• 한국의류학회지
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• 제28권5호
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• pp.713-722
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• 2004

This study examined the effects of two kinds of functional sun hats through a head-manikin test and a climatic chamber trial for farm workers in summer. Experiment was composed of four conditions. The first condition was the condition without any hat (Control). The second was the condition with a sun hat on the market (Hat A). The third was the condition with a functional sun hat made of reflective fabric (Hat B). The last was the condition with a functional sun hat having a ventilating structure as well as reflective fabric (Hat C). For the subjects in the climatic chamber trials, 12 healthy males volunteered. Air temperature, relative humidity and globe temperature in the chamber was maintained at $33{\pm}0.5^{\circ}C,\;65{\pm}5%RH\;and\;39{\pm}1^{\circ}C\;(WBGT\;33^{\circ}C)$. Subjects did a simulated red pepper-work (50-min work and 10-min rest, twice repetition) for 120 min. As the result of head-manikin test, the surface temperature on middle of back-neck was the lowest in Hat B of four conditions and the surface temperature on top of head was the lowest in Hat C. As the result of climatic chamber trials, there were apparent differences between with (Hat A, Hat B, Hat C) and without a sun hat (Control). In rectal temperature ($T_{re}$), mean skin temperature ($\={T}_{sk}$), heart rate (HR), total sweat rate (TSR), The physiological heat strain was less in the condition with hats than in the condition without a sun hat. As the increasing rate in Tre, Hat B is the most effective hat for alleviation heat strain. As the subjective responses, Hat B was the most effective hat for thermal comfort even though the difference was not significant. Hat C was less effective than Hat B and the reason might be the increase of weight due to inserting the ventilating structure.

• 디지털콘텐츠학회 논문지
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• 제18권4호
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• pp.699-706
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• 2017

근육 주사 후 진동과 압력을 이용한 마사지기구와 손마사지를 환자에게 제공 하여 주사 후 통증과 통증지속시간에 미치는 효과를 비교 검증하는 것이다. 연구의 방법은 비동등성대조군 유사 실험 설계 이다. 실험 결과 실험군이 대조군보다 통증점수가 더 낮았고(t= 7.40, p =.001), 통증 지속시간도 더 짧았다(t= 5.25, p=.001). 실험을 통하여 근육 주사 후 손마사지 방법보다 진동과 압력을 이용한 마사지기를 적용하는 것이 환자의 통증 및 통증 지속시간을 감소시킬 수 있음을 보여주었다. 따라서 근육주사 후 진동과 압력을 이용한 마사지기를 적용하는 것이 환자의 안위 증진은 물론 간호사의 업무량 감소에도 긍정적인 영향을 줄 것으로 기대된다.

• 한국정보통신학회논문지
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• 제20권2호
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• pp.231-236
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• 2016

본 논문에서는 국내 DGPS 기준국 서비스 영역에서의 수신 전력의 안정도를 측정하고 변화율을 분석한다. 동절기와 하절기의 전력 측정과 주야간의 시간적 변화에 대한 DGPS 전파전파 영향을 측정 분석하여 안정된 DGPS 서비스 영역을 확보하기 위한 방안을 살펴본다. 내륙 DGPS 기준국과 해안 DGPS 기준국으로부터 일정 거리를 갖는 동일 지점에서 동절기와 하절기 그리고 낮과 밤의 전파 전파 특성을 일정시간별로 측정한다. DGPS 전파는 대지 도전율에 영향을 받으므로 대지 도전율의 시간적 변화율에 따라 수신되는 전파의 세기는 다르게 나타나며, 서비스 영역의 변화를 가져온다. 안정된 서비스 영역의 운영을 위해서는 적응형 전력 조절과 전리층의 영향을 고려한 안테나 설계가 필요할 수 있다.

• BMB Reports
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• 제38권3호
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• pp.300-306
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• 2005

