• Journal of Pharmacopuncture
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• v.21 no.1
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• pp.18-25
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• 2018

Objective: D-galactose (D-gal) is well-known agent to induce aging process. In the present study, we selected crocin, the main constituent of Crocus sativus L. (saffron), against D-gal- induced cytotoxicity in human neuroblastoma SH-SY5Y cells. Methods: Pretreated cells with crocin ($25-500{\mu}M$, 24 h) were exposed to D-gal (25-400 mM, 48 h). The MTT assay was used for determination cell viability. Dichlorofluorescin diacetate assay (DCF-DA) and senescence associated ${\beta}$-galactosidase staining assay (SA-${\beta}$-gal) were used to evaluate the generation of reactive oxygen species and beta-galactosidase as an aging marker, respectively. Also advanced glycation end products (AGEs) expression which is known as the main mechanism of age-related diseases was measured by western blot analysis. Results: The findings of our study showed that treatment of cells with D-gal (25-400 mM) for 48h decreased cell viability concentration dependency. Reactive oxygen species (ROS) levels which are known as main factors in age-related diseases increased from $100{\pm}8%$ in control group to $132{\pm}22%$ in D-gal (200 mM) treated cells for 48h. The cytotoxic effects of D-gal decreased with 24h crocin pretreatment of cells. The cell viability at concentrations of $100{\mu}M$, $200{\mu}M$ and $500{\mu}M$ increased and ROS production decreased at concentrations of 200 and $500{\mu}M$ to $111.5{\pm}6%$ and $108{\pm}5%$, respectively. Also lysosomal biomarker of aging and carboxymethyl lysine (CML) expression as an AGE protein, significantly increased in D-gal 200 mM group after 48h incubation compare to control group. Pre-treatment of SHSY-5Y cells with crocin ($500{\mu}M$) before adding D-gal significantly reduced aging marker and CML formation. Conclusion: Treatment of SH-SY5Y cells with crocin before adding of D-gal restored aging effects of D-gal concentration dependency. These findings indicate that crocin has potent anti- aging effects through inhibition of AGEs and ROS production.

• Journal of Korean Academy of Nursing
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• v.38 no.5
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• pp.676-684
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• 2008

Purpose: The purpose of this study was to identify the risk factors for falls and to suggest data for developing a program for preventing falls. Methods: This was a case-control study in five university hospitals and a general hospital. In total, 216 patients over the age of 18 yr admitted from January 1 to December 31, 2007 participated. One hundred eight patients with experience of falling were matched by gender, age level, diagnosis, and length of stay with 108 patents with no experience of falling admitted on the same unit. A quality assurance coordinator nurse in each hospital examined 35 fall risk factors developed by researchers. Results: In acute hospitals, history of falls, orientation ability, dizziness or vertigo, general weakness, urination problems, transfer/mobility difficulty, walking dependency, impatience, benzodiazepines, diuretics, and vasodilators showed significance on adjusted-odds ratios for fall. Logistic regression analysis was performed to elucidate the factors that influence falls. The probability of falls was increased by dizziness/vertigo, general weakness, and impatience/agitation. Conclusion: This finding can be used as a useful resource in developing nursing intervention programs to predict and prevent the falls of inpatients.

• The Journal of Korean Physical Therapy
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• v.20 no.2
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• pp.33-41
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• 2008

Purpose: The aim of this study was to compare the activities of daily living, mental status, and life satisfaction of elderly persons living in home with those in institutions and to investigate the factors influencing life satisfaction and mental health. Methods: Data was collected through interview with persons over 60 years of age in a nursing home and in a community elderly center in Daegu City and Kyoungsang buk-do. Subjects were included 32 persons in the nursing home and 41 persons in the community elderly center. Data collection was undertaken 11 - 22 September 2007. Results: Elderly persons living at home showed higher dependency in instrumental activities of daily living, lower cognitive function, higher depression, and higher life satisfaction than elderly persons living in institution. The two groups were significantly different in this regard. Conclusion: As the age of the general population advances, we must prioritize quality of life in elderly persons by undertaking depression prevention through various means.

• Food Science of Animal Resources
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• v.32 no.1
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• pp.45-48
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• 2012

The imidazole dipeptide carnosine and its methylated anserine analogues are the major histidine containing dipeptides in vertebrate tissue, especially in skeletal muscle, the heart, and the central nervous system. In this study, the carnosine and anserine content in chicken from different parts and of differing ages was determined and their physiological activities were compared. Anserine was more dominant than carnosine in these tissues and both of them significantly decreased with aging in all parts of chicken muscles. Chicken breast muscle showed the highest content of carnosine and anserine than drumstick and wing. Advanced glycated end-product (AGE) formation was inhibited up to 60% by the extract from 20 wk chicken breast and decreased with aging (90 wk). Anti-oxidation activity was also significantly reduced from 61.2% to 52.9% with aging. As results, anti-glycation and anti-oxidation activity of carnosine and anserine extract from chicken muscle increased proportionally to the amount of those peptides in the muscle, while these decreased with the aging process.

• KDI Journal of Economic Policy
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• v.26 no.1
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• pp.105-140
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• 2004

Korea is entering the class of aging population nations. This paper investigates the extent demographic factors and the aging population affect the saving rate, using an extended life-cycle/permanent-income hypothesis on saving. The results of the tests with Korean household survey data from 1977 to 2002 reveal that real saving rates increase when the duration of lifetime and per household real disposable income rise, and decrease when the growth rate of income and net worth-to-GDP ratio rises. The growth rate of per household real disposable income has negative effects, suggesting that households calculate their life cycle income in a forward looking manner. The elasticities with respect to a change in the lifetime horizon and the growth rate of per household income are 0.58 and -0.03, respectively. A one percent rise in the net worth to GDP ratio reduces the saving rate by 0.3 percent. A one percent rise in per household income increases it by 0.33 percent. The younger-age and the elder-age dependency ratios have insignificant effects on the household saving rate behavior. When Korean life expectancy rises, the private saving rate declines modestly and the government saving rate declines substantially. The economy's real net saving rate declines from 33 percent in 2002 to 30 percent by the year 2030.

