• The Korea Journal of Herbology
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• v.36 no.6
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• pp.1-8
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• 2021

Objectives : Atractylodis rhizoma Alba has been traditionally used as a medicinal resource that is used for enhancing Qi (氣) in traditional medicine in Korea, China, and Japan. This study investigated the protective effects of Atractylodis rhizoma Alba extract (ARE) against trimethyltin (TMT), a neurotoxin that causes selective hippocampal injury, using both in vitro and in vivo models. Methods : We investigated the effects of ARE on TMT- (5mM) induced cytotoxicity in primary cultures of mouse hippocampal cells (7 days in vitro ) and on hippocampal injury in C57BL/6 mice injected with TMT (2.6 mg/kg). Results : We observed that ARE treatment (0 - 50 ㎍/mL) significantly reduced TMT-induced cytotoxicity in cultured hippocampal neurons in a dose-dependent manner, based on results of lactate dehydrogenase and 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assays. Additionally, this study showed that orally administered ARE (5 mg/kg; between -6 and 0 days before TMT injection) significantly attenuated seizures in adult mice. Furthermore, quantitative analysis of allograft inflammatory factor-1 (Iba-1)- and glial fibrillary acidic protein (GFAP)- positive cells showed significantly reduced levels of Iba-1- and GFAP-positive cell bodies in the dentate gyrus of mice treated with ARE prior to TMT injection. These findings indicate the significant protective effects of ARE against the TMT-induced massive activation of microglia and astrocytes in the hippocampus. Conclusions : We conclude that ARE minimizes the detrimental effects of TMT-induced hippocampal neurotoxicity, both in vitro and in vivo . Our findings may serve as useful guidelines to support ARE administration as a promising pharmacotherapeutic approach to hippocampal degeneration.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.592-601
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• 2022

This study was attempted to suggest future directions for nursing ethics education by analyzing research trends related to ethical conflicts among nurses and the current status of nursing ethics education. In four domestic databases, it was searched as a combination of words 'nurse', 'ethics', 'moral', 'bioethics', 'conflict', 'sensitivity', 'dilemma', 'issue', and 'value'. As a result, 591 papers were confirmed from 2000 to December 2021, of which 111 papers were finally analyzed. The status of nursing ethics education was analyzed for 184 out of 203 schools that operated a four-year bachelor's degree program registered with the Korean Accreditation Board of Nursing Education. As a result of the study, the number of studies related to ethical conflicts among nurses steadily increasing, and quantitative studies on nurses in general hospitals were the most common. The main keywords were identified as moral sensitivity, moral agony, ethical dilemma, and biomedical ethics awareness. Nursing ethics education was operated by 68% of universities as a major subject, and more than half of universities opened it in the first and second grades with one or two credits. As a result of this study, ethical conflicts experienced by nurses are increasing according to social change. Therefore, it is necessary for universities to further expand the proportion of nursing ethics education and to establish an educational model for each grade level for the continuity of the educational effect.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.234-251
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• 2022

In this study, effects of the psychological characteristics of office workers and start-up preparation on entrepreneurship intention by mediating entrepreneurial opportunity recognition were analyzed. As sub-variables of psychological characteristics, desire for economic achievement, self-fulfillment, and risk-taking tendencies were classified. The collected 357 questionnaires, SPSS v24.0 and Process macro 3.5 were used for empirical analysis. As a result, first, it was showed that self-fulfillment and start-up preparation had a positive (+) effect on entrepreneurial intention, and the effect of desire for economic achievement and risk-taking tendencies on entrepreneurial intention was not significant. Second, it was confirmed that psychological characteristics and start-up preparation had a significant positive (+) effect on the entrepreneurial opportunity recognition. Third, it was found that the effect of the entrepreneurial opportunity recognition on the entrepreneurial intention was significant in the positive (+) direction. Fourth, entrepreneurial opportunity recognition was tested as mediating the psychological characteristics of workers, start-up preparation and entrepreneurial intention. As a follow-up study, it is recommended that studies to analyze moderated mediating effects by the conditional process model including moderating variables and to discover the third mediator other than a mediator used in the research should be conducted.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.2
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• pp.394-401
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• 2021

