• 한국소음진동공학회논문집
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• 제22권4호
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• pp.335-343
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• 2012

As a matter of fact, it has been not allowed to modify the shape of a vehicle body skeleton since the technical definition for the structure was fixed and the corresponding molds were developed. By the way, if it is available to apply an alternative to reinforce the skeleton without changing its mold, it must be much flexible to improve the performance qualities relevant to not only NVH(noise, vibration and harshness) but also crash and durability. Recently, a solution of so-called composite body becomes available for the need. We present a design method to insert the composite body inside a vehicle body skeleton in order to improve a structure-borne noise at the idle condition. The algorithms, topology optimization and design sensitivity analysis, are applied to mainly search the sensitive structural sections in the body skeleton and to extract the target stiffness of the sections. Inserting the composite bodies into the sensitive portions, it is predicted to achieve the countermeasures which can compromize the design availability in terms of the idle noise and weight. According to the validation result with test vehicles, the concerned noise transfer function is reduced and the idle booming noise is resultantly improved.

• 한국미생물·생명공학회지
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• 제46권3호
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• pp.269-276
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• 2018

Rabies virus (RABV)-specific antibodies in animals and humans are measured using standard methods such as fluorescent antibody virus neutralization (FAVN) tests and rapid fluorescent focus inhibition tests, which are based on cell culture systems. An alternative assay that is safe and easy to perform is required for rapid sero-surveillance following mass vaccination of animals. Two purified monoclonal antibodies (4G36 and B2H17) against RABV were selected as capture and detection antibodies, respectively. A genetically modified RABV, the ERAGS strain, was propagated and concentrated by polyethylene glycol precipitation. Optimal conditions for the RABV antigen, antibodies, and serum dilution for a blocking enzymelinked immune sorbent assay (B-ELISA) were established. We evaluated the sensitivity, specificity, and accuracy of the B-ELISA using serum samples from 138 dogs, 71 raccoon dogs, and 25 cats. The B-ELISA showed a diagnostic sensitivity of 95.8-96.3%, specificity of 91.3-100%, and accuracy of 96.0-97.2% compared to the FAVN test. These results suggest that the B-ELISA is useful for sero-surveillance of RABV in dogs, raccoon dogs, and cats.

• Safety and Health at Work
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• 제11권3호
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• pp.361-366
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• 2020

Background: This study aimed to identify the validity of breast cancer symptom questionnaire of worker's special health examination and its relationship with breast ultrasonography findings in young female night workers. Methods: The breast cancer symptom questionnaire data of worker's special health examination and breast ultrasonography results in young female shift workers who worked in one electronic manufacture company were collected from 2014 to 2018. Results: Of the 857 workers, 18 had a Breast Imaging Reporting and Database System category 4 or higher. Among other variables, shift work tenure alone was associated with the risk of having a Breast Imaging Reporting and Database System category higher than 4. The sensitivity, specificity, positive predictive value, and negative predictive value of the symptom questionnaire were 16.7%, 87.7%, 2.8%, and 98.0%, respectively. Conclusion: The current breast cancer symptom questionnaire of the worker's special health examination is inappropriate due to its low sensitivity and positive predictive value. In the future, female night workers will need alternative measures for more accurate screening for breast cancer.

• Advances in environmental research
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• 제2권4호
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• pp.279-290
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• 2013

In this study, a comprehensive model developed to estimate greenhouse gas (GHG) emissions from urban area with low impact development (LID) and its integrated management practices (IMPs). The model was applied to the actual urban area in Asan Tangjeong district (ATD) as a case study. A rainwater tank (1200 ton) among various LID IMPs generated the highest amount of GHG emissions ($3.77{\times}10^5kgCO_2eq$) and led to the utmost reducing effect ($1.49{\times}10^3kgCO_2eq/year$). In the urban area with LID IMPs, annually $1.95{\times}104kgCO_2eq$ of avoided GHG emissions were generated by a reducing effect (e.g., tap water substitution and vegetation $CO_2$ absorption) for a payback period of 162 years. A sensitivity analysis was carried out to quantitatively evaluate the significance of the factors on the overall GHG emissions in ATD, and suggested to plant alternative vegetation on LID IMPs.

• 대한조선학회논문집
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• 제57권3호
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• pp.124-132
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• 2020

The purpose of this paper is to establish the basic procedure and method for selection of preferred anti-fouling paint considering economic analysis according to ship's speed loss based on ISO 19030 that has been published in 2016 to prescribe practical methods for measuring changes in ship specific hull and propeller performance. In this study, six (6) anti-fouling paint products have been assumed for alternatives with each target maximum average speed loss and carried out comparison of the alternatives and sensitivity analysis in assumed conditions for selection of the preferred alternative.

• 한국압력기기공학회 논문집
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• 제15권1호
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• pp.33-39
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• 2019

An 1,500MW advanced power reactor required the standard design approval by a Korean regulatory body in 2014. The reactor has been designed to have a 4-train independent safety concept and a passive auxiliary feedwater system (PAFS). The full power risk or core damage frequency (CDF) of 1,500MW advanced power reactor has been reduced more than that of APR1400. However, the risk during the low power and shutdown (LPSD) operation should be reduced because CDF of LPSD is about 4.7 times higher than that of internal full power. The purpose of paper is to analysis design alternatives to reduce risk during the LPSD. This paper suggests design alternatives to reduce risk and presents sensitivity analysis results.

