• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1789-1795
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• 2016

Background: Breast cancer is the commonest female cancer worldwide and its propensity to metastasize negatively impacts on therapeutic outcome. Several clinicopathological parameters with prognostic/predictive significance have been associated with metastatic suppressor expression levels. The role of metastatic suppressor gene (MSG) KiSS1 in breast cancer remains unclear. Our goal was to investigate the possible clinical significance of KiSS1 breast cancer. Materials and Methods: The study was conducted on 87 histologically proven cases of breast cancer and background normal tiisue. Quantitative reverse transcriptase polymerase chain reaction (qRT PCR) and immunohistochemistry (IHC) were used to investigate KiSS1 at gene and protein levels, respectively, for correlation with several patient characteristics including age, family history, hormonal receptor status, stage, tumor size, nodal involvement and metastatic manifestation and finally with median overall survival (OS). Results: Our study revealed (i) KiSS1 levels were generally elevated in breast cancer vs normal tissue (P < 0.05). (ii) however, a statistically significant lower expression of KiSS1 was observed in metastatic vs non metastatic cases (P = 0.04). (iii) KiSS1 levels strongly correlated with T,N,M category, histological grade and advanced stage (p<0.001) but not other studied parameters. (iv) Lastly, a significant correlation between expression of KiSS1 and median OS was found (P = 0.04). Conclusions: Conclusively, less elevated KiSS1 expression is a negative prognostic factor for OS, advancing tumor stage, axillary lymph node status, metastatic propensity and advancing grade of the breast cancer patient. Patients with negative KiSS1 expression may require a more intensive therapeutic strategy.

• Korean Journal of Animal Reproduction
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• v.22 no.1
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• pp.61-66
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• 1998

In vitro contractile response of the uterus in the pregnant rat to oxytocin increases with advancing gestation. This increase coincides with an increase in uterine oxytocin receptor number. However, in vitro the change in uterine contractile response of the pregnant uterus to oxytocin with advancing gestation is not clear. The purpose of the present study was to find out that the uterine response in vitro to oxytocin changes as delivery a, pp.oaches. Secondly, to determine if the incubation of uterine tissue in vitro altered the uterine oxytocin receptor number and affinity and thus explain the ambiguity between the in vitro and in vitro results. The studies were performed on rats at days 15, 20 and 21 or pregnancy. In vitro the uterine contractile response to oxytocin was sgreater (P<0.05) at day 21 compared to days 15 and 20 (Emax : 724.8　88.9, 130.0　81.5 and 133.4　53.4, respectively). This correlated with a significant increase (P<0.05) in uterine oxytocin receptor number at day 21 (days 21, 15 and 20 : 540　89, 53　24, 89　35 fmoles/mg protein, respectively). However, the kids at days 15, 20 and 21 did not differ (P>0.05). Finally no difference (P>0.05) in oxytocin receptor number or affinity was detected between incubated and non-incubated tissue. The results of these studies suggest that either pre-oxytocin or post-oxytocin receptor factors are important in determining the uterine myometrial responsiveness to oxytocin.

• Journal of the Korean Society of Industry Convergence
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• v.17 no.4
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• pp.234-244
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• 2014

Recently it has been focused that the automobile engine has developed in a strong upward tendency for the use of the high viscosity and poorer quality fuels in achieving the high performance, fuel economy, and emission reduction. Therefore it is not easy to solve the problems between low specific fuel consumption and exhaust emission control at motor cars. In this study, it is designed and used the engine test bed which is installed with turbocharger and intercooler. In addition to equipped using CRDI by controlling injection timing with mapping modulator, it has been tested and analyzed the engine performance, combustion characteristics, and exhaust emission as operating parameters, and they were engine speeds(rpm), injection timing(bTDC), and engine load(%). From the result of an experimental analysis, peak cylinder pressure and the rate of pressure rise were increased, and the location of it was closer toward top dead center according to the increasing of engine speed and load, and with advancing injection timing. The combustion characteristics are effected by fuel injection timing due to be enhanced the mass burned fraction. Using the engine dynamometer for analyzing the engine performance, the engine torque and power have been enhanced according to advancing the fuel injection timing. In analyzing of exhaust emission, there has been a trade-off between PM and NOx with increasing of engine speed and load, and with advanced injection timing. The experimental data are shown that the formation of NOx has increased and PM, vice versa.

