• 대한토목학회논문집
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• 제31권3A호
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• pp.163-172
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• 2011

CFTA 거더는 아치형상을 갖는 콘크리트 충전 강관구조이며 초기처짐 및 공용 중 응력제어를 위해 외부긴장재를 배치한 거더 형식이다. 본 연구에서는 차량진행에 따른 거더의 동적거동에 긴장재가 미치는 영향을 분석하였다. 이를 위해 유한요소 프로그램을 이용하여 거더 및 긴장재 등을 수치모델링하였으며 긴장재의 양과 긴장력을 다양한 값으로 변화시켰다. 차량하중은 도로교설계기준의 DB-24 하중을 고려하였으며 3축-2트랙으로 모델링하였다. 차량하중은 등가절점하중으로 적용시켰으며 차량하중의 이동은 차량통과 시간 및 절점수를 고려한 각 절점에서의 시간함수로 나타내었다. 차량속도는 40 km/hr에서 100 km/hr까지 20 km/hr씩 증가시켰다. 해석결과 긴장재의 긴장력 변화는 거더의 동적거동에 영향을 주지않았으며 초기처짐에만 영향을 주었다. 긴장재의 양에 따라서는 거더의 동적거동이 다르게 나타났으며 긴장재의 양이 적을수록 동적처짐은 증가하였다. 이를 바탕으로 거더의 동적증폭계수(DAF)를 산출하였으며 긴장재가 없는 경우에도 AASHTO LRFD와 도로교 표준시방서에서 정한 기준값보다 매우 작은 안정적인 거동을 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2745-2749
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• 2015

Objective: To study the PLCE1 gene rs2274223 polymorphism with regard to esophageal cancer and its interaction with diet, lifestyle, psychological and environmental factors in Southwest Shandong province. Materials and Methods: A case series study (case-case) was conducted. Questionnaire data were collected and 3 ml-5ml venous blood was drawn for DNA extraction among the qualified research subjects. PLCE1 gene polymorphism was detected after PCR amplification of DNA. SPSS 13.0 software was used for statistical analysis of the data. Results: The three genotypes A/A, A/G and G/G PLCE1 gene rs2274223 was 31, 16 and 4 cases, accounting for 60.8%, 31.4%, 0.08% respectively. The difference of three genotypes (AA/GA/GG) proportion between negative and positive family history of patients was statistically significant, ${\chi}^2=6.213$, p=0.045. There was no statistically significant relationship between PLCE1 gene rs2274223 polymorphism and smoking, drinking, ${\chi}^2=0.119$, p=0.998, and ${\chi}^2=1.727$, p=0.786. There was no linkage of the three rs2274223 PLCE1 gene genotypes (AA/GA/GG) proportion with eating fried, pickled, hot, mildew, overnight, smoked, excitant food, eat speed, salt taste or not (p>0.05). or with living environment pollution and nine risk factors of occupational exposure (p>0.05). There was no statistically significant difference in TS scores between different genotype of rs2274223 PLCE1 gene. Conclusions: The PLCE1 rs2274223 polymorphism has a relationship with family history of esophageal cancer, but does not have any significant association with age, gender, smoking, alcohol drinking, food hygiene, eating habits, living around the environment and occupation in cases.

• Parasites, Hosts and Diseases
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• 제54권5호
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• pp.645-652
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• 2016

Toxocara vitulorum has been rarely reported in yaks at high altitudes and remote areas of Sichuan Province of Tibetan Plateau of China. The current study was designed to investigate the prevalence, associated risk factors, and phylogenetic characteristics of T. vitulorum in yak calves on the Qinghai Tibetan plateau. Fecal samples were collected from 891 yak calves and were examined for the presence of T. vitulorum eggs by the McMaster technique. A multivariable logistic regression model was employed to explore variables potentially associated with exposure to T. vitulorum infection. T. vitulorum specimens were collected from the feces of yaks in Hongyuan of Sichuan Province, China. DNA was extracted from ascaris. After PCR amplification, the sequencing of ND1 gene was carried out and phylogenetic analyses was performed by MEGA 6.0 software. The results showed that 64 (20.1%; 95% CI 15.8-24.9%), 75 (17.2; 13.8-21.1), 29 (40.9; 29.3-53.2), and 5 (7.6; 2.5-16.8) yak calves were detected out to excrete T. vitulorum eggs in yak calve feces in Qinghai, Tibet, Sichuan, and Gansu, respectively. The present study revealed that high infection and mortality by T. vitulorum is wildly spread on the Qinghai Tibetan plateau, China by fecal examination. Geographical origin, ages, and fecal consistencies are the risk factors associated with T. vitulorum prevalence by logistic regression analysis. Molecular detection and phylogenetic analysis of ND1 gene of T. vitulorum indicated that T. vitulorum in the yak calves on the Qinghai Tibetan plateau are homologous to preveiously studies reported.

