• 한국콘텐츠학회논문지
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• 제11권4호
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• pp.244-252
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• 2011

본 연구는 임상에서 시행되고 있는 64 절편 다행검출 CT(MDCT)의 방사선량에 대해 알아보고 이 선량으로 인한 암 발생의 잠재적 위험(LAR)을 정량화하고자 하였다. CT 검사의 선량길이곱과 유효선량을 측정하였고, 이로 인한 암 발생 귀속위험은 미국 전리방사선의 생물학적효과 위원회 7차보고서를 이용하였다. 결과에서 두부 CT의 유효선량은 1.48mSv, 흉부 CT(조영제 포함)의 유효선량은 7.66mSv였으며, 복부 역동적 CT는 24.52mSv였다. 두부 CT의 LAR은 남성 7463명 중 1명, 여성 4926명 중 1명이었고, 흉부 CT(조영제포함)의 LAR은 남성 1449명 중 1명, 여성 952명 중 1명이었으며, 복부 역동적 CT는 남성 453명 중 1명, 여성 298명 중 1명이었다. 따라서 64 절편 MDCT 검사는 암발생위험과 무시할 수 없는 관련성이 있었고, 선량을 줄이기 위해 프로토콜 등을 조정하는 등의 세심한 노력을 기울여야 한다.

• Clinical and Experimental Pediatrics
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• 제48권1호
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• pp.93-96
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• 2005

저자들은 출생 시부터 전신에 분포하는 밀크 커피색 반점이 있고, 액와부에 작은 주근깨를 보이며 정신 지체와 발달 지연등 제1형 신경섬유종증의 소견을 보이는 환아에서 급성 신경학적 쇠약 증세가 있어 시행한 뇌자기공명영상 촬영과 뇌동맥조영 촬영상 모야모야병의 소견이 동반된 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제42권1호
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• pp.107-110
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• 2009

자가 또는 이식혈관의 감염은 반복적인 파열 및 패혈증으로 인해 환자의 생명을 위협하는 심각한 질병이다. 대퇴동맥을 포함한 서혜부 감염이 생긴 경우 가장 성공적인 치료원칙은 감염된 조직의 광범위한 절제와 동맥재건술이다. 본원에서는 뇌동정맥루, 뇌출혈환자에서 대퇴동맥을 천자하여 시행한 혈관조영술후 패혈증을 동반한 감염된 가성동맥류가 발생하여 폐쇄공우회술을 이용하여 치험하였기에 보고하는 바이다.

• International Journal of Vascular Biomedical Engineering
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• 제1권1호
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• pp.13-23
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• 2003

Backgrounds: The present study in angulated coronary stenosis was to evaluate the influence of velocity and wall shear stress (WSS) on coronary atherosclerosis, the changes of hemodynamic indices following coronary stenting, as well as their effect of evolving in-stent restenosis using human in vivo hemodynamic parameters and computed simulation quantitatively and qualitatively. Methods: Initial and follow-up coronary angiographies in the patients with angulated coronary stenosis were performed (n=80). Optimal coronary stenting in angulated coronary stenosis had two models: < 50 % angle changed(model 1, n=43), > 50% angle changed group (model 2, n=37) according to percent change of vascular angle between pre- and post-intracoronary stenting. Flow-velocity wave obtained from in vivo intracoronary Doppler study data was used for in vitro numerical simulation. Spatial and temporal patterns of velocity vector and recirculation area were drawn throughout the selected segment of coronary models. WSS of pre/post-intracoronary stenting were calculated from three-dimensional computer simulation. Results: Follow-up coronary angiogram demonstrated significant difference in the percent of diameter stenosis between two groups (group 1: $40.3{\pm}30.2$ vs. group 2: $25.5{\pm}22.5%$, p<0.05). Negative WSS area on 3D simulation, which is consistent with re-circulation area of velocity vector, was noted on the inner wall of post-stenotic area before stenting. The negative WSS was disappeared after stenting. High spatial and temporal WSS before stenting fell into within physiologic WSS after stenting. This finding was prominent in Model 2 (p<0.01) Conclusions: The present study suggests that hemodynamic forces exerted by pulsatile coronary circulation termed as WSS might affect on the evolution of atherosclerosis within the angulated vascular curvature. Moreover, geometric change, such as angular difference between pre / post-intracoronary stenting might give proper information of optimal hemodynamic charateristics for vascular repair after stenting.

• Journal of Korean Neurosurgical Society
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• 제57권6호
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• pp.460-464
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• 2015

Objective : Bilateral C1 lateral mass and C2 pedicle screw fixation (C1LM-C2P) is an ideal technique for correcting atlantoaxial instability (AAI). However, the inevitable situation of vertebral artery injury or unfavorable bone structure may necessitate the use of unilateral C1LM-C2P. This study compares the fusion rates of the C1 lateral mass and C2 pedicle screw in the unilateral and bilateral methods. Methods : Over five years, C1LM-C2P was performed in 25 patients with AAI in our institute. Preoperative studies including cervical X-ray, three-dimensional computed tomography (CT), CT angiogram, and magnetic resonance imaging were performed. To evaluate bony fusion, measurements of the atlanto-dental interval (ADI) and CT scans were performed in the preoperative period, immediate postoperative period, and postoperatively at 1, 3, 6, and 12 months. Results : Unilateral C1LM-C2P was performed in 11 patients (44%). The need to perform unilateral C1LM-C2P was due to anomalous course of the vertebral artery in eight patients (73%) and severe degenerative arthritis in three patients (27%). The mean ADI in the bilateral group was 2.09 mm in the immediate postoperative period and 1.75 mm in 12-months postoperatively. The mean ADI in the unilateral group was 1.82 mm in the immediate postoperative period and 1.91 mm in 12-months postoperatively. Comparison of ADI measurements showed no significant differences in either group (p=0.893), and the fusion rate was 100% in both groups. Conclusion : Although bilateral C1LM-C2P is effective for AAI from a biomechanical perspective, unilateral screw fixation is a useful alternative in patients with anatomical variations.

