• 동의생리병리학회지
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• 제28권6호
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• pp.636-642
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• 2014

In the theory of Korean medicine, Angelicae Dahuricae Radix (ADR) can expel wind and relieve exterior syndrome, and eliminate dampness. Recently, ADR has been reported to have possibilities as anti-inflammatory agent and cosmetics. The purpose of this study is to evaluate the efficacy of ADR on contact dermatitis (CD). In order to investigate the anti-inflammatory effects of ADR on CD, we investigated the effects of ADR on ear thickness, ear weight, skin lesion and histopathological changes in mice with CD induced by 1-fluoro-2,4-dinitrofluorobenzene (DNFB). In addition, the effect on spleen weight was also measured. In our results, topical application of ADR lowered ear thickness and weight respectively. ADR treatment also improved skin lesions such as erythema and scale. In the histopathological observation, ADR-treated group showed diminished epidermal hyperplasia and immune cell infiltration in inflammed tissues compared to those of non-treated control group. In conclusion, These data suggest that ADR has anti-inflammatory action in inflammed skin tissue, resulting in improving skin lesion and histopathological abnormalities of CD.

• 대한지구과학교육학회지
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• 제5권1호
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• pp.51-59
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• 2012

The purpose of this study was to examine the effects of Future Problem Solving Program on creativity and scientific attitude. For this study the 4 grade, 2 class was divided into a research group and a comparative group. The class was pre-tested in order to ensure the same standard. The research group had the science class with FPSP, and the comparative group had the class with teacher centered lectures for 9 classes in 10 weeks. The FPSP was focused on finding problems, finding key problems, creating solutions, selecting the standard of judgement, making alternative solutions, and learning creative steps of solutions consisting of development of action planning. To prove the effects of this study, creativity was split up according to fluency, originality, abstractness, accuracy, and openness. Also, scientific attitude consisted of honesty, patience, curiosity, preparedness, autonomy, criticism, and openness. The results of this study are as follows. First, the science class with FPSP with finding problems, finding key problems, and creating solutions had the effect of developing the scientific creativity; fluency, originality, abstractness of the title, accuracy, and openness. Second, the FPSP had the effect of developing the scientific attitude. Students made ideas and solved the problems through divergent thinking and convergent thinking. During the class it had the effect of developing the scientific attitude; honesty, patience, curiosity, preparedness, autonomy, criticism, and openness. As a result, the elementary science class with FPSP had the effects of developing scientific creativity and scientific attitude. It means the science class with FPSP has potential possibilities and value to develop scientific creativity and scientific attitude.

• Membrane and Water Treatment
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• 제11권5호
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• pp.323-331
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• 2020

With the increasing demand on reverse osmosis (RO) membranes for water purification worldwide, the number of disposed membrane elements is expected to increase accordingly. Thus, recycling and reuse of end-of-life RO membranes should be a global environmental action. In this work, we aim to reuse the spent RO membrane for nanofiltration (NF) and ultrafiltration (UF) process by subjecting the spent membrane to solvent and oxidizing solution treatment, respectively. Our results showed that solvent-treated RO membrane could perform as good as commercial NF membrane by achieving similar separation efficiencies, but with reduced water permeability due to membrane surface fouling. By degrading the polyamide layer of RO membrane, the transformed membrane could achieve high water permeability (85.6 L/㎡.h.bar) and excellent rejection against macromolecules (at least 87.4%), suggesting its reuse potential as UF membrane. More importantly, our findings showed that in-situ transformation on the spent RO membrane using solvent and oxidizing solution could be safely conducted as the properties of the entire spiral wound element did not show significant changes upon prolonged exposure of these two solutions. Our findings are important to open up new possibilities for the discarded RO membranes for reuse in NF and UF process, prolonging the lifespan of spent membranes and promoting the sustainability of the membrane process.

• 한국실내디자인학회논문집
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• 제21권5호
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• pp.217-226
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• 2012

The purpose of this study had started from trying to look for a new standard in new media era and sounding out possibility of perspective of digital poetry, and had been extracting interpretational elements based on characteristics of otology in digital poetics research in technical method. Through examination of many documentary records, we suggested interpretive elements of medial space based on meaning and the theory of digital poetics. We deduced three perspectives based on relationship between the basic thesis in poetics and interpretive elements of medial space. We used them as tool for analysis of example. We chose as an example that change of program in space is clear through connection of media and space in where new form of creation happens through digital instruments and chose article as subject to which digital technology is applied and had been since 2000, The result of this study is as following: First, epistemological analysis about a space of digital media in new media era requires poetical approach unlike aesthetic approach. We can endow creative action and creation process with significance and pay attention to technical method of manufacturing, stating appropriateness of perspective in digital poetics. Second, the justice of digital poetics and its basic thesis help derive analytic elements from medial space and study purpose of production, technical method, ontological characteristics, which are three perspectives of digital poetics. Third, it analyzed characteristics of example according to three perspectives above and we can analyze characteristics of spacial expression in space of digital media into potential, trans-active, and semiosis space. It would be possible through analyzing examples in digital poetic perspective to overlook new methods of design in 21th and various perspectives and possibilities of medial space design.

• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1997년도 춘계학술대회논문집
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• pp.56-60
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• 1997

The study of human erroneous actions has traditionally taken place along two different lines of approach. One has been concerned with finding and explaining the causes of erroneous actions, such as studies in the psychology of "error". The other has been concerned with the qualitative and quantitative prediction of possible erroneous actions, exemplified by the field of human reliability analysis (HRA). Another distinction is also that the former approach has been dominated by an academic point of view, hence emphasising theories, models, and experiments, while the latter has been of a more pragmatic nature, hence putting greater emphasis on data and methods. We have been developing a method to make predictions about error modes. The input to the method is a detailed task description of a set of scenarios for an experiment. This description is then analysed to characterise thd nature of the individual task steps, as well as the conditions under which they must be carried out. The task steps are expressed in terms of a predefined set of cognitive activity types. Following that each task step is examined in terms of a systematic classification of possible error modes and the likely error modes are identified. This effectively constitutes a qualitative analysis of the possibilities for erroneous action in a given task. In order to evaluate the accuracy of the predictions, the data from a large scale experiment were analysed. The experiment used the full-scale nuclear power plant simulator in the Halden Man-Machine Systems Laboratory (HAMMLAB) and used six crews of systematic performance observations by experts using a pre-defined task description, as well as audio and video recordings. The purpose of the analysis was to determine how well the predictions matiched the actually observed performance failures. The results indicated a very acceptable rate of accuracy. The emphasis in this experiment has been to develop a practical method for qualitative performance prediction, i.e., a method that did not require too many resources or specialised human factors knowledge. If such methods are to become practical tools, it is important that they are valid, reliable, and robust.

• Journal of Microbiology and Biotechnology
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• 제33권4호
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• pp.449-462
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• 2023

Previously, we confirmed that Mychonastes sp. 246 methanolic extract (ME) markedly reduced the viability of BxPC-3 human pancreatic cancer cells. However, the underlying mechanism ME remained unclear. Hence, we attempted to elucidate the anticancer effect of ME on BxPC-3 human pancreatic cancer cells. First, we investigated the components of ME and their cytotoxicity in normal cells. Then, we confirmed the G1 phase arrest mediated growth inhibitory effect of ME using a cell counting assay and cell cycle analysis. Moreover, we found that the migration-inhibitory effect of ME using a Transwell migration assay. Through RNA sequencing, Gene Ontology-based network analysis, and western blotting, we explored the intracellular mechanisms of ME in BxPC-3 cells. ME modulated the intracellular energy metabolism-related pathway by altering the mRNA levels of IGFBP3 and PPARGC1A in BxPC-3 cells and reduced PI3K and mTOR phosphorylation by upregulating IGFBP3 and 4E-BP1 expression. Finally, we verified that ME reduced the growth of three-dimensional (3D) pancreatic cancer spheroids. Our study demonstrates that ME suppresses pancreatic cancer proliferation through the IGFBP3-PI3K-mTOR signaling pathway. This is the first study on the anticancer effect of the ME against pancreatic cancer, suggesting therapeutic possibilities and the underlying mechanism of ME action.

• 동의신경정신과학회지
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• 제21권2호
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• pp.125-140
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• 2010

Objectives : The purpose of this study is to examine from various angles the protective effect of Gastrodia elata Blume (GEB) against nerve cell death induced by $\beta$-amyloid by using the cell line SH-SY5Y, which is commonly utilized for toxicity testing in nerve cells, and to find out its mechanism of action. Methods : To begin with, as a result of assessing the rate of cell survival by employing MTT reduction assay, the treatment with $\beta$-amyloid at different concentrations caused cytotoxicity, which was inhibited by preprocessing GEB extract. In addition, after $\beta$-amyloid was processed with the cell SH-SY5Y, apoptosis progressed, which was reduced effectively by processing GEB extract. Results : When cytotoxicity was caused by using hydrogen peroxide, a representative ROS, in order to examine the antioxidant effect of GEB, its protective effect was also observed. Apart from ROS, reactive nitrogen species (RNS) are also known to play a crucial role in nerve cell death. The treatment with the NO donor SNAP increased the production of nitric oxide and the expression of iNOS, which was also inhibited by GEB extract. Meanwhile, as an attempt to find out the mechanism of action explaining the antioxidant effect, the intracellular antioxidant enzyme expressions were measured by RT-PCR, which showed that GEB extract increased the expressions of heme oxygenase-1, GAPDH and $\gamma$-glutamate cysteine ligase. Lastly, GEB extract had a protective effect against impaired memory induced by scopolamine in animal models (in vivo). Conclusions : These findings indicate that GEB has a protective effect against the death of cranial nerve cells, suggesting possibilities for the prevention and treatment of AD.

