• 한국콘텐츠학회논문지
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• 제9권4호
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• pp.275-285
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• 2009

2007년 1월부터 8월까지의 8개월 동안 삼성서울병원에서 병동 및 외래에서 의뢰된 전 혈구검사 검체를 대상으로 하여 S사의 자동혈액장비의 4 Diff channel과 WBC channel의 결과 비교를 통해 총 백혈구의 과다측정 여부를 판단하였다. 장기적 임상치료를 밟는 환자 중 8개월간의 백혈구 수 비교를 통해 over count라고 판단된 증례는 총 25건이었다. 해당 검체와 동일한 날짜에 실시한 생화학적 검사 중 간 기능(liver function test)의 지표가 되는 AST와ALT에서 정강범위를 벗어나는 경우가 전체 환자의 68%였으며, 총 별리루빈 범위도 전체 검체 중 60%가 허용범위를 넘는 결과를 보였다. 백혈구가 과다 측정된 시점에 환자의 임상정보 결과 Cephalosporin계 4세대 항생제인 cefepime을 98%의 환자들이 투여 받은 상태에 있었다. 백혈구 과다측정은 하나의 원인보다 다양한 원인들이 복합적으로 작용하여 발생하는 것으로 사료된다.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2000년도 제28회 학술심포지엄
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• pp.9-10
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• 2000

The aging process is multifactorial and results from the combined effects of inherited(genetic) and acquired factors including life style, food habits, physical activity, and diseases. That give rise to the various approaches in aging. We are trying to study biological changes with aging, In detail we are focused on gene and protein function accompanied by normal or abnormal aging process, especially our efforts are aimed at revealing the functional relationship of proteins in aging as a final product of gene. We expect that proteomic approach to the study of protein function involved in aging should give us variety of integrated data to understand biological changes of long lived lives, We have applied expression proteomics to rat liver bred in dietary restriction or in at libitum to elucidate the effects of food habit on aging. Expression proteomics shows us protein profile in a selected tissue or cells as a whole and gives us the information about protein expression level, posttranslational modification and degenerative modification of expressed proteins. Comparative analysis of young and old rat liver by two dimensional gels shows that gene expression of several proteins was down regulated in old rats and some protein expression level is increased with aging. Dietary restriction slows down these changes of gene expression and in some proteins there's no difference in protein expression level at same ages in comparison with rats bred in at libitum. About forty protein was identified by peptide mass fingerprint with MALDI-TOF and rest of the protein of interest is in the course of identification, Also we are trying to make mitochondrial and cytosolic proteom reference map. These suborganelle proteom map will gives us the information about low abundance proteins and cellular localization of proteins. Proteomics is a growing methodology to study biological system. High throughput qualitative and qualitative aspect of this approach will gives us large amount of integrated information and speed up our understanding about biological system

• 대한한방내과학회지
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• 제40권6호
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• pp.1026-1034
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• 2019

Objective: This study was conducted to investigate the lipid-lowering effect and safety of Daeshiho-tang in patients with uncontrolled lipid levels by statins. Methods: We investigated patients who had an abnormal lipid profile even when taking statins and who were administered Daeshiho-tang at Kyung-Hee University Korean Medical Hospital for at least one day between January 2008 and December 2018. Their basal characteristics and examinations were reviewed retrospectively with respect to lipid profile, AST, ALT, GGT, BUN, and creatinine. The lipid profile was composed of total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol. Subgroup analysis was performed on each component of dyslipidemia. Results: Among 20 participants, there were 10 males and 10 females. The mean BMI was 23.52. Eighty five percent of the participants were diagnosed as having cerebral infarction. After the administration of Daeshiho-tang, total cholesterol and LDL cholesterol were significantly reduced, to 41.3 mg/dl and 33.95 mg/dl, respectively. In subgroup analyses, total cholesterol and LDL cholesterol were significantly decreased, to 63 mg/dl and 54.6 mg/dl, respectively. Liver and kidney function showed no significant difference after taking Daeshiho-tang. Conclusions: Daeshiho-tang as a decoction or powder had significant lipid-lowering effects on total cholesterol and LDL cholesterol in patients with dyslipidemia. The lipid-lowering effect on total and LDL cholesterol increased in patients with hypercholesterolemia and hyper-LDL-cholesterolemia, respectively. Based on the minimal changes in the liver and kidney function test, Daeshiho-tang would be safe enough to be used in clinics.