Tamoxifen citrate is an anti-estrogenic drug used for the treatment of breast cancer. It showed a degree of hepatic carcinogenesis, when it used for long term as it can decrease the hexose monophosphate shunt and thereby increasing the incidence of oxidative stress in liver rat cells leading to liver injury. In this study, a model of liver injury in female rats was done by intraperitoneal injection of tamoxifen in a dose of 45 mg/kg body weight for 7 successive days. This model produced a state of oxidative stress accompanied with liver injury as noticed by significant declines in the antioxidant enzymes (glutathione-S-transferase, glutathione peroxidase and catalase) and reduced glutathione concomitant with significant elevations in TBARS (thiobarbituric acid reactive substance) and liver transaminases; sGPT (serum glutamate pyruvate transaminase) and sGOT (serum glutamate oxaloacetate transaminase) levels. The oral administration of dimethyl dimethoxy biphenyl dicarboxylate (DDB) in a dose of 200 mg/kg body weight daily for 10 successive days, resulted in alleviation of the oxidative stress status of tamoxifen-intoxicated liver injury in rats as observed by significant increments in the antioxidant enzymes (glutathione-S-transferase, glutathione peroxidase and catalase) and reduced glutathione concomitant with significant decrements in TBARS and liver transaminases; sGPT and sGOT levels. The administration of DDB before tamoxifen intoxication (as protection) is more little effective than its curative effect against tamoxifen-induced liver injury. The data obtained from this study speculated that DDB can mediate its biochemical effects through the enhancement of the antioxidant enzyme activities and reduced glutathione level as well as decreasing lipid peroxides.

• Journal of Acupuncture Research
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• 제25권5호
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• pp.117-125
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• 2008

Objectives : In these days Low back pain is most common, and the weakness of muscle strength is important factor. The aim of this study is to prove the influence of the exercise therapy on pain control and muscle strength in acute low back pain patient. Methods : Subjects of this research were 30 inpatients with acute low back pain from 2008. 3. 20 to 2008. 6. 20. 15 patients in each, 2 groups; Non exercise therapy, exercise therapy were divided and the conclusions for treatment are as follows. Results : 1. Regarding alleviation of pain by VAS, both non exercise therapy Group I and exercise therapy Group II showed significant decrease of VAS. 2. Muscle strengthening by extension and flexion peak torque, the exercise therapy Group II showed higher rate of improvement than the non exercise therapy Group I in extension peak torque. 3. Muscle strengthening by extension and flexion peak torque ratio, the exercise therapy Group II showed higher rate of improvement and distribution approach to normal ratio than the non exercise therapy Group I. Conclusions : Exercise therapy was effective in muscle strengthening of acute low back pain.

• Molecules and Cells
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• 제38권10호
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• pp.851-858
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• 2015

Disturbed blood flow with low-oscillatory shear stress (OSS) is a predominant atherogenic factor leading to dysfunctional endothelial cells (ECs). Recently, it was found that disturbed flow can directly induce endoplasmic reticulum (ER) stress in ECs, thereby playing a critical role in the development and progression of atherosclerosis. Ursodeoxycholic acid (UDCA), a naturally occurring bile acid, has long been used to treat chronic cholestatic liver disease and is known to alleviate endoplasmic reticulum (ER) stress at the cellular level. However, its role in atherosclerosis remains unexplored. In this study, we demonstrated the anti-atherogenic activity of UDCA via inhibition of disturbed flow-induced ER stress in atherosclerosis. UDCA effectively reduced ER stress, resulting in a reduction in expression of X-box binding protein-1 (XBP-1) and CEBP-homologous protein (CHOP) in ECs. UDCA also inhibits the disturbed flow-induced inflammatory responses such as increases in adhesion molecules, monocyte adhesion to ECs, and apoptosis of ECs. In a mouse model of disturbed flow-induced atherosclerosis, UDCA inhibits atheromatous plaque formation through the alleviation of ER stress and a decrease in adhesion molecules. Taken together, our results revealed that UDCA exerts anti-atherogenic activity in disturbed flow-induced atherosclerosis by inhibiting ER stress and the inflammatory response. This study suggests that UDCA may be a therapeutic agent for prevention or treatment of atherosclerosis.

• The Korean Journal of Pain
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• 제20권1호
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• pp.31-39
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• 2007

Background: Cervical radicular pain can arise fromvarious structures, including spinal nerves, discs, zygapophyseal joints, ligaments, and myofascial connective tissue. However, no adequate experiments have been found regarding methods for the microadhesiolysis of adhesional connective tissue around the zygapophyseal joints and nerves. The first objective of this study was to ascertain the effect of fluoroscopy guided interventional microadhesiolysis and nerve stimulation (FIMS) on chronic cervical radicular pain caused by zygapophyseal joint dysfunction. The second objective was to identify the duration of pain alleviation, as well as commonly occurring regions for zygapophyseal joint dysfunction. Methods: Twenty-eight patients were diagnosed with cervical radicular pain. The cervical zygapophyseal joints and adhesional structures around the cervical zygapophyseal joints were stimulated by adhesiolysis with a rounded needle; the procedure was performed once every second week. A visual analogue scale (VAS) for pain and neck range of motion (ROM) were used as indices for evaluating the degree of pain 1 and 3 months after completion of the procedures. A relief effect of FIMS was accepted when the VAS index decreased 50% compared with a previous VAS, and when there was absence of limitation of ROM. Results: Among the patients, 52% showed zygapophyseal joint dysfunction in C5-6, 38% in C4-5, 7% in C2-3, and 3% in C6-7. After performing FIMS, the VAS index decreased in most of the patients after 1 and 3 months (92.8% and 75%, respectively), and treatment frequency was $2.7{\pm}1.2$. There was no correlation between the number of FIMS procedures and the degree of VAS. Conclusions: FIMS is considered an effective modality in patients suffering from cervical radicular pain.

