• Korean Journal of Remote Sensing
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• v.34 no.6_4
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• pp.1531-1544
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• 2018

We detected the coseismic ionospheric disturbance generated by the earthquakes of magnitude 5.0 and greater in Korean Peninsula. We considered the seismic events such as Gyeongju earthquake in September 2016 with magnitude 5.8, the Pohang earthquake in November 2017 with magnitude 5.4, and the underground nuclear explosion from North Korea in September 2017 with magnitude 5.7. Although all GPS stations were not detected, the ionospheric disturbance induced by these earthquakes occurred approximately 10-30 minutes and 40-60 minutes after the events. We inferred that the time difference within each variation is due to the different focal depth and the geometry of epicenter, satellite, and GPS station. In the case of the Gyeongju earthquake, the earthquake had relatively deeper depth than the other earthquakes. However, the seismic magnitude was bigger and it occurred at nighttime when the ionospheric activity was stable. So we could observe such anomalous variations. It is considered that the ionospheric disturbance caused by the difference in velocity of the upward propagating waves generated by earthquake appears more than once. Our results indicate that the detection of ionospheric disturbances varies depending on the geometry of the GPS station, satellite, and epicenter or the detection method and that the apparent growth of amplitude in the time series varies depending on the focal depth or the site-satellite-epicenter geometry.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.7
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• pp.469-478
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• 2019

Multirotor configurations such as VTOL and urban air mobility have been focused on today due to the high maneuverability. Aerodynamic and aeroacoustic characteristics of multirotor have much difference to those of a single rotor. In this study, a numerical analysis based on the free wake vortex lattice method is used for identifying the wake interaction effect. In order to compare the various configurations and operating conditions, the effects of the spacing between the rotors in hovering flight and the effects of the advancing ratio and the formation in forward flight are discussed. In the hovering flight, the unsteady loading of multirotor changes periodically and loading fluctuation increases as decreasing the spacing. It causes the variation in unsteady loading noise and the noise directivity pattern. In the forward flight, the difference in loading fluctuation and noise characteristics are observed according to the diamond and square formation of rotors. By comparing with results of single rotor analysis, multirotor configurations have different directivity pattern and amplitude of loading noise according to the location of each rotor. As a result, wake interaction effect becomes a highly important factor for aerodynamic and aeroacoustic analysis according to multirotor configurations and operating conditions.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.5
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• pp.657-673
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• 2019

A monitoring method based on acoustic emission (AE) sensor has been widely used to evaluate the damage of structures in underground rock. The acoustic emission signal generated from cracking in material is analyzed as various acoustic emission parameters in time and frequency domain. To investigate from initial crack generation to final failure of rock material, it is important to understand the characteristics of acoustic emission parameters according to the stress ratio and rock strength. In this study, uniaxial compression tests were performed using very strong and weak rock specimen in order to investigate the acoustic emission parameters when the failure of specimen occurred. In the results of experimental tests, the event, root-mean-square (RMS) voltage, amplitude, and absolute energy of very strong rock specimen were larger than those of the weak rock specimen with an increase of stress ratio. In addition, the acoustic emission parameters related in frequency were more affected by specification (e.g., operation and resonant frequency) of sensors than the stress ratio or rock strength. It is expected that this study may be meaningful for evaluating the damage of underground rock when the health monitoring based on the acoustic emission technique will be performed.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.32 no.1
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• pp.15-23
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• 2021

Background and Objectives During speech, the vocal folds oscillate at frequencies ranging from 100-200 Hz with amplitudes of a few millimeters. Mechanical stimulation is an essential factor which affects metabolism of human vocal folds. The effect of mechanical vibration on the cellular response in the human vocal fold fibroblasts cells (hVFFs) was evaluated. Materials and Method We created a culture systemic device capable of generating vibratory stimulations at human phonation frequencies. To establish optimal cell culture condition, cellular proliferation and viability assay was examined. Quantitative real time polymerase chain reaction was used to assess extracellular matrix (ECM) related and growth factors expression on response to changes in vibratory frequency and amplitude. Western blot was used to investigate ECM and inflammation-related transcription factor activation and its related cellular signaling transduction pathway. Results The cell viability was stable with vibratory stimulation within 24 h. A statistically significant increase of ECM genes (collagen type I alpha 1 and collagen type I alpha 2) and growth factor [transforming growth factor β1 (TGF-β1) and fibroblast growth factor 1 (FGF-1)] observe under the experimental conditions. Vibratory stimulation induced transcriptional activation of NF-κB by phosphorylation of p65 subunit through cellular Mitogen-activated protein kinases activation by extracellular signal regulated kinase and p38 mitogen-activated protein kinases (MAPKs) phosphorylation on hVFFs. Conclusion This study confirmed enhancing synthesis of collagen, TGF-β1 and FGF was testified by vibratory stimulation on hVFFs. This mechanism is thought to be due to the activation of NF-κB and MAPKs. Taken together, these results demonstrate that vibratory bioreactor may be a suitable alternative to hVFFs for studying vocal folds cellular response to vibratory vocalization.

