• Korean Journal of Optics and Photonics
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• v.1 no.2
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• pp.185-190
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• 1990

Balanced CPM ring dye laser was fabricated. Pulses as short as 62 fs were measured using noncollinear second harmonic generation autocorrelator. The optimum conditions were studied by changing the concentration of staturable absorber, pumping power of Ar+ laser and alignments of the intracavity four-prism sequence.

• Journal of Korean Vacuum Science & Technology
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• v.6 no.1
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• pp.1-4
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• 2002

A simple method for real-time monitoring the molecular orientation in a polymeric film was suggested. This method was examined in the polarization holograms by two recording beams on a poly(malonic ester) containing disperse red 1. The spatial distributions of the photo-induced alignment were measured and analyzed at various polarization states of two recording beams. As the result, the directions of molecular alignments could be identified easily by our method.

• Polymer(Korea)
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• v.39 no.1
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• pp.174-179
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• 2015

Alignments of photo-reactive mesogen were induced using bare glass substrates without a polymer alignment layer. It was found by using polarized FTIR spectroscopy, polarized microscopy, and birefringence measurement experiments that the reactive mesogen could be aligned along the rubbing direction although the glass substrate without an alignment layer was used. The induction mechanism of the rubbed bare glass is ascribed to that polymers from rubbing clothes are coated on the glass substrate along the rubbing direction and lead the alignment of liquid crystals through intermolecular interactions.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.2
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• pp.677-685
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• 2014

Despite the significant benefits of BIM (Building Information Modeling), it is not being vitalized for the facilities that are designed based on the horizontal and vertical alignments because of the lack of flexibility in manipulating surface models generated based on alignments. Alignment-based design produces a surface model in one piece through the definition of the typical cross-section along the alignment. Therefore, linking these alignment-based 3D surface models, that are not modularized and difficult to partition, to the required attribute information is very difficult This paper presents design of a flexible BIM technology suitable for the alignment-based civil infrastructure by providing the partitioning functionality for surface models, the contents library for cross-sectional design components, and the attribute information along with the critical functionalities needed for the design, construction and maintenance of alignment-based civil infrastructure.

• Applied Chemistry for Engineering
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• v.31 no.1
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• pp.25-29
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• 2020

In this study, a polymer/graphene hybrid composite was prepared by a simple roll-method and a simple sensor was produced by a convenient surface engineering procedure. The sensor performance was examined and the effect of graphene content on the sensing behavior was monitored. A polymer (polydimethylsiloxane, PDMS) paste containing graphene powder was prepared by a three-roll apparatus and polymer/graphene hybrid composite was produced by a two-roll technique. The sensing medium, cyclodextrin (CD) was introduced by a convenient bio-conjugation method. The efficacy of surface modification was confirmed by FT-IR spectroscopy and the ohmic relation was observed on composite surfaces. An analyte (e.g., methyl paraben, MePRB) at a 10 nM concnetration could be detected. When the graphene loading was low, the sensor performance was relatively poor. This was attributed to the absence of graphene alignments, which were observed for the composites having a high graphene loading. This indicates that the sensor performance was influenced by physical alignments of the filler. This article can provide important information for future research on developing sensing devices.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.5
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• pp.2033-2040
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• 2013

There have been noticeable developments for the optimization of the highway and railroad alignments with the IT and computerized tools. The designers expect that all of the quantitative design elements should be considered. This study developed a methodology which can be useful for the vertical alignment design. It provides a accurate "vertical control point" searching method, and makes the vertical alignment optimization more efficiently. The vector method makes the searching faster and calculates more accurate application sections. The results from this method generate more reliable vertical alignments than the conventional raster method for less computation time.

• Bioinformatics and Biosystems
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• v.1 no.1
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• pp.82-87
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• 2006

The most popular protein structure prediction method is comparative modeling. To guarantee accurate comparative modeling, the sequence alignment between a query protein and a template should be accurate. Although choosing the best template based on the protein sequence alignments is most critical to perform more accurate fold-recognition in comparative modeling, even more critical is the sequence alignment quality. Contrast to a lot of attention to developing a method for choosing the best template, prediction of alignment accuracy has not gained much interest. Here, we develop a method for prediction of the shift score, a recently proposed measure for alignment quality. We apply support vector regression (SVR) to predict shift score. The alignment between a query protein and a template protein of length n in our own library is transformed into an input vector of length n +2. Structural alignments are assumed to be the best alignment, and SVR is trained to predict the shift score between structural alignment and profile-profile alignment of a query protein to a template protein. The performance is assessed by Pearson correlation coefficient. The trained SVR predicts shift score with the correlation between observed and predicted shift score of 0.80.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.183-192
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• 2003

