional standard triple therapy. However, the effectiveness of these treatments is limited in regions where the resistance rate to various antibiotics is high. Bismuth quadruple therapy is another alternative therapy, but again the eradication rate is not sufficiently high. Tailored therapy based on individual characteristics, including antibiotic susceptibility, may be ideal, but there are several limitations for clinical application and further research is needed. New potassium-competitive acid blocker-based therapies could emerge as effective alternatives in the near future. A consensus is needed to establish a strategy for applying new eradication therapies in Korea.

• 급식외식위생학회지
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• 제3권1호
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• pp.19-27
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• 2022

The use of cultured meat, also known as in vitro meat, is claimed to be a way of meeting the growing demand for meat worldwide in a safe and disease-free manner, without sacrificing animal and lowering greenhouse gas emissions. However, its economic feasibility is limited by its cost, scale-up complexity, public neophobia and technophobia, and an imperfect knowledge of its impacts on human health. Cultured meat, which is obtained from stem cells using tissue engineering techniques, has been described as a potential alternative to the current meat production systems, which have extensive negative effects. To ensure that a food product is safe for human consumption, it is important to consider all aspects of its life cycle. In this context, the current review analyzes the major elements of the cultured meat life cycle, including the incorrect use of chemicals, such as pesticides or antibiotics, as well as improper processing and storage methods that determine the food safety of cultured meat. The purpose of this review is to determine food safety, health issues, and the potential risks associated with cultured meat production.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.94.1-94
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• 2003

Control of bacterial blossom blight of kiwifruit (Actinidia deliciosa) has been mainly depended on chemical control. Recently cultural practices such as trunk girdling of kiwifruit trees and rainproof installation over kiwifruit trees also were conducted as the alternative control practices. Each of the control methods was evaluated for the best practicing conditions for the control of bacterial blossom blight of kiwifruit. Among the various combinations of spray times and spray periods, optimum spray program of antibiotics was turned out to be 3 times with intervals of 10 days from early May during the flowering season of kiwifruits. Optimum periods of trunk girdling of kiwifruit trees were from late March to late April. Trunk girdling with 20-30 mm wide showed best control efficacies on bacterial blossom blight, irrespective of the heights of girdling on trunks of kiwifruit trees. Optimum period of rainproof installation over kiwifruit trees was from March till late April, irrespective of installation methods.

• 한국유기농업학회지
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• 제18권4호
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• pp.527-539
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• 2010

본 시험은 생균제를 자돈 사료에 첨가하여 자돈의 성장능력, 영양소 이용률, 유해가스 및 분내 미생물 발생정도를 비교하여 항생제 대체효과를 규명하여 하기 위하여 실시하였다. 본 시험은 삼원교잡종(Landrace${\times}$Large White${\times}$Duroc) 자돈(22.5kg) 96두를 선발하여 28일간 사양시험을 실시하였다. 본 시험은 3처리 4반복의 난괴법 배치로 T1 처리구 항생제, T2 처리구는 무항생제에 복합생균제 0.2% 첨가, T3 처리구는 무항생제에 단일생균제 0.3%를 첨가하였다. 자돈의 일당 증체량, 일일 사료섭취량 및 사료요구율은 처리간에 유의적인 차이가 없었다. 그러나 건물, 조단백질, 조지방 및 조회분의 소화율은 처리간에 유의성이 있었으며, 특히 복합생균제와 Bacillus subtillis natto 생균제가 대조구인 항생제 처리구보다 소화율이 높았다. 돈 분뇨의 유해가스 발생량에서는 암모니아($NH_3$), 아민(R-$NH_2$), 황화수소($H_2S$) 및 멜캅탄($CH_2$-SH)의 발생량은 항생제 처리구보다 생균제 첨가구가 적어 돈사내 가스 감소에 효과가 있었다. 그러나 분의 수분함량은 처리간에 유의적인 차이가 없었다. 돈분내 총균, 대장균 및 내열성균은 처리간에 유의적인 차이가 있었다. 즉 총균과 대장균의 수는 생균제 첨가에 의하여 감소하였으며, 내열성 포자의 수는 T3 처리구가 다른 처리구보다 많았다. 따라서 생균제를 항생제 대체물질로 급여한 결과 자돈의 장내 환경을 개선하고 돈사 내 유해가스 감소시킬 뿐만 아니라 자돈의 생산성 향상에도 기여한 것으로 판단되었다.

• 한국축산식품학회지
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• 제30권2호
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• pp.261-268
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• 2010

본 연구는 환경온도($21^{\circ}C$, $32^{\circ}C$) 및 항생제 대체재가 냉장저장 중 닭 가슴살의 품질에 미치는 영향을 알아보고자 실시하였다. 그 결과, 사후 72시간째 pH 값은 $32^{\circ}C$의 에션셜오일 처리구가 다른 처리구에 비해 유의적으로(p<0.05) 높게 나타났다. 황색도의 경우 $32^{\circ}C$의 고온조건에서 생산된 닭 가슴살은 $21^{\circ}C$의 조건에서 생산된 닭 가슴살에 비해 유의적으로(p<0.05) 높게 나타났다. 사후 72시간째 $32^{\circ}C$의 고온조건에서 생산된 닭 가슴살의 지방산화도는 에션셜오일 처리구에서 낮게 나타났으며, 염용성 단백질 추출성에 있어서는 약용식물 처리구에서 높게 나타나 효과적인 것으로 나타났다. 근원섬유 단백질의 분포 양상에 있어서도 액틴밴드의 경우, 유산균 및 에션셜오일 처리구가 $21^{\circ}C$의 항생제(+) 처리구와 비슷한 양상을 보였다. 이상의 결과를 종합해 볼 때 상기의 항생제 대체물질들은 항생제를 대체하더라도 저장 중 닭고기의 품질을 개선시키는 효과가 있으며, 이와 아울러 항생제 대체물 급여시 닭고기의 품질에 미치는 지표로 지방산화도 및 염용성 단백질 추출성 등이 이용될 수 있을 것으로 사료된다. 특히, 에션셜오일 급여는 고온조건에서 고품질의 닭고기를 생산할 경우 항생제 대체 효과가 가장 우수한 것으로 판단된다.