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Plasma metabolites associated with physiological and biochemical indexes indicate the effect of caging stress on mallard ducks (Anas platyrhynchos)

  • Zheng, Chao;Wu, Yan;Liang, Zhen Hua;Pi, Jin Song;Cheng, Shi Bin;Wei, Wen Zhuo;Liu, Jing Bo;Lu, Li Zhi;Zhang, Hao
    • Animal Bioscience
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    • v.35 no.2
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    • pp.224-235
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    • 2022
  • Objective: Cage rearing has critical implications for the laying duck industry because it is convenient for feeding and management. However, caging stress is a type of chronic stress that induces maladaptation. Environmental stress responses have been extensively studied, but no detailed information is available about the comprehensive changes in plasma metabolites at different stages of caging stress in ducks. We designed this experiment to analyze the effects of caging stress on performance parameters and oxidative stress indexes in ducks. Methods: Liquid chromatography tandem mass spectrometry (LC/MS-MS) was used to determine the changes in metabolites in duck plasma at 5 (CR5), 10 (CR10), and 15 (CR15) days after cage rearing and traditional breeding (TB). The associated pathways of differentially altered metabolites were analyzed using Kyoto encyclopedia of genes and genomes (KEGG) database. Results: The results of this study indicate that caging stress decreased performance parameters, and the plasma total superoxide dismutase levels were increased in the CR10 group compared with the other groups. In addition, 1,431 metabolites were detected. Compared with the TB group, 134, 381, and 190 differentially produced metabolites were identified in the CR5, CR10, and CR15 groups, respectively. The results of principal component analysis (PCA) show that the selected components sufficiently distinguish the TB group and CR10 group. KEGG analysis results revealed that the differentially altered metabolites in duck plasma from the CR5 and TB groups were mainly associated with ovarian steroidogenesis, biosynthesis of unsaturated fatty acids, and phenylalanine metabolism. Conclusion: In this study, the production performance, blood indexes, number of metabolites and PCA were compared to determine effect of the caging stress stage on ducks. We inferred from the experimental results that caging-stressed ducks were in the sensitive phase in the first 5 days after caging, caging for approximately 10 days was an important transition phase, and then the duck continually adapted.

Development of a Software for Re-Entry Prediction of Space Objects for Space Situational Awareness (우주상황인식을 위한 인공우주물체 추락 예측 소프트웨어 개발)

  • Choi, Eun-Jung
    • Journal of Space Technology and Applications
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    • v.1 no.1
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    • pp.23-32
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    • 2021
  • The high-level Space Situational Awareness (SSA) objective is to provide to the users dependable, accurate and timely information in order to support risk management on orbit and during re-entry and support safe and secure operation of space assets and related services. Therefore the risk assessment for the re-entry of space objects should be managed nationally. In this research, the Software for Re-Entry Prediction of space objects (SREP) was developed for national SSA system. In particular, the rate of change of the drag coefficient is estimated through a newly proposed Drag Scale Factor Estimation (DSFE), and is used for high-precision orbit propagator (HPOP) up to an altitude of 100 km to predict the re-entry time and position of the space object. The effectiveness of this re-entry prediction is shown through the re-entry time window and ground track of space objects falling in real events, Grace-1, Grace-2, Tiangong-1, and Chang Zheng-5B Rocket body. As a result, through analysis 12 hours before the final re-entry time, it is shown that the re-entry time window and crash time can be accurately predicted with an error of less than 20 minutes.

Efficacy of combination of endo-xylanase and xylan-debranching enzymes in improving cereal bran utilization in piglet diet

