• Journal of the Korean Applied Science and Technology
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• v.38 no.6
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• pp.1466-1475
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• 2021

Compound K (20-O-β-(_D-glucopyranosyl)-20(S)-protopanaxadiol) is an active ingredient of ginsenosides. Compound K has been known to produce from biotransformation by β-glucosidase action of human intestinal microbes after oral admistration of ginseng. We have investigated the cytotoxicity of compound K obtained from bio-converted ginseng extract. As a result, compound K showed no significant cytotoxicity in the concentration of 0.001 to 1 ㎍/mL and inhibited the production of TNF-α, MCP-1, IL-6 and NO in RAW 264.7 cells induced by LPS inflamation. In the same concentration, HaCaT cells induced by inflammation with TNF-α and IFN-γ decreased IL-8 production due to compound K treatment. In the brine shrimp lethality assay, the LC₅₀ of compound K was 0.37 mg/mL indicating some toxicity, but the bioconverted product containing 35% compound K showed relatively low toxicity with an LC₅₀ of 0.87 mg/mL. These results suggest that the compound K enriched extract is a potential functional material for acne relief cosmetic products.

• Journal of the Korean Society of Marine Environment & Safety
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• v.28 no.6
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• pp.1023-1035
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• 2022

In the current situation where clearly the ship officer is avoiding boarding, the purpose of this study is to investigate the satisfaction of onboard training in shipping companies during the COVID-19 situation and to suggest plans to improve onboard training. Furthermore, by improving satisfaction, students of maritime university can improve their career awareness as a ship officer in the future. The survey was conducted with the cadets of Mokpo Maritime University after completion of onboard training in shipping companies. The questionnaire contains seven factors: education administration, education contents, officer, facility, education ef ect, education satisfaction and career awareness. The survey analysis results indicated that the satisfaction with education administration and education effect was relatively low, and the satisfaction differed by gender and vessel type. In addition, hypothesis verification revealed that the education contents did not have a positive effect on education satisfaction and career awareness. Furthermore, a great correlation existed between education satisfaction and career awareness. We suggested that education and promotion must be improved before onboard training. In addition, the officer must be educated on the method to teach cadets and establish a training plan such that the officer can systematically guide the cadets with an educator mindset.

• Clinical and Experimental Pediatrics
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• v.64 no.12
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• pp.632-641
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• 2021

Background: Over the past few decades, various goals have been defined to reduce the mortality of children caused by acute lower respiratory infections (ALRIs) worldwide. However, few spatial studies to date have reported on ALRI deaths. Purpose: We aimed to assess the spatial modeling of mortality from ALRI in children under 5 years of age during 2000-2017 using a global data. Methods: The data on the mortality of children under 5 years old caused by ALRI were initially obtained from the official website of the World Health Organization. The income status of their home countries was also gathered from the Country Income Groups (World Bank Classification) website and divided into 5 categories. After that, in the ArcGIS 10.6 environment, a database was created and the statistical tests and related maps were extracted. The Global Moran's I statistic, Getis-Ord Gi statistic, and geographically weighted regression were used for the analyses. In this study, higher z scores indicated the hot spots, while lower z scores indicated the cold spots. Results: In 2000-2017, child mortality showed a downward trend from 17.6 per 100,000 children to 8.1 and had a clustered pattern. Hot spots were concentrated in Asia in 2000 but shifted toward African countries by 2017. A cold spot that formed in Europe in 2007 showed an ascending trend by 2017. Based on the results of geographically weighted regression test, the regions identified as the hot spots of mortality from ALRI in children under 5 years old were among the middle-income countries (R²=0.01, adjusted R²=8.77). Conclusion: While the total number of child deaths in 2000-2017 has decreased, the number of hot spots has increased among countries. This study also concluded that, during the study period, Central and Western Africa countries became the main new hot spots of deaths from ALRI.