• Journal of the Korean Home Economics Association
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• v.28 no.3
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• pp.171-186
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• 1990

The purpose of this study is to analyze the desirable life emotion and life interchange between lod parents and married children. The focus was particulary laid on the investigation of the life emotion and life interchange between the aged living with their married sons and those living with their married daughters. The major findings of this study can be summarized as follows: 1. More old parents live with their married sons than with their married daughters. Also was found that they live with their eldest married sons or daughters and that they keep a normal relation with their married sons, and an emotional relation with their married daughters. This shows that more old people will live with their married daughters than with their married sons in the future. 2. The facts which affect the realtion between old parents2 2and their marreid children are age, sex, religion, marital status, educational background, health condition. These facts prove that they may improve the life interchange with their married children through such deliberate effects as the life-long marriage life with their spouse, the maintenance of health, and the religious life. 3. The affection relation between old parents and the married children was found to be high and the conflict between them was found to be low. Those who live with their married daughters especially showed a higher rate of love relation, and a lower rate of conflict than those who live with their married sons. The former were of more service interchange to their married children than the latter. Furthermore, the aged people were more satisfied with emotional and kindly daughters than with normal sons. 4. Affection was found to be the most importnat variable in promoting the emotional life interchange, and dependency was found to be a negative variable. Therefore, both the aged and the marreid children should try to show high affection to each other and try not to impose and dependency on the other.

• Korean Journal of Adult Nursing
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• v.15 no.4
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• pp.650-659
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• 2003

Purpose: The purpose of this study was to identify predictors of depression and quality of life among older adults with osteoarthritis. The predictors included in the model were the client's characteristics(age, pain, disease duration, ADLs), personal resources(hardiness, self-care agency and family support), and depression. Method: 150 subjects who were older than 65 years and had diagnosis of osteoarthritis participated in the study. To answer the research questions, descriptive analysis, Pearson correlation, and hierarchical multiple regression were utilized using SPSS WIN program. Result: Older adults who were younger and had lower levels of pain and dependency on ADLs, and higher levels of self care agency and hardiness reported lower levels of depression($R^2=0.517$). Older adults who had lower levels of depression, pain, and dependency on ADLs, higher levels of family support and hardiness, and who are younger reported higher levels of quality of life($R^2=0.084$). Conclusion: Based on the findings of this study, development of nursing intervention program including pain reduction, enhancing ADL abilities and personal resources (hardiness, family support) can be suggested. Further study is needed to increase the ability of generalization of the study findings to the broader population.

• Nuclear Engineering and Technology
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• v.56 no.6
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• pp.2247-2257
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• 2024

To investigate the impact of the recently released pediatric reference voxel phantoms (0-, 1-, 5-, 10-, 15-year-old males and females) of the International Commission on Radiological Protection (ICRP) on organ dose estimates for radioactive iodine (RAI) treatment in pediatric patients, we calculated and analyzed pediatric-specific iodine131 S values (r_T ← thyroid) for the 30 radiosensitive organs by conducting Monte Carlo simulations using the Geant4. The gender dependency in the S values was frequently seen for the 15-year-old phantoms with higher S values of female than male. In addition, the age dependency in the S values was observed for most target organs; that is, the S values tend to decrease for older ages (e.g., ~120 times for the gonads between the adult and newborn) due mainly to the inter-organ distances generally longer for older ages. Moreover, we observed that the iodine-131 S values tend to be significantly greater by up to ~145.5 times than those of the stylized phantoms that have been widely used for organ dose estimates of pediatric RAI patients. We believe that the pediatric-specific iodine-131 S values (r_T ← thyroid) of the ICRP pediatric reference voxel phantoms should be beneficial to improve the dosimetry of pediatric RAI patients.

• Journal of Information Technology Services
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• v.10 no.4
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• pp.33-46
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• 2011

This research focus on the economic activity as consumer and producer traits of future customers in the convergence age. We assess level of convergence for digital devices and services respectively by questionnaire survey and interview for 14 professions. And then, for evaluating convergence level and usage of digital services of each respondents, we conducted the questionnaire survey for 343 samples. Findings of our research hold that the group who showed higher level of convergence tends to use the socialized digital services more. Convergence generation were heavy users in appstore on smart-phone and wireless game and more participating. In digital service area, facebook/cyworld, twitter, UCC, portal, internet community in digital service. Convergence generation are global network communication, buying decision making activity, actively opinion expression, prosumer attitude, dependency on digital device, experience based purchase behavior, enthusiastic information sharing.

• Journal of Astronomy and Space Sciences
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• v.23 no.2
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• pp.91-96
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• 2006

We use near-infrared observations of eight selected Galactic globular clusters to estimate their distances by comparing the observed and theoretically predicted K magnitudes of the red giant branch bumps and tips. The K magnitude levels of the RGB bump and tip have been measured from the luminosity function of the selected RGB stars in the clusters. Theoretical absolute $M_k$ magnitudes of the RGB bump and tip are taken from the Yonsei-Yale isochrones. Comparing the observed apparent K magnitude with the derived absolute $M_k$ magnitude, we calculate the distance moduli of the clusters. We discuss the dependency of the derived distance modulus on the cluster age and the uncertainty of the distance measurement from the near-infrared photometry of the RGB bump and tip.