  • Wang, Weiwei;Zheng, Dawen;Zhang, Zhenzhen;Ye, Hui;Cao, Qingyun;Zhang, Changming;Dong, Zemin;Feng, Dingyuan;Zuo, Jianjun
    • Animal Bioscience
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    • v.35 no.11
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    • pp.1733-1743
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    • 2022
  • Objective: This study was aimed to explore the efficacy of combination of endo-xylanase (Xyn) and xylan-debranching enzymes (arabinofuranosidase, Afd and feruloyl esterase, FE) in improving utilization of bran in piglet diet. Methods: In vitro experiments were firstly conducted to examine the enzymological properties of Xyn, Afd, and FE, concurrent with their effect on degradation of arabinoxylan (Abx) in bran. In vivo experiment was then implemented by allocating two hundred and seventy 35-d-old postweaning piglets into 3 groups (6 replicates/group), which received bran-containing diet supplemented with Xyn (1,600 U/kg) or its combination with Afd (0.8 U/kg) and FE (4 U/kg) or without enzyme. Results: Both Xyn, Afd, and FE are relatively stable against the changes in temperature and pH value. Combining Xyn with Afd and FE had a superiority (p<0.05) over Xyn alone and its combination with Afd or FE in promoting (p<0.05) degradation of Abx in different brans. Combined treatment with Xyn, Afd, and FE was more beneficial than Xyn alone to induce increasing trends (p<0.10) of average daily gain, final body weight and feed efficiency of piglets fed bran-containing diet. Moreover, combination of Xyn, Afd, and FE showed advantages (p<0.05) over Xyn alone in causing reductions (p<0.05) in diarrhea rate and cecal pH value, concurrent with increases (p<0.05) in cecal and colonic acetic acid and total volatile fatty acid concentrations, as well as cecal butyric acid concentration of piglets fed bran-containing diet. Conclusion: Combining Xyn with Afd and FE was more beneficial than Xyn alone in promoting degradation of Abx in bran, along with growth performance and intestinal volatile fatty acid profile of piglets received bran-containing diet. Thereby, combination of Xyn, Afd, and FE had a superior efficacy relative to Xyn alone in improving application of cereal bran in piglet diet.

A Comparative Study on the International Competitiveness of Korea-China Cultural Products Trade (한중 문화상품무역 국제경쟁력 비교 연구)

  • Zheng, Yingrong;Bae, Ki-Hyung;Li, Na
    • The Journal of the Korea Contents Association
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    • v.22 no.9
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    • pp.349-359
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    • 2022
  • At present, with the diversified development of the global economy, the trade of cultural products has become an important factor affecting the competition of comprehensive strength among countries. As a neighboring country to China, South Korea has a similar cultural development environment to China. As an important pillar of South Korea's economy, cultural product trade, its development experience has reference significance for China. This paper adopts literature research method, comparative analysis method and empirical analysis method to conduct research. The article firstly analyzes the export level of China and South Korea from the scale of the import and export of cultural products, and finds the difference between the import and export of cultural products between the two countries. Then, it compares and analyzes the insufficiency of China's cultural product trade structure and the advantage of Korea's cultural product trade structure. Finally, this paper uses the stochastic frontier gravity model to conduct empirical analysis and draws relevant conclusions about the trade potential of cultural products between China and South Korea. The research results show that: (1) the international competitiveness of cultural products trade in China and South Korea is relatively high, but the competitiveness of China's cultural products has been improved slowly; (2) compared with South Korea, China's cultural product exports are affected by trade inefficiency factors larger. (3) The improvement of government efficiency has a great effect on reducing the inefficiency of trade in China.

Mechanical model for analyzing the water-resisting key stratum to evaluate water inrush from goaf in roof

  • Ma, Kai;Yang, Tianhong;Zhao, Yong;Hou, Xiangang;Liu, Yilong;Hou, Junxu;Zheng, Wenxian;Ye, Qiang
    • Geomechanics and Engineering
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    • v.28 no.3
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    • pp.299-311
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    • 2022
  • Water-resisting key stratum (WKS) between coal seams is an important barrier that prevents water inrush from goaf in roof under multi-seam mining. The occurrence of water inrush can be evaluated effectively by analyzing the fracture of WKS in multi-seam mining. A "long beam" water inrush mechanical model was established using the multi-seam mining of No. 2+3 and No. 8 coal seams in Xiqu Mine as the research basis. The model comprehensively considers the pressure from goaf, the gravity of overburden rock, the gravity of accumulated water, and the constraint conditions. The stress distribution expression of the WKS was obtained under different mining distances in No. 8 coal seam. The criterion of breakage at any point of the WKS was obtained by introducing linear Mohr strength theory. By using the mechanical model, the fracture of the WKS in Xiqu Mine was examined and its breaking position was calculated. And the risk of water inrush was also evaluated. Moreover, breaking process of the WKS was reproduced with Flac3D numerical software, and was analyzed with on-site microseismic monitoring data. The results showed that when the coal face of No. 8 coal seam in Xiqu Mine advances to about 80 m ~ 100 m, the WKS is stretched and broken at the position of 60 m ~ 70 m away from the open-off cut, increasing the risk of water inrush from goaf in roof. This finding matched the result of microseismic analysis, confirming the reliability of the water inrush mechanical model. This study therefore provides a theoretical basis for the prevention of water inrush from goaf in roof in Xiqu Mine. It also provides a method for evaluating and monitoring water inrush from goaf in roof.