• Journal of Intelligence and Information Systems
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• v.19 no.4
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• pp.11-20
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• 2013

In designing Intelligent Traffic Systems, it should be necessary to consider telecommunications, appearance, environment, auxiliary functions, safety, and so on. Also, in choosing a car, a consumer considers those properties. This paper tried to elucidate the fact that car color has a very significant meaning for car safety when administrating intelligent traffic services and making car-purchasing decision. We first studied on occurrence probability of car accident according to car color that has something to do with car safety. Then, we studied on the concepts of advancing color and receding color. Advancing color causes less accidents since the color looks closer than it actually is. And receding color causes more accidents since the color looks farther than it actually is. And we classified car colors into eight classes and assign their ranking to each class, considering the number of car accidents. We tried to verify our research by use of telephone questionnaire for residents in Kunsan, Republic of Korea.

• Journal of Ship and Ocean Technology
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• v.12 no.1
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• pp.16-27
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• 2008

The interaction between advancing ships and the waves generated by them plays important roles in wave resistances and ship motions. Wave breaking phenomena near the ship bow at different speeds are investigated both numerically and experimentally. Numerical simulations of free surface profiles near the fore bodies of ships are performed and visualized to grasp the general trend or the mechanism of wave breaking phenomena from moderate waves rather than concentrating on local chaotic irregularities as ship speeds increase. Navier-Stokes equations are differentiated based on the finite difference method. The Marker and Cell (MAC) Method and Marker-Density Method are employed, and they are compared for the description of free surface conditions associated with the governing equations. Extra effort has been directed toward the realization of extremely complex free surface conditions at wave breaking. For this purpose, the air-water interface is treated with marker density, which is used for two layer flows of fluids with different properties. Adaptation schemes and refinement of the numerical grid system are also used at local complex flows to improve the accuracy of the solutions. In addition to numerical simulations, various model tests are performed in a ship model towing tank. The results are compared with numerical calculations for verification and for realizing better, more efficient research performance. It is expected that the present research results regarding wave breaking and the geometry of the fore body of ship will facilitate better hull form design productivity at the preliminary ship design stage, especially in the case of small and fast ship design. Also, the obtained knowledge on the impact due to the interaction of breaking waves and an advancing hull surface is expected to be applicable to investigation of the ship bow slamming problem as a specific application.

• Journal of Navigation and Port Research
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• v.27 no.4
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• pp.431-436
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• 2003

It's about time we had to think an alternative to recover out insufficient fishery market caused by IMF locally as well as the fishery agreement on Japan and China. The Ministry of Maritime Affairs ＆ Fisheries have planning the advancing fishery information integrated system for the fishing present condition, marine resource administration and applicability consideration. The fishery information communication system is build up to the raw data ＆ process-network-content. The communication system must be small size, low cost and adapted SSB transceiver, that is using fishery shipping. In this paper We present digital data communication network to exchange information for fishery and safety between fishing ship and coast station in cheeper communication fee using SSB(single Side Band) in HF(High Frequency) band.

• Journal of The Korean Society of Grassland and Forage Science
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• v.4 no.2
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• pp.108-114
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• 1983

This study was conducted to investigate the effects of existing vegetation on seedling establishment and herbage production of oversown grasses in the Pinus rigida forest. The dominant existing vegetations were Miscanthus sinensis, Festuca ovina, and Lycopodium serratum. In establishment year, seedling stands and herbage production were not affected in Miscanthus sinensis and Festuca ovina, while in Lycopodium serratum it was affected relatively seriously. The pattern of sown species response to the existing vegetations was trend to toward simplified two or three species as Dactylis glomerata, Lolium perenne, and Trifolium repens to advancing the time. Among sown species, Dactylis glomerata was a major dominant species in all existing vegetation area. The content of sown pasture grasses in the sward increased markedly, while the existing vegetations before seeding seriously decreased to advancing the cutting time. The above results shown that the improvement of forest pasture with a surface seeding was better in Miscanthus sinensis and Festuca ovina, but in Lycopodium serratum was found very difficult to improvement of pasture without surface treatment, also establishment method must favor the low herbage production potential.

