• The Korean Journal of Physiology and Pharmacology
• /
• v.21 no.6
• /
• pp.667-674
• /
• 2017

Angiotensin II (Ang II) is metabolized from N-terminal by aminopeptidases and from C-terminal by Ang converting enzyme (ACE) to generate several truncated angiotensin peptides (Angs). The truncated Angs have different biological effects but it remains unknown whether Ang-(4-8) is an active peptide. The present study was to investigate the effects of Ang-(4-8) on hemodynamics and atrial natriuretic peptide (ANP) secretion using isolated beating rat atria. Atrial stretch caused increases in atrial contractility by 60% and in ANP secretion by 70%. Ang-(4-8) (0.01, 0.1, and $1{\mu}M$) suppressed high stretch-induced ANP secretion in a dose-dependent manner. Ang-(4-8) ($0.1{\mu}M$)-induced suppression of ANP secretion was attenuated by the pretreatment with an antagonist of Ang type 1 receptor ($AT_1R$) but not by an antagonist of $AT_2R$ or $AT_4R$. Ang-(4-8)-induced suppression of ANP secretion was attenuated by the pretreatment with inhibitor of phospholipase (PLC), inositol triphosphate ($IP_3$) receptor, or nonspecific protein kinase C (PKC). The potency of Ang-(4-8) to inhibit ANP secretion was similar to Ang II. However, Ang-(4-8) $10{\mu}M$ caused an increased mean arterial pressure which was similar to that by 1 nM Ang II. Therefore, we suggest that Ang-(4-8) suppresses high stretch-induced ANP secretion through the $AT_1R$ and $PLC/IP_3/PKC$ pathway. Ang-(4-8) is a biologically active peptide which functions as an inhibition mechanism of ANP secretion and an increment of blood pressure.

• Journal of Industrial Convergence
• /
• v.21 no.7
• /
• pp.83-92
• /
• 2023

The bullet shape of the plasma jet using the atmospheric-pressure dielectric barrier discharge method changes depending on the applied fluid rate and the intensity of the electric field. This changes appear as a difference in spectral distribution due to a difference in density of the DBD plasma jet. It is an important factor in utilizing the plasma device that difference between the occurrence of active species and the intensity through the analysis of the spectrum of the generated plasma jet. In this paper, a plasma jet generator of the atmospheric pressure volume DBD method using Ar gas was make a prototype in accordance with the proposed design method. The characteristics jet fluid rate analysis of Ar gas was accomplished through simulation to determine the dependence of flow rate for the generation of plasma jets, and the characteristics of plasma jets using spectrometers were analyzed in the prototype system to generate optimal plasma jet bullet shapes through MFC flow control. Through the design method of the proposed system, the method of establishing the optimal plasma jet characteristics in the device and the results of active species on the EOS were verified.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.26 no.2
• /
• pp.195-202
• /
• 2016

In this study, a concept of active sound enrichment (ASE) control system was implemented and demonstrated for improving engine sound quality inside the cabin of a passenger car during acceleration. Unlike the active noise control cancels the noise for disturbance rejection, the ASE adds additional sound to the noise for tracking control. This approach requires a new algorithm to provide additional artificial sound to the original engine sound using active control strategy to achieve a target sound profile, which is predefined to satisfy required interior sound quality. The ASE algorithm was implemented in a digital controller dSPACE DS1401 and real-time control experiment was accomplished in an actual car. The ASE control results show that the actively enriched sound of each engine order against RPM tracks the target profiles precisely and quickly and improves the discontinuity, the level ratios and the sound pressure level of each engine order. Thus it is anticipated the ASE system can be applied for the improvement of the engine sound quality inside the cabin during acceleration.

• Smart Structures and Systems
• /
• v.20 no.3
• /
• pp.273-283
• /
• 2017

This paper presents and compares three feedback control strategies for active control of noise inside a 3-D vibro-acoustic cavity. These are a) control strategy based on direct output feedback (DOFB) b) control strategy based on linear quadratic regulator (LQR) to reduce structural vibrations and c) LQR control strategy with a weighting scheme based on structural-acoustic coupling coefficients. The first two strategies are indirect control strategies in which noise reduction is achieved through active vibration control (AVC), termed as AVC-DOFB and AVC-LQR respectively. The third direct strategy is based on active structural-acoustic control (ASAC). This strategy is an LQR based optimal control strategy in which the coupling between the various structural and the acoustic modes is used to design the controller. The strategy is termed as ASAC-LQR. A numerical model of a 3-D rectangular box cavity with a flexible plate (glued with piezoelectric patches) and with other five surfaces treated rigid is developed using finite element (FE) method. A single pair of collocated piezoelectric patches is used for sensing the vibrations and applying control forces on the structure. A comparison of frequency response function (FRF) of structural nodal acceleration, acoustic nodal pressure, and piezoelectric actuation voltage is carried out. It is found that the AVC-DOFB control strategy gives equal importance to all the modes. The AVC-LQR control strategy tries to consume the control effort to damp all the structural modes. It is seen that the ASAC-LQR control strategy utilizes the control effort more intelligently by adding higher damping to those structural modes that matter more for reducing the interior noise.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.16 no.12
• /
• pp.8140-8146
• /
• 2015

