• Journal of Society of Preventive Korean Medicine
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• v.21 no.2
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• pp.1-13
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• 2017

Objectives : This paper serves to explore current trends of systems biology in Traditional Chinese Medicine (TCM) and examine how it may influence the Traditional Korean medicine. Methods : Literature review method was collectively used to classify Introduction to systems biology, diagnosis and syndrome classification of systems biology in TCM perspective, physiotherapy including acupuncture, herbs and formula functions, TCM systems biology, and directions of academic development. Results : The term 'Systems biology' is coined as a combination of systems science and biology. It is a field of study that tries to understand living organism by establishing a theory based on an ideal model that analyzes and predicts the desired output with understanding of interrelationships and dynamics between variables. Systems biology has an integrated and multi-dimensional nature that observes the interaction among the elements constructing the network. The current state of systems biology in TCM is categorized into 4 parts: diagnosis and syndrome, physical therapy, herbs and formulas and academic development of TCM systems biology and its technology. Diagnosis and syndrome field is focusing on developing TCM into personalized medicine by clarifying Kidney yin deficiency patterns and metabolic differences among five patterns of diabetes and analyzing plasma metabolism and biomarkers of coronary heart disease patients. In the field of physical therapy such as acupuncture and moxibustion, researchers discovered the effect of stimulating acupoint ST40 on gene expression and the effects of acupuncture on treating functional dyspepsia and acute ischemic stroke. Herbs and formulas were analyzed with TCM network pharmacology. The therapeutic mechanisms of Si Wu Tang and its series formulas are explained by identifying potential active substances, targets and mechanism of action, including metabolic pathways of amino acid and fatty acid. For the academic development of TCM systems biology and its technology, it is necessary to integrate massive database, integrate pharmacokinetics and pharmacodynamics, as well as systems biology. It is also essential to establish a platform to maximize herbal treatment through accumulation of research data and diseases-specific, or drug-specific network combined with clinical experiences, and identify functions and roles of molecules in herbs and conduct animal-based studies within TCM frame. So far, few literature reviews exist for systems biology in traditional Korean medicine and they merely re-examine known efficacies of simple substances, herbs and formulas. For the future, it is necessary to identify specific mechanisms of working agents and targets to maximize the effects of traditional medicine modalities. Conclusions : Systems biology is widely accepted and studied in TCM and already advanced into a field known as 'TCM systems biology', which calls for the study of incorporating TCM and systems biology. It is time for traditional Korean medicine to acknowledge the importance of systems biology and present scientific basis of traditional medicine and establish the principles of diagnosis, prevention and treatment of diseases. By doing so, traditional Korean medicine would be innovated and further developed into a personalized medicine.

• Bulletin of the Korean Chemical Society
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• v.31 no.1
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• pp.52-58
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• 2010

Human histamine H1 receptor (HHR1) is a G protein-coupled receptor and a primary target for antiallergic therapy. Here, the ligand-based three-dimensional pharmacophore models were built from a set of known HHR1 inverse agonists using HypoGen module of CATALYST software. All ten generated pharmacophore models consist of five essential features: hydrogen bond acceptor, ring aromatic, positive ionizable and two hydrophobic functions. Best model had a correlation coefficient of 0.854 for training set compounds and it was validated with an external test set with a high correlation value of 0.925. Using this model Maybridge database containing 60,000 compounds was screened for potential leads. A rigorous screening for drug-like compounds unveiled RH01692 and SPB00834, two novel molecules for HHR1 with good CATALYST fit and estimated activity values. The new lead molecules were docked into the active site of constructed HHR1 homology model based on recently crystallized squid rhodopsin as template. Both the hit compounds were found to have critical interactions with Glu177, Phe432 and other important amino acids. The interpretations of this study may effectively be deployed in designing of novel HHR1 inverse agonists.