• 대한한방내과학회지
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• 제40권3호
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• pp.478-490
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• 2019

Purpose: This work is a retrospective clinical case study evaluating the efficacy of Injinoryung-san granule administration to patients who showed an abnormal hepatic function test level. Methods: We analyzed the chart records of seven patients with elevated levels of the hepatic function test treated with Injinoryung-san granules. Results: The patients who were treated with Injinoryung-san showed a significant improvement in their elevated hepatic function test levels. Conclusion: In patients with elevated hepatic function test levels, Injinoryung-san granules can improve the hepatic level without adverse effects or changes in existing drugs.

• Clinical and Experimental Pediatrics
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• 제45권7호
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• pp.923-927
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• 2002

우연히 발견된 간비장 종대를 주소로 내원한 3세 여아에서 신낭종을 동반한 선천성 간섬유화증을 진단한 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Clinical and Experimental Pediatrics
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• 제54권6호
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• pp.260-266
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• 2011

Purpose: Infantile hepatic hemangioendothelioma (IHHE) is the most common type of hepatic vascular tumor in infancy. We conducted this study to review our clinical experience of patients with IHHE and to suggest management strategies. Methods: We retrospectively analyzed the medical records of 23 IHHE patients (10 males, 13 females) treated at the Asan Medical Center between 1996 and 2009. Results: Median age at diagnosis was 38 days (range, 1 to 381 days). Seven patients (30%) were diagnosed with IHHE based on sonographically detected fetal liver masses, 5 (22%) were diagnosed incidentally in the absence of symptoms, 5 (22%) had congestive heart failure, 3 (13%) had skin hemangiomas, 2 (9%) had abnormal liver function tests, and 1 (4%) had hepatomegaly. All diagnoses were based on imaging results, and were confirmed in three patients by histopathology analysis. Six patients were observed without receiving any treatment, whereas 12 received corticosteroids and/or interferonalpha. One patient with congestive heart failure and a resectable unilobar tumor underwent surgical resection. Three patients with congestive heart failure and unresectable tumors were managed by hepatic artery embolization with/without medical treatment. At a median follow-up of 29 months (range, 1 to 156 months), 21 (91%) patients showed complete tumor disappearance or >50% decrease in tumor size. One patient died due to tumor-related causes. Conclusion: IHHE generally has a benign clinical course with low morbidity and mortality rates. Clinical course and treatment outcome did not differ significantly between medically treated and non-treated groups. Surgically unresectable patients with significant symptoms may be treated medically or with hepatic artery embolization.

• 사상체질의학회지
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• 제17권2호
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• pp.32-45
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• 2005

1. Objectives The purpose of this study was to find out prevalence of chronic diseases according to Sasang constitutional. 2. Methods The medical records of 1,453 subjects who have taken health examinations and diagnosis of Sasang constitution from January 2003 to June 2003 at a health examination center of a university hospital in Seoul were reviewed. Sociodemographic factors and the prevalences of chronic diseases according to Sasang Constitution are compared and analyzed. 3. Results (1) Among the 1,453 subjects, 683(47.0%) were Taeumin, 421(29.0%) were Soyangin, and 349(24.0%) were Soeumin. (2) The prevalences of gastric polyp, diabetes mellitus, obesity, hypertension, hyperlipidemia, dyslipoproteinemia, abnormal liver function and fatty liver of T aeurnin were significantly higher than those of the other constitutions (p-value<0.05). And the prevalences of hepatic cyst and gall stone disease of Taeumin were higher than those of the other constitutions(p-value<0.l). (3) The prevalences of liver cirrhosis of Soyangin was significantly higher than that of the other constirutions(p-value <0. 05). (4) The prevalences of pulmonary tuberculosis on X-ray and anemia of Soeurnin were significantly higher than those of the other constitutions (p-value<0.05). And the prevalences of gastric xanthelasma and hypothyroidism of Soeumin were higher than those of the other constitutions(p-value<0.1). 4. Conclusions There were significant differences on the prevalences of some chronic diseases according to Sasang wnstirution.

