• 설비공학논문집
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• 제15권10호
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• pp.879-887
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• 2003

Buildings with heating and cooling systems have been increased, since the requirement of thermal comfort for residents is grown. Heating and cooling systems, have been changed from two separate systems to one multi-function system which includes both heating and cooling. Especially, heat pump heating and cooling system has been adopted for general classrooms in schools since education environment improvement project has been launched. This research suggests the best option for the heat pump heating and cooling system in educational buildings through economic assessments for four alternative systems based on electric heat pump (EHP) and gas engine driven heat pump (GHP), which are most widely used for elementary, middle and high schools. The model buildings are in the Y high school which has 24 classes of new construction building, which will be built soon. Annual energy consumption for alternative systems uses BECS 3.10, which can be used for system simulation.

• 재무관리연구
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• 제2권1호
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• pp.21-34
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• 1986

The purpose of this study is to analyse the risk and uncertainty involved in the capital budgeting which is executed in long periods and requires massive capital expenditure. Under risk and uncertainty conditions, the estimates in the capital budgeting are random variables rather than known constants. Two approaches have emerged in performing economic analysis that explicitly incorporate risk and uncertainty conditions in the analysis. One approach is to develop a descriptive model which describes the economic performance of an individual investment alternative. But no recomendation would be forthcoming from the model. Rather, the decision-maker would be furnished descriptive information concerning each alternative; the final choice among the alternatives would required a separate action. The second approach is to develop a normative model which includes an objective function to be maximized or minimized. The output from the model prescribes the course of action to be taken. Owing to the fact that the normative approach considers the fitness of criteria for decision-making its reasonableness looks better. But it is almost imposible that we correctly and easily derive the individuals' utility function. So within we recognize the limits of the descriptive methods, it is more practicle to analyse the investment alternatives by sensitivity analysis.

• 한국지하수토양환경학회지:지하수토양환경
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• 제24권5호
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• pp.31-41
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• 2019

In 2013, the Ministry of Environment in South Korea promulgated a new regulatory bulletin that contained revised enforcement ordinance on soil management protocols. The bulletin recommends the use of Universal Soil Loss Equation (USLE) for the soil erosion estimation, but USLE has limited applicability in prediction of soil erosion because it does not allow direct estimation of actual mass of soil erosion. Therefore, there is a great need of revising the protocol to allow direct comparison between the measured and estimated values of soil erosion. The Korean Soil Loss Equation (KORSLE) was developed recently and used to estimate soil loss in two fields as an alternative to existing USLE model. KORSLE was applied to estimate monthly rainfall erosivity indices as well as temporal variation in potential soil loss. The estimated potential soil loss by KORSLE was adjusted with correction factor for direct comparison with measured soil erosion. The result was reasonable since Nash-Stucliff efficiency were 0.8020 in calibration and 0.5089 in validation. The results suggest that KORSLE is an appropriate model as an alternative to USLE to predict soil erosion at field scale.

• International Journal of Oral Biology
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• 제46권1호
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• pp.1-6
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• 2021

Since the outbreak of coronavirus disease 2019 (COVID-2019), the infection has spread worldwide due to the highly contagious nature of severe acute syndrome coronavirus (SARS-CoV-2). To manage SARS-CoV-2, the development of diagnostic assays that can quickly and accurately identify the disease in patients is necessary. Currently, nucleic acid-based testing and serology-based testing are two widely used approaches. Of these, nucleic acid-based testing with quantitative reverse transcription-PCR (RT-qPCR) using nasopharyngeal (NP) and/or oropharyngeal (OP) swabs is considered to be the gold standard. Recently, the use of saliva samples has been considered as an alternative method of sample collection. Compared to the NP and OP swab methods, saliva specimens have several advantages. Saliva specimens are easier to collect. Self-collection of saliva specimens can reduce the risk of infection to healthcare providers and reduce sample collection time and cost. Until recently, the sensitivity and accuracy of the data obtained using saliva specimens for SARS-CoV-2 detection was controversial. However, recent clinical research has found that sensitive and reliable data can be obtained from saliva specimens using RT-qPCR, with approximately 81% to 95% correspondence with the data obtained from NP and OP swabs. These data suggest that self-collected saliva is an alternative option for the diagnosis of COVID-19.