• Journal of the Society of Disaster Information
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• v.18 no.3
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• pp.550-559
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• 2022

Purpose: Pipes are widely used as applied devices in many industrial fields such as machinery, electronics, electricity, and plants, and are also widely used in safety-related fields such as firefighting and chemistry. With the diversification of products, the importance of technology in the piping field is also increasing. In particular, when changing the existing copper pipe to stainless steel, it is necessary to evaluate safety and flow characteristics through structural analysis or flow analysis. Method: This study investigated the safety by flow analysis of the 6.35 inch socket model, which are integrated insert type connectors developed by a company, using CFD analysis technique. For CDF analysis, RAN model and LES model are used. Result: As results of the analysis, amplitude of the pressure fluctuation acting on the wall of the piping system is formed at a level of 3,780 Pa or less, which is a very small level of pressure compared with the operating pressure or design stress of the refrigerant piping. Conclusion: These results mean that the effect of vibration caused by turbulence on the structural safety of the pipe is negligible.

• Journal of the Korea Convergence Society
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• v.13 no.5
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• pp.9-19
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• 2022

In this study, a systematic review was conducted to analyze the method of applying sEMG to evaluate the swallowing function of the elderly at each stage of swallowing, and to help objectively measure the swallowing stage of the older adults in clinical practice. From 2011 to 2021, 7 studies that met the selection criteria were selected using Pubmed, Scopus, and Web of Science (WoS). As a result of this study, the older adults and adults were divided into an experimental group and a control group and the swallowing phase was analyzed using sEMG only for the older adults. sEMG was used to evaluate swallowing in the oral and pharyngeal stages, and the sEMG attachment site was attached to the swallowing muscle involved in each stage. The collected sEMG data were filtered using a bandpass-filter and a notch-filter, and were analyzed using RMS, amplitude, and maximum spontaneous contraction. In this study, it was found that sEMG can be used as a tool to objectively and quantitatively evaluate the swallowing function in stages. Therefore, it is expected that this study will activate various studies that incorporate sEMG to evaluate the swallowing function in stages.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.33 no.3
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• pp.166-171
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• 2022

Background and Objectives Vocal fold (VF) scar is known to be the most common cause of dysphonia after laryngeal microsurgery (LMS). Steroids reduce postoperative scar formation by inhibiting inflammation and collagen deposition. However, the clinical evidence of whether steroids are helpful in reducing VF scar formation after LMS is still lacking. The purpose of this study is to determine whether intralesional VF steroid injection after LMS helps to reduce postoperative scar formation and voice quality. Materials and Method This study was conducted on 80 patients who underwent LMS for VF polyp, Reinke's edema, and leukoplakia. Among them, 40 patients who underwent VF steroid injection after LMS were set as the injection group, and patients who had similar sex, age, and lesion size and who underwent LMS alone were set as the control group. In each group, stroboscopy, multi-dimensional voice program, Aerophone II, and voice handicap index (VHI) were performed before and 1 month after surgery, and the results were statistically analyzed. Results There were no statistically significant differences in the distribution of sex, age, symptom duration, occupation and smoking status between each group. Both groups consisted of VF polyp (n=21), Reinke's edema (n=11), and leukoplakia (n=9). On stroboscopy, the lesion disappeared after surgery, and the amplitude and mucosal wave were symmetrical on both sides of the VFs in all patients. Acoustic parameters and VHI significantly improved after surgery in all patients. However, there was no significant difference between the injection and control group in most of the results. Conclusion There was no significant difference in the results of stroboscopy, acoustic, aerodynamic, and subjective evaluation before and after surgery in the injection group and the control group.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.3
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• pp.267-275
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• 2023

