• ALGAE
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• v.30 no.2
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• pp.163-170
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• 2015

Tyrosinase inhibitors are an important component of cosmetic products. Our previous studies have proposed that eckol isolated from the brown alga Ecklonia cava, can be explored as a tyrosinase inhibitor. However, cellular activities and mechanism of action of eckol remain unknown. Therefore, the current study analyzed the eckol binding modes using the crystal structure of Bacillus megaterium tyrosinase. The effects of eckol on melanin synthesis induced by ${\alpha}$-melanocyte stimulating hormone in B16F10 melanoma cells were also investigated. We predicted the 3D structure of tyrosinase and used a docking algorithm to simulate binding between tyrosinase and eckol. These molecular modeling studies were successful (calculated binding energy value, $-115.84kcal\;mol^{-1}$) and indicated that eckol interacts with Asn205, His208, and Arg209. Furthermore, eckol markedly inhibited tyrosinase activity and melanin synthesis in B16F10 melanoma cells. We also found that eckol decreased the expression of tyrosinase, tyrosinase-related protein (TRP) 1, and TRP2. These results indicate that eckol is a potent inhibitor of melanogenesis, and this finding may be useful for the development of novel pharmaceutical and cosmetic agents.

• Toxicological Research
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• v.32 no.4
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• pp.289-300
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• 2016

Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be applied to develop early identifiers for long term phenotypes. In this study, we used rat liver expression profiles from the NTP (National Toxicology Program, Research Triangle Park, USA) DrugMatrix Database to construct a gene classifier that can distinguish between non-genotoxic carcinogens and other chemicals. The model was based on short term exposure assays (3 days) and the training was limited to oxidative stressors, peroxisome proliferators and hormone modulators. Validation of the predictor was performed on independent toxicogenomic data (TG-GATEs, Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System, Osaka, Japan). To build our model we performed Random Forests together with a recursive elimination algorithm (VarSelRF). Gene set enrichment analysis was employed for functional interpretation. A total of 770 microarrays comprising 96 different compounds were analyzed and a predictor of 54 genes was built. Prediction accuracy was 0.85 in the training set, 0.87 in the test set and increased with increasing concentration in the validation set: 0.6 at low dose, 0.7 at medium doses and 0.81 at high doses. Pathway analysis revealed gene prominence of cellular respiration, energy production and lipoprotein metabolism. The biggest target of toxicogenomics is accurately predict the toxicity of unknown drugs. In this analysis, we presented a classifier that can predict non-genotoxic carcinogenicity by using short term exposure assays. In this approach, dose level is critical when evaluating chemicals at early time points.

• The Journal of Korean Physical Therapy
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• v.13 no.3
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• pp.509-527
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• 2001

The Sun's ray is composed of Infrared(49%), Visible light(40%) and Ultra violet(11%), however the ray getting to the earth is FIR(Far infrared; 60%), IR(Infrared; 20%), and UV(Ultra Violet; 20%). Human beings has utilized FIR already from time immemorial. Hershel found out Infrared for the first time. in the Industrial Revolution the Infrared and FIR had been begun to use making products. In these days, with contemporary science FIR would be begun to clear up the implication in the human body and organic compound. IR classified by wavelength three parts NlR, MIR, FIR. There is FIR which is radiated from healthy human body the wave length is 8-l4m. The human body is composed of proteins which get easily changed by a thermal factor (about 42 $^{\circ}$C over). FIR with low temperature can deeply penetrate on the human body composed things without troublesomes, since FIR has effectively operated on the human body at low temperature (35-40 $^{\circ}$C). When FlR penetrated on the human body. it would inhibit the abnormal genes and cells expression, and then information of DNA and RNA would be reexpressed for arranging DNA and RNA abnormal state. As FlR's receptors in the body, it could be presumed that N-glycosyl linkage of purine and deoxyribose, RNA splicing process, and Heat shock protein. To take the FIR which was a optimized wavewlength and strength, at first, we induced the characteristic algorithm and the computerized programing. Then we formed that the formular of optimized FIR with physical, mathematical logic and theory. especially, Plank, Kirchhoff, Wien, Stefan-Boltzmann's logic and law. In the long run, the formular was induced with integration mathematical, since we had to know the molecular wavelength. Based on the induced formular as above, we programmed the optimized FlR radiating computerized program. In this research, we designed the eletronic circuit f3r interfacing with human body to diagnosis and treatment with FIR sensor which radiated FIR wavelength optimized.

• Journal of Institute of Control, Robotics and Systems
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• v.18 no.12
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• pp.1079-1085
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• 2012

For precise motion control, S-curve velocity profile is generally used but it has disadvantage of relatively long calculation time for floating-point arithmetics. In this paper, we present a new generating method for velocity profile to reduce delay time of profile generation so that it overcomes such disadvantage and enhances the efficiency of precise motion control. In this approach, the velocity profile is designed based on the gamma correction expression that is generally used in image processing to obtain a smoother movement without any critical jerk. The proposed velocity profile is designed to support both T-curve and S-curve velocity profile. It can generate precise profile by adding an offset to the velocity profile with decimals under floating point that are not counted during gamma correction arithmetic operation. As a result, the operation time is saved and the efficiency is improved. The proposed method is compared with the existing method that generates velocity profile using ring buffer on a 8-bit low-cost MCU. The result shows that the proposed method has no delay in generating driving profile with good accuracy of each cycle velocity. The significance of the proposed method lies in reduction of the operation time without degrading the motion accuracy. Generated driving signal also shows to verify effectiveness of the proposed method.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.12
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• pp.66-72
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• 2009

This paper proposes an efficient binary arithmetic encoder for CABAC which is used one of the entropy coding methods for H.264/AVC. The present binary arithmetic encoding algorithm requires huge complexity of operation and data dependency of each step, which is difficult to be operated in fast. Therefore, renormalization exploits 2-stage pipeline architecture for efficient process of operation, which reduces huge complexity of operation and data dependency. Context model updater is implemented by using a simple expression instead of transIdxMPS table and merging transIdxLPS and rangeTabLPS tables, which decreases hardware size. Arithmetic calculator consists of regular mode, bypass mode and termination mode for appearance probability of binary value. It can operate in maximum speed. The proposed binary arithmetic encoder has 7282 gate counts in 0.18um standard cell library. And input symbol per cycle is about 1.

