• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.5
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• pp.2660-2679
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• 2017

Crypton is a SP-network block cipher that attracts much attention because of its excellent performance on hardware. Based on Crypton, mCrypton is designed as a lightweight block cipher suitable for Internet of Things (IoT) and Radio Frequency Identification (RFID). The security of Crypton and mCrypton under meet-in-the-middle attack is analyzed in this paper. By analyzing the differential properties of cell permutation, several differential characteristics are introduced to construct generalized ${\delta}-sets$. With the usage of a generalized ${\delta}-set$ and differential enumeration technique, a 6-round meet-in-the-middle distinguisher is proposed to give the first meet-in-the-middle attack on 9-round Crypton-192 and some improvements on the cryptanalysis of 10-round Crypton-256 are given. Combined with the properties of nibble permutation and substitution, an improved meet-in-the-middle attack on 8-round mCrypton is proposed and the first complete attack on 9-round mCrypton-96 is proposed.

• Journal of Electrical Engineering and Technology
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• v.13 no.5
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• pp.1956-1964
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• 2018

Since the stator winding of High-Speed Permanent Magnet Generator (HSPMG) has few winding turns and low inductance value, it is more prone to be influenced by harmonic current. Moreover, the operation efficiency and the torque stability of HSPMG will be greatly influenced by harmonic current. Taking a 117 kW, 60 000 rpm HSPMG as an example, in order to analyze the effects of harmonic current on HSPMG in this paper, the 2-D finite element electromagnetic field model of the generator was established and the correctness of the model was verified by testing the generator prototype. Based on the model, the losses and torque of the generator under different frequency harmonic current were studied. The change rules of the losses and torque were found out. Based on the analysis of the influence of the harmonic phase angle on torque ripple, it is found that the torque ripple could be weakened through changing the harmonic phase angle. Through the analysis of eddy current density in rotor, the change mechanism of the rotor eddy current loss was revealed. These conclusions can contribute to reduce harmonic loss, prevent demagnetization fault and optimize torque ripple of HSPMG used in distributed power supply system.

• Molecules and Cells
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• v.42 no.9
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• pp.628-636
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• 2019

Altered genetic features in cancer cells lead to a high rate of aerobic glycolysis and metabolic reprogramming that is essential for increased cancer cell viability and rapid proliferation. Pyruvate kinase muscle (PKM) is a rate-limiting enzyme in the final step of glycolysis. Herein, we report that PKM is a potential therapeutic target in triple-negative breast cancer (TNBC) cells. We found that PKM1 or PKM2 is highly expressed in TNBC tissues or cells. Knockdown of PKM significantly suppressed cell proliferation and migration, and strongly reduced S phase and induced G2 phase cell cycle arrest by reducing phosphorylation of the CDC2 protein in TNBC cells. Additionally, knockdown of PKM significantly suppressed $NF-{\kappa}B$ (nuclear factor kappa-light-chain-enhancer of activated B cells) activity by reducing the phosphorylation of p65 at serine 536, and also decreased the expression of $NF-{\kappa}B$ target genes. Taken together, PKM is a potential target that may have therapeutic implications for TNBC cells.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.1
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• pp.114-130
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• 2021

With the drastic growth of Information and Communication Technology (ICT) industry, global energy consumption is exponentially increased by mobile communications. The huge energy consumption and increased environmental awareness have triggered great interests on the research of dynamic distribution of cell user and traffic, and then designing the energy efficient cellular network. In this paper, we explore the temporal and spatial characteristics of human mobility and traffic distribution using real data set. The analysis results of cell traffic illustrate the tidal effect in temporal and spatial dimensions and obvious periodic characteristics which can be used to design Base Station (BS) dynamic with sleeping or shut-down strategy. At the same time, we designed a new Cell Zooming and BS cooperation mode. Through simulation experiments, we found that running in this mode can save about 35% of energy consumption and guarantee the required quality of service.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.11
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• pp.3892-3912
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• 2021

The recent rapid growth of mobile network traffic places multi-access edge computing in an important position to reduce network load and improve network capacity and service quality. Contrasting with traditional mobile cloud computing, multi-access edge computing includes a base station cooperative cache layer and user cooperative cache layer. Selecting the most appropriate cache content according to actual needs and determining the most appropriate location to optimize the cache performance have emerged as serious issues in multi-access edge computing that must be solved urgently. For this reason, a cache placement algorithm based on comprehensive utility in big data multi-access edge computing (CPBCU) is proposed in this work. Firstly, the cache value generated by cache placement is calculated using the cache capacity, data popularity, and node replacement rate. Secondly, the cache placement problem is then modeled according to the cache value, data object acquisition, and replacement cost. The cache placement model is then transformed into a combinatorial optimization problem and the cache objects are placed on the appropriate data nodes using tabu search algorithm. Finally, to verify the feasibility and effectiveness of the algorithm, a multi-access edge computing experimental environment is built. Experimental results show that CPBCU provides a significant improvement in cache service rate, data response time, and replacement number compared with other cache placement algorithms.