• 농약과학회지
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• 제18권1호
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• pp.8-13
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• 2014

본 연구는 5가지 제품농약을 이용하여 어류 급성독성시험 결과 (반수치사농도)와 잉어의 표피에서 유래된 EPC 세포를 이용한 neutral red uptake 결과 (반수저해농도)를 비교함으로써 동물 실험의 대체 가능성을 평가하기 위하여 수행되었다. 어류 급성 독성시험은 왜몰개 (Aphyocypris chinensis)를 포함하여 OECD와 농촌진흥청의 농약에 대한 독성시험기준에서 추천하는 어종인 송사리 (Oryzias latipes)와 잉어 (Cyprinus carpio)를 이용하여 수행하였다. 5가지 제품 농약에 대한 민감도는 어류에 비하여 세포에서 약 10배 더 낮게 확인되었지만, 독성을 서열화 하였을 때 나타나는 순서는 두 가지 방식에서 모두 비슷하게 나타났다. 5가지 제품 농약에 대한 세포와 어류 독성값의 상관성을 분석한 결과는 A. chinensis, O. latipes와 C. carpio에서 각각 $r^2=0.38$ (p = 0.26), $r^2=0.76$ (p = 0.05), $r^2=0.90$ (p = 0.01)을 나타내었다. 본 시험의 결과, EPC 세포를 이용한 NRU 시험은 O. latipes와C. carpio에 대한 어류 독성시험 결과와 상관성이 높으므로 향후 더 많은 약제시험을 통해 어류 급성독성시험의 대체시험법으로서의 가능성이 기대된다.

• 한국컴퓨터정보학회논문지
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• 제18권12호
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• pp.197-205
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• 2013

본 연구에서는 동적 임분 생장모델과 Simulated Annealing 휴리스틱 기법을 적용하여 최적의 산림시업체계를 도출하기 위한 임분탄소최적화 프로그램을 개발하였다. SA 휴리스틱 알고리즘은 다양한 경영목표를 다룰 때 비교적 짧은 시간 내에 만족할만한 수준의 경영안을 제공할 수 있는 최적화 기법으로서, 더 이상 최적해를 찾지 못하고 목표 값이 어떤 일정한 값(Local Optimum)에 계속 머무는 현상을 해결하기 위해 열균형 테스트를 이용하고 있다. 열균형 테스트에 적용되는 온도저감율 파라미터 값이 최적화 프로세스의 목적함수 값과 반복횟수에 미치는 영향을 분석하기 위해 본 연구에서는 온도저감율에 따른 민감도 분석을 실시하였다. 개발된 프로그램을 이용하여 기존의 산림경영에 주로 적용되고 있는 시업체계(베이스라인), 목재수확량 최대와 탄소저장량 최대의 3가지 산림시업 시나리오에 대해 비교 분석을 한 결과, 목재수확량 최대를 목표로 한 시나리오가 3개 시나리오 가운데 목재수확량이 가장 높은 것으로 나타났으며, 또한 탄소저장량을 최대로 하는 시나리오가 탄소저장량이 가장 높은 것으로 나타나, 본 연구에서 개발된 프로그램이 최적화된 결과를 도출하는 것으로 판단됐다. 온도저감율 파라미터 값에 대한 민감도 분석에서는 온도저감율에 따라 목적함수의 최적 값과 최적화 프로세스 반복횟수가 뚜렷한 영향을 받는 것으로 나타났다. 본 연구를 통해 개발된 임분탄소 최적화 프로그램은 앞으로 우리나라 산림의 탄소 최적화 시업체계 개발에 활용 될 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1655-1658
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• 2014

Objective: To find a more appropriate alternative to D-dimer cutoff value for the diagnosis of deep vein thrombosis (DVT) in cancer patients. Methods: A total of 711 cancer patients with symptoms suspicious of DVT were included in the study. D-dimer levels were assessed using ELISA. All patients were subjected to imaging procedures. Results: Among 711 patients with cancer, 466 (65.5%) were females and 245 (34.5%) were males, with an average age of $57.3{\pm}13.23$ years. The mean age in the DVT group was significantly higher than in the non-DVT group (P<0.05). The D-dimer levels of the DVT group were significantly higher than those of the non-DVT group (P<0.05). The incidence rate of DVT varied significantly according to cancer type (P<0.05). Increasing age and lung cancer were significantly correlated with D-dimer levels (P<0.05), and a one-year increase in age was associated with a 14.28 ng/ml increase in the D-dimer value. The optimal cutoff point for D-dimer was found to be 981 ng/ml, with a sensitivity of 86.4%, specificity of 79.4%, and accuracy of 82.6%. If the D-dimer cutoff point was set to 981ng/ml, the specificity would increase from 61.8% to 85.5% without loss of sensitivity in patients aged 40 years or younger. In patients aged more than 40 years, the new cutoff almost doubled the specificity with slightly reduced sensitivity. Conclusion: In cancer patients, a new cutoff value of 981 ng/ml effectively improved the exclusion of DVT, especially for patients aged more than 40 years.