• Journal of Korean Neurosurgical Society
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• 제45권3호
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• pp.164-168
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• 2009

Objective : Bilateral C1-2 transarticular screw fixation (TAF) with interspinous wiring has been the best treatment for atlantoaxial instability (AAI). However, several factors may disturb satisfactory placement of bilateral screws. This study evaluates the usefulness of unilateral TAF when bilateral TAF is not available. Methods : Between January 2003 and December 2007, TAF was performed in 54 patients with AAI. Preoperative studies including cervical x-ray, three dimensional computed tomogram, CT angiogram, and magnetic resonance image were checked. The atlanto-dental interval (ADI) was measured in preoperative period, immediate postoperatively, and postoperative 1, 3 and 6 months. Results : Unilateral TAF was performed in 27 patients (50%). The causes of unilateral TAF were anomalous course of vertebral artery in 20 patients (74%), severe degenerative arthritis in 3 (11%), fracture of C1 in 2, hemangioblastoma in one, and screw malposition in one. The mean ADI in unilateral group was measured as 2.63 mm in immediate postoperatively, 2.61 mm in 1 month, 2.64 mm in 3 months and 2.61 mm in 6 months postoperatively. The mean ADI of bilateral group was also measured as following; 2.76 mm in immediate postoperative, 2.71 mm in 1 month, 2.73 mm in 3 months, 2.73 mm in 6 months postoperatively. Comparison of ADI measurement showed no significant difference in both groups, and moreover fusion rate was 100% in bilateral and 96.3% in unilateral group (p=0.317). Conclusion : Even though bilateral TAF is best option for AAI in biomechanical perspectives, unilateral screw fixation also can be a useful alternative in otherwise dangerous or infeasible cases through bilateral screw placement.

• Journal of Chest Surgery
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• 제37권7호
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• pp.597-600
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• 2004

57세 남자 환자로 약 2개월 전부터 호흡곤란이 있어오다 1주일 전부터 악화되어 폐동맥 혈전색전증으로 오인된 폐동백 육종을 치험하여 보고하는 바이다. 환자는 지방병원에서 흉부전산화 단층촬영을 시행하였고 급성 폐동맥 색전증 진단 하에 본원으로 전원 되었다. 흉부전산화 단층촬영 및 폐동맥 혈관 조영술, 폐 관류 검사를 시행하였고 체외순환을 이용하여 수술적 치료를 시행하였다. 환자는 폐동맥 육종으로 최종 진단되었으며 이에 문헌과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제50권6호
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• pp.710-717
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• 2001

본 증례에서는 객혈을 주소로 내원한 두 환자에서 폐격리증의 소견이 없이 좌측 기저폐구역에 흉부 하행 대동맥에서 기인하는 기형적인 전신동맥의 혈액공급, 좌측 상폐구역을 제외한 하폐동맥의 결손과 함께 좌측 폐정맥을 거치어 좌심방으로 유입되는 혈관기형을 경험하였기에 보고 하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제51권1호
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• pp.53-58
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• 2001

기관지 동맥 색전술에도 불구하고 반복되는 대량 객혈을 보이는 동공성 폐결핵 환자에서 나선형 CT를 이용하여 Rassmusen 동맥류의 위치 및 크기를 비교적 정확히 진단하여 coil 이용한 경도관 폐동맥 색전술로 성공적으로 지혈 시킨 사례를 경험하였기에 보고하는 바이다.

• Current Optics and Photonics
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• 제3권6호
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• pp.555-565
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• 2019

Development of a biomarker for predicting tumor-treatment efficacy is a matter of great concern, to reduce time, medical expense, and effort in oncology therapy. In a preclinical study, we hypothesized that the blood-flow parameter based on laser speckle flowmetry (LSF) could be a potential indicator to estimate the efficacy of breast-cancer treatment. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber applied to a nude mouse, and the change in blood flow rate (BFR) - or the speckle flow index (SFI) is used together as the same meaning in this manuscript - was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily LSF angiogram, several BFR parameters (baseline SFI, normalized SFI, and △rBFR) were compared to tumor size in the normal, treated, and untreated tumor groups. Despite the incomplete tumor treatment, we found that the daily changes in all BFR parameters tended to have partially positive correlation with tumor size. Moreover, we observed that the changes in baseline SFI and normalized SFI responded one day earlier than the tumor shrinkage during chemotherapy. However, daily variations in the hypercapnia-induced △rBFR lagged tumor shrinkage by one day. This study would contribute not only to evaluating tumor vascular response to treatment, but also to monitoring blood-flow-mediated diseases (in brain, skin, and retina) by using LSF in preclinical settings.