• 생약학회지
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• 제28권2호
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• pp.65-71
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• 1997

This study was carried out to purify and to characterize various bioactive material acemannan from Aloe vera. Purified acemannan was mannose (67%) and acetyl group (23%), and the rest of glucose was galactose that consists of long chain polydispered beta-(1, 4) linked mannan polymers. The sugar and acetyl group in the molecule were linked by molar ratio of 3 : 1. This polysaccharide from Aloe vera may provide functional flood and potential drug source with antiviral and immunomodulating properties.

• 대한수의사회지
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• 제26권1호
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• pp.38-42
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• 1990

The effect of Aloe vera administration(500mg/kg, P.O.) for 21 days on the total white blood cell, packed cell volume, hemoglobin, total protein, serum glutamic pyruvic transaminase and sorbitol dehydrogenase values in cobalt-60 gamma irradiated rats was s

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.149.1-149.1
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• 2003

Active ingredients, therapeutic and adverse effects of Aloe vera were comprehensively investigated. Aloe vera contains active components. including sugars, proteins, lipids, vitamins, minerals, phenolic compounds and other several compounds like phthalate esters, gibberellin, lectin-like substances, lignin, saponins, salicylic acid and uric acid. (omitted)

• Natural Product Sciences
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• 제7권2호
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• pp.60-62
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• 2001

Ulmus davidiana, Formitella fraxinea, and Aloe vera extracts were detected to have inhibitory effects against topoisomerase I at treatment of $5{\mu}g$. Ulmus davidiana and Aloe vera extracts were found to show inhibitory effect similar to camptothecin, Formitella fraxinea extract was found to have weak activity. We also found the potential use of those extracts as a radiation sensitizer. Radiosensitizing effect at combination treatment was increased more than 2 times at single treatment of radiation, Ulmus davidiana or Formitella fraxinea extracts. Ulmus davidiana and Formitella fraxinea extracts were found to have significant radiosensitizing effect on test tumor cell line. But, Aloe vera extract was not detected to have activity as a radiosensitizer. Ulmus davidiana and Formitella fraxinea extracts are potent radiosensitizers on tumor cell lines and should be considered for further study of active compounds.

• Applied Biological Chemistry
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• 제49권1호
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• pp.65-69
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• 2006

알로에 베라와 알로에 센스 추출물에 의한 phosphatidic acid(PA)로 염증을 유발한 Raw 264.7 세포에서 항염증 효과를 측정하였다. 알로에 자체는 염증반응에 관여하지 않았으며, 알로에 추출물들이 PA처리에 의해 증가된 염증관련 COX-2의 발현을 억제함으로서 항염증 효과가 있음이 확인되었다.

• 한국식품조리과학회지
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• 제16권5호
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• pp.385-389
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• 2000

알로에 베라(Aloe vera)와 아보레센스(Aloe avoresence)를 증류수, 메탄올, 에탄올, 헥산 및 에칠에테르로 각각 추출한 후 이들 용매별 추출물을 수용성 분획과 비수용성 분획으로 분리하여 NDP에 대한 항변이원성을 검색하였다. 알로에 베라와 아보레센스의 수용성 획분 모두 직접 변이원 물질인 NPD에 대하여 4~56%의 항변이 효과를 보였다. 반면, 알로에 베라의 용매별 비수용성 분획은 TA97 및 TA98 균주에서 54~100%의 높은 활성을 보였다. 특히 에칠에테르 추출물은 두 시험균주 모두에서 항변이 활성이 높게 나타났다. 알로에 아보레센스의 비수용성 분획은 74~100%의 높은 항변이 활성을 나타내었는데, 시료를 plate당 20 $\mu$ι 투여했을 때 모든 추출물들이 두 시험균주에서 90% 이상의 높은 항변이 활성을 나타내었다.

• 한국식품과학회지
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• 제33권6호
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• pp.753-759
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• 2001

Aloe vera 껍질로부터 구내염등 항염증제재를 개발하기 위해 항염증 활성이 있는 분획을 분리, 동정하고, 염증과 관련된 효소활성에 대한 저해효과를 조사하였다. Aloe vera 껍질의 추출물을 용매에 따라 분획하였고, 활성이 우수한 ethylacetate층을 silica gel column chromatography 및 preparative thin layer chromatography를 통해 두 가지 활성물질을 정제하였다. 정제된 두 가지 물질은 UV spectrum과 FT-IR, $^1H-NMR$, 및 Mass spectrum 분석을 통해 aloe-emodin과 barbaloin으로 동정하였다. Aloe vera 분획물의 hyaluronidase 활성저해를 측정한 결과는 aloe-emodin은 $40\;{\mu}g/mL$, barbaloin은 $70\;{\mu}g/mL$의 $IC_{50}$값을 나타내었다. Leucko-cyte elastase 활성 저해를 측정한 결과는 aloe-emodin은 $50\;{\mu}g/mL$, barbaolin은 $60\;{\mu}g/mL$의 $IC_{50}$값을 나타내었다. Collagenase 활성 저해를 측정한 결과는 aloe-emodin은 $40\;{\mu}g/mL$, barbaloin은 $60\;{\mu}g/mL$의 $IC_{50}$값을 나타내었다. 또한 prostaglandin endoperoxide synthase 활성 저해를 측정한 결과는 aloe-emodin은 $40\;{\mu}g/mL$, barbaloin은 $70\;{\mu}g/mL$의 $IC_{50}$값을 나타내었다. 쥐를 이용한 carrageenan족 부종 억제효과는 aloe-emodin의 경우 100mg/kg 투여량으로 52.9%의 억제효과를 나타내었으며, 이 억제효과는 indomethacin의 약 1/10이었으며, aspirin과는 유사한 활성을 보였다. 반면 barbaloin의 경우 100mg/kg의 투여량으로 74.9%의 억제효과를 나타내었으며 이 억제효과는 indomethacin의 약 1/5이었으며, aspirin의 약 1.5배 효과를 나타내어 우수한 항염증 활성을 갖는 것으로 판단된다. 인체치은세포에 대한 독성은 aloe-emodin보다 barbaloin이 적게 나타났으며 이 두 가지 물질은 1 및 $5\;{\mu}g/mL$농도에서는 독성이 전혀 나타나지 않으나 10 및 $20\;{\mu}g/mL$에서는 독성이 있는 것으로 나타났다. 그러나 상용되고 있는chlorhexidin에 비해서는 유의적으로 독성이 적은 것으로 나타났다. 이상의 결과로 보아 aloe-emodin 과 barbaloin은 항우식 및 항염증 활성이 우수할 뿐만 아니라 치은세포의 독성이 비교적 낮아 구강병 예방제재로의 개발 가능성이 우수하다고 사료된다.