• 한국강구조학회 논문집
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• 제15권2호
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• pp.197-206
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• 2003

본 논문에서는 유전자 알고리즘을 이용한 비선형 탄성 최적설계 방법을 제시하였다. 제안한 비선형 탄성해석은 종래 설계의 단점 즉 탄성해석 후 비선형 효과를 고려하기 위하여 $B_1$, $B_2$ 계수를 사용하는 불합리성을 극복하였다. 유전자 알고리즘은 다윈(Darwin)의 적자생존의 개념을 기본으로 선택, 교배 및 돌연변이라는 세 가지 연산을 수행함으로써 최적설계에 필요한 설계변수 즉 부재 단면을 형성하여, 제약조건을 모두 만족하는 최소 구조물 중량을 제공하는 설계변수를 선택하면서 최적설계를 수행하였다. 목적함수로는 구조물의 총중량을 사용하였으며, 제약조건식으로는 하중저항능력, 사용성 및 연성도를 사용도를 사용하여 최적설계를 수행하였다. 2차원 강뼈대 구조물, 3차원 강뼈대 구조물, 그리고 3차원 강아치교의 설계예제를 수행하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권2호
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• pp.112-117
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• 2010

Aurora kinases represent a novel family of serine/threonine kinases crucial for cell cycle control. Aurora-2 kinase is mainly involved in centrosome function, mitotic entry, and spindle assembly. Aurora-2 kinase overexpression causes centrosome amplification and the formation of multipolar mitotic spindles, which leads to tumor aneuploidy and so it has been found to play an important role in tumorigenicity in many cancers such as colorectal cancer, breast cancer and cervical cancer. Hence, the goal of this study is to identify the correlation of clinicopathlogical factors and overexpression of Aurora-2 kinase in oral squamous cell carcinoma. We studied the immunohistochemical staining of Aurora-2 kinase in 20 specimens of 20 patients with oral squamous cell carcinoma and the relationships between Aurora-2 kinase over expression and each of the clinico-pathological parameters were analyzed by Pearson correlation analysis. Statistical significance was set at P < 0.05. The results were as follows. 1. In the immunohistochemical study of poorly differentiated and invasive oral squamous cell carcinoma, the high level staining of Aurora-2 kinase was observed. 2. The correlation between immunohistochemical Aurora-2 kinase expression and histopathological differentiation of specimens was significant. These findings suggest that overexpression of Aurora-2 kinase may play a important role in carcinogenesis of oral squamous cell carcinoma.

• 대한미생물학회지
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• 제34권6호
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• pp.513-518
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• 1999

A total of 113 Vibrio sp. strains were examined for plasmid content which were subjected to digestion with restriction enzymes. About the 55% Vibrio spp. have the plasmid more than one. Most of these plasmid various derivatives ranged from $2.4\;kb{\sim}23\;kb$, especially two strains of V. mimicus and one strain of V. furnissii carried one high-molecular weight plasmid (molecular weight ranging between $70\;kb{\sim}100\;kb$). Results of restriction analysis for plasmid of this three strains were by no means the rule. For detection of tdh and ctx gene, the virulence factor involved in the pathogenesis, we carried out the TDH and CT assay, PCR amplification, and hybridization. A total 11 strains were produced TDH, involved in 9 strains of V. parahaemolyticus and 1 strain of V. alginolyticus from clinical isolates and 1 strains of V. mimicus from environmental isolates. In the experiments of tdh gene detection, in all, 3 strains of V. parahaemolyticus from clinical isolates and 2 strains from environmental isolates could be successfully amplified in 400 bp by PCR. The PCR results were consistent with DNA hybridization tests. In the experiments of CT assay, in all, 3 strains of V. cholerae from clinical isolate and 1 strain of V. cholerae from environmental isolates were observed CT-producing. These CT-producing strains amplified in 302 bp by PCR for the detection of ctx gene. All CT-producing strains hybridized with digoxigenin-labeled DNA probe, while CT-negative strains did not hybridize. Also hybridization tests results for detection of ctx gene consistent with PCR.

