• Journal of Preventive Medicine and Public Health
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• v.54 no.3
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• pp.161-165
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• 2021

Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads heterogeneously, disproportionately impacting poor and minority communities. The relationship between poverty and race is complex, with a diverse set of structural and systemic factors driving higher rates of poverty among minority populations. The factors that specifically contribute to the disproportionate rates of SARS-CoV-2 infection, however, are not clearly understood. Methods: We evaluated SARS-CoV-2 test results from community-based testing sites in Los Angeles, California, between June and December, 2020. We used tester zip code data to link those results with United States Census report data on average annual household income, rates of healthcare coverage, and employment status by zip code. Results: We analyzed 2 141 127 SARS-CoV-2 test results, of which 245 154 (11.4%) were positive. Multivariable modeling showed a higher likelihood of SARS-CoV-2 test positivity among Hispanic communities than among other races. We found an increased risk for SARS-CoV-2 positivity among individuals from zip codes with an average annual household income

• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.17-17
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• 2005

In this presentation, we will discuss several recent achievements developed in my laboratory for microarray-based diagnosis of human genetic mutations including HNF-1 and BRCA1 mutations. To determine the presence of the genetic mutations in a human sample, we prepared allele-specific oligonucleotide chips from selected mutation sites and generated target probes using a tow-step method for Cy-3 DNA $samples^{1)}$ or in vitro transcription of promoter-tagged PCR products for Cy-3 RNA $samples^{2)}$. Hybridization of the target probes to the chips successfully identified all of the genotypes for the tested sites. For more reliable diagnosis, we also employed single base extension (SBE) reaction and zip-code microarray technique for our strategy. Particularly we developed an efficient PNA zip-code microarray for the detection of $HNF-1{\alpha}$ $mutations^{3)}$. Using multiplex SBE reactions and zip-code strategy, we were able to correctly diagnose several mutation sites in exon 2 of $HNF-1{\alpha}$ with a wild-type and mutant including a MODY3 patient. These works represent successful applications of DNA microarray technology for the diagnosis of human genetic mutations.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.712-713
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• 2011

2012년부터 시행 예정인 신재생에너지 의무할당제(RPS)의 도입으로 향후 태양광 및 풍력 등의 그린 에너지가 향후 지속적으로 배전계통에 연계, 운용될 것으로 예상된다. 이때 정상상태의 계통전압을 해석하기 위해서는 부하모델링이 필수적이다. 본 논문에서는 가장 많이 활용되고 있는 ZIP 부하모델을 활용하여 배전계통에서 효과적인 전압해석법을 제안하고, 수치해석 및 PSCAD/EMTDC를 이용하여 제안한 전압해석법의 유효성을 검증한다.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.10
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• pp.1703-1707
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• 2008

Low frequency oscillation of inter-area system is important problem in power system areas because the operation conditions of power system depend on it. Generally, the analysis of the problem is used by small signal stability. Especially, the analysis results are affected by decision of load models. In this paper, the effect of the analysis results was studied according to load component characteristics. ZIP model, popular in large-scaled power system analysis, was used as the load model. Many cases were studied according to the combination of ZIP model in inter-area system.

• Korean Journal of Plant Resources
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• v.30 no.5
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• pp.571-577
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• 2017

Abscisic acid (ABA) is an important phytohormone involved in abiotic stress tolerance in plants. The group A bZIP transcription factors play important roles in the ABA signaling pathway in Arabidopsis but little is known about their functions in rice. In our current study, we have isolated and characterized a group A bZIP transcription factor in rice, OsABF3 (Oryza sativa ABA responsive element binding factor 3). We examined the expression patterns of OsABF3 in various tissues and time course analysis after abiotic stress treatments such as drought, salinity, cold, oxidative stress, and ABA in rice. Subcellular localization analysis in maize protoplasts using a GFP fusion vector further indicated that OsABF3 is a nuclear protein. Moreover, in a yeast one-hybrid experiment, OsABF3 was shown to bind to ABA responsive elements (ABREs) and its N-terminal region found to be necessary to transactivate a downstream reporter. A homozygous T-DNA insertional mutant of OsABF3 is more sensitive to salinity, drought, and oxidative stress compared with wild type plants ＆ OsABF3OX plants. In addition, this Osabf3 mutant showed a significantly decreased sensitivity to high levels of ABA at germination and post-germination. Collectively, our present results indicate that OsABF3 functions as a transcriptional regulator that modulates the expression of abiotic stress-responsive genes through an ABA-dependent pathway.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2000.05a
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• pp.106-113
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• 2000

본 논문은 다량우편물의 대부분을 차지하는 창이 있는 봉투와 최근 증가되고 있는 명도 값이 높은 색깔이 있는 우편봉투 영상에서 구조적 방법을 분석하여 수취인 주소 영역을 자동적으로 추출하고 추출된 영역에서 우편번호를 찾아 제안된 신경망으로 인식 및 검증할 수 있는 실용적인 시스템을 구현하였다.

• Bulletin of the Korean Chemical Society
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• v.20 no.11
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• pp.1319-1322
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• 1999

Leucine zipper dynamically tunes the degree of bifurcation of the DNA binding segments in the basic region of the Fos-Jun bZIP complex. Molecular dynamics simulation indicated that site-specific mutagenesis of conserved leucine residues inside the leucine zipper domain caused the change of dynamic behavior of the basic region, and efficient DNA binding occurs only within a certain range of distance between the two DNA binding segments in the basic region. Distribution of α-helices in the hinge region is also suggested to influence the bifurcation of the DNA binding segments.

• Korean Architects
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• s.598
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• pp.36-43
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• 2019

• Journal of Internet Computing and Services
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• v.21 no.4
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• pp.35-41
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• 2020

This paper proposes an algorithm to improve the compression performance of the adaptive multi-rate (AMR) speech coding using the context tree weighting (CTW) method. AMR is the voice encoding standard adopted by IMT-2000, and supports 8 transmission rates from 4.75 kbit/s to 12.2 kbit/s to cope with changes in the channel condition. CTW as a kind of the arithmetic coding, uses a variable-order Markov model. Considering that CTW operates bit by bit, we propose an algorithm that re-orders AMR data and compresses them with CTW. To verify the validity of the proposed algorithm, an experiment is conducted to compare the proposed algorithm with existing compression methods including ZIP in terms of compression ratio. Experimental results indicate that the average additional compression rate in AMR data is about 3.21% with ZIP and about 9.10% with the proposed algorithm. Thus our algorithm improves the compression performance of AMR data by about 5.89%.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.153-153
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• 2017

Potato (Solanum tubersosum L.) is susceptible to various environmental stresses such as frost, high temperature, and drought. Enhancement of potato drought tolerance can reduce yield loss under drought that has negative effect on potato tuber growth. Genetic engineering can be utilized to achieve this goal, but such approaches using endogenous potato genes have rarely been applied. Since unpredictable global weather changes cause more severe and frequent water limiting conditions, improvement of potato drought tolerance can minimize such adverse effects under drought and can impact on sustainable potato production. Genetic engineering can be utilized to improve potato drought tolerance, but such approaches using endogenous potato genes have rarely been applied. We were obtained AtbZIP28 gene transgenic potato plants. It is identified transcript levels at various stress conditions, polyethylene glycol (PEG), NaCl, abscisic ${\underline{acid}}$ (ABA). Also, For identification to regulate ER stress response genes in AtbZIP28 gene transgenic potato plant, we screened seven potato genes from RNA-seq analysis under TM treatment. Five and two genes were up- and down-regulated by TM, respectively. Their expression patterns were re-examined at stress agents known to elicit TM, DTT, DMSO and salt stress.