• 한국게임학회 논문지
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• 제8권1호
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• pp.15-27
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• 2008

게임의 장르는 플레이어에게 주로 제공되는 플레이 방식에 따라 액션, 어드벤처, 롤플레잉, 시뮬레이션 등으로 나뉘며, 각 장르에서 게임은 다양한 형태의 밸런싱을 갖는다. 이 중 대전 격투 게임은 액션 장르의 한 형태로서, 단순해 보이지만 여러 가지의 복합적인 밸런싱 요소들을 가지고 있으며, 비교적 빠른 기간에 독립 장르로 확립되고 백여 편에 이르는 게임이 제작되어 초기의 불안정한 형태에서 최근의 안정된 형태에 이르기까지 다양한 게임 밸런싱 구조를 확인할 수 있다. 게임 밸런싱은 게임 내의 여러 구성요소 간 불균형을 해소하여 플레이어가 게임이 제공하는 모든 콘텐츠를 고루 이용하도록 유도하고, 그 과정에서 게임 플레이의 재미가 유지되는 것을 목표로 한다 또한 진행과정에 있어서 당위성을 부여하고, 조작에 따른 효율성을 증대시키며, 플레이어의 감정이입을 유도하여 몰입감을 향상시키는 등 게임의 완성도에 대한 평가와 수명(흥행)에 절대적인 영향을 미치는 중요한 요소로 인식되고 있다. 따라서 본 논문에서는 주요 대전 격투 게임의 사례 분석을 통해 해당 장르의 발전모습과 그 과정에서 수립된 밸런싱 모델을 파악하므로써, 타 장르로의 확대 적용 가능성을 연구해 보고자 한다.

• 동아시아식생활학회지
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• 제18권3호
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• pp.322-330
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• 2008

This study was performed to the possibility of developing anti-aging convenient food that is to Koreans' taste. Editor: this abstract appears to describe a study of public opinion and not related to the development of anti-aging convenient foods. In total, The 150 adults, living in Seoul (Korea), participated in this study in the capacity of subjects. Editor: You really have to mention the age-range of the subjects, as senility is an old age disease. In particular, you talk about the intention of subjects (discussed below) to buy anti-aging food products. This would be directly related to their age, as I assume that older people would be more concerned about senility that relatively younger subjects. They were randomly assigned to 25 groups. In result initial descriptive analysis revealed that, 82 percent of subjects awoke to were aware of senility, and the while 26.7 percent were seriously thought of it concerned. Furthermore, The 58.7 percent said that believed food has the possibility has a role in of controlling senility, and the while 64.0 percent said stated that senility may be controlled by eating constitutional foods. Further comparative analysis of In the case of the group of which members subjects have been who were trying to control senility revealed that their, the reliance on food general and constitutional food was significantly higher than those who have not tried to do so did nothing. The From the 61.3 percent have been of subject who were trying to control senility, from among them, the 74.0 percent and the 22.7 percent were relied on physical taking exercises and anti-aging foods, respectively. Likewise, it was ascertained When asked whether subjects intend to purchase anti-aging convenient food if it was is developed. The 67.3 percent and the 72.7 percent indicated their intentionded to purchase the normal product and constitutional products, respectively. Resultantly, anti-aging convenient food was in demand to some extent. Given that anti-aging products are in high demand, In such a case, senile severity (p<0.05), anti-aging possibility in constitutional foods (p<0.001) and anti-aging action (p<0.001) are regarded as variables in the purchase of the normal products. In the case of relation to constitutional products, anti-aging possibility in constitutional food (p<0.001) and anti-aging action (p<0.001) were regarded as variables.

• 비교문화연구
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• 제46권
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• pp.173-197
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• 2017

본 연구는 헤수스 페르난데스 산토스의 "용감한 사람들"에 나타난 공간의 의미를 연구했다. 주요 내용은 작품에 나타난 공간에 대한 다양한 측면을 담고 있다. 시간의 흐름에 따라 공간의 개념도 소설의 진화와 함께 변화되었음을 볼 수 있다. 과거 아리스토텔레스는 공간을 사물과 인물이 존재하는 곳으로 여겼다. 르네상스까지 이러한 개념이 유지되었다. 19세기에 공간은 당시 낭만주의 작가들이 그 중요성을 더 부여해서 단순한 행동 묘사에만 그치지 않았다. 그리고 이후 사실주의는 집 안 내부 등과 같이 구체적인 공간에 관심을 보였다. 본 논문에서는 "용감한 사람들"에서의 공간의 다양한 의미에 초점을 두었다. 우선 실재적인 공간과 이상적인 공간에 대하여 살펴보았고, 인물들에 따른 치유적인 공간도 찾아보았다. 도시와 시골의 대립적인 공간이 어떻게 묘사되었는지, 마지막으로는 남성과 여성의 대립적인 공간을 보았다. 연구에 따르면, 어떤 인물은 자신의 이상적인 공간을 찾아 떠나기 했고, 여자 인물들은 부엌이라는 공간에서 편안함을 찾았고, 남자들은 카페에 모여 친구들과 이야기를 하는 광경을 자주 볼 수 있었다. 문이나 창문은 집 안의 구조적인 경계일 수도 있지만, 남성과 여성의 심리적 경계가 되기도 했다.