• Neonatal Medicine
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• v.17 no.1
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• pp.136-140
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• 2010

Galactosemia is a group of inherited enzyme deficiencies characterized by increase in the blood galactose levels. This condition may be associated with deficiencies of galactose-1-phosphate uridyl transferase, galactokinase, or uridine diphosphate galactose-4-epimerase. However, the elevated galactose identified by neonatal screening tests has several other possible etiologies, including hepatic hemangioendothelioma, hepatic hemangioma, and patent ductus venosus with hypoplasia of the portal vein. We report a 13-day-old Korean male with hepatic hemangioendothelioma, which was incidentally detected during the evaluation for suspected galactosemia. Laboratory studies revealed that mildly elevated levels of galactose, galactose-1-phosphate and alpha- fetoprotein, at the time of admission, were graduallydecreased to the normal range over the 6 months of observation. Ultrasonography showed a well-defined heterogeneous hypoechoic mass in the liver, and magnetic resonance imaging study showed multiple enhanced mass lesions, which was compatible with the diagnosis of a hepatic hemangioendothelioma. Thus, hepatic imaging, especially ultrasonography, should be performed if neonatal screening suggests galactosemia.

• Korean Journal of Medicinal Crop Science
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• v.17 no.1
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• pp.54-60
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• 2009

This study was performed to improve immune activities of Rubus coreanus Miquel by encapsulation of nanoparticles. Immuno-activities of R. coreanus were investigated through aqueous extracts associated with process of water at $60^{\circ}C$. It showed high promotion of human B and T cells growth about 50%, compared to the case of other conditions. The secretion of IL-6 and TNF-${\alpha}$ was also enhanced as $2.44{\times}10^{-4}$pg/cell and $1.94{\times}10^{-4}$pg/cell, results by adding nano samples. NK cell activation was improved up to 29% higher than the conventional extraction process. The secretion of NO from macrophage showed 14.9 ${\mu}M$ on the nano-encapsulation process extracts, which was higher than others. The size of nanoparticles was in the range of 50${\sim}$300 nm, which can effect the penetration into the cells. It was clearly observed by real time confocal microscope.

• Magazine of the Korean Society of Agricultural Engineers
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• v.31 no.1
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• pp.82-95
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• 1989

This study was carried out for the stability analysis of earth dam by the variation of compaction density. The test samples were taken from five kinds of soil used for banking material and the degree of compaction for this samples were chosen 100, 95, 90, 85, and 80 percent. The stability problems were analysed by the settlement and camber( extra banking) of dam, strength parameter and dam slope, and coefficient of permeability and seapage flow through dam body. The results of the stability analysis of earth dam are as follows. 1. The more the fine particle increases and lower the compaction degree becomes, the lower the preconsolidation load becomes but the compression index becomes higher. 2. Sixty to eighty percent of settlement of dam occurs during the construction period and the settlement ratio after completion of dam is inversly proportional to the degree of compaction. 3. The camber of dam has heigher value in condition that it has more fine particle(N) and heigher dam height(H) with the relation of H= e(aN-bH-e). 4. The cohesion(C) decreases in proportion to compaction degree(D) and fine particle(N) with the relation of C= aD+ bN-c, but the internal friction angle is almost constant regardless of change of degree of compaction. 5. In fine soil, strength parameter from triaxial compression test is smaller than that from direct shear test but, they are almost same in coarse soil regardless of the test method. 6. The safety factor of the dam slope generally decreases in proportion to cohesion and degree of compaction but, in case of coarse soil, it is less related to the degree of compaction and is mainly afected by internal friction angle. 7. Soil permeability(K) decreases by the increases of the degree of compaction and fine particle with relation of K=e(a-bl)-cN) 8. The more compaction thickness is, the less vertical permeability (Kv) is but the more h6rzontal permeability (KH) is, and ratio of Kv versus KH is largest in range from 85 to 90 percent of degree of corn paction. 9. With the compaction more than 85 percent and coefficient of permeability less than ${\alpha}$X 10-$^3$cm/sec, the earth dam is generally safe from the piping action.