The objective of this study is to experimentally investigate the cooling performance characteristics with the consideration of the temperature variations of the enclosure of the 400W ferrofluid active speaker having both woofer and amplifier heat sinks. In order to do this, the heat sinks for both woofer and amplifier was designed ant applied to 400W ferrofluid active speaker. As a result, the cooling performance of the developed 400W ferrofluid active speaker was improved and the temperature of the enclosure after 120 min at steady state increased by $2.8^{\circ}C$ with the increase of the outdoor temperatures from $25^{\circ}C$ to $29^{\circ}C$. In addition, the overall sound pressure level of the developed 400W ferrofluid active speaker showed 111.8 dB and improved 1.9 dB higher than 109.9 dB of the existed speaker.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.46 no.8
• /
• pp.687-693
• /
• 2018

In this paper, we studied on the thermal design of the active antenna system for stable performance considering thermal reliability. The active antenna has high performance and heat flux elements in T/R modules. Thermal heating of elements in T/R modules has to be dissipated effectively and the antenna has to be operated over the range of suggested temperature by the thermal design. T/R modules of high heat flux in the active antenna can be dissipated effectively by liquid cooling. In this study, we studied on the thermal design including the liquid cooling system to optimize the thermal performance of the active antenna. And the thermal design was verified by numerical analysis.

• International Journal of Highway Engineering
• /
• v.15 no.4
• /
• pp.95-105
• /
• 2013

PURPOSES: The purpose of this study is to research the influence of road traffic noise by road slope through the analysis of the field road traffic noise and determine consideration of road slope in the case of appling active noise cancellation. METHODS: This study measures vehicle's noise by the NCPX method at the three field sections such as uphill, downhill, and flatland. Total sound pressure and sound pressure level by the 1/3 octave band frequency are calculated through the raw field data. Total sound pressure level is compared by ANOVA test and T test statistically. The results obtained are compared in accordance with the road slope and the progress of the uphill section. RESULTS : The noise characteristic of early, medium, and last parts of uphill was found to be consistent when the vehicle was travelling uphill section. The result of statistical test, it was shown that total sound pressures are not different each other. According to the comparison by the geometry, sound pressure of the uphill section was higher than those of the flatland and downhill section in high frequency band. By the result of statistical test, total sound pressure are different according to geometry in the case of high vehicle speed. In the comparison result by road slope, each sound pressure level was found to be consistent in total frequency. However, total sound pressure proportionally increased according to road slope. CONCLUSIONS: It is found that the effect of road slope on noise generation was little in this experimental sites.

• Journal of Energy Engineering
• /
• v.26 no.3
• /
• pp.71-77
• /
• 2017

In the event of loss of coolant accident (LOCA) and station black out (SBO) in the primary system of a nuclear reactor, the coolant water should be injected to reactor coolant system (RCS) without any intervention of operators or active components. To satisfy the requirements, hybrid safety injection tank (Hybrid SIT) was suggested by Korea Atomic Energy Research Institute (KAERI). The pressure equalizing time of Hybrid SIT is an important parameter to determine the timing of coolant injection. To predict the pressure equalizing time of the Hybrid SIT, a separate effect test facility was constructed and sensitivity tests were conducted in various conditions. The main parameter determining the pressure equalizing time was obtained from separate effect test (SET) results. The wall of condensation on the inner wall of SIT and direct contact condensation on the water surface affected to the pressure equalizing time very much. In this study, the effect of each condensation phenomena on pressure equalizing time was quantitatively analyzed from results of SET and a prediction method of pressure equalizing time was proposed.

• Journal of the Society of Naval Architects of Korea
• /
• v.56 no.2
• /
• pp.175-186
• /
• 2019

Number of studies on the buckling of thin cylindrical pressure vessels, such as submarine pressure hull and pipe with a large ratio of diameter/thickness, have been carried out in the naval and ocean engineering. However, research about thick cylinder pressure vessel has not been active except for the specific application in nuclear area. There are not many papers for the estimation of buckling and ultimate load capacity of thick cylinders for the deep sea usage. Thus, it is important to understand the theoretical bases of the buckling and collapse process and the derivation process of such loads for the proper design and structural analysis. The objective of this study is to survey the collapse behavior, to analyse and clarify the derivation procedure and to estimate the ultimate collapse load for thick cylinder by analyzing relevant books and papers. It is found that the yielding begins at the internal surface of the thick cylinder and plasticity develops from the internal surface to the external surface to generate collapse. Also the initial imperfection of cylinder develops flattening and consequently accelerates buckling and finally ultimate collapse. By comparing the collapse loads of aluminum thick cylinder by applying equations herein, it is shown that the equations analyzed are appropriate to obtain collapse load for thick cylinder.

• Journal of the Korean Geotechnical Society
• /
• v.25 no.1
• /
• pp.21-29
• /
• 2009

On plane strain condition, many researchers have investigated the earth pressure according to the shape of wall, and standardized method has been applied to the design of the retaining wall. But on cylindrical diaphragm wall, at-rest earth pressure has been generally used. Even though this method is on conservative side, it may lead to over-design. In this paper, the application of convergence confinement method to the calculation of the earth pressure acting on the cylindrical diaphragm wall of a shaft was suggested. In addition, a model test was carried out to investigate the distributions of earth pressure. Model test results show that the earth pressures of diaphragm wall are about 1.4 times larger than active earth pressure and about 0.8 times less than at-rest earth pressure.