• Proceedings of the Botanical Society of Korea Conference
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• 2002.04a
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• pp.62-72
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• 2002

This study has investigated the biosynthesis and function of the heavy metal binding peptides, the phytochelatins, in plants. PCs are synthesised enzymatically from glutathione by the enzyme PC synthase in the presence of heavy metal ions. Using Arabidopsis thaliana as a model organism cadmium-sensitive, phytochelatin-deficient mutants have been isolated and characterised in previous studies. The cadl mutants have wildtype levels of glutathione, are PC deficient and lack PC synthase activity. Thus, the CADl gene has been proposed to encode PC synthase. The CADl gene was isolated by a positional cloning strategy The gene was mapped and a candidate identified. Each of four cadl mutants had a single base pair change in the candidate gene and the cadmium-sensitive, cadl phenotype was complemented by the candidate gene. This demonstrated the CADl gene had been cloned. A homologous gene in the fission yeast, Schizosaccharomyces pombe was identified through database searches. A targeted-deletion mutation of this gene was constructed and the mutant, like cadl mutants of Arabidopsis, was cadmium-sensitive and PC-deficient. A comparison of the redicted amino acid sequences reveals a highly conserved N-terminal region Presumed to be the catalytic domain and a variable C-terminal region containing multiple Cys residues proposed to be involved in activation of the enzyme by metal ions. Similar genes were also identified in animal species. The Arabidopsis CADl/AtPCSl and S. pombe SpbPCS genes were expressed in E. coli and were shown to be sufficient for glutathione-dependent, heavy metal activate PC synthesis in vitro, thus demonstrating these genes encode PC synthase enzymes. Using RT-PCR, AtPCSl expression appeared to be independent of Cd exposure. However, at higher levels of Cd exposure a AtPCSl-CUS reporter gene construct appeared to be more highly expressed. Using the reporter gene construct, AtPCSl was expressed most tissues. Expression appeared to be greater in younger tissues and same higher levels of expression was observed in some regions, including carpels and the base of siliques. AtPCS2 was a functional gene encoding an active PC synthase. However, its Pattern of expression and the phenotype of a mutant (or antisense line) have not been determined. Assuming the gene is functional then it has clearly been maintained through evolution and must provide some selective advantage. This implies that, at least in some cells or tissue, it is likely to be the dominant PC synthase expressed. This remains to be determined

• The Journal of Korean Medicine
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• v.33 no.4
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• pp.60-68
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• 2012

Objectives: By grasping trends in research, technology, and general characteristics of learning support tools, this study was conducted to present a model for research on Korean Medicine (KM) to make use of information technology to support teaching and learning. The purpose is to improve the future clinical competence of medical personnel, which is directly linked to national health. Methods: With papers and patents published up to 2011 as the objects, 438 papers were extracted from "Web of Science" and 313 patents were extracted from the WIPS database (DB). Descriptive analysis and network analysis were conducted on the annual developments, academic journals, and research fields of the papers, patents searched were subjected to quantitative analysis per application year, nation, and technology, and an activity index (AI) was calculated. Results: First, research on medical learning support tools has continued to increase and is active in the fields of computer engineering, education research, and surgery. Second, the largest number of patent applications on medical learning support tools were made in the United States, South Korea, and Japan in this order, and the securement of remediation technology-centered patents, rather than basic/essential patents, seemed possible. Third, when the results of the analysis of research trends were comprehensively analyzed, international research on e-PBL- and medical simulation-centered medical learning support tools was seen to expand continuously to improve the clinical competence of medical personnel, which is directly linked to national health. Conclusions: The KM learning support tool model proposed in the present study is expected to be applicable to computer-based tests at KM schools and to be able to replace certain functions of national KM doctor license examinations once its problem DB, e-PBL, and TKM simulator have been constructed. This learning support tool will undergo a standardization process in the future.

• The Journal of the Korea Contents Association
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• v.15 no.5
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• pp.570-581
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• 2015

In recent years, many institutions predict that cloud services and big data will be popular IT trends in the near future. A number of leading IT vendors are focusing on practical solutions and services for cloud and big data. In addition, cloud has the advantage of unrestricted in selecting resources for business model based on a variety of internet-based technologies which is the reason that provisioning and virtualization technologies for active resource expansion has been attracting attention as a leading technology above all the other technologies. Big data took data prediction model to another level by providing the base for the analysis of unstructured data that could not have been analyzed in the past. Since what cloud services and big data have in common is the services and analysis based on mass amount of data, efficient operation and designing of mass data has become a critical issue from the early stage of development. Thus, in this paper, I would like to establish data processing architecture based on technological requirements of mass data for cloud and big data services. Particularly, I would like to introduce requirements that must be met in order for distributed file system to engage in cloud computing, and efficient compression technology requirements of mass data for big data and cloud computing in terms of cost-saving, as well as technological requirements of open-source-based system such as Hadoop eco system distributed file system and memory database that are available in cloud computing.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1152-1156
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• 2009

