• Nuclear Engineering and Technology
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• 제38권2호
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• pp.185-194
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• 2006

Transient operations for an integral type reactor, SMART-P, have been experimentally investigated using a thermal-hydraulic integral test facility, VISTA (Experimental Verification by Integral Simulation of Transients and Accidents), in order to verify the system design and performance of the SMART-P, a pilot plant of SMART. The VISTA facility was subjected to various accident conditions such as feedwater increase and decrease, loss of coolant flow, and control rod withdrawal accidents in order to elucidate the thermal-hydraulic responses following such accidents and finally to verify the system design of the SMARTP. Full functional control logics have been implemented in the VISTA facility in order to control the required control action for an accident simulation. As one of the sensitivity tests to verify the PRHRS performance, the effects of the initial water level in the compensation tank are experimentally investigated. When the initial water level is 16%, the water is quickly drained and nitrogen gas is then introduced into the PRHR system, resulting in deterioration of the PRHRS performance. It is thus found that nitrogen ingression should be prevented to ensure stable PRHRS operation.

• 한국의류학회지
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• 제32권3호
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• pp.395-407
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• 2008

As global interest in clothing spreads over the smart clothing which arouses high added-value in the apparel industry, this study is to develop a smart jacket with an electrically-vibrating device maintaining excellent appearance and comfort. The vibrating device has a massage function that could relieve muscle pain near shoulders and neck. The purposes of this research are to develop jacket pattern for men in their thirties considering body shapes and fashion trend, to develop a wearable device that is composed of motor and controller and integrate it into a jacket, and to assess the external appearance and functional satisfaction of the smart jacket through the wearing test. The results are as follows: 1. In order to develope an appropriate jacket pattern for men in their thirties, several patterns were assessed for their fitting comfort. The final pattern was completed after making alterations some parts, and showed high satisfaction as 3.6(on a five-point scale) in all categories. 2. A vibrating device was developed by connecting motor, controller, battery and switch. Developing this device, focus was maximizing the strength of motor and minimizing the heat generated from motor and controller. Snaps were placed between inner and outer cloth of jacket so that the vibrating device could be easily attachable and detachable. The motor was located around Trapezius where muscles often get stiff. A switch was designed to be used in selecting the modes of Strong, Weak, and Cross Tapping. 3. The wearing test was conducted to examine outer appearance, comfort for motion, and functionality of the smart jacket. The results of assessing outer appearance showed that the location for attaching the vibrating device was not noticeable but looked natural, and there is almost no change in outer appearance when the vibrating device operates. The result of assessing comfort of action revealed that wearer's satisfaction was high in all categories about activity, wearer's comfort, etc. The result also showed that wear's satisfaction for effects of vibrating massage, easiness in using the device, heat generation was not less than 3.5 in all categories except a category about noise.

• Preventive Nutrition and Food Science
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• 제19권3호
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• pp.187-193
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• 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution For decades, Spergularia marina, a local food that is popular in South Korea, has been regarded as a nutritious source of amino acids, vitamins, and minerals. While several halophytes are reported to possess distinct bioactivities, S. marina has yet to be promoted as a natural source of bioactives. In this study, the effects of S. marina on the adipogenic differentiation of 3T3-L1 fibroblasts and the osteoblastic differentiation of MC3T3-E1 pre-osteoblasts and C2C12 myoblast cells were evaluated. The anti-adipogenic effect of S. marina was assessed by measuring lipid accumulation and adipogenic differentiation marker expression. S. marina treatment significantly reduced lipid accumulation and notably decreased the gene levels of peroxisome proliferator-activated receptor ${\gamma}$, CCAAT/enhancer-binding protein ${\alpha}$, and sterol regulatory element binding protein 1c. In addition, S. marina enhanced osteoblast differentiation, as indicated by increased alkaline phosphatase activity and increased levels of osteoblastogenesis indicators, namely bone morphogenetic protein-2, osteocalcin, and type I collagen. In conclusion, S. marina could be a source of functional food ingredients that improve osteoporosis and obesity. Further studies, including activity-based fractionation, will elucidate the mechanism of action and active ingredients of S. marina, which would provide researchers with a better understanding of the nutraceutical and therapeutic applications of S. marina.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5445-5451
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• 2015

Fascin-1 (FSCN1) is an actin-bundling protein that induces cell membrane protrusions, increases cell motility, and is overexpressed in various human epithelial cancers, including esophageal squamous cell carcinoma (ESCC). We analyzed various protein-protein interactions (PPI) of differentially-expressed genes (DEGs), in fascin knockdown ESCC cells, to explore the role of fascin overexpression. The node-degree distributions indicated these PPI sub-networks to be characterized as scale-free. Subcellular localization analysis revealed DEGs to interact with other proteins directly or indirectly, distributed in multiple layers of extracellular membrane-cytoskeleton/ cytoplasm-nucleus. The functional annotation map revealed hundreds of significant gene ontology (GO) terms, especially those associated with cytoskeleton organization of FSCN1. The Random Walk with Restart algorithm was applied to identify the prioritizations of these DEGs when considering their relationship with FSCN1. These analyses based on PPI network have greatly expanded our comprehension of the mRNA expression profile following fascin knockdown to future examine the roles and mechanisms of fascin action.

