• 한국패류학회지
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• 제2권1호
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• pp.10-12
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• 1986

Pettancylus nipponicus (freshwater limpet) collected from the Lake Choon Cheon were cultrued in aquarium and studied in the respects of an egg deposition and the developmental characters of cleavage. The species were collected only in the Lake Uiam and Choon Cheon and easily sampled on the debris like vinyls and cans. Those smooth surfaces were suitalble substrata for attaching. P. nipponicus, about 4 mm in adult, deposited an egg in one calcareous egg-capsule on the aquarium walls, while many eggs are surrounded in a jelly-like egg-envelope in the most gastropods. And another special features was that an egg-capsule was consisted of two valves and the suture was opended as hatching. A diameter of its egg was $55{{\mu}m}$ and the length of an egg capsule was $620{{\mu}m}$ and $510{{\mu}m}$ in long and short diameter, respectively. It took about 8 hours from beginning cleavage to 16-cell stage and about one year to become an adult.

• 성인간호학회지
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• 제26권3호
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• pp.287-299
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• 2014

Purpose: The aim of this study was to investigate the factors contributing to health-related quality of life (HRQOL) among patients with chronic hepatitis B (CHB). Methods: A cross-sectional, descriptive design was used. The sample included 114 patients in a gastroenterology outpatient department at one hospital located in G city. Data were collected using a structured questionnaire from June to December 2009. The collected data were analyzed using SPSS/WIN 15.0. Results: Health-related quality of life was most strongly related to age, sex, income, occupation, and the care provider. Old age, female gender, lower income, not having an occupation and having a non-medical person were associated with lower HRQOL ($R^2$=.03~.22, p=.041~<.001). Conclusion: CHB infection had a negative impact on HRQOL among the older, female gender, low socioeconomic status and not having medically knowledgeable care givers. Interventions beyond nursing care may be needed to improve the quality of health for patients with Chronic Hepatitis B.

• 성인간호학회지
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• 제27권3호
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• pp.337-346
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• 2015

Purpose: This study was to develop and test the resilience scale for Korean nursing college students. Methods: The initial 82 items (7 factors) were developed through literature review and student interviews. Items were reduced to 55 items through content validity test by 5 experts and face validity tests by 20 nursing students. The preliminary Resilience Scale for Korean Nursing Students (RS_KNS) was administered to 302 nursing students of 4 universities in Chungnam. Data were analyzed using item analysis, factor analysis, Pearson correlation coefficients, and Cronbach's ${\alpha}$. Results: Twenty-four items were selected for the final scale. Seven factors evolved from the factor analysis, which explained 61.9% of the total variance. The internal consistency, Cronbach's ${\alpha}$ was .84 and reliability of the subscales ranged from .60 to .77. Conclusion: The resilience scale for Korean nursing college students demonstrated acceptable validity and reliability. It can be used to assess the resilience of nursing college students and is expected to get utilized in teaching and research.

• 성인간호학회지
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• 제22권1호
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• pp.70-79
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• 2010

Purpose: This study was conducted to develop a Web-based learning program on cardiopulmonary emergency care for clinical nurses and to evaluate learners' responses. Methods: Based on the assessment of learning needs of clinical nurses, a total of three self-directed learning modules were developed according to the procedure of the ADDIE (assessment, design, development, implementation, & evaluation) model. Results: Each learning module included the emergency treatments and drugs used in the real patients' situations with cardiopulmonary crisis, which had been adopted from the emergency department of a C University hospital located in G-city. Real video clips for endotracheal intubation and ACLS (advanced cardiac life support) were developed with the help of the staff of the department of emergency medicine using a human simulator, $SimMan^{(R)}$. The program published on the Web was evaluated by 20 clinical nurses who are working in the emergency department and wards of a C-University hospital. About 80% of the respondents were satisfied with the program contents, design, and learning strategy. Conclusions: Web-based learning programs on cardiopulmonary emergency care are needed for clinical nurses as educational material for staff education to increase their knowledge for making immediate clinical decisions and in giving skilled care in emergency situations.

• Journal of Biosystems Engineering
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• 제29권6호
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• pp.531-538
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• 2004

This study examined the muscle fatigue of the erector spinae according to box size during lifting activity. Ten healthy adult man participated in the experiment for lifting the boxes 10 times with 0.2 lift/s frequency. Bilateral surface EMG (Electomyogtamphy) recordings were made regarding M. (Muscle) Longissimus, M. Iliocostal and M, Multifidus activity throughout lifting working. The median frequency in back muscle fatigue was investigated using power spectral analysis of surface EMG. When the box larger than shoulder width was lifted, the muscle fatigue of M, Multifidus was shown larger than one of the other muscles. Accordingly, the result far M. Multifidus can be applied in optimizing design parameter of box. Also, the standard of box width for box makers have to be below about 420 mm, being average shoulder width of adult male.

• Parasites, Hosts and Diseases
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• 제53권5호
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• pp.627-639
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• 2015

Metagonimus yokogawai (Katsurada, 1912) Katsurada, 1912 (Trematoda: Heterophyidae) is parasitic in the small intestine of mammals including man and birds in Far Eastern Russia, Korea, Japan, China, and Taiwan. In the present study, the metacercariae and adults of M. yokogawai were redescribed to designate a neotype of this fluke together with reviews of previous studies including study histories from the first discovery to now. We particularly, attempted to review the study histories and morphological descriptions of M. yokogawai for the species validity, and compared with the morphological characteristics and life cycles of the closely related species, Metagonimus takahashii and Metagonimus miyatai. Finally, we proposed a differential key for the 8 known Metagonimus species distributed in East Asia. Metacercariae were obtained from the body muscles of sweetfish (Plecoglossus altivelis) collected in the Asahi River at Takebe-cho, Kita-ku, Okayama City, Okayama Prefecture, Japan. Adults were recovered from the small intestine of Syrian golden hamsters, to which the metacercariae had been fed 14 days before. A neotype was selected out of the present adult specimens. The Asahi River at Takebo-cho became the type locality of M. yokogawai. In conclusion, the present review shows that M. yokogawai, M. takahashii, and M. miyatai are valid and discriminated by means of morphological characteristics.