• Geomechanics and Engineering
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• v.29 no.6
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• pp.683-696
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• 2022

Dams are inevitably planned to be built on thick overburden with high permeability and deformability. The connection part between concrete cut-off wall in overburden and earth core in dam body is not only a key part of the anti-seepage system, but also a weak position. Large uneven settlement will be aroused at the concoction part. However, the interaction behavior and the scope of the connection part cannot be determined effectively. In this paper, numerical analysis of a high earth core dam built on thick overburden was carried out with large deformation FE method. The mechanical behavior of the connection part was detail studied. It can be drawn that there is little differences in dam integral deformation for different analysis method, but big differences were found at the connection part. The large deformation analysis method can reasonably describe the process that concrete wall penetrates into soil. The high plasticity clay has stronger ability to adapt to large uneven deformation which can reduce stress level, and stress state of concrete wall is also improved. The scope of high plasticity clay zone in the connection part can be determined according to stress level of soils and penetration depth of concrete wall.

• Wind and Structures
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• v.34 no.4
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• pp.335-353
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• 2022

The current work numerically investigates the transient force and dynamic response of an overhead transmission tower-line structure caused by the passage of a high-speed train (HST). Taking the CRH2C HST and an overhead transmission tower-line structure as the research objects, both an HST-transmission line fluid numerical model and a transmission tower-line structure finite element model are established and validated through comparison with experimental and theoretical data. The transient force and typical dynamic response of the overhead transmission tower-line structure due to HST-induced wind are analyzed. The results show that when the train passes through the overhead transmission tower-line structure, the extreme force on the transmission line is related to the train speed with a significant quadratic function relationship. Once the relative distance from the track is more than 15 m, the train-induced force is small enough to be ignored. The extreme value of the mid-span dynamic response of the transmission line is related to the train speed and span length with a significant linear functional relationship.

• Structural Engineering and Mechanics
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• v.90 no.4
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• pp.345-356
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• 2024

This paper aims to investigate the seismic behavior of double steel plate and concrete composite shear wall (DSCW) of shield buildings in nuclear power engineering through experimental study. Hence, a total of 10 specimens were tested to investigate the hysteretic performance of DSCW specimens in detail, in terms of load vs. displacement hysteretic curves, skeleton curves, failure modes, flexural strength, energy dissipation capacity. The experimental results indicated that the thickness of steel plate, vertical load and stiffener have great influence on the shear bearing capacity of shear wall, and the stud space has limited influence on the shear capacity. And finally, a novel simplified formula was proposed to predict the shear bearing capacity of composite shear wall. The predicted results showed satisfactory agreement with the experimental results.

• Journal of Microbiology and Biotechnology
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• v.27 no.3
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• pp.584-590
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• 2017

Ginkgo biloba extract (EGb 761) has been widely used clinically to reduce myocardial ischemia reperfusion injury (MIRI). Microvascular endothelial cells (MVECs) may be a proper cellular model in vitro for the effect and mechanism study against MIRI. However, the protective effect of EGb 761 on MVECs resisting hypoxia/reoxygenation (H/R) injury is little reported. In this study, H/R-injured MVECs were treated with EGb 761, and then the cell viability, apoptosis, ROS production, SOD activity, caspase-3 activity, and protein level of ATM, ${\gamma}$-H2AX, p53, and Bax were measured. ATM siRNA was transfected to study the changes of protein in the ATM pathway. EGb 761 presented protective effect on H/R-injured MVECs, with decreasing cell death, apoptosis, and ROS, and elevated SOD activity. Next, EGb 761 could inhibit H/R-induced ATM, ${\gamma}$-H2AX, p53, and Bax in a dose-dependent manner. Moreover, ATM siRNA also could inhibit H/R-induced ATM, ${\gamma}$-H2AX, p53, and Bax. Overall, these findings verify that EGb 761 protects cardiac MVECs from H/R injury, and for the first time, illustrate the influence on the ATM pathway and apoptosis by EGb 761 via dampening ROS.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6565-6570
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• 2014

Objective: To observe the curative effects of rh-endostatin combined with DP regimen in treating patients with advanced esophageal cancer and analyze the correlation of CT perfusion (CTP) parameters and the expression of vascular endothelial growth factor (VEGF). Methods: Twenty patients with esophageal cancer confirmed pathologically were randomly divided into combined treatment (rh-endostatin+DP regimen) group and single chemotherapy group, 10 patients in each group, respectively. All patients were given conventional CT examination and CTP imaging for primary tumor. The level of VEGF, the size of tumor and CTP parameters (BF, BV, PS and MTT) before treatment and after 2 cycles of treatment were determined for the comparison and the correlation between CTP parameters and VEGF expression was analyzed. Results: the therapeutic effect of rh-endostatin+DP regimen group was superior to single chemotherapy group. VEGF level after treatment in rh-endostatin+DP regimen group was obviously lower than single chemotherapy group (P<0.01). The expression of VEGF had positive correlation with BF and BV but negative correlation with MTT. Compared with treatment before for rh-endostatin+DP regimen group, BF, BV and PS decreased while MTT increased after treatment (P<0.05). However, there were no significant differences between treatment before and after treatment in single chemotherapy (P>0.05). Conclusions: Rh-endostatin can down-regulate the expression of VEGF in esophageal cancer, change the state of hypertransfusion and high permeability of tumor vessels and had the better curative effect and slighter adverse reactions when combined with chemotherapy.