• Journal of East Asia Management
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• v.4 no.1
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• pp.23-51
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• 2023

We investigate whether the association between management overconfident tone and the level of audit effort measured by audit fees and hours differs depending on the level of earnings management. Prior studies suggest that firms led by overconfident managers are likely to initiate risky investments, report low quality financial statements, and have material weaknesses in internal control system. These characteristics, combined together, result in higher audit risk. At the same time, auditors assess audit risk based on the quality of financial reporting, measured by level of earnings management. As a result, the assess audit risk is likely to reflect the combined effect of management overconfidence and the level of earnings management. In this paper, we investigate whether auditors differentiate the effects of real earnings management (REM) and accrual-based earnings management (AEM) when they assess the audit risk related management overconfident. Using the CEO's letter published in 2018, we measure the CEO's tone representing the degree of overconfidence (i.e., activity). Based on this measure, we find that the positive association between managerial overconfident tone and audit effort is more pronounced as the level of REM is higher. However, we find that the baseline association does not vary depending on the level of AEM. These results suggest that auditors consider the managerial overconfident severer when such characteristic accompany the higher level of REM, which can be outcome of aggressive business decisions possibly leading to the higher audit risks. We further find that these results are stronger for Big 4 auditors and continuing auditors. This paper contributes to the literature and practice as follows. First, we provide contextual evidence on how auditors reflect managerial characteristics in the audit process by documenting that auditors actively increase their audit efforts only when overconfident managerial characteristics are highly likely to lead to audit risk. This result suggests that auditors conduct external auditing considering both the efficiency and effectiveness of the audit process. Second, we suggest that auditors use information obtained from a wide range of sources to identify audit risks. Our results provide evidence of how the auditing standards, which do not provide detailed guidelines for audit risk assessment, are being applied in practice. Finally, our results also enhance the understanding of how audit fees are determined. Combined with the studies related to audit pricing, we provide the important reference for discussion between the auditor and the auditee about the audit fee that has created acute tension after the enforcement of the new External Audit Act.

• The Journal of the Acoustical Society of Korea
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• v.42 no.1
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• pp.7-15
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• 2023

Recently, as interest in air quality in vehicles increases, the use of fine dust detection sensors for air quality measurement is becoming common. An axial-flow fan is inserted in the fine dust sensor installed in the air conditioning system in the vehicle to prevent dust from sinking directly on the sensor. When the sensor operates, the flow noise caused by the rotation of the axial-flow fan acts as a major noise source of the fine dust sensor. flow noise is recognized as one of the product competitiveness of fine dust sensors. In this study, the noise was gradually reduced at the same flow rate by improving the flow performance of the small axial flow fan. First, a virtual fan performance tester consisting of about 20 million grids was developed to analyze the aerodynamic performance of the target small axial-flow fan. In addition, the flow field was simulated by using compressible Large Eddy Simulation for direct computation of flow noise as well as high-accurate prediction of flow rate. The validity of numerical method are confirmed through the comparison of predicted results with experimental ones. After the effects of pitch angle on flow performance were analyzed using the verified numerical method, the pitch angle was determined to maximize the flow rate. It was found that the flow rate was increased by 8.1 % and noise was reduced by 0.8 dBA when the axial-flow fan with the optimum pitch angle was used.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.33 no.1
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• pp.22-30
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• 2023

Currently, almost all product development in the jewelry industry utilizes 3D CAD and 3D printing. In this situation, 3D CAD modeling and 3D printing ability units in colleges, Tomorrow Learning Card Education, and Course Evaluation-type jewelry design related education are conducted with developed curriculum based on the standards for training standards, training hours, training equipment, and practice materials presented by NCS. Accordingly, this study analyzes 3D CAD modeling and 3D printing training facilities, training hours, training equipment, etc into three categories of NCS precious metal processing and jewelry design, and studies the development of educational systems such as 3D CAD/3D printing curriculum and various environments that meet these standards. Education using this 3D CAD/3D printing education system will enable us to continuously supply professional talent with practical skills not only in the jewelry industry but also in the entire 3D CAD/3D printing manufacturing industry, which is called as one of the pillars of the 4th Industry. The quality of employment of trainees receiving education and the long-term retention rate after employed can also have a positive effect. In addition, excellent educational performance will help improve the recruitment rate of new students in jewelry jobs or manufacturing-related departments, which are difficult to recruit new students in recent years.

