• Journal of Korean Society of Transportation
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• v.30 no.4
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• pp.95-106
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• 2012

Driver's capability of identifying the change in freeway alignments and environments is one of important factors associated with traffic safety on freeways. In particular, driver's visibility and recognition capability are highly dependent on the altitude of the sun by sunset, sunrise, and nighttime. The purpose of this study is to identify the characteristics of geometric conditions affecting crash occurrences at sunset, sunrise, and nighttime. Poisson and negative binomial regressions were adopted to predict freeway crash frequency in this study. Freeway crash data during 2007~2010 were used for developing the crash frequency models. A set of variables representing the characteristics of geometric conditions were identified as significant ones affecting crash occurrences. The results of this study would be useful in deriving effective countermeasures for preventing traffic crashes that mainly occur at sunset, sunrise, and nighttime on freeways.

• Clinical and Experimental Pediatrics
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• v.52 no.9
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• pp.1053-1058
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• 2009

Cytomegalovirus (CMV) is one of the most commonly encountered viral pathogens in newborn infants and is found in 0.3-2.4% of all live births. It has been demonstrated that 40-96% of seropositive mothers shed the virus via their breast milk. Breast milk containing CMV can cause almost one-third of CMV infections occurring in infants. A case of postnatal CMV infection in an extremely premature infant (gestational age $24^{+5}$ weeks, birth weight 750 g) transmitted via breast milk is presented. For neonatal intensive care unit (NICU) management of severe thrombocytopenia, anemia, and sepsis syndrome, the infant received repeated transfusions of platelets; intravenous (IV) immunoglobulins; and gamma- irradiated, filtrated packed red cells and was fed her mother's breast milk since the second week of life. CMV infection was diagnosed with positive CMV immunoglobulin M (IgM) and positive urine CMV culture at the second month of life. Considering the negative CMV IgM and urine CMV culture at birth, postnatally-acquired CMV infection was suspected and confirmed with completely identical nucleotide sequence alignments of the infantile blood isolate and the maternal breast milk isolate. To our knowledge, this is the first case of proven postnatal CMV infection transmitted via breast milk in an extremely premature infant in Korea.

• The Journal of the Korea Contents Association
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• v.18 no.4
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• pp.99-113
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• 2018

Recently, global warming has widened the habitat of mosquitoes and infection chances for mosquito-borne diseases are increasing. Flavivirus is a typical mosquito-borne virus. Flaviviruses with a relatively high frequency of infection in Asian countries include Zika, Dengue, and Japanese encephalitis viruses. Although distinctive diagnosis of flaviviruses is required because the symptoms and therapeutic method differ, there is no diagnostic method that can distinguish them accurately yet. In this study, we propose distinctive diagnosis method of flaviviruses using informations and analysis tools constructed in bioinformatic databases. The envelope protein and non-structural protein 1 which are useful protein for the immuno-diagnostics of three flaviviruses were selected. Their homology was analyzed by multiple sequence alignments and epitope candidates consisting of 10-15 amino acids were selected. Finally two epitopes were suggested to be most useful by immunogenicity analysis and 3D structure prediction. These approaches and results are expected to be great value in the distinctive diagnosis of three flaviviruses with a high frequency of infection in Asian countries.

• The Journal of Korean Society for Radiation Therapy
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• v.27 no.1
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• pp.79-86
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• 2015

Purpose : The purpose of this study was to determine the proper treatment time of stereotactic body radiation therapy for spine metastasis cancer by using the image guidance system of CyberKnife(Accuray Incorporated, USA) which is able to correct movements of patients during the treatment. Materials and Methods : Fifty seven spine metastasis cancer patients who have stereotactic body radiation therapy of CyberKnife participate, 8 of them with cervical spine cancer, 26 of them with thoracic spine cancer, and 23 of them with lumbar spine cancer. X-ray images acquired during the treatment were classified by treatment site. From the starting point of treatment, motion tendency of patients is analyzed in each section which is divided into every 5 minutes. Results : In case of cervical spine, there is sudden increase of variation in 15 minutes after the treatment starts in rotational direction. In case of thoracic spine, there is no significantly variable section. However, variation increases gradually with the passage of time so that it is assumed that noticeable value comes up in approximately 40 minutes. In case of lumbar spine, sharp increase of variation is seen in 20 minutes in translational and rotational direction. Conclusion : Without having corrections during the treatment, proper treatment time is considered as less than 15 minutes for cervical spine, 40 minutes for thoracic spine, and 20 minutes for lumbar spine. If treatment time is longer than these duration, additional patient alignments are required or PTV margin should be enlarged.