• 대한중풍순환신경학회지
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• 제20권1호
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• pp.25-32
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• 2019

■ Objectives In this case report, we address a case of a 83-year-old female patient diagnosed with suspicious autoimmune hepatitis. ■ Methods A patient was treated with herbal medication, Injinoryung-san gagam. We evaluated the improvements of symptoms by AST, ALT, GGT, ALP and total score of Fatigue Severity Scale(FSS). ■ Results After 4 weeks of taking Injinoryung-san gagam, there were decrease in abnormal liver enzyme levels with improvement of the patient's fatigue. ■ Conclusion This study suggested that Injinoryung-san gagam might be effective in autoimmune hepatitis patient's liver enzyme levels and fatigue recovery.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.91-96
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• 2013

Background: p53 alterations have been implicated in the development of many cancers, such as gastric cancer, but there is no evidence of p53 intron alterations in gastritis lesions. The aim of this study was to investigate the p53 intron alterations in gastritis along with p53 and mismatch repair protein expression and microsatellite status. Materials and Methods: PCR-sequencing was conducted for introns 2-7 on DNA extracted from 97 paired samples of gastritis lesions and normal adjacent tissue. Abnormal accumulation of p53 and mismatch repair proteins was investigated using immunohistochemistry. In addition, microsatellite status was evaluated with reference to five mononucleotide markers. Results: Gastritis cases included 41 males and 56 females in the age range of 15-83 years, 87.6% being H.pylori positive. IVS2+38, IVS3ins16 and IVS7+72 were the most polymorphic sites. Their minor allele frequency values were as follows: 0.38, 0.21 and 0.06, respectively. Samples with GG genotype at IVS2+38 and CT at IVS7+72 had no insertion. Moreover, most of the stable samples (91.9 %) had a G allele at IVS2+38. All of the samples were IHC negative for p53 protein, microsatellite stable and expressed mismatch repair proteins. p53 alterations were prominent in the H. Pylori+ group, but without statistical significance. Conclusions: According to our results, some p53 polymorphisms such as IVS2+38, IVS3ins16 and IVS7+72, because of their correlations together or with microsatellite status may contribute to gastritis development. However, so far effects on p53 expression and function remain unclear. Therefore, a comprehensive survey is needed to delineate their biological significance.

• 한국산학기술학회논문지
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• 제16권5호
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• pp.3230-3242
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• 2015

본 연구는 건강검진 남성 수검자들의 AUDIT 수준과 비만지표(BMI, 허리둘레, 체지방률), 간 기능 검사치(AST, ALT, GGT, 총빌리루빈) 및 혈청 지질치(TC, TG, HDL-C, LDL-C)와의 관련성을 규명하고자 2012년 1월 1일부터 12월 31일까지의 기간에 C대학교병원 건강증진센터에서 종합건강검진을 받았던 30~79세의 남성 수검자 558명을 대상으로 문진표와 건강검진결과자료를 분석하였다. 연구결과, 조사대상자의 AUDIT 수준은 Zone I 58.2%, Zone II 25.3%, Zone III 7.0%, Zone IV 9.5%로 나타났다. 또한 AUDIT 수준은 연령, 흡연, 체지방률, GGT 및 TG와 유의한 관련성이 있었으며, 특히 허리둘레, GGT 및 TG는 AUDIT 등급이 낮은 군(Zone I)보다 높은 군(Zone II~Zone IV)에서 비정상으로 나타날 위험비가 유의하게 상승하는 것으로 나타나고 있어 AUDIT 수준이 높아지는 문제음주는 비만지표, 간 기능 검사치 및 혈청 지질치의 비정상치의 증가와 유의한 관련성이 있음을 시사하고 있다.