• 대한후두음성언어의학회지
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• 제32권2호
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• pp.104-108
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• 2021

The etiology of laryngeal hemangioma is unclear, and it is classified into infant and adult types. The former is capillary hemangioma and relatively common, the latter is cavernous type and very rare. The adult laryngeal hemangioma mainly occurs in supraglottis and glottis. A 75-year-old man came to our clinic with a voice change that started four months ago. The laryngoscopic finding showed that the surface of oval-shaped mass is covered with turbid exudates. We performed the laryngeal microsurgery with CO₂ laser. The mass was pathologically proven as cavernous hemangioma. We report a very rare and didactic case with review of relevant literature.

• Biomolecules & Therapeutics
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• 제25권6호
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• pp.648-658
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• 2017

7-O-Succinyl macrolactin A (SMA) exerts several pharmacological effects including anti-bacterial, anti-inflammation, and anti-cancer activities. Recently, SMA has been extensively evaluated as an anti-cancer drug. Thus, the objectives of the present study were to characterise the pharmacokinetics of SMA via both non-compartmental and compartmental analysis in mice, rats, and dogs, and to derive an appropriate first-in-man dose based on allometric scaling of the animal data. The time courses of plasma SMA concentrations after intravenous administration to rats and dogs were analysed retrospectively, as were data collected after intraperitoneal SMA injection in mice. Pharmacokinetic parameters were estimated via both noncompartmental and compartmental analysis, and were correlated with body weight and/or the potential maximum life-span. The clearance and distribution volume of SMA in humans were predicted, and a first-in-man dose proposed. A two-compartment model best described the time courses of SMA plasma concentrations after a saturation elimination process was applied to fit the dataset obtained from rats. Incorporation of the maximum potential life-span during allometric scaling was required to improve the estimation of human clearance. The SMA clearance and the distribution volume in the steady state, in a 70-kg adult male, were estimated to be 30.6 L/h and 19.5 L, respectively. To meet the area under the curve (AUC) required for anti-tumour activity, a dose of 100 mg (~1.5 mg/kg) was finally proposed as the first dose for a 70-kg human. Although toxicological profiles derived from non-clinical studies must be considered before any final decision is made, our work will facilitate clinical studies on SMA.

• Parasites, Hosts and Diseases
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• 제44권1호
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• pp.7-13
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• 2006

Heterophyid metacercarial infections in brackish water fishes, i.e., perch, shad, mullet, redlip mullet, and goby, of Jinju-man (Bay), Kyongsangnam-do, Korea, were investigated using a digestion technique. Among 45 perch (Lateolabrax japonicus), the metacercariae of Heterophyopsis continua were found in $55.6\%$ (18.5 metacercariae per fish), Stictodora spp. in $28.9\%$ (3.6), and Metagonimus takahashii in $6.7\%$ (17.0). The metacercariae of H. continua were detected in 23 $(65.7\%)$ of 35 shad (Konosirus punctatus). Among 15 mullet (Mugil cephalus), the metacercariae of Pygidiopsis summa were found in $100\%$ (105.9 metacercariae per fish), Heterophyes nocens in $40.0\%$ (8.5), H. continua in $13.3\%$, and Stictodora spp. in $6.7\%$. Among 12 redlip mullet (Chelon haematocheilus), the metacercariae of P. summa were detected in $91.7\%$ (1,299 metacercariae per fish), H. nocens in $16.7\%$, and Stictodora spp. in $16.7\%$. Among 35 gobies (Acanthogobius flavimanus), the metacercariae of Stictodora spp. were found in $82.9\%$ (44.5 metacercariae per fish), and H. continua in $25.7\%$ (2.8). The adult flukes recovered from a cat experimentally infected with metacercariae from perches were compatible with M. takarashii. The results confirm that the estuarine fish in Jinju-man (Bay) are heavily infected with heterophyid metacercariae. Furthermore, it was found for the first time that the perch acts as a second intermediate host for M. takahashii.

• Parasites, Hosts and Diseases
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• 제51권5호
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• pp.551-555
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• 2013

Complicated malaria is mainly caused by Plasmodium falciparum, but, increasingly, Plasmodium vivax is also being reported as a cause. Since the reemergence of indigenous vivax malaria in 1993, cases of severe malaria have been steadily reported in Korea. Herein, we report a case of vivax malaria complicated by adult respiratory distress syndrome (ARDS) that was successfully managed with extracorporeal membrane oxygenation (ECMO). A 59-year-old man presented at our hospital with fever and abdominal pain, which had persisted for 10 days. On admission, the patient had impaired consciousness, shock, hypoxia and haziness in both lungs, jaundice, thrombocytopenia and disseminated intravascular coagulation, metabolic acidosis, and acute kidney injury. A peripheral blood smear and a rapid diagnostic test verified P. vivax mono-infection. Ten hours after admission, hypoxia became more severe, despite providing maximal ventilatory support. The administration of antimalarial agents, ECMO, and continuous venovenous hemofiltration resulted in an improvement of his vital signs and laboratory findings. He was discharged from the hospital 7 weeks later, without any sequelae.