• Clinical and Experimental Pediatrics
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• 제53권2호
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• pp.262-266
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• 2010

$TNF-{\alpha}$ 는 소아기 류마티스모양 관절염의 병태생리학에 관여하는 주요 cytokine 이다. Etanercept 는 $TNF-{\alpha}$ 억제제 중 하나로 소아기 류마티스모양 관절염에 효과적인 약물로 각광받고 있다. Etanercept의 주요 부작용은 면역력 저하에 의한 감염으로, 대게 중등도의 상기도 감염이 대부분으로 알려져 있으나, 최근 중증의 감염도 보고되고 있다. 저자들은 소아기 류마티스모양 관절염 환자가 etanercept를 14개월간 투약 후 발생한 뇌염 1예를 경험하였기에 보고하는 바이다.

• 대한간호학회지
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• 제42권4호
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• pp.549-558
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• 2012

Purpose: The purpose of this study was to validate the Needs Assessment Tool for Case Management (NATCM) for use with Korean medical aid beneficiaries. Methods: Psychometric testing was performed with a sample of 645 Korean medical aid beneficiaries, which included 41 beneficiaries who were selected using proportional sampling method, to examine intraclass correlation coefficients (ICC). Data were evaluated using item analyses, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), Cronbach's alpha, and ICC. Results: Through psychometric testing the final version of NATCM was found to consist of two subscales: 1) Appropriateness of Health Care Utilization (5 items) and 2) Self Care Ability (6 items). The two subscale model was validated by CFA (RMSEA=.08, GFI=.97, and CFI=.93). Internal consistency measured by Cronbach's alpha was .82, and subscale reliability ranged from .79 to .84. The ICC of the NATCM between case managers was .73 and between case managers and health care professionals. .82. Conclusion: This study suggests that the final version of NATCM is a brief, reliable, and valid instrument to measure needs of Korean medical aid beneficiaries. Therefore, the NATCM can be effectively utilized as an important needs assessment as well as outcome evaluation tool for case management programs in Korea.

• 산업공학
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• 제25권4호
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• pp.382-392
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• 2012

Reactor protection system to keep nuclear safety and operational economy of plants requires high reliability. Such a high reliability of the system can be achieved through the redundant design of components. However, common cause failures of components reduce the benefits of redundant design. Thus, the common cause failure analysis, to accurately calculate the reliability of the reactor protection system, is carried out using alpha-factor model. Analysis results to 24 operating months are that 1) the system reliability satisfies the reliability goal of EPRI-URD and 2) the common cause failure contributes 90% of the system unreliability. The uncertainty analysis using alpha factor parameters of 0.05 and 0.95 quantile values shows significantly large difference in the system unreliability.

• 제어로봇시스템학회논문지
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• 제10권4호
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• pp.295-303
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• 2004

Previously it has been shown that the all pole systems resulting good time responses can be characterized by so called K-polynomial. The polynomial is defined in terms of the principal characteristic ratio $\alpha_1$ and the generalized time constant $\tau$ . In this paper, Part II presents several sensitivity analyses of such systems with respect to $\alpha_1$ and $\tau$ changes. We first deal with the root sensitivity to the perturbation of $\alpha_1$ . By way of determining the unnormalized function sensitivity, both time response sensitivity and frequency response sensitivity are derived. Finally, the root sensitivity relative to $\tau$ change is also analyzed. These results provide some useful insight and background theory when we select of and l to compose a reference model of which denominator is a K-polynomial, which is illustrated by examples.

• 대한수학회보
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• 제33권1호
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• pp.107-110
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• 1996

Usng the Pochhammer symbol $(\lambda)_n$ given by $$ (1.1) (\lambda)_n = {1, if n = 0 {\lambda(\lambda + 1) \cdots (\lambda + n - 1), if n \in N = {1, 2, 3, \ldots}, $$ we define a general double hypergeometric series by [3, pp.27] $$ (1.2) F_{q:s;\upsilon}^{p:r;u} [\alpha_1, \ldots, \alpha_p : \gamma_1, \ldots, \gamma_r; \lambda_1, \ldots, \lambda_u;_{x,y}][\beta_1, \ldots, \beta_q : \delta_1, \ldots, \delta_s; \mu_1, \ldots, \mu_v; ] = \sum_{l,m = 0}^{\infty} \frac {\prod_{j=1}^{q} (\beta_j)_{l+m} \prod_{j=1}^{s} (\delta_j)_l \prod_{j=1}^{v} (\mu_j)_m)}{\prod_{j=1}^{p} (\alpha_j)_{l+m} \prod_{j=1}^{r} (\gamma_j)_l \prod_{j=1}^{u} (\lambda_j)_m} \frac{l!}{x^l} \frac{m!}{y^m} $$ provided that the double series converges.