Cardiotoxicity, particularly drug-induced Torsades de Pointes (TdP), is a concern in drug safety assessment. The recent establishment of human induced pluripotent stem cell-derived cardiomyocytes (human iPSC-CMs) has become an attractive human-based platform for predicting cardiotoxicity. Moreover, electrophysiological assessment of multiple cardiac ion channel blocks is emerging as an important parameter to recapitulate proarrhythmic cardiotoxicity. Therefore, we aimed to establish a novel in vitro multiple cardiac ion channel screening-based method using human iPSC-CMs to predict the drug-induced arrhythmogenic risk. To explain the cellular mechanisms underlying the cardiotoxicity of three representative TdP high- (sotalol), intermediate- (chlorpromazine), and low-risk (mexiletine) drugs, and their effects on the cardiac action potential (AP) waveform and voltage-gated ion channels were explored using human iPSC-CMs. In a proof-of-principle experiment, we investigated the effects of cardioactive channel inhibitors on the electrophysiological profile of human iPSC-CMs before evaluating the cardiotoxicity of these drugs. In human iPSC-CMs, sotalol prolonged the AP duration and reduced the total amplitude (TA) via selective inhibition of I_Kr and I_Na currents, which are associated with an increased risk of ventricular tachycardia TdP. In contrast, chlorpromazine did not affect the TA; however, it slightly increased AP duration via balanced inhibition of I_Kr and I_Ca currents. Moreover, mexiletine did not affect the TA, yet slightly reduced the AP duration via dominant inhibition of I_Ca currents, which are associated with a decreased risk of ventricular tachycardia TdP. Based on these results, we suggest that human iPSC-CMs can be extended to other preclinical protocols and can supplement drug safety assessments.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5C
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• pp.351-358
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• 2006

The purpose of this study is to recommend the simulation method and procedure of behaviors of CFRD(Concrete Faced Rockfill Dam) concrete face slab with impoundment by centrifuge tests, to examine the effects of the flexural rigidity of the concrete face slab on the face slab deformation from the centrifuge tests, and to evaluate the effects of the stiffness of face supporting zone on the displacement and moment of face slab by numerical analysis which is verified by the centrifuge tests. In this study, the centrifuge tests on the two model dams with the concrete face slab of different flexural rigidity were carried out. Also, the centrifuge tests were simulated by numerical analysis of which input material properties were obtained by the triaxial tests on the model materials. The validity of numerical analysis was evaluated by comparison between the results of centrifuge tests and numerical simulation. The deformation pattern of the concrete face slab was examined with the various stiffness of the face supporting zone by numerical analysis. From the results of centrifuge tests, the effects of face slab thickness on the deformation of face slab were negligible. From the results of centrifuge tests and numerical analysis, it was found that the amplitude of the maximum displacement of face slab and the position where the maximum displacement was mobilized with impoundment were affected by the stiffness of face supporting zone rather than the flexural rigidity of concrete face slab.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5A
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• pp.887-899
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• 2006

The aim of this study is to investigate a correlation between fundamental data on aerodynamic characteristics of bridge girder cross-sections, such as aerodynamic force coefficients and flutter derivatives, and their aerodynamic behaviour. The section model tests were carried out in three stages. In the first stage, seven deck configurations were studied, namely; Six 2-edge girders and one box girder. In this stage, changes in aerodynamic force coefficients due to geometrical shape of girders, incidence angle of flow, wind directions and turbulence intensities were studied by static section model tests. In the second stage, the dynamic section model tests were carried out to investigate the relativity of static coefficients to dynamic responses. And finally, the two-dimensional (lift-torsion) aerodynamic derivatives of three bridge deck configurations were investigated by dynamic section model tests. The aerodynamic derivatives can be best described as a representation of the aerodynamic damping and the aerodynamic stiffness provided by the wind for a given deck geometry. The method employed here to extract these unsteady aerodynamic properties is known as the initial displacement technique. It involves the measurement of the decay in amplitude with time of an initial displacement of the deck in heave and torsion, for various wind speeds, in smooth flow. It is suggested that the proposed aerodynamic force coefficients and flutter derivatives of bridge girder sections will be potentially useful for the aeroelastic analysis and buffeting analysis.