• Biomolecules & Therapeutics
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• v.25 no.4
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• pp.404-410
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• 2017

Benzylideneacetophenone derivative (1E)-1-(4-hydroxy-3-methoxyphenyl) hept-1-en-3-one (JC3) elicited cytotoxic effects on MDA-MB 231 human breast cancer cells-radiation resistant cells (MDA-MB 231-RR), in a dose-dependent manner, with an $IC_{50}$ value of $6{\mu}M$ JC3. JC3-mediated apoptosis was confirmed by increase in sub-G1 cell population. JC3 disrupted the mitochondrial membrane potential, and reduced expression of anti-apoptotic B cell lymphoma-2 protein, whereas it increased expression of pro-apoptotic Bcl-2-associated X protein, leading to the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase. In addition, JC3 activated mitogen-activated protein kinases, and specific inhibitors of these kinases abrogated the JC3-induced increase in apoptotic bodies. JC3 increased the level of intracellular reactive oxygen species and enhanced oxidative macromolecular damage via lipid peroxidation, protein carbonylation, and DNA strand breakage. Considering these findings, JC3 is an effective therapy against radiation-resistant human breast cancer cells.

• Korean Journal of Clinical Pharmacy
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• v.32 no.1
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• pp.37-46
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• 2022

Background: Non-valvular atrial fibrillation (NVAF) is associated with ischemic stroke risk in the aging population. Observational studies have indicated beneficial effects of direct-acting oral anticoagulant (DOAC) against ischemic stroke compared to warfarin. This study aimed to investigate ischemic stroke incidence and bleeding risk in patients on DOAC therapy. Methods: Using the database of Korean Health Insurance Review and Assessment-Aged Patient Sample 2015, we conducted a retrospective cohort study. Study subjects with NVAF diagnosis and prescribed anticoagulants were enrolled. Propensity score (PS) matching by age, sex, comorbidities, and medications were used. The clinical outcomes were major adverse cerebro-cardiovascular events (MACCEs, ischemic stroke/systemic embolism, myocardial infarction, cardiac death) and bleeding events. A cox proportional hazard model analysis was performed to compare the outcomes with hazard ratio (HR) and 95% confidence interval (CI). Results: Total 4,773 elderly patients with NVAF were initially included. Four PS-matched groups including rivaroxaban vs. warfarin-only (n=1,079), dabigatran vs. warfarin-only (n=721), rivaroxaban vs. dabigatran (n=721), and switchers of warfarin to rivaroxaban vs. warfarin-only (n=287) were analyzed. Every group showed statistically similar results of MACCEs and bleeding events, except for the group of rivaroxaban vs. dabigatran. Rivaroxaban users showed higher risks of bleeding events than dabigatran users (HR 2.25, 95% CI 1.01-4.99). Conclusion: In the elderly patients with NVAF, efficacy and safety outcomes among oral anticoagulants including DOACs and warfarin were similar, while rivaroxaban are more likely to have higher bleeding risks than dabigatran. Further research using large size sample is needed.

• Journal of Advanced Technology Convergence
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• v.1 no.2
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• pp.57-62
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• 2022

In order to support women with career breaks to re-enter the labor market, it is not only necessary to discover and select promising jobs, but also to provide objective and accurate job information on selected promising jobs so that women with career breaks can make reasonable career choices. need arises. It can be pointed out that the government support course has no burden of tuition compared to the general course, and because the quality of education is high, it is possible to select trainees with a high willingness to find employment through competition in the recruitment process. In addition, the government support process secures relatively high-quality programs and instructors, increasing trainees' concentration, satisfaction, and willingness to find a job. Job literacy and employment preparation education are obligatory, job design support through job counseling, and continuous follow-up support. The system also works. Accordingly, if systematic and continuous development and support are made in the process of selecting promising occupations for women with career breaks and designing education and training programs, it is expected that women with career breaks will be more active in their re-entry into the labor market.

• Convergence Security Journal
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• v.23 no.4
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• pp.153-158
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• 2023

Massacres of civilians are being committed in the Russia-Ukraine war, and the war is becoming a long-term war due to a lack of support for reserve combat forces. Considering the reality that South Korea is experiencing a rapid population decline and is rapidly entering an aging society, we are at a point where the nature of the war with North Korea must change. Among them, if private security guards are placed under the control of the police as regular security and crime prevention personnel and used as an alternative resource for reserve forces to ensure the safety of wartime areas and residents and prepare for long-term wars, it will help preserve combat power and maintain sustainability.Regarding private security, considering Japan's further development, we compared it with ours and looked into ways to utilize it as a reserve force for a divided country. In a future where low birth rates will lead to a decrease in military strength, if private security guards are used in local security vacuums during peacetime and participate in local defense during wartime, it could help improve the Korean military's reserve force.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2895-2899
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• 2016