With the availability of complete whole-genomes such as the human, mouse, fugu and chimpanzee chromosome 22, comparative analysis of large genomes from cross-species at varying evolutionary distances is considered one of a powerful approach for identifying coding and functional non-coding sequences. Here we describe a fast and efficient global alignment method especially for large genomic regions over mega bases pair. We used an approach for identifying all similarity regions by HSP (Highest Segment Pair) regions using local alignments and then large syntenic genome based on the both extension of anchors at HSP regions in two species and global conservation map. Using this alignment approach, we examined rearrangement loci in human chromosome 21 and chimpanzee chromosome 22. Finally, we extracted syntenic genome 30 Mb of human chromosome 21 with chimpanzee chromosome 22, and then identified genomic rearrangements (deletions and insertions ranging h size from 0.3 to 200 kb). Our experiment shows that all jnsertion/deletion (indel) events in excess of 300 bp within chimpanzee chromosome 22 and human chromosome 21 alignments in order to identify new insertions that had occurred over the last 7 million years of evolution. Finally we also discussed evolutionary features throughout comparative analyses of Ka/ks (non-synonymous / synonymous substitutions) rate in orthologous 119 genes of chromosome 21 and 53 genes of MHC-I class in human and chimpanzee genome.

• Tuberculosis and Respiratory Diseases
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• v.81 no.3
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• pp.216-221
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• 2018

Background: The number of immigrants with tuberculosis (TB) increases each year in South Korea. Determining the transmission dynamics based on whole genome sequencing (WGS) to cluster the strains has been challenging. Methods: WGS, annotation refinement, and orthology assignment for the GenBank accession number acquisition were performed on two clinical isolates from Chinese immigrants. In addition, the genomes of the two isolates were compared with the genomes of Mycobacterium tuberculosis isolates, from two native Korean and five native Chinese individuals using a phylogenetic topology tree based on the Multiple Alignment of Conserved Genomic Sequence with Rearrangements (Mauve) package. Results: The newly assigned accession numbers for two clinical isolates were CP020381.2 (a Korean-Chinese from Yanbian Province) and CP022014.1 (a Chinese from Shandong Province), respectively. Mauve alignment classified all nine TB isolates into a discriminative collinear set with matched regions. The phylogenetic analysis revealed a rooted phylogenetic tree grouping the nine strains into two lineages: strains from Chinese individuals and strains from Korean individuals. Conclusion: Phylogenetic trees based on the Mauve alignments were supposed to be useful in revealing the dynamics of TB transmission from immigrants in South Korea, which can provide valuable information for scaling up the TB screening policy for immigrants.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.3
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• pp.117-125
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• 2020

PURPOSE: Aging causes changes in the postural alignment and gait due to changes in the nervous and musculoskeletal systems. On the other hand, the relationship between the changes in posture alignment and gait is unclear. This study examined the relationship between the postural alignment and spatiotemporal gait parameters in Korean elderly women. METHODS: Thirty-two-healthy elderly women participated in this study. All subjects were assessed for their posture alignment and gait ability. Stepwise multiple linear regression was performed to determine to what extent the postural alignments could explain the spatiotemporal gait parameters. RESULTS: Coronal head angle was moderately correlated with the velocity (r = -.51), normalized velocity (r = -.46) and gait-stability ratio (r = .58) (p < .05). The trunk angle was moderately correlated with the normalized velocity (r = -.32) and gait-stability ratio (r = .32) and weakly correlated with the velocity (r = -.28) (p < .05). The coronal shoulder angle was moderately correlated with the swing phase (r = -.57), stance phase (r = .56), single limb stance (r = -.56) and double limb stance (r = .51) (p < .05). The coronal head angle and trunk angle accounted for 36% of the variance in velocity, 33% variance in normalized velocity and 46% variance in the gait-stability ratio (p < .05). The coronal shoulder angle accounted for 32% variance in the swing phase, 32% variance in the stance phase, 31% variance in the single limb stance and 26% variance in the double limb stance (p < .05). CONCLUSION: Changes in posture alignment in elderly women may serve as a biomarker to predict a decrease in walking ability due to physical aging.