• 한국통신학회논문지
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• 제38B권6호
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• pp.485-491
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• 2013

최근 소셜 네트워크 서비스가 급속히 증가함에 따라 많은 기업들과 사용자들은 자신들의 정보가 더욱 빠르게 확산되길 바란다. 이러한 소셜 네트워크에서의 정보 확산을 연구하기 위하여 많은 알고리즘들이 제안되었는데 그중 대표적인 알고리즘은 그리디 알고리즘(Greedy Algorithm)과 휴리스틱 알고리즘(Heuristic Algorithm)이다. 하지만 그리디 알고리즘의 경우 복잡성으로 인하여 실제 소셜 네트워크에 사용이 제한적이며, 기존 휴리스틱 기반의 메시지 전파 기법의 경우 균일한 소셜 네트워크 환경을 고려하였기 때문에 현재 소셜 네트워크의 특성을 반영한 연구가 요구된다. 이에 본 논문에서는 휴리스틱 알고리즘 기반의 정보 확산 확률과 노드 연결성을 고려한 정보 확산 능력 최대화 알고리즘을 제안하고, 실제 소셜 네트워크 데이터베이스를 이용하여 제안 알고리즘의 성능을 분석하였다. 그 결과 기존 알고리즘이 비해 더 많은 노드를 활성화 시킬 수 있어 정보 확산 능력을 향상시킬 수 있음을 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제22권6호
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• pp.818-825
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• 2012

Keratinases are exciting keratin-degrading enzymes; however, there have been relatively few studies on their immobilization. A keratinolytic protease from Chryseobacterium sp. kr6 was purified and its partial sequence determined using mass spectrometry. No significant homology to other microbial peptides in the NCBI database was observed. Certain parameters for immobilization of the purified keratinase on chitosan beads were investigated. The production of the chitosan beads was optimized using factorial design and surface response techniques. The optimum chitosan bead production for protease immobilization was a 20 g/l chitosan solution in acetic acid [1.5% (v/v)], glutaraldehyde ranging from 34 g to 56 g/l, and an activation time between 6 and 10 h. Under these conditions, above 80% of the enzyme was immobilized on the support. The behavior of the keratinase loading on the chitosan beads surface was well described using the Langmuir model. The maximum capacity of the support ($q_m$) and dissociation constant ($K_d$) were estimated as 58.8 U/g and 0.245 U/ml, respectively. The thermal stability of the immobilized enzyme was also improved around 2-fold, when compared with that of the free enzyme, after 30 min at $65^{\circ}C$. In addition, the activity of the immobilized enzyme remained at 63.4% after it was reused five times. Thus, the immobilized enzyme exhibited an improved thermal stability and remained active after several uses.

• 한국기록관리학회지
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• 제18권2호
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• pp.109-133
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• 2018

행정정보 데이터세트의 기록관리 필요성은 기록관리 연구자들 사이에서 넓은 공감대를 형성하고 있으며 지속적으로 연구되어 왔다. 그동안 정보 기술의 발전에 따라 행정정보시스템의 신규 구축 및 재개발이 증가하고 있음에도 불구하고 실제 공공기관에서 운영 중인 각종 행정정보시스템에서 생산된 데이터세트는 관리하지 못 하고 있는 실정이다. 그 원인은 현실 적용이 가능한 관리 방안의 부재에 있다고 하겠다. 본 연구는 구현 가능한 행정정보 데이터세트 관리 방안은 데이터세트 관리 환경의 실상에 기초하여야 한다는 판단 하에, 현재 운영 중인 행정정보시스템에서의 데이터세트 생산 및 관리 환경 사례를 조사함으로써 관리 방안 개발의 기초 자료와 유사 연구에서 활용할 수 있는 조사방법론을 제시하고자 한다.

• 천문학회보
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• 제38권1호
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• pp.43.2-43.2
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• 2013

The local environmental effects on the triggering of active galactic nucleus(AGN) activity has been studied with many authors, but there still be controversy. We perform statistical analysis for nearby(0.01 < z < 0.05) volume limited(Mr < -19) samples with visual inspection based on Sloan Digital Sky Survey Data Release7. We inspect ~60,000 galaxy images visually to find peculiar objects which show not only ongoing merging features and tidal features, but also post merging features like ring or shell structures. We found that these peculiar features were shown at least 2 times more frequently among AGN host galaxies than non AGN galaxies, and this trend was still visible when galaxy properties such as color or stellar mass are fixed. Furthermore, L[OIII] and L(Ha) of peculiar galaxies are found to be more increased than those of normal galaxies. In order to ensure this results, we also checked it for a smaller subsample with ~2mag deeper monochromatic images provided from SDSS Stripe82 database, and found consistent results. At last, we perform the same work for pair(r_p<80kpc/h, delta_v<200km/s) systems. Because of some pair systems which do not interact gravitationally in actuality but fulfill the criteria for identification of pair system, the trends are found to be slightly weaker. We also found that line luminosities are increased consistently as projected distance between central and companion galaxy decreased, and as companion color gets bluer. Overall, the results of this study tell us that the local environment of galaxies affect the frequency as well as the strength of AGN activity. Local environmental effects, however, may not be the dominant triggering mechanism for AGN activity since the majority of peculiar galaxies are non AGN galaxies.