The construction of new renewable energy facilities is steadily increasing every year. In particular, the offshore wind farm market, which has abundant development scalability and a high production coefficient, is growing rapidly. The southwest sea has the highest possible offshore wind power potential, and related projects are to be promoted. This study presents a basic design procedure by the EUROCODE and considers structural safety in the development of an effective of shore wind foundation in the clay layer. In a previous study, the wind power generator of 5MW class was the main target, but the 8MW of wind turbine generator, which meets the technical trend of the wind turbine market in the Southwest sea, was selected as the standard model. Furthermore, a foundation that fulfills the geological conditions of the Southwest sea was developed. The structural safety of this foundation was verified using finite element method. Moreover, structural safety was secured by proper reinforcement from the initial design. Based on the results of this study, structural safety check for various types of foundations is possible in the future. Additionally, specialized structural design and evaluation guidance were also established.

• Journal of the Korean Applied Science and Technology
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• v.38 no.2
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• pp.368-377
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• 2021

The present study aimed to evaluate the effects of radiation mutant Perilla frutescens var. crispa and Atractylodes macrocephala Koidzumi complex extract(Perilla frutescens var. crispa complex extract) on the mediators related to degenerative arthritis in a monosodium iodoacetate-induced rat model of degenerative arthritis. Perilla frutescens var. crispa complex extract was administered orally at doses of 25, 50 or 100 mg/kg/day for 2 weeks before direct injection of monosodium iodoacetate (3 mg/50 µl of 0.9% saline) into the intra-articular space of the rats' right knees. The rats subsequently received the same doses of oral Perilla frutescens var. crispa complex extract for another 4 weeks. It was evaluated that the treatment effects based on serum bio-markers, and morphological and histopathological analysis of the knee joints. Compared with those in negative control rats, the Perilla frutescens var. crispa complex extract treatments significantly reduced the serum levels of inflammation, bone metabolism markers (i.e., TNF-α, MMP-3, COX-2, PGE₂, COMP, and Aggrecan). Otherwise, it was significantly increased the production of CTX-2 in cartilage absorption mediators. In addition, the Perilla frutescens var. crispa complex extract treatments effectively preserved the knee cartilage and synovial membrane. As a result, it indicates that the Perilla frutescens var. crispa complex extract improved degenerative arthritis symptoms. Thus, the Perilla frutescens var. crispa complex can be used in food material for the management of degenerative arthritis.

• Journal of the Korea Convergence Society
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• v.12 no.4
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• pp.229-236
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• 2021

There has been a lot of research on the real estate market, but a lack of research on the supply and demand of housing supply in each region, reflecting the changes in population growth and supply. It is calculated as the transition probability of the Markov chain model by reflecting the data on the number of houses per 1,000 people in the past 35 years and the forecast data for population change by region, in terms of supply (housing) to demand (population) for factors on the real estate market. According to the calculation results of the real estate market by region, the housing supply to the metropolitan area such as Gyeong-gi, Incheon, and Seoul is expected to be insufficient for a considerable period of time, considering the population changes by region. To stabilize the real estate market, it was confirmed that it was necessary to actively apply the differentiation of housing supply by region. It is meaningful in terms of verifying long term trends in the real estate market by region that reflect the prediction of population change, and it is expected that the methods used in this study will be practical through the analysis results using the historical data.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.325-333
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• 2021