• Journal of the Korea Society of Computer and Information
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• v.8 no.4
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• pp.165-175
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• 2003

The concept of measurement uncertainty has been recognised for many years since "Guide to the Expression of Uncertainty in Measurement" was published 1993 by ISO. This study firstly propose the mathematical model to evaluate uncertainty considering the dispersion of samples because the mathematical model of a measurement is an important to evaluate uncertainty, and it must contains every quantify which contribute significantly to uncertainty in the measurement result. Secondly the standard uncertainty of the result of a measurement, namely combined standard uncertainty is evaluated using the law of propagation of uncertainty, what is termed in GUM method. In GUM method, a measurand is usually approximated by a linear function of its variables by the transforming its input quantities. Furthermore central limit theorem is applied to the input quantity. However the mathematical model of a measurement is generally not always a linearity function, and a distribution function of input or output quantity is not necessarily normal distribution. Then, in some cases GUM method is not favorable to evaluate a measurement uncertainty. Therefore this study propose a new method and its algorithm which use the Monte-carlo simulation to evaluate a measurement uncertainty in both case of linearity or non-linearity function. function.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.2
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• pp.433-438
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• 2012

With technologies available now, there are only a few virtual objects that augmented reality content can create. So, wider application of it is limited. If people want to realize any augmented reality content, out of a vast amount of materials available as well as virtual objects, the number of virtual objects that markers can render should be made to go up along with the content. In a precedent study, IR LEDs markers render marker information following On-Off signals. The number of LEDs should be raised to render as much information as possible, subsequently leading to the problem of oversized markers. This problem can be solved by generating data signals through the blinking of LEDs. This research puts forward OOK Code algorithm that represents the mode of data transmission using the light of LEDs. The amount of information that can be rendered by a marker increases and the size of the marker gets smaller, which is a merit, when it receives data signals from light.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.95-100
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• 2016

Background: Survival time of lymphoma patients can be estimated with the help of microarray technology. In this study, with the use of iterative Bayesian Model Averaging (BMA) method, survival time of Mantle Cell Lymphoma patients (MCL) was estimated and in reference to the findings, patients were divided into two high-risk and low-risk groups. Materials and Methods: In this study, gene expression data of MCL patients were used in order to select a subset of genes for survival analysis with microarray data, using the iterative BMA method. To evaluate the performance of the method, patients were divided into high-risk and low-risk based on their scores. Performance prediction was investigated using the log-rank test. The bioconductor package "iterativeBMAsurv" was applied with R statistical software for classification and survival analysis. Results: In this study, 25 genes associated with survival for MCL patients were identified across 132 selected models. The maximum likelihood estimate coefficients of the selected genes and the posterior probabilities of the selected models were obtained from training data. Using this method, patients could be separated into high-risk and low-risk groups with high significance (p<0.001). Conclusions: The iterative BMA algorithm has high precision and ability for survival analysis. This method is capable of identifying a few predictive variables associated with survival, among many variables in a set of microarray data. Therefore, it can be used as a low-cost diagnostic tool in clinical research.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5273-5278
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• 2015

Background: Chronic myeloid leukemia (CML) is a stem cell disorder characterized by the fusion of two oncogenes namely BCR and ABL with their aberrant expression. Autophosphorylation of BCR-ABL oncogenes results in proliferation of CML. The study deals with estimation of rate constant involved in each step of the cellular autophosphorylation process, which are consequently playing important roles in the proliferation of cancerous cells. Materials and Methods: A mathematical model was proposed for autophosphorylation of BCR-ABL oncogenes utilizing ordinary differential equations to enumerate the rate of change of each responsible system component. The major difficulty to model this process is the lack of experimental data, which are needed to estimate unknown model parameters. Initial concentration data of each substrate and product for BCR-ABL systems were collected from the reported literature. All parameters were optimized through time interval simulation using the fminsearch algorithm. Results: The rate of change versus time was estimated to indicate the role of each state variable that are crucial for the systems. The time wise change in concentration of substrate shows the convergence of each parameter in autophosphorylation process. Conclusions: The role of each constituent parameter and their relative time dependent variations in autophosphorylation process could be inferred.

• The Transactions of the Korea Information Processing Society
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• v.6 no.8
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• pp.2031-2041
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• 1999

In this paper, we present the HVIS (Hybrid Video Information System) which bolsters up meaning retrieval of all the various users by integrating feature-based retrieval and annotation-based retrieval of unformatted formed and massive video data. HVIS divides a set of video into video document, sequence, scene and object to model the metadata and suggests the Two layered Hybrid Object-oriented Metadata Model(THOMM) which is composed of raw-data layer for physical video stream, metadata layer to support annotation-based retrieval, content-based retrieval, and similarity retrieval. Grounded on this model, we presents the video query language which make the annotation-based query, content-based query and similar query possible and Video Query Processor to process the query and query processing algorithm. Specially, We present the similarity expression to appear degree of similarity which considers interesting of user. The proposed system is implemented with Visual C++, ActiveX and ORACLE.