• Transactions on Electrical and Electronic Materials
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• 제6권6호
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• pp.280-283
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• 2005

The moving photocarrier grating (MPG) technique for the determination of the carrier mobilities and the recombination lifetime of $\alpha$-Se:As films has been studied. The electron and hole drift mobility and the recombination lifetime of $\alpha$-Se films with arsenic (As) additions have been obtained from measurement of the short circuit current density $j_{sc}$ as a function of grating velocity and spatial period. The hole mobility decreases due to defect density of hole traps when x exceeds 0.003, whereas the hole mobility increases for the case of low As addition (x$\le$0.003). We have found an increase in hole drift mobility and recombination lifetime, especially when As with (x = 0.003) is added into the $\alpha$-Se film.

• 호남수학학술지
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• 제31권4호
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• pp.505-513
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• 2009

Let {$X_k;k{\in}N^d$} be centered and identically distributed random field which is asymptotically negative dependent in a certain case. In this note we prove that for $p{\alpha}$ > 1 and ${\alpha}$ > ${\frac{1}{2}}$ $E{\mid}X_1{\mid}^p(log^+{\mid}X_1{\mid}^{d-1})$ < ${\infty}$ if and only if ${\sum}_n{\mid}n{\mid}^{p{\alpha}-2}P$($max_{1{\leq}k{\leq}n{\mid}S_k{\mid}}$ > ${\epsilon}{\mid}n{\mid}$) < ${\infty}$ for all ${\epsilon}$ > 0, where log$^+$x = max{1,log x}.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 1998년도 제2회 박판성형심포지엄 논문집 박판성형기술의 현재와 미래
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• pp.140-147
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• 1998

The texture evolution by deep drawing was investigated and the lattice rotation rate was predicted using rate sensitive model with full constraints boundary conditions. The calculated textures show different behaviors with the amount of the flange deformation and initial crystal orientations. Among the crystal orientations located parallel to RD, the crystal orientations around the D component rotated toward the Cu component, the crystal orientations along the ${\alpha}$ fiber rotated toward the {110}<001> and {110}<111> components during deep drawing. In the case of the part parallel to 45$^{\circ}$ with respect to RD, the crystal orientations around the D component rotated about ND and the crystal orientations along the ${\alpha}$ fiber also rotated toward the (110)[23] and (110)[27] components about ND. In the part parallel to TD, the crystal orientations around the D component rotated toward the Rotated Cube and the crystal orientations along the ${\alpha}$ fiber rotated toward the {110}<113> component.

• 한국염색가공학회지
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• 제19권5호
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• pp.8-16
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• 2007

The dye-resist effect of reactive dye-resist agents in reactive dyeing of silk was investigated. The dichlorotriazine-based dye-resists achieved a higher effectiveness than others since they make a charge barrier of diffusion in the silk fiber periphery due to high reactivity of dichlorotriazine group. Similarly, in the case of hetero-multifunctional dye-resist agent, the dye-resist agent containing both a dichlorotriazine and an ${\alpha}$-bromoacrylamide reactive groups achieved better resist effectiveness than those containing both a monochlorotriazine and an ${\alpha}$-bromoacrylamide groups. Also, their resist effectiveness was improved by increasing the number of sulfonate groups in the dye-resist agents and the number of reactive groups in the reactive dyes applied to them.

• Clinical and Experimental Pediatrics
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• 제57권10호
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• pp.440-444
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• 2014

Purpose: Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remains unclear. Recent studies have shown that cytokines may play a role in the pathogenesis of febrile seizures. The present study was conducted to identify potential links between serum interleukin-1beta (IL-$1{\beta}$), tumor necrosis factor-alpha (TNF-${\alpha}$), and febrile seizures. Methods: Ninety-two patients with simple or complex febrile seizures (46 patients per seizure type), and 46 controls with comparable age, sex, and severity of temperature were enrolled. Results: The median concentrations of serum IL-$1{\beta}$ in the simple, complex febrile seizure, and control groups were 0.05, 0.1, and 0.67 pg/mL, respectively (P=0.001). Moreover, the median concentrations of TNF-${\alpha}$ in the simple, complex febrile seizure, and control groups were 2.5, 1, and 61.5 pg/mL, respectively (P=0.001). Furthermore, there were significant differences between the case groups in serum IL-$1{\beta}$ and TNF-${\alpha}$ levels (P<0.05). Conclusion: Unlike previous studies, our study does not support the hypothesis that increased IL-$1{\beta}$ and TNF-${\alpha}$ production is involved in the pathogenesis of febrile seizures.