• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.2
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• pp.142-148
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• 2005

This paper proposes a cell age model for Penicillium chrysogenum fed-batch cultivation to supply a qualitative insight into morphology-associated dynamics. The average ages of the segregated cell populations, such as growing cells, non-growing cells and intact productive cells, were estimated by this model. A combined model was obtained by incorporating the aver-age ages of the cell sub-populations into a known but modified segregated kinetic model from literature. For simulations, no additional effort was needed for parameter identification since the cell age model has no internal parameters. Validation of the combined model was per-formed by 20 charges of industrial-scale penicillin cultivation. Meanwhile, only two charge-dependent parameters were required in the combined model among approximately 20 parameters in total. The model is thus easily transformed into an adaptive model for a further application in on-line state variables prediction and optimal scheduling.

• Communications for Statistical Applications and Methods
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• v.19 no.6
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• pp.859-868
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• 2012

Due to a rapidly aging society, the future Korea mortality rate is important for planning national financial strategies and social security policies. Old age mortality statistics are very limited in their ability to project a future mortality rate; therefore, it is essential to accurately estimate the old age mortality rate. In this paper, we show that the CK model with a Relational model as a base model provides accurate estimates of old age mortality rates.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2007.04a
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• pp.411-414
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• 2007

The confinement-shear lattice(CSL) model for hardened concretes developed by Cusatis is extended for early age concretes. The uniaxial behaviors available in the literature for 3 to 28 days were simulated by the CSL model to identify the change of the model parameters for various ages. The change with respect to the age was interpolated based on the chemomechanics to develop the extended version of CSL model.

• Korean Journal of Radiology
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• v.24 no.11
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• pp.1151-1163
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• 2023

Objective: To develop a deep-learning-based bone age prediction model optimized for Korean children and adolescents and evaluate its feasibility by comparing it with a Greulich-Pyle-based deep-learning model. Materials and Methods: A convolutional neural network was trained to predict age according to the bone development shown on a hand radiograph (bone age) using 21036 hand radiographs of Korean children and adolescents without known bone development-affecting diseases/conditions obtained between 1998 and 2019 (median age [interquartile range {IQR}], 9 [7-12] years; male:female, 11794:9242) and their chronological ages as labels (Korean model). We constructed 2 separate external datasets consisting of Korean children and adolescents with healthy bone development (Institution 1: n = 343; median age [IQR], 10 [4-15] years; male: female, 183:160; Institution 2: n = 321; median age [IQR], 9 [5-14] years; male: female, 164:157) to test the model performance. The mean absolute error (MAE), root mean square error (RMSE), and proportions of bone age predictions within 6, 12, 18, and 24 months of the reference age (chronological age) were compared between the Korean model and a commercial model (VUNO Med-BoneAge version 1.1; VUNO) trained with Greulich-Pyle-based age as the label (GP-based model). Results: Compared with the GP-based model, the Korean model showed a lower RMSE (11.2 vs. 13.8 months; P = 0.004) and MAE (8.2 vs. 10.5 months; P = 0.002), a higher proportion of bone age predictions within 18 months of chronological age (88.3% vs. 82.2%; P = 0.031) for Institution 1, and a lower MAE (9.5 vs. 11.0 months; P = 0.022) and higher proportion of bone age predictions within 6 months (44.5% vs. 36.4%; P = 0.044) for Institution 2. Conclusion: The Korean model trained using the chronological ages of Korean children and adolescents without known bone development-affecting diseases/conditions as labels performed better in bone age assessment than the GP-based model in the Korean pediatric population. Further validation is required to confirm its accuracy.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.42.1-42
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• 2002

A model to predict population by sex, age and district over a long-range period is proposed based on fuzzy theories. First, a fuzzy model is described. Second, a method to estimate the social increase by sex and age in each district is proposed based on a fuzzy clustering method for dealing with long-range socioeconomic changes in population migration. By the proposed methods, it became possible to predict the population by sex, age and district over a long-range period. Third, the structure and characteristics of the three models of employment model, time distance model, and land use model constructed to predict various socioeconomic indicators, which are require...

• Journal of Korea Society of Digital Industry and Information Management
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• v.10 no.4
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• pp.127-132
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• 2014

Some laws and regulations may require internet service providers to provide services based on the age of users. Age verification in the online environment should be used as a tool to provide service that is appropriate to child based on age. Using the minimum attribute information, processes on age verification provides the proper guidance to the internet services. However, there is a lack of a globally accepted trust framework for age verification process including evaluation factors for age verification information. In this paper the federation model of user attributes were described and evaluation factors for the age verification information were suggested. Also using the suggested evaluation factors, performance evaluation of federation model of user evaluation was performed. To meet the requirements of evaluation factors, framework of federation model should consider the unlinkability pseudonym support, eavesdropping protection and cloning protection.

