• 제목/요약/키워드: acetylcholinesterase dopaminergic antagonist

검색결과 1건 처리시간 0.017초

EVIDENCE FOR HE CHANGES IN THE DOPAMINERGIC ACTIVITY AFTER THE SUBACUTE ADMINSTRATION WITH PHYSOSTIGMINE

  • Lim, Dong-Koo;Lee, Kyung-Min;Moon, Ae-Ra
    • Toxicological Research
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    • 제8권1호
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    • pp.71-81
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    • 1992
  • Rats were treated with physostigamine acutely and subacutely for 7 days. The duration of tremor, striatal acetylcholinesterase(AChE) activity and the occurrences of dopaminal antagonist-induced catalepsy were measured. During the daily treatment with 0.75mg/kg of physostigmine, the durations of tremor were markedly reduced. However, the tremors were ot occurred in the continuous infusion up to 0.20mg/kg/hr. Striatal AChE activities were significantly inhibited(8.25%) early hour, but twenty-four hour after daily administration with physostigmine AChE activities during the continuous infusion with physostigmine were also significantly inhibites (30-60%).

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