Background: Increasing breast cancer (BC) incidence rates have been reported from India; causal factors for this increased incidence are not understood and diagnosis is mostly in advanced stages. Trivandrum exhibits the highest BC incidence rates in India. This study aimed to estimate trends in incidence by age from 2005-2014, to predict rates through 2020 and to assess the stage at diagnosis of BC in Trivandrum. Materials and Methods: BC cases were obtained from the Population Based Cancer Registry, Trivandrum. Distribution of stage at diagnosis and incidence rates of BC [Age-specific (ASpR), crude (CR) and age-standardized (ASR)] are described and employed with a joinpoint regression model to estimate average annual percent changes (AAPC) and a Bayesian model to estimate predictive rates. Results: BC accounts for 31% (2681/8737) of all female cancers in Trivandrum. Thirty-five percent (944/2681) are <50 years of age and only 9% present with stage I disease. Average age increased from 53 to 56.4 years (p=0.0001), CR (per $10^5$ women) increased from 39 (ASR: 35.2) to 55.4 (ASR: 43.4), AAPC for CR was 5.0 (p=0.001) and ASR was 3.1 (p=0.001). Rates increased from 50 years. Predicted ASpR is 174 in 50-59 years, 231 in > 60 years and overall CR is 80 (ASR: 57) for 2019-20. Conclusions: BC, mostly diagnosed in advanced stages, is rising rapidly in South India with large increases likely in the future; particularly among post-menopausal women. This increase might be due to aging and/or changes in lifestyle factors. Reasons for the increased incidence and late stage diagnosis need to be studied.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.4
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• pp.429-439
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• 2021

In order to cope with the decrease of construction manpower caused by the aging population and to improve construction productivity, Japanese Ministry of Land, Infrastructure, Transport and Tourism has been promoting construction methodology using ICT (Information & Communication Technology) since 2016. The ministry has established and implemented new cost estimation standards, delivery systems, and government support policies to boost automated earthwork using ICT, and is expanding the types of automated construction methodology applied at the construction sites. To utilize ICT at construction sites in Korea, as in case of Japan, laws, systems, and policies should be readjusted first. By comparing the ICT-related systems and policies between Japan and Korea, this paper scrutinizes critical benchmarking factors. As a result, we have reached the conclusion that in order to promote ICT methodology at Korean construction sites, Korean government should establish ICT-related cost estimation standards, delivery systems, and economic support policies in advance.

• 한국생물공학회:학술대회논문집
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• 2003.04a
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• pp.302-305
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• 2003

It is difficult to obtain sufficient healthy skin for coverage of a wide area of skin wound. In the skin, an additional population of living epithelial cells is located in the outer root sheath (ORS) of hair $follicles.^{1),2)}$ ORS cells should be a good source of epithelium because they are easily obtainable and patients do not have to suffer from scar formation at donor sites. We modified ordinary primary culture technique for the purpose of solving such problem that epithelial cells have a low propagation and easy aging during culture periods. First of all, we improved primary cultivation methods. In the ordinary primary culture, average yield of human ORS cells was $2\;{\times}\;10^3$ cells/follicle by direct incubation with trypsin (0.1%)/EDTA (0.02%) solution for 15 min at $37^{\circ}C$ but we could obtain about $6.5\;{\times}\;10^3$ cells/follicle by two step enzyme digestion method with dispase (1.2 U/ml) and trypsin (0.1%)/EDTA (0.02%) solution. So we could achieve three times higher primary cultured ORS cell yield. Secondly, we could obtain total $2\;{\times}\;10^7$ cells in serum free medium and even more total $6\;{\times}\;10^7$ cells in modified E-medium with mitomycin C-treated feeder cells during 17 days. Using the cultured ORS cells, and we could make bioartificial skin equivalent in vitro and concluded that ORS cells were progenitor cells for skin epithelial cell.

• The Journal of the Convergence on Culture Technology
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• v.8 no.6
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• pp.899-904
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• 2022

As the world becomes an aging society due to a decrease in the birth rate and an increase in life expectancy, a system for health management of the elderly population is needed. Among them, various studies on occupancy and activity types are being conducted for smart home care services for indoor health management. In this paper, we propose a random forest model that classifies activity type as well as occupancy status through indoor temperature and humidity, CO2, fine dust values and UWB radar positioning for smart home care service. The experiment measures indoor environment and occupant positioning data at 2-second intervals using three sensors that measure indoor temperature and humidity, CO2, and fine dust and two UWB radars. The measured data is divided into 80% training set data and 20% test set data after correcting outliers and missing values, and the random forest model is applied to evaluate the list of important variables, accuracy, sensitivity, and specificity.

• Journal of Internet Computing and Services
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• v.25 no.3
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• pp.19-25
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• 2024

The worldwide aging population trend is causing an increase in the incidence of major retinal diseases that can lead to blindness, including glaucoma, cataract, and macular degeneration. In the field of ophthalmology, there is a focused interest in diagnosing diseases that are difficult to prevent in order to reduce the rate of blindness. This study proposes a deep learning approach to accurately diagnose ocular diseases in fundus photographs using less data than traditional methods. For this, Convolutional Neural Network (CNN) models capable of effective learning with limited data were selected to classify Conventional Fundus Images (CFI) from various ocular disease patients. The chosen CNN models demonstrated exceptional performance, achieving high Accuracy, Precision, Recall, and F1-score values. This approach reduces manual analysis by ophthalmologists, shortens consultation times, and provides consistent diagnostic results, making it an efficient and accurate diagnostic tool in the medical field.

• Journal of Digital Contents Society
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• v.16 no.3
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• pp.457-462
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• 2015

Hybrid video call healthcare system that we propose in thesis is a service for powerless people rather than ordinary people. This system is for communication between users and protectors(or volunteers). To reduce the underprivileged through the 'Malbeot Nanumi' is the purpose of the system. Hybrid Health Care System using a video call and temperature/humidity/pulse sensors that we propose in thesis can connect sensors with software, and save p2p connection information for 'Malbeot Nanumi' service by database. And health check data can save locally. Hybrid Health Care System in a Wireless Network Environment is a system that elderly people living alone is to be a conversation. The purpose of this thesis is to develop the software and to design a convenient UI to the user, And increasing consumption of care system by increasing the happiness index and increasing aging population.