• 대한수의학회지
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• 제60권1호
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• pp.25-32
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• 2020

Natural killer (NK) cells play have a crucial role in the early phase of immune responses against various pathogens. We compared characteristics of canine NK cells against two canine mammary carcinoma cell lines, REM134 and CF41.Mg. REM134 showed higher expression of progesterone receptor, proliferative cell nuclear antigen, Ki67, multiple drug resistance, Bmi-1, c-myc, E-cadherin, and human epidermal growth factor receptor type-2 than that of CF41.Mg. For specific expansion and activation of NK cells, we isolated CD5 negative cells from canine peripheral blood mononuclear cells and co-cultured K562 cells in the presence of interleukin (IL)-2, IL-15, and IL-21 for 21 days. As a result, we found that expression markers of activated NK cells such as NKp30, NKp44, NKp46, NKG2D, CD244, perforin, granzyme B, and tumor necrosis factor alpha were highly upregulated. In addition, we found there was upregulated production of interferon gamma of activated NK cells against target cells such as REM134 and CF41.Mg. Specifically, we observed that cytotoxicity of NK cells against target cells was more sensitively reacted to CF41.Mg than REM134. Based on the results of this study, we recommend the development of an experimental application of CF41Mg, which has not been reported in canine mammary carcinoma research.

• Journal of Positioning, Navigation, and Timing
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• 제2권1호
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• pp.49-57
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• 2013

When pseudolite navigation system is applied to wide area, the tropospheric delay is the main error factor. In this study, we experimentally compared and analyzed the performance of the conventional pseudolite tropospheric delay models. The integration method using radiosonde meteorological data was suggested to derive the reference value for the comparison and analysis. Flight tests were carried out to analyze the performance of the tropospheric delay models according to the elevation angle and distance conditions between the user receiver and the pseudolite. As the results of this study, we provided the basis for the choice of tropospheric delay model appropriate to the relative location characteristics of the pseudolite and the user.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 추계학술대회 논문집
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• pp.585-590
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• 1997

Conventional foaming process has defects such as lower mechanical properties than ur~foaming material due to non-uniform cell distribution and environmental pollution problem caused by chemical blowing agency. So, a new foaming process such as Microcelluar plastics has been introduced to use inactive gases as a foaming agency. In order to apply Microcellular plastics for mass production process system such as extrusion, injection molding and blow molding, it needs to predict the change in material properties of polymer according to the amount of meltingas. In Polymer molding applying Microcelluar plastics, the change of viscosity among several material properties is the most important factor. Therefore, this paper is aimed to establish the method which not only finds out but also predicts the change of viscosity of ABS(Acrylonitri1e Butadiene Styrene) resin according to inert gas amount in extrusion molding.

• 제어로봇시스템학회논문지
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• 제22권7호
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• pp.530-535
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• 2016

In this paper, the TTSE (Target size and Triangulation-based target Size Estimator) algorithm is proposed to estimate static target size in an imaging environment. The target size information is an important factor for accurate imaging target tracking. However, the imaging sensor cannot generate distance between the missile and target to calculate the target size. To overcome the problem, we propose the TTSE algorithm, which is based on target size and triangulation. The proposed method performance is tested in a target intercept scenario. The experiment results show that the proposed algorithm has better performance than the conventional algorithm (ET-TSE) for accurate CCD target size estimation.

• 유통과학연구
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• 제13권8호
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• pp.49-59
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• 2015

Purpose - This purpose of this research is to verify the influence of the care workers' environment on their job satisfaction and on their voluntary behavior. Research design, data, and methodology - Data were collected from care workers at elderly medical and home care facilities in Korea in Seoul and Kyung-ki. Of 367 total respondents, 285 responses were used. This study performed exploratory factor analysis in order to verify the validity and credibility of the data. Regression analysis was conducted to verify the influence of the working environment, which encompasses the worker's relationship with the agency and with the elderly, on job satisfaction. Results - The hypothesis results were: First, from analyzing the influence of the working environment on the worker's job satisfaction, both relationship with the agency (p<.001) and relationship with the elderly (p<.05) positively affect job satisfaction; second, the exploratory analysis verifies the influence or the working environment on job satisfaction. Conclusions - The results indicate that the relationship with the agency (p<.001) and relationship with the elderly (p<.001) both positively affect the voluntary behavior of the workers.