• Journal of Internet Computing and Services
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• v.21 no.5
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• pp.75-85
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• 2020

The application of Internet technology has created enormous impact on banking sector with the implementation of many techno-oriented services like Internet banking, EFT, branchless banking, Automated Clearing House (ACH) transactions etc. Study of customer's attitude in terms of trust, perceived risk and ease of use of a particular technology is as an important parameter for acceptance or rejection of a technology. To explore the customers'attitude for Internet banking this research is undertaken. The research is carried out in Pokhara valley which is the second largest city and tourism capital of Nepal. The study employs descriptive research design with stratified sampling procedure for eight top commercial banks. A set of 25 customers is taken from each selected 8 banks making a sample size of 200 respondents. A fixed set of question related to demographic factors is provided personally or by visiting the location of the customers of Internet banking service and collected accordingly. Reliability test is performed using Cronbach's alpha and data is analyzed using inferential statistics to present the results of the study. This study provides knowledge on the current scenario of Internet banking and helps banks in cost saving, mass customization, product innovation, improved marketing and communication. This study is very important for financial institutions like banks, government agencies and business houses to understand the perception of customers towards Internet banking and technology as a whole. The study also supplements the gap in literature on technology and banking in Nepal and serves as an important knowledge base.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.10 no.1
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• pp.27-30
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• 2010

3-Methylcrotonyl-CoA carboxylase deficiency (3-MCCD) is an autosomal-recessive inborn error of leucine catabolism caused by the deficiency of 3-methylcrotonyl-CoA carboxylase (3-MCC). With the introduction of tandem mass spectrometry in newborn screening, this disorder has been identified with unexpectedly high prevalence. The clinical manifestations of 3-MCCD are highly variable ranging from asymptomatic to severe neurological manifestations. 3-MCC is an heteromeric enzyme consisting of ${\alpha}$ - and ${\beta}$ - subunits, encoded by the MCCC1 and the MCCC2 gene, respectively. In the currentreport, a Korean patient with 3-MCCD is described. She was identified by newborn screening test, and has been asymptomatic with normal development and intelligence up to 3.8 years of age. She carries p.[D280Y]+[D280Y] mutations in the MCCC2 gene.

• Journal of Communications and Networks
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• v.13 no.6
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• pp.602-611
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• 2011

The inter-domain routing scalability issue is a major challenge facing the Internet. Recent wide deployments of multihoming and traffic engineering urge for solutions to this issue. So far, tunnel-based proposals and compact routing schemes have been suggested. An implicit assumption in the routing community is that structured address labels are crucial for routing scalability. This paper first systematically examines the properties of identifiers and address labels and their functional differences. It develops a simple Internet routing model and shows that a binary relation T defined on the address label set A determines the cardinality of the compact label set L. Furthermore, it is shown that routing schemes based on flat address labels are not scalable. This implies that routing scalability and routing stability are inherently related and must be considered together when a routing scheme is evaluated. Furthermore, a metric is defined to measure the efficiency of the address label coding. Simulations show that given a 3000-autonomous system (AS) topology, the required length of address labels in compact routing schemes is only 9.12 bits while the required length is 10.64 bits for the Internet protocol (IP) upper bound case. Simulations also show that the ${\alpha}$ values of the compact routing and IP routing schemes are 0.80 and 0.95, respectively, for a 3000-AS topology. This indicates that a compact routing scheme with necessary routing stability is desirable. It is also seen that using provider allocated IP addresses in multihomed stub ASs does not significantly reduce the global routing size of an IP routing system.

• Journal of Adhesion and Interface
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• v.2 no.1
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• pp.18-22
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• 2001

Surface morphology of [poly(vinylidene fluoride)/poly(methyl methacrylate)] (PVDF/PMMA) was investigated on the basis of atomic force microscopy and differential scanning calorimeter measurements. The surface of (PMMA/PVDF) and (H14-PMMA/PVDF) blend films was fully composed with PVDF crystals. Although the difference of surface free energy between PMMA and PVDF is increased with increasing carboxyl group content in PMMA, however, in the case of (H24-PMMA/PVDF) blend film surface, the existence of aggregated H-PMMA was observed. It was found that the degree of surface enrichment of the blend is more affected by the magnitude of intermolecular interaction than the surface free energy difference, Besides, the introduction of carboxyl group for miscible (PVDF/PMMA) blend decreased the miscibility in the blend.