• 한국콘텐츠학회논문지
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• 제10권5호
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• pp.152-164
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• 2010

현대에 주요하게 부각되고 있는 상호작용 공간을 효과적으로 디자인하기 위해서는 상호작용성 영향요인들을 이해하고 이를 수용하는 사용자 중심적인 공간디자인 방법론이 필요하다. 본고는 이를 위한 기반을 마련하고자 하였으며 이 연구주제로 수행될 3편의 연계논문 중 첫번째 연구이다. 디자인의 기본 관련영역을 기반으로 설정한 분석지표(시스템영역, 사용자영역, 관계영역)에 의거하여 상호작용성 영향요인에 대해 분석한 결과, 상호작용성의 첫번째 영향요인은 상호작용성을 위한 접속의 장인 인터페이스로 분석되었다. 이의 세부유형 분석은 연계연구 II 편의 연구과제이다. 두번째 영향요인은 상호작용성의 발생 주체인 인터서브젝트이다. 이의 세부유형은 사용자의 상호작용 욕구의 측면에서 파악되어 기능적 & 조형적욕구, 외현 & 잠재 욕구, 정보커뮤니케이션 & 공감 욕구의 6개 세부유형이 분석되었다. 세번째 영향요인은 상호작용성의 실제 수행과정인 인터랙션이다. 이의 세부유형은 상호작용 행태 프로세스의 측면에서 파악되었고 접속, 몰입, 심성모형 형성, 상호작용 행위, 변형, 경험적 발생의 여섯 단계로 분석되었다.

• Nutritional Sciences
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• 제9권3호
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• pp.159-166
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• 2006

This study was performed to investigate antioxidative and anti-aging action of extracts from Sancho (Zanthoxylum schinifolium) leaves. Two extracts were obtained by 80% methanol extraction followed by subsequent fractionation with methylene chloride (MC) and n-butanol (B) and fed at one or three levels to rats on normal level (5%) of fat (control) and high fat(20%) in diets. Male Sprague-Dawley rats weighing about 100 g were divided into ten groups such as control diet group(C), control diet+0.50%B group (CB), control diet+0.50%MC group (CMC), high-fat diet group (HF), high-fat diet+0.25%B group (HBL), high-fat diet+0.50%B group (HBM), high-fat diet+0.75%B group (HBH), high-fat diet+0.25%MC group (HMCL), high-fat diet+0.50%MC group (HMCM) and high-fat diet+ 0.75%MC group (HMCH) and fed each diet for four weeks. The effects of the extracts on antioxidant enzyme activities and indices of lipid peroxidation and aging were seen only in high fat diet groups. Hepatic superoxide dismutase and aryleaterase activities were not changed by Sancho extracts. But glutathione peroxidase, catalase and paraxonase activities were significantly restored by both MC and B at the level of 0.75% lipid peroxide which was increased by high fat diet was significantly reduced by B and MC at the level of 0.25% and over. Lipofuscin fluorescence and cabonyl value were increased by high fat diet were reduced by B and MC at the level of 0.5% and over. It is concluded that the Sancho extracts can be utilized as functional ingredients of health foods for reducing oxidative stress.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.747-752
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• 2013

Oncostatin M (OSM) is a multifunctional cellular regulator acting on a wide variety of cells, which has potential roles in the regulation of gene activation, cell survival, proliferation and differentiation. Previous studies have shown that OSM can induce morphological and/or functional differentiation and maturation of many tumor cells. However, the action of OSM on the induction of differentiation of human hepatocellular carcinoma (HCC) has not been reported. Here, we investigated the effects of different concentrations of OSM on human HCC cell line SMMC-7721 growth, proliferation, cell cycling, apoptosis and differentiation in vitro. Cell growth was determined via MTT assay, proliferation by cell cycle analysis, apoptosis by flow cytometry, morphology by transmission electronic microscopy, and cell function by detection of biochemical markers. Our results demonstrated that OSM strongly inhibited the growth of SMMC-7721 cells in a dose-dependent manner, associated with decreased clonogenicity. Cell cycle analysis revealed a decreased proportion of cells in S phase, with arrest at G0/G1. The apotosis rate was increased after OSM treatment compared to the control. These changes were associated with striking changes in cellular morphology, toward a more mature hepatic phenotype, accompanied by significant reduction of the expression of AFP and specific activity of ${\gamma}$-GT, with remarkable increase in secretion of albumin and ALP activity. Taken together, our findings indicate that OSM could induce the differentiation and reduce cell viability of SMMC-7721 cells, suggesting that differentiation therapy with OSM offers the opportunity for therapeutic intervention in HCC.