• Clinical and Experimental Vaccine Research
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• 제13권2호
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• pp.91-104
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• 2024

This narrative review describes genomic characteristic, serotyping, immunogenicity, and vaccine development of Streptococcus pneumoniae capsular polysaccharide (CPS). CPS is a primary virulence factor of S. pneumoniae. The genomic characteristics of S. pneumoniae CPS, including the role of biosynthetic gene and genetic variation within cps (capsule polysaccharide) locus which may lead to serotype replacement are still being investigated. One hundred unique serotypes of S. pneumoniae have been identified through various methods of serotyping using phenotypic and genotypic approach. The advantages and limitations of each method are various, emphasizing the need for accurate and comprehensive serotyping for effective disease surveillance and vaccine targeting. In addition, we elaborate the critical role of CPS in vaccine development by providing an overview of immunogenicity, ongoing research of pneumococcal vaccines, and the impact on disease burden.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 2004년도 High Temperature Superconductivity Vol.XIV
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• pp.50-50
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• 2004

• 한국인공지능학회지
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• 제12권1호
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• pp.7-16
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• 2024

This study aims to explore driving factors of Artificial Intelligence application for city marketing strategy with perspectives of millennials and generation Z. This study proposed the following research questions: i) how perceived place branding factor, public service factor, affective factor, immersive experience factor, cognitive factor, cost benefit factor, social networking factor, and promotional value factor affect attitude toward AI application for city marketing; and ii) how attitude affect satisfaction and prospect toward AI application for city marketing? This study conducted an online survey with the assistance of a well-known research agency and applied factor and regression analysis to test hypotheses. The results found that effects of place branding, cognitive, social networking, and promotional value affect attitude significantly in the case of millennials, while effects of public service, affective, cost benefit, social networking, and promotional value affect attitude significantly in the case of generation Z. The results found that effects of attitude on satisfaction and prospect of AI showed significance. The results provide implications and different aspects for AI application of city marketing strategy with perspectives by generations, while millennials and generation Z perceived effects of promotional value as the most significant factor for AI application of city marketing strategy.

• 대한수의학회지
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• 제58권4호
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• pp.211-217
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• 2018

Mesenchymal stem cells (MSCs) are useful candidates for tissue engineering and cell therapy. Physiological cell environment not only connects cells to each other, but also connects cells to the extracellular matrix that provide mechanical support, thus exposing the entire cell surface and activating signaling pathways. Hydrogel is a polymeric material that swells in water and maintains a distinct 3-dimensional (3D) network structure by cross linking. In this study, we investigated the optimized cellular function for canine adipose tissue-derived MSCs (cAD-MSCs) using hydrogel. We observed that the expression levels of Ki67 and proliferating cell nuclear antigen, which are involved in cell proliferation and stemness, were increased in transwell-hydrogel (3D-TN) compared to the transwell-normal (TN). Also, transforming growth factor-${\beta}1$ and SOX9, which are typical bone morphogenesis-inducing factors, were increased in 3D-TN compared to the TN. Collagen type II alpha 1, which is a chondrocyte-specific marker, was increased in 3D-TN compared to the TN. Osteocalcin, which is a osteocyte-specific marker, was increased in 3D-TN compared to the TN. Collectively, preconditioning cAD-MSCs via 3D culture systems can enhance inherent secretory properties that may improve the potency and efficacy of MSCs-based therapies for bone regeneration process.

• 지역사회간호학회지
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• 제28권4호
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• pp.421-430
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• 2017

Purpose: This study investigates the social network, self-care agency, and quality of life of high-risk beneficiaries in case management of Medicaid and the correlations between these variables. It also identifies influencing factors on their quality of life. Methods: The subjects included 187 individuals chosen from the high-risk beneficiaries in case management of Medicaid in D Metropolitan City. Data was collected through direct interviews based on a structured questionnaire on home visits. Results: The perceived health status was the most influential factor in their quality of life, followed by self-care agency, mutual support network, and natural support network in order. These factors explained 40.6% of their quality of life. Conclusion: These findings raise a need to develop a nursing intervention program to increase the self-care agency of the high-risk beneficiaries in case management of Medicaid.