• 한국콘텐츠학회논문지
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• 제10권7호
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• pp.23-30
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• 2010

메이크업 스타일이 고객 중심으로 다변화 되어가는 생활환경 속에서 감성과 선호 정도를 파악하는 것은 화장품 판매 전략의 중요한 성공요소가 되고 있다. 본 논문에서는 사용자의 감성과 선호도를 중심으로 메이크업 스타일을 개발하는 방법의 하나로 협력적 필터링 기법을 응용하여 상황 센서정보를 이용한 감성 공학적 메이크업 추천 시스템(MakeupRS)을 제안하였다. 협력적 필터링 기법에서, 사용자들간의 유사도 가중치를 계산하기 위해서 상태 강조를 적용한 피어슨 상관계수를 사용한다. 메이크업 스타일에 따른 감성을 조사하기 위해서, 메이크업 스타일을 6가지 스타일 요소(파운데이션, 컬러렌즈, 아이섀도, 속눈썹, 볼터치, 립스틱)에 따라 분석하였다. 감성공학적 메이크업 추천 시스템을 개발하여 논리적 타당성과 유효성을 검증하기 위해 실험적인 적용을 시도하고자 한다.

• 한국항해항만학회지
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• 제27권5호
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• pp.519-526
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• 2003

초대형 부유식 구조물의 초기 설계단계에서 부체구조물과 상부구조물을 분리하여 해석하는 것이 일반적이며, 부체의 탄성응답해석의 변형모드를 이용하여 상부구조물의 주각부에 강제수직변위를 입력하여 파랑하중에 의한 영향을 고려한다. 하지만 이와 같은 해석법의 경우 각 지점에 변위하중을 입력하는데 어려움이 있다. 본 논문에서는 파랑하중을 지점변위하중으로 직접 입력하지 않고 고정하중과 적재하중에 의한 강도설계 결과를 이용하여 파랑하중의 영향을 증폭계수의 형태로 도출하는 근사 실용정적해석법을 제안한다. 이 연구에서는 4경간 3층 구조물을 예제로 하여 파랑하중의 진폭과 주기, 보 경간을 매개변수로 한 증폭계수의 추이를 분석하였으며 보 모멘트의 증폭계수는 특정회귀방정식으로 나타내었다.

• 한국지진공학회논문집
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• 제15권5호
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• pp.25-33
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• 2011

비선형 시간이력응답해석에서 입력지진동은 구조물의 탄소성 지진응답을 결정짓는 중요한 요소이다. 시간이력해석에 사용되는 기록지진동파형은 지진발생 메카니즘, 전달경로, 지반의 성질에 따른 여러 가지 인자가 복잡하게 관련되어 있기 때문에 구조물의 지진응답해석에 사용될 일반성을 갖는 입력지진동을 선정하는 것은 매우 어려운 문제이다. 본 논문은 실무에서 내진설계용 지진동으로 가장 선호하지 않는 입력지진동을 선정하여 인공지진동파형을 작성하였다. 인공지진동은 기록지진동과 동일한 위상각을 가지며, 감쇠정수 h=5%일 때의 설계용 스펙트럼과 거의 일치하도록 작성되었다. 기록지지동과 인공지진동을 입력한 1자유도계의 탄성 및 탄소성 지진 응답해석을 수행하여 탄소성 응답스펙트럼 및 입력에너지 응답 특성을 분석하였다. 본 연구에서 작성된 인공지진동은 건축구조물의 탄소성 지진응답해석용 입력지진동으로 충분히 타당성이 있다고 사료된다.

• Earthquakes and Structures
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• 제17권6호
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• pp.557-566
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• 2019

The evaluation of the seismic hazard for a given site is to estimate the seismic ground motion at the surface. This is the result of the combination of the action of the seismic source, which generates seismic waves, the propagation of these waves between the source and the site, and site local conditions. The aim of this work is to evaluate the sensitivity of dynamic response of extended structures to spatial variable ground motions (SVGM). All factors of spatial variability of ground motion are considered, especially local site effect. In this paper, a method is presented to simulate spatially varying earthquake ground motions. The scheme for generating spatially varying ground motions is established for spatial locations on the ground surface with varying site conditions. In this proposed method, two steps are necessary. Firstly, the base rock motions are assumed to have the same intensity and are modelled with a filtered Tajimi-Kanai power spectral density function. An empirical coherency loss model is used to define spatial variable seismic ground motions at the base rock. In the second step, power spectral density function of ground motion on surface is derived by considering site amplification effect based on the one dimensional seismic wave propagation theory. Several dynamics analysis of a curved viaduct to various cases of spatially varying seismic ground motions are performed. For comparison, responses to uniform ground motion, to spatial ground motions without considering local site effect, to spatial ground motions with considering coherency loss, phase delay and local site effects are also calculated. The results showed that the generated seismic signals are strongly conditioned by the local site effect. In the same sense, the dynamic response of the viaduct is very sensitive of the variation of local geological conditions of the site. The effect of neglecting local site effect in dynamic analysis gives rise to a significant underestimation of the seismic demand of the structure.