• 한국식품위생안전성학회지
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• 제22권4호
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• pp.235-242
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• 2007

Aerosolization 기술은 미생물 제어를 위한 살균처리에 있어서 여러 가지 장점을 가지고 있어서 식품과 식품가공을 위한 시설 및 설비 등에 새로운 살균처리 방법으로의 이용가능성이 높다. 따라서 본 연구에서는 국내에서 유통되고 있는 5종류의 상업적 살균소독제를 aerosol 형태로 model cabinet에서 처리하여 E. coli O157:H7, S. typhimurium, L. monocytogenes에 대한 살균효과를 조사하였다. 과산화수소계와 4급암모늄계를 aerosol 형태로 처리했을 때 세 가지의 병원성 미생물에 대하여 가장 높은 살균력을 관찰하였으며 반면에 다른 종류의 살균소독제인 염소계, 요오드계, 알콜계는 세가지 병원성 미생물을 거의 저해하지 못하거나 아주 약한 저해를 나타냈다. 과산화수소계는 세가지 병원성 미생물에 우수한 살균력(> 4 log reductions)을 나타냈으며 L. monocytogenes에 대하여는 특히 aerosol형태의 4급암모늄계가 강한 살균력을 나타내어 9 log 이상의 저해를 나타내었다. 1.6 MHz와 2.4 MHz 진동자를 비교하였을 때 살균소독제의 종류와 처리된 병원성 미생물에 대하여 차이를 나타내었으나 처리 효과와 특정한 상관관계를 나타내지 않았다. Aerosolization 기술은 새로운 살균기법으로 이용가능성이 높을 것으로 사료되나 응용되는 살균소독제의 종류에 따라서 살균효과에 차이가 크고 미생물이 오염되어 있는 물질 및 표면 등의 처리조건의 차이에 따라서 결과가 달라질 수 있으므로 이 기술의 응용을 위해서는 보다 다양한 조건과 다양한 미생물의 종류에 대한 연구가 이루어져야 할 것으로 사료된다.

• 식품기술
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• 제18권1호
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• pp.91-98
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• 2005

Aims: As a preliminary experiment on new sanitizer delivery tools, the efficacy of aerosolizedsanitizer on foodborne pathogens was investigated in larger model chamber system.Methods: Peroxyacetic acid and hydrogen peroxide were aerosolized in a model system againstartificially inoculated target microorganisms on laboratory media. Cultures of 4 different foodborne pathogens were inoculated and affixed onto 3 different heights (bottom, wall, and ceiling), and 3different orientations (face-down, vertical, and face-down) inside a commercial semi-trailer cabinet(14.6 x 2.6 x 2.8 m). Sanitizer was aerosolized into 2 m droplet size fog and treated for 1 h atambient temperature.Results: Populations of Bacillus cereus, Listeria innocua, Staphylococcus aureus, and Salmonellatyphimurium were reduced by an average of 3.09, 7.69, 6.93 and 8.18 log units per plate, respectively.Interestingly, L. innocua, Staph. aureus, and Salm. typhimurium showed statistically not different (P$\leq$ 0.05) reduction patterns relative to height and orientation that were never expected in a sprayingsystemConclusion and significance: Aerosolized sanitizers diffuse like gaseous sanitizers, so it has greatpotential for use in commercial applications.

• 한국임상약학회지
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• 제27권4호
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• pp.207-213
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• 2017