• Journal of International Academy of Physical Therapy Research
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• v.4 no.2
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• pp.573-587
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• 2013

The purpose of this study was conducted in order to analyze the effects of the manual intervention and self-corrective exercise models of general coordinative manipulation(GCM) on the balance restoration of spine & extremities joints with distortions and mal-alignment areas. The subjects were the members who visited GCM Musculoskeletal Prevent Exercise Center from March 1 2012 to December 31 2013 because of spine & extremities joints distortion and mal-alignments, poor posture, and body type correction. All subjects were diagnosed with the four types of the GBT diagnosis. And according to the standards of the mobility vs stability types of the upper & lower body, they were classified into Group 1(40 persons) and Group 2(24 persons). For every other day for three times a week, GCM intervention models were applied to all subjects for four weeks, adding up to 12 times in total. Then the balance restoration effects were re-evaluated with the same methods. The results are as follows. 1) Balance restoration effects of VASdp(Visual analysis scale pain & discomfort) and ER(Equilibrium reaction: ER) came out higher in GCM body type(GBT) II III IV of Group 1. 2) In case of balance restoration effects in Moire and postural evaluation areas, Group 1 was higher and cervical and scapular girdle were higher in Group 2. The balance restoration of the four GBT types was significant in all regions(p<.05), and the scapular girdle came out as high in the order of GBTII IV I. 3) In case of thoracic-lumbar scoliosis and head rotation facial asymmetric cervical scoliosis ribcage forward, the balance restoration effects of the upper body postural evaluation areas came out the highest in Group 1 and Group 2, respectively. The balance restoration effects of the four GBT types were significant in all regions(p<.05), and came out the highest in lumbar scoliosis GBTIII I, ribcage forward and thoracic scoliosis GBTII IV. 4) The balance restoration effects of the lower body postural evaluation areas came out higher in Group 1 and Group 2 for pelvis girdle deviation patella high umbilicus tilt and hallux valgus foot longitudinal arch: FLA patella direction, respectively. The balance restoration effects of the four GBT types were significant in all regions(p<.05), and came out the highest in pelvis girdle deviation GBTIII I and patella high-direction GBTIV II I. 5) The balance restoration effects between the same GBT came out significant (p<.05) in all evaluation areas and items. The conclusions of this study was the manual intervention and self-corrective exercise models of the GCM about the mal-alignment of the spine & extremities joints across the whole body indicated high balance restoration effects(p<.05) in spine & extremities joints in all evaluation areas.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.20 no.4
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• pp.169-179
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• 2015

To understand the transport pathways of muddy sediment of the Kunsan basin in Yellow Sea, grain sizes and clay mineral of 32 surface sediments and a sediment core were analyzed. In the study area, illite is predominant (63.4~71.9%), followed by chlorite (15.1~20.2%), kaolinite (10.3~17.2%) and smectite (2~6.9%), According to the spatial distribution of the clay minerals, illite, kaolinite+chlorite and smectite show relatively higher contents in the center of the north, northeast, and the south of the study area, respectively. Considering the spatial distribution of clay mineral contents the sand ridge alignments and tidal current pathways, the smectite particles were probably derived from the south of the study area, but kaolinite and/or chlorite particles were mainly transported from the Korean coastal zone. Meanwhile, down-core variation in the contents of clay minerals of the core revealed a distinct change in fine-grained muddy sediment provenance: muddy sediment input from the Korean coastal areas has increased while the input from China has decreased since the last 5,000 year ago, by showing the amount decrease of smectite and the increase of kaolinite+chlorite at the top layer of the late Holocene muddy sediment unit of the core.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.135-135
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• 2017

The Gramene database (http://www.gramene.org) is a powerful online resource for agricultural researchers, plant breeders and educators that provides easy access to reference data, visualizations and analytical tools for conducting cross-species comparisons. Learn the benefits of using Gramene to enrich your lectures, accelerate your research goals, and respond to your organismal community needs. Gramene's genomes portal hosts browsers for 44 complete reference genomes, including crops and model organisms, each displaying functional annotations, gene-trees with orthologous and paralogous gene classification, and whole-genome alignments. SNP and structural diversity data, available for 11 species, are displayed in the context of gene annotation, protein domains and functional consequences on transcript structure (e.g., missense variant). Browsers from multiple species can be viewed simultaneously with links to community-driven organismal databases. Thus, while hosting the underlying data for comparative studies, the portal also provides unified access to diverse plant community resources, and the ability for communities to upload and display private data sets in multiple standard formats. Our BioMart data mining interface enable complex queries and bulk download of sequence, annotation, homology and variation data. Gramene's pathway portal, the Plant Reactome, hosts over 240 pathways curated in rice and inferred in 66 additional plant species by orthology projection. Users may compare pathways across species, query and visualize curated expression data from EMBL-EBI's Expression Atlas in the context of pathways, analyze genome-scale expression data, and conduct pathway enrichment analysis. Our integrated search database and modern user interface leverage these diverse annotations to facilitate finding genes through selecting auto-suggested filters with interactive views of the results.