Silent information regulator 2 (Sir2) or sirtuins are NAD(+)-dependent deacetylases, which hydrolyze the acetyllysine residues. In mammals, sirtuins are classified into seven different classes (SIRT1-7). SIRT1 was reported to be involved in age related disorders like obesity, metabolic syndrome, type II diabetes mellitus and Parkinson’s disease. Activation of SIRT1 is one of the promising approaches to treat these age related diseases. In this study, we have used HipHop module of CATALYST to identify a series of pharmacophore models to screen SIRT1 enhancing molecules. Three molecules from Sirtris Pharmaceuticals were selected as training set and 607 sirtuin activator molecules were used as test set. Five different hypotheses were developed and then validated using the training set and the test set. The results showed that the best pharmacophore model has four features, ring aromatic, positive ionization and two hydrogen-bond acceptors. The best hypothesis from our study, Hypo2, screened high number of active molecules from the test set. Thus, we suggest that this four feature pharmacophore model could be helpful to screen novel SIRT1 activator molecules. Hypo2-virtual screening against Maybridge database reveals seven molecules, which contains all the critical features. Moreover, two new scaffolds were identified from this study. These scaffolds may be a potent lead for the SIRT1 activation.

• Journal of Korean Medical Ki-Gong Academy
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• v.18 no.1
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• pp.52-112
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• 2018

Objective : The purpose of this study is to understand trends of "Gi-Gong" related studies from 1950 to 2016 and to help guide the research direction of Gigong study. Methods : The computerized Korean database was searched from 1950 to 2016. The search terms used were only Korean language terms such as '기, '기공', '도인', '명상', '생체에너지', '수련', '양생'. Results : 1. A total of 310,184 (155,565(1950~2007) + 13,705(2016) + 140,914(2008~2016)) studies were searched in this study. A total of 6,240 studies were finally selected as Gigong related studies. 2. In the results according to the Main Subject Categories(KCI;Korea Citation Index), the 'Humanities' was the largest with 2,686 studies and the 'Marine Agriculture, Fishery' was the least with 10 studies. 3. In the results according to the Middle Subject Categories(KCI;Korea Citation Index), the 'Philosophy' was the largest with 1,014(16.26%) studies. 4. A result of the Gigong Categories showed that the 'Philosophy of Gi' was the highest with 2,151(33.82%) not including duplication. 5. As a result of Research Method, the most frequently used method was 'Analysis Research' with 4,199(67.33%) studies. 6. In the author search, 'Kim Nak Pil' was searched 112 times and was the most.. 7. The journal that published the most relevant studies with Gigong was 『Conference Proceedings OF The Korean Society OF Jungshin Science』 (189), and the university that had the largest number of studies related to Gigong was 'Wonkwang University'(212). Conclusions : 1. The number of Gigong related studies had increased rapidly from the late 1990s to the early 2000s, and reached to a peak in 2007 and has been gradually increasing since 2008. 2. The three major academic fields of Gigong related studies are Thought Field, Korean Medicine Field, and Kinesic Field. 3. In the Gigong related studies, the best authority is 'Kim Nak-pil' and the most active academy is the 'Korean Society OF Jungshin Science'. 4. Although most categories of Gigong have been generally studied evenly, studies on External Gi Therapy and Taoist Sexual Practices are very insufficient.