• Biomolecules & Therapeutics
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• 제31권5호
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• pp.573-582
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• 2023

Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise. In the exercise group, each mouse was trained on a treadmill for 2 weeks. On the last day, all groups were evaluated for several atrophic behaviors and skeletal muscles, including the soleus, plantaris, gastrocnemius, and extensor digitorum longus were analyzed. In the exercise group, muscle mass was restored, causing in attenuation of muscle atrophy. The gastrocnemius and extensor digitorum longus muscles showed improved fiber cross-sectional area and reduced myofibrils. Further, they produced regulated atrophy-related proteins (i.e., muscle atrophy F-box, muscle RING-finger protein-1, and myosin heavy chain), indicating that aerobic exercise stimulated their muscle sensitivity to reverse skeletal muscle atrophy. In conclusion, shortness of the gastrocnemius caused by methylglyoxal may induce the dynamic imbalance of skeletal muscle atrophy, thus methylglyoxal may be a key target for treating skeletal muscle atrophy. To this end, aerobic exercise may be a powerful tool for regulating methylglyoxal-induced skeletal muscle atrophy.

• 한국공간정보시스템학회 논문지
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• 제1권1호
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• pp.79-88
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• 1999

본 논문에서는 화물운송체계에 GIS/GPS 기반의 AVL을 적용하기 위한 핵심요소기술을 검토하고, 시스템 구성대안을 설정하였다. 또한 시스템 구성대안들을 Life-Cycle Cost 분석을 통하여 평가하였다. 기본가정 및 비용단가에 의한 분석결과 개별차량의 무선통신비용의 부담이 노변통신시설의 유지보수 비용에 비해 전체 LCCE에 큰 영향을 미치는 것으로 나타나 무선통신대안이 상대적으로 고비용의 시스템 구성안인 것으로 분석되었다. 그러나 여러 가지 요인에 따른 민감도 분석결과 노변시설의 설치간격, 무선통신비용단가의 하락 등을 가정할 경우 무선통신대안이 운영측면의 경제성을 갖는 것으로 분석되었다. 무선통신대안과 노변통신대안 모두 각각의 장단점을 갖고 있으므로 지역적 특성 내지는 교통시설의 특성에 따라 혼합적용하는 방안이 검토되어야 한다. 본 연구는 GIS/GPS-AVL의 화물운송체계 적용시 시스템구성요소 및 구축방향을 결정하는데 도움을 줄 것이다.

• Earthquakes and Structures
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• 제18권2호
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• pp.249-261
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• 2020

Seismic loss estimation studies require fragility curves which are usually derived using ground motion datasets. Ground motion records can be either in the form of recorded or simulated time histories compatible with regional seismicity. The main purpose of this study is to investigate the use of alternative ground motion datasets (simulated and real) on the fragility curves. Simulated dataset is prepared considering regional seismicity parameters corresponding to Erzincan using the stochastic finite-fault technique. In addition, regionally compatible records are chosen from the NGA-West2 ground motion database to form the real dataset. The paper additionally studies the effects of hazard variability and two different fragility curve derivation approaches on the generated fragility curves. As the final step for verification purposes, damage states estimated for the fragility curves derived using alternative approaches are compared with the observed damage levels from the 1992 Erzincan (Turkey) earthquake (Mw=6.6). In order to accomplish all these steps, a set of representative masonry buildings from Erzincan region are analyzed using simplified structural models. The results reveal that regionally simulated ground motions can be used alternatively in fragility analyses and damage estimation studies.

• 대한수의학회지
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• 제46권2호
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• pp.119-125
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• 2006

The objective of this study was to investigate the use of extract from mesenteric lymph nodes as an alternative to serum for ELISA to detect Salmonella antibodies in slaughter pigs. Among 324 slaughter pigs, 65 (20.1 %) were positive in the serum ELISA and 76 (23.5%) were positive in the ELISA with extract from lymph nodes. A total of 24 (7.4%) Salmonella representing 6 serotypes were isolated from mesenteric lymph nodes and 35 (10.8%) Salmonella belonging to 2 serotypes were also recovered from cecal contents of slaughter pig samples, respectively. The most prevalent serogroup was B (55.9% of isolates) and serotype was Typhimurium (52.5% of isolates). In the comparison of the results of between the serum ELISA and Salmonella isolation, kappa value was 0.28 with mesenteric lymph nodes and 0.37 with cecal contents, respectively. However, the extract ELISA had sensitivity of 98.5%, specificity of 95.4% and kappa value of 0.88 as compared with the serum ELISA. Because high degree of concordance between the serum ELISA and the extract ELISA was observed (P=0.24), extract from lymph nodes could be used as an alternative to serum for the detection of Salmonella antibodies in the ELISA.