• 보건행정학회지
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• 제23권4호
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• pp.349-357
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• 2013

Background: Although interferon-gamma release assay (IGRA) is now available alternatives to tuberculin skin test (TST) for detection of latent tuberculosis infection (LTBI), the cost of IGRA test is much higher than TST. So economic analysis of LTBI screening strategies have been done in many countries, but there are few reports in Korea. This study examined cost analysis of LTBI screening strategies in Korea. Methods: The economic outcomes were evaluated by five strategies. These were 1) TST alone, 2) IGRA alone, 3) combination of TST and IGRA (TST followed by IGRA) and 4) no testing no prevention, 5) no testing all prevention. Last two strategies were added to compare with three main LTBI screening strategies. Decision analysis model were used to perform economic analysis. A cohort study of Korean Institute of Tuberculosis and the data of published literatures were used to estimate the cost analysis. Results: In a base-case scenario which was assumed that TST specificity was 80%, TST alone was the least expensive strategy. In a alternative scenario which was assumed that TST specificity was 97%, the combination of TST and IGRA was the least expensive strategy. Sensitivity analysis shows that patients adherent rate to LTBI treatment, TST sensitivity, IGRA sensitivity and IGRA specificity did not have a significant impact on the outcomes. Conclusion: In Korea, for the diagnosis of LTBI at the time of child and adolescent, TST alone reduces medical costs compared with IGRA alone or combination of TST and IGRA.

• 대한영양사협회학술지
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• 제6권1호
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• pp.33-43
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• 2000

Environmental pressures from such sources an economic condition, the government and inter-institutional competition create managerial challenges. Economic pressures may be forcing dietetic dept, in hospital to utilize cost∙benefit analysis to assist them in their problem solving. Cost∙benefit analysis have been widely used in business, industry and many other fields with only limited application to foodservice. Due to the lack or this information the purposes of this study were to identify use of cost∙benefit analysis in hospital foodservice system to evaluate the economic efficiency of alternatives, and to make recommendation for operation system change. Using the cost∙benefit method, cash flows are separated into cost and benefits. For an alternative to be selected, indicators, such as NPV, benefit-cost ratio (B/C ratio) with 5% discount rate per annum. The sensitivity analysis was also conducted with difference rate 3%, 7% respectively and reduced employee payroll change. The result of this study can be summarized as follows : 1. The total cost of investment for operation system change was 390,570 thousand won and the total benefit through operation system change was 865,808 thousand won. 2. Net present value(NPV) for 5 years was 475,239 thousand won and benefit-cost ratio was 2.22. 3. In sensitivity analysis with different discount rate 3%, 7%, benefit-cost ratio was 2.25, 2.18 respectively, with total reduced employee payroll change, benefit-cost ratio was 2.86. In conclusion, total benefits were exceeded total costs. Therefore, the project of operation system change in hospital foodservice was found to be economically efficient.

• 한국정보처리학회논문지
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• 제6권12호
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• pp.3490-3499
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• 1999

초기하분포 소프트웨어 신뢰성 성장 모델(HGDM)은 최근에 개발되어 테스트와 디버그의 시작 단계에서 소프트웨어에 남아 있는 초기 결함 수를 추정할 수 있는 문제에 성공적으로 적용되고 있다. 그러나 HGDM은 시간 도메인 소프트웨어 신뢰성 성장 모델(SRGM)에 속하지만 시험자 수 등과 같은 시험에 투입하는 자원을 고려하는 과정에서 다른 시간 도메인 SRGM과 비교하기 곤란한 점을 내포하게 되었다. 특히, 시간 도메인 SRGM에서 일반적으로 사용하는 소프트웨어 신뢰성을 계산할 수 없다. 본 논문은 HGDM이 시간에 의해 기술되지 않음으로 인해 생기는 이러한 문제점을 해결하기 위해 이항 반응 계수를 가진 연속 시간형 HGDM을 개발하고 그 특성을 연구한다. 그리고 제안된 모델을 실제 자료에 적용해서 기존 HGDM을 대신하여 사용할 수 있음을 보인다.