• The Journal of Fisheries Business Administration
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• v.35 no.1
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• pp.133-168
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• 2004

The purpose of this study is to examine the state and characteristic of seafood marketing in Korean West Coast during the colonial period ruled by Japan. To accomplish the purpose, we tried to set the fisheries statistical database by reviewing of $\boxDr$Statistical Annual Report of Chosun Chongdokbu$\boxUl$ and $\boxDr$Official Report of Chosun Chongdokbu$\boxUl$. A trend analysis was carried out with the data. Also, by reviewing of articles related to the state of seafood marketing via $\boxDr$Daehan Maeil Newspaper$\boxUl$, $\boxDr$Maeil Newspaper$\boxUl$ issued at the period, we could find out some meaningful findings which backed up the statistics in realistic facts. For numbers of businessman in seafood marketing, it was clear that the number of Japanese businessmen increased more quickly than that of Korean compared with other sphere of fisheries. That means Japanese grasped Korean seafood market in a short time. In price of seafood in terms of cities, Kunsan was comparatively higher than Incheon and Mokpo. In price of seafood in terms of species, ‘Snapper’ was mostexpensive, and ‘Mackerel Pike’, ‘Anchovy’, ‘Mullet’, ‘Eel’, ‘Flatfish’ followed in that order. In price of a species in terms of ‘Yellow Croaker’, which was famous in West Sea, ‘Croaker with salt’ was more expensive than dried and fresh one. For the transition trend of number of fish market, we could ascertain that the number of market increased until 1919, however, it decreased slowly from 1932. That means Japanese government went to war against China from 1931. Of the West Coast, the number of fish market in Chungnam province was most high, but that of Chonbuk outrun from 1940. At that time, the number of fish market in West Coast reached to 34% out of that of whole country. In 1919, the proportion of seafood sales amount of West Coast neighboring provinces, such as Kyunggido, Chungnam, and Chonbuk, was 23% of whole country which rose to 28% in 1929, and 29% in 1939. Therefore, we could assure that seafood marketing was very active at that time in the region. When we consider the trend of seafood export at the main ports of West Coast, in 1910's, the export through Mokpo and Inchon port was very live but that of Kunsan was very tiny. However, in 1920's, the export amount of Inchon port did not much change, but that of Mokpo decreased, whereas, that of Kunsan increased. In the early and middle of 1910' s which was around beginning of Japanese ruling period, we realized that the imperialist Japan was very eager in political efforts to enhance the mind of seafood's quality improvement through the opening of several fisheries competitive shows and fairs.

• Journal of Digital Convergence
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• v.15 no.2
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• pp.225-232
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• 2017

This study aimed to identify worker groups that are to accidents and to track the changes in their socioeconomic status there after. We analyzed the Korean Labor and Income Panel Study (KLIPS) database(2001-2006) were recorded according to the participant's economic activity status at the beginning of follow-up, and economic activity status was. During the follow-up period, the unemployed group experienced more accidents that resulted in disability than the economically active group. Interestingly, the unemployed group also had the highest industrial accident rate. Among the employed, daily and unpaid family workers were more vulnerable to disabilities. After the accidents, the participants tended to become economically inactive or unemployed. Compared to other worker groups, the economically inactive, unemployed, and daily and unpaid family workers experienced higher rates of accidents and faced graver conditions as a result. Although they constitute a significantly large part of society, these vulnerable workers are not currently covered by any social security measures, such as accident surveillance, training, and accident insurance. Social policy should therefore be directed toward protecting these vulnerable worker groups.

• Journal of the Korean Institute of Intelligent Systems
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• v.21 no.6
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• pp.749-754
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• 2011

In this study, we propose the design of optimized pRBFNNs-based face recognition system using two-dimensional Image and ASM algorithm. usually the existing 2 dimensional face recognition methods have the effects of the scale change of the image, position variation or the backgrounds of an image. In this paper, the face region information obtained from the detected face region is used for the compensation of these defects. In this paper, we use a CCD camera to obtain a picture frame directly. By using histogram equalization method, we can partially enhance the distorted image influenced by natural as well as artificial illumination. AdaBoost algorithm is used for the detection of face image between face and non-face image area. We can butt up personal profile by extracting the both face contour and shape using ASM(Active Shape Model) and then reduce dimension of image data using PCA. The proposed pRBFNNs consists of three functional modules such as the condition part, the conclusion part, and the inference part. In the condition part of fuzzy rules, input space is partitioned with Fuzzy C-Means clustering. In the conclusion part of rules, the connection weight of RBFNNs is represented as three kinds of polynomials such as constant, linear, and quadratic. The essential design parameters (including learning rate, momentum coefficient and fuzzification coefficient) of the networks are optimized by means of Differential Evolution. The proposed pRBFNNs are applied to real-time face image database and then demonstrated from viewpoint of the output performance and recognition rate.