• Biomolecules & Therapeutics
• /
• v.21 no.4
• /
• pp.307-312
• /
• 2013

Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.38 no.8
• /
• pp.767-773
• /
• 2010

This paper describes development of a non-explosive separation device which can be equipped on small satellites. The spur geared micro DC motor, which has high reliability and advantage of price, is adopted as an actuator. The proposed separation device has resettability and it does not need extra jig to reload. In addition, the simple structure makes it easy to fabricate and assemble. To verify the performance of the proposed device, the response time tests, maximum preload tests and maximum shock level tests were performed. Also, through the vibration tests and thermal vacuum tests, feasibility of the proposed separation device was shown in launching and space environments. Therefore, we expect that the proposed separation device can replace the imported separation devices in near future.

• Journal of the Korean Geotechnical Society
• /
• v.20 no.9
• /
• pp.91-103
• /
• 2004

A series of shaking table model tests were performed to verify the validity of similitude law, which is suggested by lai (1989) to simulate the dynamic behavior of soil-fluid-structure system for is shaking table tests. In the tests, the similitude law suggested by lai was applied to determine the length and the time scaling factors. Also, the steady state concept was used in determining the density of model backfill soil, which is a key factor in simulating the development of excess pore pressure during shaking. The similitude law was verified by checking whether three different sizes of quay walls show the identical behavior or not. The similar responses of acceleration, excess pore pressure and horizontal displacement of walls were obtained far the small and large models. However, the medium model showed larger responses than those of the small and large models because of the resonance between the frequency of input acceleration and the natural frequency of the wall system. In addition, the vertical displacement and rotational angle of the walls became larger with the increase of model size.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2008.10a
• /
• pp.1559-1570
• /
• 2008

A new grouting material named 3S is developed that can be used effectively for reinforcing cut surface of weathered rock in processing of tunneling. The new material is composed of mostly micro slag cement and general Portland cement, but the material is foundered again upto $8,000\;cm^2/g$ of specific area so that it can be easily infiltrated in to the ground. For verifying technical and engineering quality of the material several laboratory tests with specially designed test apparatus were performed including compression tests, infiltration tests and resonant column tests. It was verified that the newly developed grouting material at early age of 1 or 3 days generates 200~1500% higher compressive strength and 400~560% larger elastic modulus than those of the LW(LW-1) or micro-cement(LW-2) grouting materials in the market. In addition, the new 3S grouting material could be so easily infiltrated into the model ground in the lab tests that it produces 4 times larger grouted roots in average compared to the usual water glass type grouting material(LW-1). Thus, it can be said that the newly developed grouting material can effectively prevent inflow water into tunnel compared to LW grouting materials.

• Journal of Korean Association for Spatial Structures
• /
• v.19 no.2
• /
• pp.63-72
• /
• 2019

Wireless sensors are more favorable in measuring structural response compared to conventional sensors in terms of them being easier to use with no issues with cables and them being considerably cheaper. Previous tests have been conducted to analyze the performance of MEMS (Micro Electro Mechanical Systems) sensor in sinusoidal excitation tests. This paper analyzes the performance of in-built MEMS sensors in devices by comparing with an ICP sensor as the reference. Earthquake input amplitude excitation in shaking table tests was done. Results show that MEMS sensors are more accurate in measuring higher input amplitude measurements which range from 100gal to 250gal than at lower input amplitudes which range from 10gal to 50gal. This confirms the results obtained in previous sinusoidal tests. It was also seen that natural frequency results have lower error values which range from 0% to 3.92% in comparison to the response spectra results. This also confirms that in-built MEMS sensors in mobile devices are good at estimating natural frequency of structures. In addition, it was also seen that earthquake input amplitudes with more frequency contents (Gyeongju) had considerably higher error values than Pohang excitation tests which has less frequency contents.

• Journal of Korea Entertainment Industry Association
• /
• v.15 no.1
• /
• pp.181-189
• /
• 2021

The purpose of this study is to investigate the relationship between "Mental Status and Dementia Tests" and "predictive diagnosis of severity of dementia". This is a descriptive research, analyze the data collected from Alzheimer's patients and identify which "Mental Status and Dementia Tests" has the most impact to determine the severity of dementia. For this study, Alzheimer's patient's CDR, MMSE-K, SGDS, NPI-Q, BADL and IADL were collected and analyzed. This study will provide a predictive factor to determine the severity of dementia when "Mental Status and Dementia Testss" are being used and also to provide the right treatment. For this study, a total of 617 cases of data from Alzheimer's patients were collected and analyzed with SPSS Statistics. In addition, effective "Mental Status and Dementia Tests" for evaluating the severity of dementia were CDR, ADL, MMSE-K, and SGDS whereas NPI-Q and IADL. Based on the findings of the study, it was recommended to implement more efficient diagnostic method by utilizing a standardized "Mental Status and Dementia Tests".