• International Journal of Highway Engineering
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• v.15 no.2
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• pp.121-129
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• 2013

PURPOSES : This study deals with the traffic accidents of rotary in Korea. The objective of this study is to develop the accident models by age group based on the various data of rotaries. METHODS : In pursuing the above, this study gives particular attentions to classifying the accident data of 17 rotaries by age, collecting the data of geometric structure, traffic volume and others, and developing the models using SPSS 17.0 and EXCEL. RESULTS : First, 3 multiple linear regression models which were all statistically significant were developed. The value of model of under 30-49 age group were, however, evaluated to be 0.688 and be less than those of other models. Second, the most powerful variables were analyzed to be traffic volume in the model of under 30 age group, circulatory roadway width in the model of 30-49 age group, and the number of approach lane in the model of above 50 age group. Finally, the test results of accident models using RMSE were all evaluated to be fitted to the given data. CONCLUSIONS : This study propose install streetlights, speed humps and widen Circulatory as effective improvements for reduction of accident in rotary.

• Proceedings of the Korea Concrete Institute Conference
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• 2005.11a
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• pp.591-594
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• 2005

Concrete structure that has been constructed in real field is on multi-axial stress state condition. After placing of concrete, hydration heat and shrinkage of concrete can cause various stress conditions with respect to the restraint level and condition. So, to predict the early age behavior of concrete structure, multi-axial material model is required and microplane model is acceptable. Recently, many studies have been performed on the microplane model, but the model developed up to now has been related to hardened concrete that material property is constant with concrete age. So, it is inappropriate to apply this model immediately to analyze the early age behavior of concrete. In this study, microplane model that can predict early age behavior of concrete was developed and cracking analysis using that was performed to describe cracking behavior for massive concrete sturucture.

• Korean Journal of Radiology
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• v.22 no.12
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• pp.2017-2025
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• 2021

Objective: To evaluate the accuracy and clinical efficacy of a hybrid Greulich-Pyle (GP) and modified Tanner-Whitehouse (TW) artificial intelligence (AI) model for bone age assessment. Materials and Methods: A deep learning-based model was trained on an open dataset of multiple ethnicities. A total of 102 hand radiographs (51 male and 51 female; mean age ± standard deviation = 10.95 ± 2.37 years) from a single institution were selected for external validation. Three human experts performed bone age assessments based on the GP atlas to develop a reference standard. Two study radiologists performed bone age assessments with and without AI model assistance in two separate sessions, for which the reading time was recorded. The performance of the AI software was assessed by comparing the mean absolute difference between the AI-calculated bone age and the reference standard. The reading time was compared between reading with and without AI using a paired t test. Furthermore, the reliability between the two study radiologists' bone age assessments was assessed using intraclass correlation coefficients (ICCs), and the results were compared between reading with and without AI. Results: The bone ages assessed by the experts and the AI model were not significantly different (11.39 ± 2.74 years and 11.35 ± 2.76 years, respectively, p = 0.31). The mean absolute difference was 0.39 years (95% confidence interval, 0.33-0.45 years) between the automated AI assessment and the reference standard. The mean reading time of the two study radiologists was reduced from 54.29 to 35.37 seconds with AI model assistance (p < 0.001). The ICC of the two study radiologists slightly increased with AI model assistance (from 0.945 to 0.990). Conclusion: The proposed AI model was accurate for assessing bone age. Furthermore, this model appeared to enhance the clinical efficacy by reducing the reading time and improving the inter-observer reliability.

• Proceedings of the Korea Concrete Institute Conference
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• 2001.11a
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• pp.641-646
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• 2001

In early-age concrete, volumetric deformations due to thermal expansion and moisture transfer are restrained by various boundary conditions, and then restraint stresses occur in proportion to developed stiffness. With increase of the age, these stresses are gradually relieved by significant relaxation behavior of early-age concrete. Therefore, it is necessary to consider the stress relaxation in order to analyze the behavior of early-age concrete more accurately. In this paper, we propose a unified algorithm which combines a relaxation model with hydration model, heat conduction model, micropore structure formation model, moisture diffusion model and mechanical properties development model and develop a finite element program based on the algorithm. The program is applied to evaluate stress development if a temperature-stress test machine (TSTM) specimen and a massive concrete structure, and then validity of the program is discussed and evaluated.