• 한국초지조사료학회지
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• 제41권3호
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• pp.210-216
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• 2021

Pollution of agricultural soil by alkaline salts, such as Na₂CO₃, is a critical and long-lasting problem in cultivable land. The aim of the study was to examine the putative role of citric acid (CA) in alleviating Na₂CO₃-stress in alfalfa. In this study, Na₂CO₃ significantly induced leaf chlorosis, inhibited plant growth and photosynthesis related parameters, increased hydrogen peroxide (H₂O₂) and reduced major antioxidant enzymes (SOD, CAD, APX) in alfalfa. However, the presence of CA these negative effects of Na₂CO₃-stress largely recovered. Interestingly, expression of antioxidant and ion transporter genes (Fe-SOD, CAT, APX, DHAR and NHX1) involved in Reactive oxygen species (ROS) homeostasis and oxidative stress tolerance in alfalfa. These findings suggest that CA-mediated Na₂CO₃ stress alleviation is an ecofriendly approach that would be useful to local farmer for alfalfa and other forage crop cultivation in alkaline soils.

• Journal of Microbiology and Biotechnology
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• 제29권5호
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• pp.827-837
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• 2019

The present study was conducted with the aim to investigate the ameliorative effects of a new soybean product (cheonggukjang) fermented with Bacillus amyloliquefaciens SCGB1 (SFBA) in atopic dermatitis (AD) mouse model. Visual evaluation of AD induction in the mice indicated the remarkable control of SFBA in reducing the pathological severity of AD-like skin lesions reported as the SCORAD score of AD clinical symptoms. The results revealed that SFBA reduced dorsal skin and epidermal thickness to a similar extent with prednisolone. Further analysis revealed the dominance of SFBA in restraining mast cell infiltration in the dermis; immunoglobulin-E expression in serum; and TH2 IL-4 cytokine and itch-related IL-31 cytokine in the mice skin and serum. SFBA also suppressed scratching behaviours in mice induced by compound 48/80. Further histological findings also revealed the alleviation of collagen fiber deposition in dermal skin of the AD mice model. These actions of SFBA were examined to be mediated by its suppression of the phosphorylation activation of key signalling molecules such as $NF-{\kappa}B$ and MAPK responsible for the induction of cytokine production. Thus, SFBA can be considered as a promising functional food for managing clinical, histological and immunological spectra associated with AD.

• Biomolecules & Therapeutics
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• 제29권5호
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• pp.455-464
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• 2021

Uncontrolled inflammation is considered the pathophysiological basis of many prevalent metabolic disorders, such as nonalcoholic fatty liver disease, diabetes, obesity, and neurodegenerative diseases. The inflammatory response is a self-limiting process that produces a superfamily of chemical mediators, called specialized proresolving mediators (SPMs). SPMs include the ω-3-derived family of molecules, such as resolvins, protectins, and maresins, as well as arachidonic acid-derived (ω-6) lipoxins that stimulate and promote resolution of inflammation, clearance of microbes, and alleviation of pain and promote tissue regeneration via novel mechanisms. SPMs function by binding and activating G protein-coupled receptors, such as FPR2/ALX, GPR32, and ERV1, and nuclear orphan receptors, such as RORα. Recently, several studies reported that SPMs have the potential to attenuate lipid metabolism disorders. However, the understanding of pharmacological aspects of SPMs, including tissue-specific biosynthesis, and specific SPM receptors and signaling pathways, is currently limited. Here, we summarize recent advances in the role of SPMs in resolution of inflammatory diseases with metabolic disorders, such as nonalcoholic fatty liver disease and obesity, obtained from preclinical animal studies. In addition, the known SPM receptors and their intracellular signaling are reviewed as targets of resolution of inflammation, and the currently available information on the therapeutic effects of major SPMs for metabolic disorders is summarized.