• Bulletin of the Korean Chemical Society
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• v.12 no.5
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• pp.495-499
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• 1991

The changes in the free energy and hydration free energy of N-acetyl-N'-methylalaninamide in the unhydrated and hydrated states were calculated with ECEPP/2 and the hydration shell model. The configurational entropy change of each conformation in both states were computed by a harmonic method. To understand the hydration structure of each hydrated conformation, the hydration-shell coordination numbers of functional. groups of the molecule were estimated from water-accessible volumes, and the contributions of water-accessible volume and polarization of each group to the hydration free energy were analyzed. The results show a reasonable agreement with those of recent theoretical studies and experiments.

• Geomechanics and Engineering
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• v.31 no.6
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• pp.637-651
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• 2022

The seismic design of embankment dams requires more comprehensive studies to understand the behaviour of dams. Deformations primarily control this behaviour occur during or after earthquake loading. Dam failures and incidents show that the impacts of deformations should be reviewed for existing and new embankment dams. Overtopping erosion failure can occur if crest deformations exceed the freeboard at the time of the deformations. Therefore, crest settlement is one of the most critical deformations. This study developed empirical formulas using Gene Expression Programming (GEP) based on 88 cases. In the analyses, dam height (H_d), alluvium thickness (H_a), the magnitude-acceleration-factor (MAF) values developed based on earthquake magnitude (Mw) and peak ground acceleration (PGA) within this study have been chosen as variables. Results show that GEP models developed in the paper are remarkably robust and accessible tools to predict earthquake-induced crest settlement of embankment dams and perform superior to the existing formulation. Also, dam engineering professionals can use them practically because the variables of prediction equations are easily accessible after the earthquake.

• Bulletin of the Korean Chemical Society
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• v.27 no.5
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• pp.657-662
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• 2006

Identification of accessible sites in targeted RNAs is a major limitation to the effectiveness of antisense oligonucleotides. A class of antisense oligodeoxynucleotides, known as the “10-23” DNA enzyme or DNAzyme, which is a small catalytic DNA, has been shown to efficiently cleave target RNA at purine-pyrimidine junctions in vitro. We have designed a strategy to identify accessible cleavage sites in the target RNA, which is hepatitis C virus nonstructural gene 3 (HCV NS3) RNA that encodes viral helicase and protease, from a pool of random DNAzyme library. A pool of DNAzymes of 58 nucleotides-length that possess randomized annealing arms, catalytic core sequence, and fixed 5'/3'-end flanking sequences was designed and screened for their ability to cleave the target RNA. The screening procedure, which includes binding of DNAzyme pool to the target RNA under inactive condition, selection and amplification of active DNAzymes, incubation of the selected DNAzymes with the target RNA, and target site identification on sequencing gels, identified 16 potential cleavage sites in the target RNA. Corresponding DNAzymes were constructed for the selected target sites and were tested for RNA-cleavage in terms of kinetics and accessibility. These selected DNAzymes were effective in cleaving the target RNA in the presence of $Mg^{2+}$. This strategy can be applicable to identify accessible sites in any target RNA for antisense oligonucleotides-based gene inactivation methods.

• Journal of the Korean housing association
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• v.28 no.2
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• pp.23-33
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• 2017

This study was aimed to assess accessibility situation of pedestrian environment of University-C focusing on accessibility of manual wheelchair users and to develop accessibility campus map. During March and April 2016, barrierfree design application situation of pedestrian environment and building entrances were investigated using a structured checklist and a digital distance and slope meter. Major findings are as follow. (1) Except one case, widths of all pedestrian routes (both sidewalk and non-sidewalk routes) exceeded 2 meters. (2) As for sidewalk and driveway contact point condition, there were many spots lacking curb ramp or alterative ramp that are accessible for manual wheelchair users. (3) More than half of non-sidewalk pedestrian routes did not have bollard to separate pedestrian and vehicle flows, and more than 92% of the bollards installed were too close for wheelchair users to pass or too far to prevent vehicle access. (4) More than 59 percent of the building entrances were found impossible for manual wheelchair users to access without any assistance, and one third of the buildings did not have any single accessible entrance. Based on the study findings, campus accessibility map was developed by the researchers and disseminated through university homepage. Using the campus accessibility map, users can plan their accessible paths ahead the trip.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.138.2-138.2
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• 2012

Cave on the Moon is considered as the most appropriate place for human to live during the frontier lunar exploration. While the lava flows, the outer crust gets cooled and solidified. Then, the empty space is remained inside after lava flow stops. Such empty space is called the lava caves. Those lava tubes on the Earth are formed mostly by volcanic activity. However, the lava tubes on satellite like Moon and planet like Mars without volcanic activity are mostly formed by the lava flow inside of the crater made by large meteorite impact. Some part of lava tube with collapsed ceiling appears as the entrance of the cave. Such area looks like a deep crater so called a pit crater. Four large pit craters with diameter of > 60 m and depth of > 40 m are found without difficulty from Kaguya and LRO mission image archives. However, those are too deep to use as easily accessible human frontier base. Therefore, now we are going to identify some smaller lunar caves with accessible entrances using LRO camera images of 0.5 m/pixel resolution. Earth's lava caves and their entrances are well photographed by surface and aerial camera in immense volume. Thus, if the image data are sorted and archived well, those images can be used in comparison with the less distinct lunar cave and entrance images due to its smaller size. Then, we can identify the regions on the Moon where there exist caves with accessible entrances. The database will be also useful in modeling geomorphology for lunar and Martian caves for future artificial intelligence investigation of the caves in any size.