• 대한한의학원전학회지
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• 제19권2호통권33호
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• pp.30-45
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• 2006

Analyzed the subject of ‘To heart' meridian system(向心服系), and 'Circulating' meridian system(備環服系), and considered relativity between the circulating pattern of the channels, the collaterals and the circulating distinction YoungGi (營氣), WiGi(衛氣). The subject of 'To heart' meridian system is WiGi, and this system is similiar to the moving pattern of the fifteen major collaterals(十五絡服). The subject of 'Circulating' meridian system is YoungGi, and this system is same with the moving pattern of the twelve regular channels(十二經脈). YoungGi and WiGi have the same origin, and they are intrinsic one thing with functional ambivalency. It is WiGi, the subject of the movement of Collateral, because it is identical the moving pattern of Collaterals(絡服) and that of WiGi as the subject of the movement of Collateral. It is YoungGi, the subject of movement of Channel because it is identical the moving pattern of Channels(經服) and that of YoungGi. It can be defined that Wigi as the subject of the movement of Collateral, also YoungGi as the subject of movement of Channel, but that is from i 염 function and action, there's no need to be separated within the framework of going through Meridian. YoungSuBosa(迎隨補鴻) in acupuncture, defines its basis not only on the moving direction of YoungGi, but on combinated difference between the directions, moments, and sex. Until now it is under discussion the rights and wrongs, It's not contradictory concept between two basis of YoungSuBoSa, from the thought the distinct movement of WiGi and the circulation pattern of Collaterals have no specified directions.

• 한국산학기술학회논문지
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• 제17권8호
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• pp.379-388
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• 2016

현대 무기체계 제조를 위해 적용되는 수많은 생산 기술과 다양한 공정 환경으로 인해 다양한 결함이 무기체계 제조공정에 유입되고 있다. 이렇게 제조공정에 유입되는 결함 중 육안 검사, 기능 시험 등 기존 품질 관리 절차를 통해 검출할 수 있는 "명백결함(Patent Defect)"과 무기체계 복잡성과 제조공정의 복잡도로 기존 품질 관리 방식으로 검출이 제한되는 "잠재결함(Latent Defect)" 2가지 종류가 있다. 이러한 초기 결함 문제를 최소화하기 위해 무기체계 생산공정 중 유입된 결함요소를 환경부하(온도, 진동)를 활용하여 결함검출/제거/개선하기 위해 환경 부하 선별(ESS : Environmental Stress Screening) 시험을 수행해야 한다. 본 논문은 국내 무기체계 제조업체에서 정량적 환경 부하 선별 시험 설계의 어려움을 최소화하기 위해 MIL-HDBK-344(Environmental Stress Screening of Electronic Equipment)의 수학적 모델을 기반으로 정량적 환경 부하 선별시험 효과도 분석 및 프로파일 자동화 도구를 구현하였으며, 6가지(온도부하변수 3가지(온도범위/온도변화율/허용 잔류결함밀도), 진동부하변수 2가지(부하크기/허용 잔류결함밀도), 시험설계변수 1가지(허용 시험시간)) 시나리오를 통해 구현된 도구 유효성을 확인했다.

• 한국식품영양과학회지
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• 제34권10호
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• pp.1531-1535
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• 2005

C. militaris 동충하초의 기능성을 규명하기 위하여 당대사 관련 효소인 GK, PDH 및 ACC 활성을 측정하였다. C. militaris에서 추출된 CM-A와 CM-B는 GK와 PDH 및 ACC 효소에 대하여 대조군에 비해 높은 활성을 나타냈으며, CM-B 보다는 CM-A에서 유의적으로 높은 활성 증가를 나타냈다(p < 0.05). 간세포내 당질 관련 호소의 활성은 CM-A와 CM-B 분획물의 혼합 비율에 영향을 받는 것으로 나타났는데 활성이 높은 CM-A의 비율이 커질수록유의적으로 높은 활성 증가를 나타냈다. GK와 ACC는 단일 상태의 CM-A 보다는 혼합된 상태일 때 활성이 증가하였지만, PDH는 혼합된 상태보다는 CM-A 단독일 때 가장 높은 활성을 나타냈다. 결론적으로 C. miliaris는 GK, PDH 및 ACC 등의 효소 활성을 증가시킴으로써 혈중 포도당의 상승을 억제하며 이로 인해 항당뇨 작용을 한다고 판단된다.