• Journal of the East Asian Society of Dietary Life
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• v.19 no.1
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• pp.96-104
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• 2009

Three kinds of grape yakju (Kyoho, Campbell and Moru) and grape-free control were fermented with rice using koji of Aspergillus kawachii as a fermenting agent, and their fermentation characteristics were investigated. For the three yakju, reducing sugar content decreased slowly over 2 days fermentation after an initial rapid decrease. In case of Brix, the reducing sugar content increased gradually after increasing rapidly during the first 2 days of fermentation. The Kyoho and Moru groups displayed a gradual increase in reducing sugar content after an initial 2-day decrease, and the sugar content of the Campbell group increased gradually during fermentation. Uniformly, pH increased gradually after an initial 2-day decrease, however total acid increased continuously throughout fermentation. Alcohol content of yakju showed almost no change after increasing until day 6 (Kyoho) of day 4 (others), with the control displaying the highest content. Control $\alpha$-amylase activity decreased gradually after an initial 2-day increase, while that of the three yakju decreased throughout fermentation. Activities of $\beta$-amylase activities paralleled the results of reducing sugar. Concerning total anthocyanin, the Moru and Campbell groups displayed a rapid increase until day 2, a decrease until day 12, and a gradual increase thereafter. While the Kyoho and control groups displayed virtually no change after an initial 2-day increase until day 12, after which a gradual increase also occurred. In concerning sensory evaluation, Moru yakju scored highest for violetness, flavor of grape, and sweet taste, and also displayed a low alcohol content. These attributed Moru yakju the preferred choice.

• Clinical and Experimental Pediatrics
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• v.55 no.8
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• pp.293-296
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• 2012

M$\acute{e}$n$\acute{e}$trier's disease is a rare form of acquired gastropathy characterized by giant rugal folds in the stomach and protein-losing gastropathy. Children with M$\acute{e}$n$\acute{e}$trier's disease tend to follow a benign self-limited course with symptoms typically completely resolving within 2 to 10 weeks in contrast to the chronic course in adults. A 9-year-old girl presented with a history of gradually worsening abdominal distension, increasing body weight, and abdominal pain for 2 weeks. Physical examination on admission indicated periorbital swelling, pitting edema in both the legs, and abdominal distension with mild diffuse tenderness and shifting dullness. Laboratory tests on admission showed hypoalbuminemia, hypoproteinemia, and peripheral eosinophilia. The test result for anti-cytomegalovirus immunoglobulin M was negative. Increased fecal alpha 1 anti-trypsin excretion was observed. Radiological findings showed massive ascites and pleural effusion in both the lungs. On gastroscopy, large gastric folds, erythema, erosion, and exudation were noted in the body and fundus of the stomach. Microscopic findings showed infiltration of eosinophils and neutrophils in the gastric mucosa. Her symptoms improved with conservative treatment from day 7 of hospitalization and resolved completely.

• The Korean Journal of Pharmacology
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• v.11 no.2
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• pp.19-27
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• 1975

Haloperidol, a butyrophenone, was synthetized by Janssen and introduced for the treatment of psychosis. Although structurally different from the phenothiazines, the butyrophenones share many of their pharmacological properties, such as inhibition of conditioned avoidance response, blocking effect of amphetamine reaction, producing catalepsy, antishock effect and protection against the lethal effects of catecholalmines. Chlorpromazine can lower the arterial blood pressure through its adrenergic blocking activity, its direct effect in relaxing vascular smooth muscle, its direct effect in depressing the myocardium and its action in a complex manner on the central nervous system. In the case of haloperidol, however, was not clarified the mechanism of lowering the blood pressure. The present paper describes the effects of haloperidol on cardiovascular system to investigate the mechanisms of its actions on the arterial blood pressure. The results are followings; 1. In anesthetized cats, intravenous administration of haloperidol and chlorpromazine in the dose of 0.1mg/kg produced a slight decrease in the blood pressure, which followed by complete recovery within $30{\sim}60$ minutes. In the dose of 3mg/kg, however, both produced an abrupt and marked decrease of the blood pressure, which followed by delayed recovery. 2. Haloperidol in the dose ranges of 0.1mg to 3.0mg/kg tended to produce the heart rate slowing in the cats, while chlorpromazine has no effect on the rate. 3. Following administration of haloperidol or chlorpromazine, epinephrine reversal in the arterial blood pressure was observed in the cat, however the responses of norepinephrine and acetylcholine were little affected. 4. In the isolated rabbit atrium the contractility was depressed by haloperidol in the doses over 0.5mg per 100ml, but the rate was not affected. In contrast, the epinephrine-induced contractility was not depressed after haloperidol treatment. However, the increased rate of atrium by epinephrine was partially blocked after haloperidol. 5. In the isolated rabbit aortic strip, epinephrine-induced contraction was blocked by haloperidol. With the above results, it may be concluded that the hypotensive effect of haloperidol was largely due to ${\alpha}$-adrenergic blocking properties and the direct effect in depressing the myocardium as well as its action on central nervous system.