• 산업식품공학
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• 제13권4호
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• pp.251-261
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• 2009

In vitro physiological functions such as jack bean (Canavalia ensiformis) urease inhibitory activity and retarding effect of glucose/bile acid of Aloe vera gel concentrated by the optimized DIS (Dewatering Impregnation & Soaking) process conditions were examined. Urease inhibitory activity of DIS aloes ranged from 84.6 to 94.4%, which was similar to or higher than 86.3% of fresh aloe. Also, urease inhibitory activity of DIS aloes was maintained at initial levels after heat treatment (90$^{\circ}C$, 10 min.) and drying treatment (freeze or hot air drying). Urease inhibition pattern from Lineweaver-Burk plot indicated general non-competitive inhibition, and inhibition constants ($K_{IE}$ and $K_{IES}$) of DIS aloes were 41-149 and 87-163 $\mu$L/mL, respectively. DIS(glucose) and DIS(polyethylene glycol) exhibited the highest retarding effect of glucose and bile acid. Their retarding effects were about 1.6 and 1.8 folds higher than that of fresh aloe after 0.5 and 1 hr of the dialysis, respectively. Conclusively, the above in vitro physiological functions of Aloe vera gel concentrated by DIS process suggested that aloe products treated with DIS would have the potential benefits for protection against Helicobacter pylori and reduction of blood glucose and cholesterol levels.

• Applied Microscopy
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• 제46권2호
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• pp.76-82
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• 2016

Aloe vera has been used in the pharmaceutical, food and cosmetic industry for its therapeutic properties. However, there are not many current studies on the microstructure of A. vera compared to studies on the chemical constituents and health efficacy of A. vera. Therefore, we compared the morphology of an A. vera leaf using an optical microscope, a conventional scanning electron microscope (SEM) and a cryo-SEM. Especially, this study focused on observing the gel in the inner leaf of A. vera, which is challenging using standard imaging techniques. We found that cryo-SEM is most suitable method for the observation of highly hydrated biomaterials such as A. vera without removing moisture in samples. In addition, we found the optimal analytical conditions of cryo-SEM. The sublimation conditions of $-100^{\circ}C$ and 10 minutes possibly enable the surface of the inner leaf of A. vera to be observed in their "near life-like" state with retaining moisture. The experiment was repeated with A. arborescens and A. saponaria to confirm the feasibility of the conditions. The results of this study can be applied towards the basic research of aloe and further extend previous knowledge about the surface structures of the various succulent plants.

• Journal of Periodontal and Implant Science
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• 제24권2호
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• pp.283-302
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• 1994

Gingivectomy has been utilized as a therapeutic method to remove diseased periodontal pocket wall in order to aid in root planing. Although chemical agents and electrosurgery has been used in addition to the conventional method of using surgical blades, difficulties in controling the depth of chemical penetration and effectively regenerating the gingival tissue as well as the slow wound healing has been pointed out as shortcomings of these methods. This study was designed to assess the effect of Aloe vera on wound healing of gingivectomy sites created by $CO_2$ laser on palatal gingiva of maxillary molar region of white rats. Those sites treated by surgical blades were designated as control, by $CO_2$ laser as Experimental group I, by surgical blades in addition to topical application of Aloe vera as Experimental group II, and by $CO_2$ laser and Aloe vera application as Experimental group III. Animals were sacrificed at 2 days, 3 days, 1 week, 2 weeks and 3 weeks postoperatively, and the specimens were histologically analyzed. The results were as follows : 1. Resorption of blood clots were observed in the control at 3rd day, followed by the rest of the experimental groups at 1 week postoperatively. 2. Persistent inflammation was observed up to 1 week in the control and Experimental group II and III, and until the 2nd week in Experimental group I. 3. Granulation tissue was observed up to 1 week in the control, and 2 weeks in the rest of the groups. 4. Epithelization started on the 2nd day. The control showed the most rapid epithelization, and the process was completed by the 2nd week in all groups. 5. Experimental group II and III, which were treated with Aloe vera, showed similar healing patterns to the control and Experimental group I.