• The Korean Journal of Food And Nutrition
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• v.22 no.2
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• pp.252-260
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• 2009

According to Article 7 and Annex B of the World Trade Organization(WTO) Agreement on the Application of Sanitary and Phytosanitary(SPS) Measures, WTO members are required to notify their newly established or amended SPS measures that might affect international trade. This study analyzed SPS notifications from 1995 to 2008 to identify international trends for food safety measures. The notifications were collected from the SPS information management system and the official document distribution system of WTO. The 153 WTO members represented 37 developed countries, 84 developing countries and 32 least developed countries. The number of overall notifications was 9,820. The annual notifications increased from 198 in 1995 to 1,264 in 2008. The monthly average notifications were from 44.8 in December to 69.5 in June; however, there were no statistical differences among them. The six leading Members in terms of notification submissions were United States(U.S.), Brazil, New Zealand, Canada, European Community and Korea. Among the regular and emergency notifications, 62.7% notifications were concerned with food safety, followed by animal and plant protections. Among animal protection notifications, 54.8% were emergency situations. Of the 4,821 food safety notifications, 60.4% were from developed countries, and 39.3% were from developing countries. Measures concerning pesticide residues and risk assessments were mainly from developed countries. In contrast, 77.5% of the measures concerning zoonoses were from developing countries. However considering the numbers of developing and developed countries, the average number of measures for each country was similar. Food safety measures were mainly involved pesticide residues followed by food additives, zoonoses, new regulations, labeling. As the overall notifications, zoonosis measures were mainly emergency notifications. Measures concerning pesticide residues, food additives, zoonoses, new regulations, veterinary drugs, and labeling were submitted most often by the U.S., Korea, Albania, U.S., Australia, and U.S., respectively. Identifying the exact trends of food safety measures was complicated by a number of factors. However, WTO notifications might be useful tool in providing a general view of international trends.

• The Korean Journal of Physiology
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• v.28 no.2
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• pp.225-231
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• 1994

The present study was undertaken to investigate the role of endogenous nitric oxide in renin release under different physiological conditions. In the first series of experiments, renin release was either inhibited by acute volume-expansion (VE) or stimulated by clipping one renal artery in the rat. VE was induced by intravenous infusion of saline (0.9% NaCl) up to 5% of the body weight over 45 min under thiopental (50 mg/kg, IP) anesthesia. VE caused a decrease of plasma renin concentration (PRC). With $N^G-nitro-L-arginine$ methyl ester $(L-NAME,\;5\;{\mu}g/kg\;per\;min)$ superadded to VE, PRC decreased further. The magnitude of increase in plasma atrial natriuretic peptide levels following VE was not affected by the L-NAME. In two-kidney, one clip rats, L-NAME-supplementation resulted in a decrease, and L-arginine-supplementation an increase of PRC. Plasma atrial natriuretic peptide levels were significantly lower in the L-arginine group than in the control. Blood pressure did not differ among the L-NAME, L-arginine, and control groups. In another series of experiments, the renin response to a blockade of NO synthesis was examined using in vitro preparations from isolated renal cortex. L-NAME significantly increased basal renin release, although it was without effect on the isoproterenol-stimulated release. These findings suggest that endogenous nitric oxide significantly contributes to the renin release. Since many factors may affect the renin release in vivo, an interaction between NO and renin under various pathophysiological states is to be further defined.

• Journal of the Korean association of regional geographers
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• v.16 no.5
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• pp.549-558
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• 2010

This study is to investigate the relative impacts of urban growth boundaries(UGBs) on metropolitan growth patterns in the United States over a period of time. Through statistical analyses, we evaluate the extent to which UGBs affect the density of residential development in metropolitan areas with UGBs. We also attempt to understand the overall impact of UGBs and the importance of UGBs relative to other determinants of urban growth patterns. Our works found that urban growth patterns differ significantly between cities with UGBs and cities without. UGBs have significant causal effect on urban housing and population densities, but are relatively less important than other factors. This implies that there are factors affecting the variation for which the given data cannot account. Despite the limitations of the data, the findings of this analysis suggest that UGBs have some positive effects on curbing urban sprawl.