• 한국임상약학회지
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• 제28권2호
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• pp.117-123
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• 2018

Background: Prostatitis, one of the most common diseases of the prostate, is a complex disease with various clinical features. This study aims to analyze the utilization and prescribing patterns of antibiotics in Korean patients with prostatitis between 2008 and 2015. Methods: We used the National Health Insurance Database complied from the Health Insurance Review and Assessment Service (HIRA). The outcomes included the number of claims, number of patients, medical cost, and length of stay for each year. In addition, the prescribing patterns of antibiotics, including fluoroquinolone, and low-dose use of ciprofloxacin and levofloxacin were investigated. Results: The total number of patients and medical cost increased by 9.5% and 51.7% from 2008 to 2015, respectively. Most prostatitis patients were classified as chronic prostatitis patients. The prescribing proportion of antibiotics for chronic prostatitis outpatients decreased from 71.0% to 66.9% from 2008 to 2015, and fluoroquinolone accounted for more than half of the total antibiotics. Over 80% of prescription of levofloxacin and ciprofloxacin was identified to be for low-dose use. Conclusion: Most of the patients with prostatitis experienced pain relief and condition improvement after antibiotic treatment; however, chronic prostatitis and chronic pelvic pain syndrome recur easily. Therefore, active disease management and further studies are needed to enhance our understanding of effective treatment for prostatitis.

• 천문학회보
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• 제41권1호
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• pp.36.2-37
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• 2016

We study the long-term radio variability of 43 radio bright AGNs by exploiting the data base of the University of Michigan Radio Astronomy Observatory (UMRAO) monitoring program. The UMRAO database provides high quality lightcurves spanning 25 - 32 years in time at three observing frequencies, 4.8, 8, and 14.5 GHz. We model the periodograms (temporal power spectra) of the observed lightcurves as simple power-law noise (red noise, spectral power $P(f){\propto}f^{-{\beta}}$ using Monte Carlo simulations, taking into account windowing effects (red-noise leak, aliasing). The power spectra of 39 (out of 43) sources are in good agreement with the models, yielding a range in power spectral index (${\beta}$) from ${\approx}1$ to ${\approx}3$. We find a strong anti-correlation between ${\beta}$ and the fractal dimension of the lightcurves, which provides an independent check of the quality of our modelling of power spectra. We fit a Gaussian function to each flare in a given lightcurve to obtain the flare duration. We discover a correlation between ${\beta}$ and the median duration of the flares. We use the derivative of a lightcurve to obtain a characteristic variability timescale which does not depend on the assumed functional form of the flares, incomplete fitting, and so on. We find that, once the effects of relativistic Doppler boosting on the observed timescales are corrected, the variability timescales of our sources are proportional to the black hole mass to the power of ${\alpha}=1.70{\pm}0.49$. We see an indication for AGNs in different regimes of accretion rate, flat spectrum radio quasars and BL Lac objects, having different scaling relations with ${\alpha}{\approx}1$ and ${\approx}2$, respectively. We find that modelling the periodograms of four of our sources requires the assumption of broken powerlaw spectra. From simulating lightcurves as superpositions of exponential flares we conclude that strong overlap of flares leads to featureless simple power-law periodograms of AGNs at radio wavelengths in most cases (The paper is about to be submitted to ApJ).

• 한국실내디자인학회논문집
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• 제23권4호
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• pp.248-256
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• 2014

According to data from the national office of Statistics Korea and Ministry of Health and Welfare, as the elderly population increases, the dementia elderly population continues to increase and its future population growth rate is expected to be even faster. In particular, the Dementia Management Act has been in effect since February 2012, and active efforts has been made for a policy for the dementia management. The purpose of this study is to establish standards on building plans based on the appropriate scale and spatial configuration on facilities planning for the elderly with dementia. Specifically, the basic data were collected with a request for a total of 103 points on the basis of a database of group homes in the survey managed by the Japan Association of Group Homes. Specific information of the research includes the management body of facilities operation, scale of the facilities, number of units and configuration of personal living space, and the collected survey data and drawings were statistically proceed and analyzed using the SPSS WIN 20.0. analysis results are summarized as follows. first, most of the group homes come to the small size of the 1-2 story home ; the approximate number of units is one or two per home, and each unit consists of nine rooms. second, a number of group homes with the building area of $300m^2$ have the U-shaped arrangement which is advantageous in the extension and facilities maintenance. In conclusion, this study is to be the fundamental data for judgments that can be used to establish standards for the facilities for the dementia elderly whose population continues to increase. In addition, further study is necessary to establish suitable design conditions of our country.