Background: It is recommended to use aerosolized (AS) colistin in patients undergoing mechanical ventilation therapy as an adjunctive in the latest guidelines, in spite of high nephrotoxicity and limited studies. In this study, systematic reviews and meta-analyzes were conducted to evaluate the safety and efficacy of AS colistin in patients with ventilator-associated pneumonia Methods: Two authors independently searched related literature published from Pubmed and EMBASE until July 2016 and included a study comparing adjunctive AS colistin with intravenous (IV) colistin monotherapy. The primary outcome was the clinical response rate, the secondary outcome was the overall mortality, and nephrotoxicity. The publication bias was evaluated using the Egger's test. Results: Of the total 279 articles, nine were finally included in the final analysis. There was a significant difference between the adjunctive AS colistin group and the IV colistin monotherapy group for the treatment-response rate (odds ratio (OR), 1.56; 95% CI, 1.14-2.14; p = 0.005; $I^2=36%$), although there was no significant difference in overall mortality (OR, 0.77; 95% CI, 0.57-1.04; p = 0.09; $I^2=20%$). However, there was no significant difference between the two groups in nephrotoxicity (OR, 1.13; 95% CI, 0.74-1.74; p = 0.57; $I^2=4%$). Conclusion: The addition of aerosolized colistin to IV colistin monotherapy showed better results in terms of efficacy than IV colistin monotherapy and did not show any significant difference in terms of total mortality and nephrotoxicity. Additional large-scale studies of this need to be verified.

• Tuberculosis and Respiratory Diseases
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• 제64권2호
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• pp.102-108
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• 2008

연구배경: 최근 다제내성 A. baumannii에 의한 폐렴이 중환자실 환자에서 매우 빈번하게 발생하고 있으며, 이탈 지연, 중환자실 재원기간 및 사망률의 증가가 초래되기도 한다. 수 년 전부터 colistin이 치료제로 다시 주목받고 있으나 병원획득폐렴에 대한 치료 경험은 많지 않으며, 분무치료의 효과에 대해서는 근거가 매우 부족하다. 이에 저자들은 한 대학병원 중환자실에서 발생한 다제내성 A. baumannii에 의한 병원획득폐렴에서 colistin 분무치료의 적용 가능성을 평가해보고자 하였다. 방법: 다제내성 A. baumannii에 의한 병원획득폐렴의 발생이 확인되어 colistin 분무치료를 시행한 환자 10명을 대상으로 후향적 분석을 시행하였다. 결과: Colistin 분무치료 기간은 평균 $12.7{\pm}2.4$일이었다. 10명의 대상환자 중 9명(90.0%)의 환자에서 효과적인 치료 반응을 나타내었다. 치료 종료 후 추적한 객담 배양 검사에서 다제내성 A. baumannii는 단 한 명도 분리되지 않았다. 1명의 환자에서 기관지연축이 발생하였으나 기관지확장제 치료 후 호전되었다. 결론: 다제내성 A. baumannii에 의한 병원획득폐렴에서 colistin 분무치료는 매우 효과적일 가능성이 있으며, 향후 전향적인 연구를 진행할 가치가 있을 것으로 판단된다.

• 식품기술
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• 제18권2호
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• pp.99-108
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• 2005

As an alternative to gaseous sanitizer which having penetrating and diffusing capacities, aerosolsanitizer’s effect on killing pathogens was investigated. To test the efficacy of aerosolized sanitizer, peroxyacetic acid was aerosolized($5.42-11.42\mum$) by nebulizer(Royal-G Enterprise, ShenZhen,China) in a model cabinet against artificially inoculated target microorganisms on lettuce. Lettuceleaves were inoculated with a cocktail of three strains each of Escherichia coli O157:H7, Listeriamonocytogenes, and Salmonella Typhimurium and treated with sanitizer aerosol for 10 min, 30 and60 min in a model aerosol cabinet at room temperature($22\pm2^\circC$). After treatment, surviving cellsincluding injured cells were enumerated on appropriate selective agar or using the over-lay agar method, respectively. Inoculated lettuce leaves exposed to antimicrobial aerosol for 10 min experienceda 0.8 log reduction in E. coli O157:H7, a 0.3 log reduction in Salmonella Typhimurium and a 2.5 logreduction in L. monocytogenes when compared to the control. After 30 min treatment, the threepathogens were reduced in number of CFU by 2.2, 3.3, and 2.7-log and after 60 min, the reductions were 3.4, 4.5, and 3.8-log, respectively. Aerosolization can be new antimicrobial agents deliverysystem in food sanitizing.