• Explosives and Blasting
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• v.26 no.2
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• pp.38-44
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• 2008

Recently, planning road construction in South Korea is focused on upgrading of the existing road by rerouting or restructuring. For this, roads under current construction in Korea go for more straight in its alignments and routing. Straight routing makes it all the more required to construct many mountain tunnels and bridges in Korea where mountains are so widely spread. Some portal of mountain tunnel is not rarely planed at high steep slope of mountain valley where it is not easy to secure working space for tunnel excavation. Reverse excavation is an alternative measure for excavation of tunnel portal at high steep slope. Construction in reverse excavation method has three important points requiring careful consideration: 1)planning of pilot tunnel in proper width, height, and length etc., 2)measure against the effect of one-side earth pressure to the direction of tunnel portal, 3)securing tunnel safety against shallow ground condition at portal zone. This paper intends to suggest applicable range of pilot tunnel for reverse excavation at the portal zone located at high steep slope, and shows result of study on the appropriateness of a reverse excavation by means of 3D numerical analysis. Result of 3D numerical analysis for reverse excavation at high steep slope shows that pilot tunneling will be applicable to start from the point $20{\sim}25m$ before the portal from inside the tunnel.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.614-627
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• 2018

Urban railway lines have been constructed adjacent to residential buildings and urban areas. The expansion of transportation networks and reconstruction of residential buildings in highly populated urban areas require deep excavations in areas adjacent to urban railways. Mobilized soil stresses and changes in the groundwater level induced by deep excavations results in track irregularities in urban railways. In this study, a three-dimensional finite difference model using the commercial program FLAC3D was adopted to estimate the horizontal displacements of earth retaining structures, settlements of backfill, the stability of track irregularity and underground box structure based on the criteria of each railway organization and its relationships. In deep excavations, a change in groundwater level induces relatively very small differences for track gauge irregularities, whereas relatively large differences for longitudinal irregularities of 72.5%, twist irregularities of 83.3%, cross level irregularities of 61.9%, and alignments of 43.3% were found to be the maximum differences when the horizontal displacement of earth retaining wall and settlement of backfill were 65.1% and 21.4%, respectively, because the groundwater level (GWL) on the ground surface-mobilized tensile strength of the underground box structure exceeds the allowable value. Therefore, three-dimensional numerical analysis was performed in this study. Overall, real-time monitoring should be carried out to prevent railway accidents in advance when a deep excavation adjacent to urban railway structures is constructed.

• Proceedings of the Microbiological Society of Korea Conference
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• 2002.10a
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• pp.180-182
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• 2002

Substantial genomic diversity has been expected among clinical isolates of H. pylori. We have suggested that the two complete H. pylori genomes already sequenced may be insufficient for providing a discriminatory tool for typing clinical isolates as well as an insight into the genomic diversity, which enable to establish strategy for control of H. pylori infection. In this study, we determine the nucleotide sequence of the entire genome of Korean strain 51 and compare it with two reported genomic sequences to suggest validity for extensive genomic sequencing of H. pylori. The genome of H. pylori 51 consists of a circular chromosome with a size of 1,591,297 bp, which is corresponding to $95.4\%\;and\;96.8\%$ of the 26695 and J99 chromosome length, respectively. We predict that there are 1,454 open reading frames (ORFs) in 51, representing $91.4\%\;and\;97.2\%$ of the reported numbers of ORF of 26695 and J99, respectively. In contrast to 26695 and J99 that have 123 and 65 strain-specific genes, respectively, of the 1,454 genes, only 39 genes are unique to 51. Differences in genomic organization between 51 and each foreign strain were greater than between 2 foreign strains in pair wise entire sequence alignments by BLASTN. Particularly, the extent of genomic rearrangement observed between 51 and 26695 is higher than between 51 and J99. Multiple sequence alignment of orthologous genes among 3 strains showed that 51 is genetically closer to 26695 rather than J99. Phylogenetic analysis of nonsynonymous and synonymous mutation indicated J99 has the longest branch length in the unrooted phylogenetic tree, suggesting that J99 has higher mutation rate than the other 2 strains.