• Journal of Life Science
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• v.33 no.1
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• pp.91-101
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• 2023

Bacteriocins are antimicrobial peptides synthesized on ribosomes, produced by bacteria, that inhibit the growth of similar or closely related bacterial strains. Since the discovery of nisin, many bacteriocins with unique structures and various modes of antibacterial activity have been described, and genes encoding production, secretion, and immunity have been reported. Nisin is one of the bacteriocins applied in cheese, liquid eggs, sauces and canned foods. Many of the bacteriocins of the genus Bacillus belong to lantibiotics, which are modified peptides after translation. Other genus Bacillus also produce many non-lantibiotic bacteriocins. Bacteriocins of the genus Bacillus are sometimes becoming more important because of their broader antibacterial spectrum. Bacteriocins are considered attractive compounds in the food and pharmaceutical industries to prevent food spoilage and growth of pathogenic bacteria. Bacteriocins can be used as biological preservatives in a variety of ways in the food system. Biopreservation refers to extending shelf life and improving safety of foods using microorganisms and/or their metabolites. The demand for new antimicrobial compounds has generated great interest in new technologies that can improve food microbiological safety. Applications of bacteriocins are expanding from food to human health. Today, many researchers are shifting their interest in bacteriocins from food preservation to the treatment of bacteria that cause infections and antibiotic-resistant diseases. This exciting new era in bacteriocin research will undoubtedly lead to new inventions and new applications. In this review, we summarize the various properties and applications of bacteriocins produced by the genus Bacillus.

• Journal of the Korean Geotechnical Society
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• v.23 no.10
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• pp.5-11
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• 2007

This paper is to investigate the removal of the smear at elevated temperatures. This study utilized both small cylinder cell and large consolidometer apparatus to investigate the combination of PVD with heat and without heat. Two types of heaters are used in this study. The heater drain made of copper tube is used for all tests except large consolidometer and flexible wire heater is used for large consolidometer. Specimens demonstrated volume contraction upon heat and without heat. This contraction is dependent on temperature magnitude. When the specimen is heated, the magnitude of settlements is higher and rate of consolidation is faster. After treatment using PVD combined without heat and with heat for undisturbed specimens the $C_h$ values obtained were $3.45m^2/yr$ and $3.83m^2/yr$, respectively, from $3.2m^2/yr$ before treatment. The $K_h/K_s$ ratios were 3 for the specimen without heat and 2 for the specimen with heat. Similarly, in reconstituted specimens without heat and with heat, the $C_h$ values were $2.1m^2/yr$ and $2.5m^2/yr$ with $K_h/K_s$ ratios of 1.75 and 1.5, respectively.

• Journal of the Korea Convergence Society
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• v.13 no.1
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• pp.349-355
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• 2022

Today, apartment houses account for a very high proportion of the types of residence. This study aims to present basic data for preparing a reasonable distribution plan by identifying factors considered in calculating the amount of collection of management fees. After reviewing previous studies on common management fees and long-term repair allowances, various data on apartment houses subject to mandatory management in Busan in 2020 were collected from the Apartment Management Information System to analyze the differences in influencing factors according to type of apartment management(self-governing management, consignment management). As a result of statistical analysis, the number of households and many construction elapsed periods had a negative(-) effect on long-term repair allowances, and many construction elapsed periods had a negative(-) effect on common management fees. In addition, the degree to which many construction elapsed periods had a negative(-) effect on long-term repair allowances and common management fees had less impact on consignment management than on self-governing management. And the long-term repair allowances were imposed less by consignment management, common management fees were charged less by self-governing management. The results of this study will serve as basic data for rational distribution of long-term repair allowances and common management fees to residents and managers of apartment houses subject to mandatory management in Busan.

• Journal of Music and Human Behavior
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• v.19 no.2
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• pp.27-53
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• 2022

The purpose of this case study was to construct a social context-based musical play program for children with high-functioning Autism Spectrum disorder (ASD) and to examine its applicability in improving the social skills of the children. The participants were a group of three children with high-functioning ASD with an average age of 9 years. The children participated as a group in 40-minute sessions that were implemented twice a week for 8 weeks. The children's social communication behaviors were observed during the sessions and analyzed in terms of sharing and exchanging their ideas and voluntarily interacting with peers and an adult (i.e., the researcher). The Social Skills Rating System (SSRS) was completed by the teachers of participants before and after the intervention. For all three participants, the occurrence of behaviors to exchange their ideas with peers and voluntarily interacting with an adult increased following the intervention. However, there were individual differences between the participants in terms of changes in each target behavior depending on their level of language and social skill development. These results suggest that social context-based musical play program may produce positive changes in voluntary communication with peers and play a significant role in expanding the scope of interventions that target the social communication of children with ASD.