• Journal of agricultural medicine and community health
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• v.29 no.1
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• pp.195-206
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• 2004

Objectives: This study was conducted to investigate the patterns of medical utilization and factors affecting medical utilization of population living in islands of province of ChungCheongNam-Do. Methods: Demographic and socioeconomic state, medical utilization of 447 persons were surveyed from Sept. 9th to Sept. 18th, 2002. Results: In elder age group and lower educational group, the rate of medical utilization was high. As subjective health states get lower, the group used medical institution more(p<0.05). The group having more number of chronic diseases showed more medical utilization. And the group who needs 2 to 3 hours to reach to the medical institution showed high medical utilization(p<0.05). The factors having negative effect on using medical institution were economic concern and lack of proper clinic in the neighborhood. Conclusions: The lower economic level and the insufficiency of medical facilities on islands affect the utilization rate negatively. More accessible and effective medical systems for these population are expected.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.6 no.1
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• pp.34-42
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• 1995

Borderline personality disorder in adolescents present with suicide attempts or gestures, and they are characterized by the same patterns of splitting, devaluation, manipulation, need-gratifying object relations, impulsivity, and ego deficits that are finds in borderline adults, Symptomatolgy are depression, anxiety, identity crisis, and occasionally antisocial behavior in borderline personality disorder in adolescents. These findings should be differentiated to normal stormy adolescents. Theses borderline personality disorder in adolescents are known about the instability of object relations, labile affect, splitting, and psychotic episode in severe stress. According to thses finding, schizophrenia, mood disorder, schizoptypal personality disorder, paranoid personality disorder could be differentiated. Etiology is complex including psychodynamic, genetic, familial factor. Treatments are individual psychotherapy, group therapy, and pharmacotherapy. The continuity or discontinuity of borderline states from childhoon to adult life is controversy.

• Strategy21
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• s.32
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• pp.5-35
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• 2013

The purpose of this thesis is to suggest how to plan ROK(Republic of Korea) Navy's strategy concerning to JOAC(Joint Operation Access Concept) and ASB(Air-Sea Battle) concept of US(United States) armed forces. Since 2006, US armed forces has been developing CONOPS(Concepts of Operations), JOAC & ASB. These concepts will not only affect security environment for Korea Peninsula and West Pacific Area, but also will be affected to ROK Navy's Strategy. Therefore, Korea Navy has to consider and review those concepts and should discuss the way to secure peace of Korea Peninsula. JOAC & ASB have been developed for securing operational access ability of US armed forces against enemy forces. A2/AD(Anti-Access, Area-Denial) is the strategy of possible enemy forces against US forces' approaching into the operation area and impede operations within area. US forces had to overcome enemy's A2/AD strategy in coming century to protect national interest and sustain global leadership. The main concept of JOAC & ASB is "Cross-domain Synergy", which means 'to eliminate duplicate and improve joint operability containing space and cyber operation area.' Korea Navy's acceptance of JOAC & ASB without any revising is not a rational choice. Without the amendment some problems can be occurred by the Korea navy's acceptance for the original version of JOAC & ASB. Those are "Missing differences of operation environment between Korea and US", "Impediment from neighbor nations, especially PRC (People's Republic of China)", and "Impediment inside from Korea armed forces". Therefore, Korea Navy has to evaluate and find out the way to solve for JOAC & ASB to apply for their strategy and minimise those possible problems above. This thesis is expected to be the solution.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.74
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• pp.125-150
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• 2017

Environment protection is one of the important political goals along with trade liberalization. Some of the institutions associated with it, however, either hinder trade or exert distorted influence and can arouse trade conflicts eventually. Therefore, harmony between environment protection and trade policy is becoming a crucial issue nowadays. Among the policies for environment, those related to climatic change are regarded as major tasks to deal with in the world commonly. Saying that it is for environment protection, advanced countries impose fines for environment protection on developing countries through border tax adjustments about the items imported from them. However, there is no such agreement about it internationally, so disputes often arise regarding what extent is appropriate as countries cope with it differently in their own way. Disputes about measures for climatic change are highly influential economically, and due to the severe conflicts of interests between states, they often tend to become politicized. Accordingly, we can say that such disputes affect international trade based on the WTO system seriously. When it comes to negotiation for climatic change, we should establish international systems urgently which can work fairly and effectively for all the countries joining in it. Therefore, it is important to examine the treatment of trade restriction measures intended to solve climatic change in international negotiations and establish definite conditions about which measures are allowed and which are not. In conclusion, we should devise rules for environment protection internationally which all the countries in the world can accept and agree on and also make the definite criteria of interpretation as well. Also, through those trade regulations, we should be able to accomplish environment protection globally and at the same time produce synergy, that is, economic growth through trading.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.23 no.2
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• pp.108-113
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• 2013