• Genomics & Informatics
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• v.2 no.1
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• pp.45-52
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• 2004

The self-splicing group I intron from Tetrahymena thermophila has been demonstrated to perform splicing reaction with its substrate RNA in the trans configuration. In this study, we explored the potential use of the trans-splicing group I ribozymes to replace a specific RNA with a new RNA that exerts any new function we want to introduce. We have chosen thymidine phosphorylase (TP) RNA as a target RNA that is known as a valid cancer prognostic factor. Cancer-specific expression of TP RNA was first evaluated with RT-PCR analysis of RNA from patients with gastric cancer. We determined next which regions of the TP RNA are accessible to ribozymes by employing an RNA mapping strategy, and found that the leader sequences upstream of the AUG start codon appeared to be particularly accessible. A specific ribozyme recognizing the most accessible sequence in the TP RNA with firefly luciferase transcript as a 3' exon was then developed. The specific trans-splicing ribozyme transferred an intended 3' exon tag sequence onto the targeted TP transcripts, resulting in a more than two fold induction of the reporter activity in the presence of TP RNA in mammalian cells, compared to the absence of the target RNA. These results suggest that the Tetrahymena ribozyme can be a potent anti-cancer agent to modify TP RNAs in tumors with a new RNA harboring anti-cancer activity.

• Korean Journal of Remote Sensing
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• v.26 no.3
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• pp.317-324
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• 2010

In recent years, many automatic classification approaches have been employed. An automatic classification method can be effective, time-saving and can produce objective results due to the exclusion of operator intervention. This paper proposes a classification method based on automated training for high resolution multispectral images using ancillary data. Generally, it is problematic to automatically classify high resolution images using ancillary data, because of the scale difference between the high resolution image and the ancillary data. In order to overcome this problem, the proposed method utilizes the classification results of a Landsat image as a medium for automatic classification. For the classification of a Landsat image, a maximum likelihood classification is applied to the image, and the attributes of ancillary data are entered as the training data. In the case of a high resolution image, a K-means clustering algorithm, an unsupervised classification, was conducted and the result was compared to the classification results of the Landsat image. Subsequently, the training data of the high resolution image was automatically extracted using regular rules based on a RELATIONAL matrix that shows the relation between the two results. Finally, a high resolution image was classified and updated using the extracted training data. The proposed method was applied to QuickBird and SPOT-5 images of non-accessible areas. The result showed good performance in accuracy assessments. Therefore, we expect that the method can be effectively used to automatically construct thematic maps for non-accessible areas and update areas that do not have any attributes in geographic information system.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2004.11a
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• pp.393-398
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• 2004

It is transformed map data of different coordinate system into unique system and We triedto make topographic map on non-accessible area. We transformed Russian map coordinates(Krassovsky, G-K projection) intoWGS-84, TM projection and assessed accuracy. The RMSE(in East and West bearings : ${\pm}$13.67m, in North and South bearings ： ${\pm}$14.67m) using only SCP(Survey Control Point) is more accurate than that(in East and West bearings ： ${\pm}$24.26m, in North and South bearings : ${\pm}$25.32m) using SCP, intersection of road, bridge. Exterior orientation parameters are estimated using rigorous modelling and GCPs are classified with SCP, intersection of road, bridge. Rigorous modelling is performed with each classified GCP. The modelling result usingonly SCP(in East and West bearings : ${\pm}$13.53m, in North and South bearings ： ${\pm}$14.22m) is more accurate than that using intersection of road(in East and West bearings ： ${\pm}$16.l1m, in North and South bearings： ${\pm}$23.85m), bridge(in East and West bearings : ${\pm}$17.21m, in North and South bearings : ${\pm}$21.82m). The results means that SCP is more accurate than intersection of road, bridge because of edit to generate map. therefore, SCP is suitable for object of GCP in paper map(1:50,000). Geographic information on non-accessible area and analysis is performed. The results of stereoscopic plotting is well matched old map data on road, railroad but, many objects are generally editted. It is possible to update on new objects(building, tributary ‥‥etc). Ability of description using SPOT-5(stereo) is more than features and items included in 1:50,000 topographic map. Therefore, it is possible to make large scale map than 1:50,000 topographic map using SPOT-5 imagery. But, there are many problems(accurate GCPs, obtain of high resolution stereoscopic satellite imagery in a period ‥‥ etc) to make topographic map on non-accessible area. It is actually difficult to solve these problems. therefore, it is possible to update 1:50,000 topographic map in part of topographic map generation.

• 한국디지털정책학회:학술대회논문집
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• 2004.11a
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• pp.269-282
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• 2004

• Proceedings of the Korea Database Society Conference
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• 1994.09a
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• pp.147-161
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• 1994

Information Superhighway $\textbullet$ Definition - Communication of any type, anytime, anywhere - A material interactive, multimedia highway that is open, interconnected, and accessible to all-- a "netework of networks" $\textbullet$ Key Principles o "network of networks" o customer choice throught competition o fair and open access o open standard(omitted)