• Genomics & Informatics
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• 제14권3호
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• pp.104-111
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• 2016

Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause microcephaly, a serious birth defect during pregnancy. The recent outbreak of ZIKV in February 2016 in Brazil realized it as a major health risk, demands an enhanced surveillance and a need to develop novel drugs against ZIKV. Amodiaquine, prochlorperazine, quinacrine, and berberine are few promising drugs approved by Food and Drug Administration against dengue virus which also belong to Flaviviridae family. In this study, we performed molecular docking analysis of these drugs against nonstructural 3 (NS3) protein of ZIKV. The protease activity of NS3 is necessary for viral replication and its prohibition could be considered as a strategy for treatment of ZIKV infection. Amongst these four drugs, berberine has shown highest binding affinity of -5.8 kcal/mol and it is binding around the active site region of the receptor. Based on the properties of berberine, more similar compounds were retrieved from ZINC database and a structure-based virtual screening was carried out by AutoDock Vina in PyRx 0.8. Best 10 novel drug-like compounds were identified and amongst them ZINC53047591 (2-(benzylsulfanyl)-3-cyclohexyl-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one) was found to interact with NS3 protein with binding energy of -7.1 kcal/mol and formed H-bonds with Ser135 and Asn152 amino acid residues. Observations made in this study may extend an assuring platform for developing anti-viral competitive inhibitors against ZIKV infection.

• 대한영양사협회학술지
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• 제14권3호
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• pp.218-228
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• 2008

This study was conducted to evaluate the quantitative and qualitative aspects of Korean websites related to nutrition education. A total of 30 websites were ultimately selected through 4 major Internet search engines, including Naver, Yahoo, Daum, and Nate, using several key words (i.e., nutrition education, dietary life education, nutrition information, nutrition management, etc.). A systematic review was conducted for each of the selected websites based on the American Library Association (ALA) website checklist and a data abstract form that was adapted from a previous study. Approximately two thirds of the websites were established between 2002 and 2005, and 46.6% were administrated by public health centers or schools/colleges. The most frequently targeted group was the generally healthy population (30.0%). Among the various topics of nutrition information provided, “balanced diet” was the topic most often provided by the websites. Also, an increasing trend for utilizing multimedia tools was observed; however, little technical support or instruction was provided by the websites. Only 50.0% and 63.3% of the sites clearly stated their operators and sources of provided information, respectively. Overall, the purposes of sites were clearly stated, and were not overshadowed by advertising. And most features of design, stability, and content were found to be appropriate, but several aspects, such as establishing a help/FAQ menu, regularly updating nutrition information, and converting provided information into a database for easier search and update, needed improvement. In addition, active operational strategies are greatly needed to encourage the application of materials found on sites into real educational settings.

• 한국환경교육학회지:환경교육
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• 제19권1호
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• pp.90-103
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• 2006

The purpose of this paper is to analyze media companies' editorial viewpoints regarding environmental issues. Not only do newspaper editorials provide a variety of environmental information, but also they make it possible for the public to form an opinion and to establish communication channels regarding environmental issues. With this in mind, this paper analyzes the changes in environmental reporting over the past two decades. The newspaper companies started writing more frequently about the environment from early 1980s. To show this, I analyzed environmental articles written in the six main news-paper companies: Chosun, Donga, Hangerae, Kyunghyang, Hankook, and Munwha from 1999 to 2004. For this study, the articles have been complied by using the Korean Integrated News Database System (KINDS). Also the data has been sorted according to year, subject, and ty the company of origin. The total number of the environmental articles posted on these six daily newspapers from 1999 to 2004 is 729 and these represent 2.59% of the total articles. Hankook-Ilbo was the company that handled the most of environmental articles followed by Hangerae, Munwha, Kyunghwang, Chosun, and Donga. The major topics of discussion were environmental development and water quality issues. The number of the environmental related articles increased in 1999 and 2000, but then decreased from 2001 to 2003. Again the number increased in 2004. Interestingly while the number of articles covering the environment increased from the 1980s and into the 1990s, the number of articles decreased from 1999 to 2004 as the post-IMF period seems to have suppressed interest in the ecological issues despite the economic growth that followed. With the change in media coverage people have begun to recognize environmental issues as having social impact. As a result the people have begun to take such issues more seriously and take more active role in effecting environmental policy. Thus it is important that the media presents it's stories in an object manner to insure that the public is properly informed.