Objectives: Although several cases of lung diseases caused by indium have been reported in Japan, the United States and China, South Korea, which is estimated to have been the world's largest consumer of indium, has not yet established a criteria for the diagnosis of lung diseases caused by indium exposure. In this study, we tried to determine the applicability of the Krebs von den lungen-6, which has been widely recognized for its use with interstitial lung disease in Japan, as a biological exposure index for indium. Methods: Methods: The analysis of indium in serum was conducted by inductively coupled plasma mass spectrometry and the analysis of KL-6 in serum was carried out using enzyme-linked immunosorbent assay kit. Results: The indium levels in serum were distributed from below the detection limit to a peak of $125.78{\mu}g/L$, and the values of the KL-6 were distributed from 104.5 U/mL to 2162.2 U/mL. The serum indium and KL-6 showed good correlation ($R^2$=0.389,pfortrend=0.000) and smoking did not affect the KL-6. Conclusions: The usefulness of KL-6 as a specific biomarker for interstitial lung disease has been recognized. In addition, it is expected that effective prevention of health problems can be achieved by determining the lung-damage progress at an early stage according to individual susceptibility.

• Journal of Pharmaceutical Investigation
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• v.40 no.3
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• pp.139-153
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• 2010

Nitrosative stress is defined as pathophysiological conditions that are related to covalent modifications of proteins by nitration/nitrosylation by forms of nitrogen oxide ($NO_x$), leading to DNA damage, ultimately, cell death. This type of stress condition appears to be associated with a number of disease states, including diabetes, inflammation and neurodegenerative diseases. Since these pathological conditions are frequently chronic in nature and, thus, require long-term treatment, changes in pharmacokinetics are likely to affect the therapy. Transporters are membrane proteins that facilitate the movement of substrates, including drugs, across plasma membranes of epithelial / endothelial cells. Since it is now increasingly evident that transporters are pharmacokinetically significant, functional alteration of transporters by this stress condition may have therapeutic relevance. In this review, experimental techniques that are used to study both in vivo and in vitro nitrosative stress are summarized and discussed, along with available literature information on the functional implication of transporters under conditions of nitrosative stress conditions. In the literature, both functional induction and impa irment were apparently present for both drug transporter families [i.e., ATP-binding cassette (ABC) and solute carrier families (SLC)]. Furthermore, a change in the function of a certain transporter appears to have temporal dependency by impairment in the early phase of nitrosative stress and induction thereafter, suggesting that the role of nitrosative stress is complex in terms of functional implications of the transporters. Although the underlying mechanisms for these alterations are not fully understood, protein nitration/nitrosylation appears to be involved in the functional impairment whereas transcript factor(s) activated by nitrosative stress may play a role, at least in part, in functional induction. Interestingly, functional induction under conditions of nitrosative stress has not been observed for SLC transporters while such impairment has been documented for both ABC and SLC transporters. Further investigations appear to be necessary to fully delineate the underlying reasons for these differences on the impact and importance of nitrosative stress conditions.

• The Journal of Korea Robotics Society
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• v.15 no.4
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• pp.365-374
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• 2020

In this paper, we analyzed how 5-year-old children perceive a robot's ability to attribute mental states to oneself and to others, which shall hereafter be referred to as a robot's theory of mind (RToM). A total of 34 5-year-old children were given two typical false-belief tasks, an 'unexpected-contents task' and a 'change-of-location task', in order to evaluate whether a child's perceived RToM was connected to their own ToM. In addition, we investigated whether a child's perception of RToM was influenced by either a priori experience with robots or that child's gender. The results are as follows. Firstly, the 5- year-old preschool children universally recognized robots as beings that have a human-like mind both in 1st order and 2nd order perspectives, which indicates that children perceive robots as beings distinct from mechanical toys. Secondly, a priori child-robot interaction experience was found to have a positive influence on a child's perceived RToM. Thirdly, the gender of children did not significantly affect their perceived RToM. This study serves to add to the macroscopic results of prior research, which indicate that children perceive robots as intermediate beings between living and inanimate objects: significantly, it analyzes the children's perception of robots through the lens of theory of mind, which is one of the key elements of cognitive development. This research lays the foundations for designing effective child-robot interactions, in situations in which robots serve as peers or assistants for educational purposes.