• Corrosion Science and Technology
• /
• v.4 no.4
• /
• pp.121-129
• /
• 2005

Basic design concept of the future steel structure requires environmental compatibility and maintenance free capability to minimize economic burdens. Recent trends in alloy design for advanced weathering steel include addition of various alloying elements which can enhance formation of stable and protective rust layer even in polluted urban and/or high $Cl^{-}$ environment. The effects of Ca, Ni, W, and Mo addition on the corrosion property of Ca-modified weathering steel were evaluated through a series of electrochemical tests (pH measurement and electrochemical impedance spectroscopy: EIS) and structural analysis on rust layer formed on the steel surface. Ca-containing inclusions of Ca-Al-Mn-O-S compound are formed if the amount of Ca addition is over 25 ppm. Steels with higher Ca content results in higher pH value for condensed water film formed on the steel surface, however, addition of Ni, W, and Mo does not affect pH value of the thin water film. The steels containing a high amount of Ca, Ni, W and Mo showed a dense and compact rust layer with enhanced amount of ${\alpha}-FeOOH$. Addition of Ni, W and Mo in Ca-modified weathering steel shows anion-selectivity and contributes to lower the permeability of $Cl^{-}$ ions. Effect of each alloying element on the formation of protective rust layer will be discussed in detail with respect to corrosion resistance.

• Journal of the Korean Society of Food Culture
• /
• v.27 no.6
• /
• pp.737-742
• /
• 2012

This study examined the quality characteristics of Gondre tofu containing 0, 0.1, 0.2, and 0.3% Cirsium setidens powder. Quality and sensory tests of Gondre tofu were performed. The yield rate of tofu decreased with the addition of Cirsium setidens powder. The pH of tofu decreased after the addition of Cirsium setidens powder. During 8 days storage, the addition of Cirsium setidens powder to tofu did not effectively inhibit the number of total aerobic bacteria. The L, a and b values of tofu decreased with increasing amount of Cirsium setidens powder added. In the texture properties, the hardness, cohesiveness, gumminess and brittleness increased, whereas the springiness decreased. The results of sensory evaluation showed that tofu containing 0, 0.1, and 0.2% Cirsium setidens powder had a higher taste, texture preference and overall acceptability than 0.3% Cirsium setidens powder. Therefore, the addition up to 0.2% Cirsium setidens powder positively affects the sensory evaluation of Gondre tofu. The addition 0.2% Cirsium setidens powder might be considered the most appropriate choice for manufacturing Gondre tofu.

• Journal of the Korean institute of surface engineering
• /
• v.36 no.6
• /
• pp.480-490
• /
• 2003

Effects of plasma-nitriding on the pitting corrosion of Fe-30at%Al-5at%Cr alloy containing Ti, Hf, and Zr were investigated using potentiostat in 0.1M HCl. The specimen was casted by the vacuum arc melting. The subsequent homogenization was carried out in Ar gas atmosphere at $1000^{\circ}C$ for 7days and phase stabilizing heat treatment was carried out in Ar gas atmosphere at $500^{\circ}C$ for 5 days. The specimen was nitrided in the $N_2$, and $H_2$, (1:1) mixed gas of $10^{-4}$ torr at $480^{\circ}C$ for 10 hrs. After the corrosion tests, the surface of the tested specimens were observed by the optical microscopy and scanning electron microscopy(SEM). For Fe-30at%Al-5Cr alloy, the addition of Hf has equi-axied structure and addition of Zr showed dendritic structure. For Fe-30at%Al-5Cr alloy containing Ti, plasma nitriding proved beneficial to decrease the pitting corrosion attack by increasing pitting potential due to formation of TiN film. Addition of Hf and Zr resulted in a higher activation current density and also a lower pitting potential. These results indicated the role of dendritic structure in decreasing the pitting corrosion resistance of Fe-30Al-5Cr alloy. Ti addition to Fe-30Al-5Cr decreased the number and size of pits. In the case of Zr and Hf addition, the pits nucleated remarkably at dendritic branches.

• Advances in concrete construction
• /
• v.11 no.3
• /
• pp.261-270
• /
• 2021

In this study, a new understanding is presented on the microcracking behavior of high strength concrete (HSC) with steel fiber addition having prior compressive loading history. Microcracking behavior at critical stress (σcr) region, using seven fiber addition volume of 0.5, 0.75, 1.0, 1.25, 1.5, 1.75, and 2.0% was evaluated, at two aspect ratios (60 and 75). The specimens were loaded up to a specified compressive stress levels (0.70fc-0.96fc), and subsequently subjected to split tensile tests. This was followed by microscopic analyses afterwards. Four compressive stress levels as percentage of fc were selected according to the linearity end point based on stress-time (σ-t) diagram under uniaxial compression. It was seen that pre-compression has an effect on the linearity end point as well as fiber addition where it lies within 85-91% of fc. Tensile strength gain was observed in some cases with respect to the 'maiden' tensile strength as oppose to tensile strength loss due to the fiber addition with teething effect. Aggregate cracking was the dominant failure mode instead of bond cracks due to improved matrix quality. The presence of the steel fiber improved the extensive failure pattern of cracks where it changes from 'macrocracks' to a branched network of microcracks especially at higher fiber dosages. The applied pre-compression resulted in hardening effect, but the cracking process is similar to that in concrete without fiber addition.