• Journal of the Society of Naval Architects of Korea
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• v.38 no.3
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• pp.47-53
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• 2001

When a ship advancing in waves is subjected to impact forces or irregular forces, the motion analyses for ship are convenient for being calculated in the time domain. The added mass, wave damping coefficients, wave exciting forces and mean drift forces are calculated by 3-Dimensional panel method used the translating pulsating Green function in the frequency domain and the motion equations which are considered by the memory effect due to waves are numerically solved by using the Newmark-$\beta$ method in the time domain. The motion analyses are carried out for a Series 60($C_B=0.7$) moving in irregular waves. The items of calculation are 6-degree motions, accelerations at the fore and after position, numbers of deck wetness and numbers of exposure at ship-bottom, etc. Moreover, the thrust addition in waves is examined by considering the time mean drift forces in the motion equations of time domain.

• Journal of Preventive Medicine and Public Health
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• v.54 no.5
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• pp.330-339
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• 2021

Objectives: Tobacco control in Indonesia is very lenient compared to international standards. This study explored the perspectives of tobacco control stakeholders (TCSs) on the likelihood of advancing tobacco marketing regulation in Indonesia. Methods: Data were collected from TCSs who were members of the Indonesia Tobacco Control Network group in a modified Delphi study. We collected the data in 2 waves using a questionnaire that comprised a set of closed and open-ended questions. For this paper, we analysed 2 of the 3 sections of the questionnaire: (1) tobacco advertising, promotions, and sponsorship (TAPS) bans, and (2) marketing and retailing regulations. We conducted a descriptive analysis of the scores using Stata/IC.13 and summarised the comments for each item. Results: The TCSs viewed the measures/strategies across all aspects of TAPS and tobacco marketing regulation as highly desirable, but provided varied responses on their feasibility. They rated political feasibility lower than technical feasibility for most measures. Advancing TAPS measures and prohibition of selling to minors were considered more attainable by sub-national governments, while prohibition of tobacco corporate social responsibility was considered as the least feasible measure in the next 5 years. Conclusions: Despite little optimism for substantial national-level change, there is a positive expectation that sub-national governments will strengthen their tobacco control regulation. It is paramount that the government reduce tobacco industry leverage by implementing Article 5.3 of the World Health Organization Framework Convention on Tobacco Control. Extending advocacy networks beyond tobacco control groups and framing tobacco control more effectively are necessary steps.

• Animal Bioscience
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• v.36 no.11
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• pp.1647-1654
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• 2023

Objective: Aging roosters typically exhibit subfertility with decreasing semen quality, furthermore Thai native roosters reared in rural areas are raised for a longer duration than their usual lifespan. The present study therefore aimed to assess the effect of selenium supplementation as an antioxidative substance in diets to improve the semen cryopreservation of aged roosters. Methods: Semen samples were collected from young (n = 20) and aged (n = 20) Thai native roosters (Pradu Hang Dum) at 36 and 105 weeks of age when starting the experiment, respectively. They were fed diets either non-supplemented or supplemented with selenium (0.75 ppm). Fresh semen quality and lipid peroxidation of fresh semen was evaluated before cryopreservation using the traditional liquid nitrogen vapor method. Post-thaw sperm quality and fertility potential were determined. Results: Advancing age is unrelated to decreasing fresh semen quality (p>0.05). However, lipid peroxidation in rooster semen depended on age, and the malondialdehyde (MDA) concentration increased in aged roosters (p<0.05). Selenium supplementation in diets significantly decreased the MDA concentration and increased the sperm concentration (p<0.05). In contrast, cryopreserved semen was affected by advancing rooster age, and selenium influenced sperm quality (p<0.05). Younger roosters had higher post-thaw sperm quality and fertility potential than aged roosters (p<0.05). Likewise, diet selenium supplements improved post-thaw sperm quality and fertility compared with the non-supplement group. Conclusion: Rooster's age does not influence the rooster sperm quality of fresh semen, while sperm cryotolerance and fertility were greater in young roosters than in aged roosters. However, sperm of aged roosters could be improved by dietary selenium supplementation.