With the rapidly changing era of the fourth industrial revolution, the utilization of IT technology is increasing. In addition, the demand for security authentication is increasing as shared services or IoT technologies are being developed as new business models. Security authentication is becoming increasingly important for all intelligent devices such as self-driving cars. However, most location-based security authentication technologies are being developed mainly with technologies that utilize server proximity or satellite location tracking, which limits the scope of their physical use. Location-based security authentication technology has recently been developed as a complementary replacement technology. In this study, we introduce location-based security authentication technology using cell broadcasting technology, which has a wider range of applications and is more convenient and business-friendly than existing location-based security authentication technologies. We also introduced application cases and business models related to this. In addition to the current status of technology development, we analyzed current changes in business models being employed. Based on our analysis results, this study draws the implication that technology diversification is necessary to improve the performance of innovative technologies. It is meaningful that it has found and studied advanced technologies other than existing location authentication methods and systems.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.517-529
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• 2021

This study analyzes changes in the efficiency of the Department of Early Childhood Education in Korea to examine the effectiveness of the National Evaluation for Teacher Education Institution. We provide policy implications from exploring factors influencing efficiency and comparing characteristics of efficient and inefficient departments. With 149 Department of Early Childhood Education in Korea, DEA was conducted to estimate the relative efficiency, and the Tobit model was applied to explore factors affecting efficiency. The results confirm that the Department of Early Childhood in Korea is run efficiently, though there was no change in scale efficiency and relative efficiency after the two phases of the National Evaluation for Teacher Education Institution. The results show the number of books per student was significantly lower despite a significantly higher employment rate. Efficiency of college departments, department greater than 60 (per cohort), and department in metropolitan city (except Seoul area) is confirmed greater. These results provide policy implications on developing evaluation measure and processes to improve education quality and efficiency.

• Korean small business review
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• v.42 no.2
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• pp.93-115
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• 2020

Government funded research institutes (GFRIs) maintain a cooperative relationship with companies and stably provide their resources through the family company system. They are thereby implementing a demand-oriented support system that responds to the needs of the company. This study analyzed the changes in corporate financial performance depending on the participation in family company system and customized support. For this purpose, 2,229 companies registered with the KITECH during 2015-2017 composed the "Family company group", and 80 companies that participated in the customized support were selected as the "customized support group". The effect of participation on the corporate financial performance was analyzed using the PSM-DID model. The analysis verified that companies in a cooperative relationship with GFRIs had a higher sales growth rate than others. Furthermore, when these companies received additional customized support, their OI and ROE were significantly improved. The value of this study lies in that it quantitatively analyzed the cooperation performance of partner companies following a sustainable SME-GRI relationship. In addition, it provides insight into the strategic support system for SMEs by confirming the necessity of a customized support based on the relationship.

• Korean Association of Arts Management
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• no.53
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• pp.207-247
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• 2020

is a project for the senior generation with humanistic knowledge to become a mentor and communicate with them to present the wisdom and direction of life to the new generations of mentees based on various life experiences. has been expanding since 2015, starting with the pilot operation in 2014. In general, projects such as these are assessed to establish effectiveness indicators to verify effectiveness and to establish project management and development strategies. However, most of the evaluations have been conducted quantitatively and qualitatively based on the short-term duration of the project. Therefore, in the case of continuous projects such as , especially in the field of culture and arts where long-term effectiveness verification is required, the short-term evaluation is difficult to predict and judge the actual meaningful effects. In this regard, tried to examine the qualitative change of key participants in this project through the 2017 and 2018 image tracking survey. For this purpose, we adopted qualitative research methodology through interview video shooting, field shooting, and value coding as a research method suitable for the research subject. To analyze the results, first, the interview images were transcribed, keywords were extracted, value encoding works were matched with human psychological values, and the theoretical method was used to identify changes and to derive the meaning. In fact, despite the fact that the study conducted in this study was a follow-up survey, it remained a limitation that it analyzed the changed pattern in a rather short time of 2 years. However, this study systemized the specific methodology that researchers should conduct for follow-up and provided the flow of research at the present time when there is hardly a model for follow-up in the field of culture and arts education business in Korea as well as abroad. Significance can be derived from this point. In addition, it can be said that it has great significance in preparing the detailed system and case of comparative analysis methodology through value coding.