• Pediatric Infection and Vaccine
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• 제19권3호
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• pp.162-167
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• 2012

RSV는 2세 미만의 소아에서 급성 하기도 감염으로 인한 입원의 주원인이다. 특히 미숙아, 선천성 심폐질환, 면역결핍이 동반된 경우 주요 위험군으로 알려져 있다. 고위험군의 소아에서 중증 RSV 감염의 경우 리바비린 흡입요법이 허가가 되어 있으나 고비용, 안전성 등의 문제로 국내 임상에서의 사용은 매우 제한적인 실정이다. 저자들은 8개월 여환이 급성 림프구성 백혈병으로 관해유도요법 항암치료 중 발생한 RSV 폐렴으로 기흉, 기종격동, 호흡부전이 동반된 중증 감염을 경험하였다. 정맥용 면역글로불린, 경구 리바비린 투여에 반응이 없어 리바비린 흡입 치료를 시행하였고, 이후 임상적 호전을 경험하였기에 보고하는 바이다.

• 한국대기환경학회지
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• 제29권2호
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• pp.125-134
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• 2013

Various antimicrobial technologies have been developed to inactivate bioaerosols in indoor environments. In this study, air filter media were treated with a natural antibacterial agent of Sophora flavescens in order to inactivate the bacteria collected on the air filter. Three treatment methods were applied to manufacture the test antibacterial air filter media: electrospray, nebulization and dip-coating methods. In case of electrospray and nebulization processes, the size distribution of aerosolized natural antibacterial agent was measured using a scanning mobility particle sizer. Staphylococcus epidermidis bacteria were aerosolized to test inactivation of the filter media treated with a natural antibacterial agent. The pressure drop and the antibacterial efficiency of the filter media increased with increasing the mass loading of natural antibacterial agent in each treatment method. The antibacterial efficiency per loaded antibacterial agent mass by the electrospray method was the highest and the filter treated by the dip-coating method was the lowest among three treatment methods.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.193.2-194
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• 2003

Effect of phenylpropanoids on Phospholipase A2 (PLA2) and phosphodiesterase (PDE) activities in the asthmatic lung tissue were studied in guinea pigs. Bronchial asthma were introduced by the challenge of aerosolized ovalbumin (OA) in the double-chambered plethysmograph at twenty one days after sensitization of OA in guinea pigs. Bronchoalveolar lavage fluids (BALF) were taken by brochalveolar lavage with HEPES buffer. (omitted)

• 한국입자에어로졸학회지
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• 제5권1호
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• pp.9-16
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• 2009

Pressure drop and particle removal efficiency of two commercial fibrous medium filters were measured with 20~1,000 nm sized aerosolized KCl particles. Pressure drop and particle removal efficiency were also theoretically predicted and the results qualitatively agreed with the experimental data. For this given particle removal efficiency, a filter design method for obtaining minimum pressure drop (and therefore minimum fan power) was suggested in this study by selecting solidity and fiber diameter as parameters. Therefore, by carrying out theoretical and experimental approaches together, this paper introduced a way of finding conditions for low pressure drop and high performance of a fibrous filter, especially if the filter would be used in mechanical ventilation system.

• 한국대기환경학회지
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• 제25권4호
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• pp.255-263
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• 2009

The antifungal activity of silver, copper, and titania nanoparticles against fungal spores was investigated. Cladosporium cladosporioides spores were aerosolized and sampled on a solid agar plate using an Anderson impactor. The solid agar plate contained different concentration of nanoparticles ranging from 0 to $500{\mu}g/mL$. Silver and copper nanoparticles were shown to be an effective antifungal agent, while titania nanoparticles were not. Antifungal activity of these effective nanoparticles appeared at $300{\mu}g/mL$ concentration.