The Impact of Government Development Policy on Land Investment and Land Price: Evidences from Linyi (토지개발 및 토지가격에 대해서 정부 개발 정책의 영향 린이시 중심으로)

  • Zhong, Shengyang;Zheng, Ziyang;Liu, Zhao
    • The Journal of the Korea Contents Association
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    • v.21 no.12
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    • pp.337-347
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    • 2021
  • Land is key natural resource that Chinese government actually owns. Real estate and land development have played an important part in China's urban development and economic development. The Chinese local governments' land development policies can mainly be characterized as the establishment of economic development zones and the development of new towns. Given the great importance of these measures, we can expect that these policies can generate noticeable impacts on land development and land price. However, little research has explored these impacts empirically. Using the data collected from land development projects of three districts in Linyi city-old town, new town, economic development zone, this paper attempts to investigate the impact of government development policy on land development and land price. This research chooses investment amount and land price as dependent variables. The multiple regression results demonstrate that the local government's land Development policies can affect land investment size and land price significantly. As we have noticed, the target of government development policy is to make use of urban land resources more scientifically and efficiently. Based on my empirical analysis, some useful insights can be provided for improving our understanding concerning the effects of these government land development policies.

Fe3O4 magnetic nanoparticles provide a novel alternative strategy for Staphylococcus aureus bone infection

  • Youliang, Ren;Jin, Yang;Jinghui, Zhang;Xiao, Yang;Lei, Shi;Dajing, Guo;Yuanyi, Zheng;Haitao, Ran;Zhongliang, Deng;Lei, Chu
    • Advances in nano research
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    • v.13 no.6
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    • pp.575-585
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    • 2022
  • Due to its biofilm formation and colonization of the osteocyte-lacuno canalicular network (OLCN), Staphylococcus aureus (S.aureus) implant-associated bone infection (SIABI) is difficult to cure thoroughly, and may occur recurrently subsequently after a long period dormant. It is essential to explore an alternative therapeutic strategy that can eradicate the pathogens in the infected foci. To address this, the polymethylmethacrylate (PMMA) bone cement and Fe3O4 nanoparticles compound cylinder were developed as implants based on their size and mechanical properties for the alternative magnetic field (AMF) induced thermal ablation, The PMMA mixed with optimized 2% Fe3O4 nanoparticles showed an excellent antibacterial efficacy in vitro. It was evaluated by the CFU, CT scan and histopathological staining on a rabbit 1-stage transtibial screw model. The results showed that on week 7, the CFU of infected soft tissue and implants, and the white blood cells (WBCs) of the PMMA+2% Fe3O4+AMF group decreased significantly from their controls (p<0.05). PMMA+2% Fe3O4+AMF group did not observe bone resorption, periosteal reaction, and infectious reactive bone formation by CT images. Further histopathological H&E and Gram Staining confirmed there was no obvious inflammatory cell infiltration, neither pathogens residue nor noticeably burn damage around the infected screw channel in the PMMA+2% Fe3O4+AMF group. Further investigation of nanoparticle distributions in bone marrow medullary and vital organs of heart, liver, spleen, lung, and kidney. There were no significantly extra Fe3O4 nanoparticles were observed in the medullary cavity and all vital organs either. In the current study, PMMA+2% Fe3O4+AMF shows promising therapeutic potential for SIABI by providing excellent mechanical support, and promising efficacy of eradicating the residual pathogenic bacteria in bone infected lesions.

Percentile-Based Analysis of Non-Gaussian Diffusion Parameters for Improved Glioma Grading

  • Karaman, M. Muge;Zhou, Christopher Y.;Zhang, Jiaxuan;Zhong, Zheng;Wang, Kezhou;Zhu, Wenzhen
    • Investigative Magnetic Resonance Imaging
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    • v.26 no.2
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    • pp.104-116
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    • 2022
  • The purpose of this study is to systematically determine an optimal percentile cut-off in histogram analysis for calculating the mean parameters obtained from a non-Gaussian continuous-time random-walk (CTRW) diffusion model for differentiating individual glioma grades. This retrospective study included 90 patients with histopathologically proven gliomas (42 grade II, 19 grade III, and 29 grade IV). We performed diffusion-weighted imaging using 17 b-values (0-4000 s/mm2) at 3T, and analyzed the images with the CTRW model to produce an anomalous diffusion coefficient (Dm) along with temporal (𝛼) and spatial (𝛽) diffusion heterogeneity parameters. Given the tumor ROIs, we created a histogram of each parameter; computed the P-values (using a Student's t-test) for the statistical differences in the mean Dm, 𝛼, or 𝛽 for differentiating grade II vs. grade III gliomas and grade III vs. grade IV gliomas at different percentiles (1% to 100%); and selected the highest percentile with P < 0.05 as the optimal percentile. We used the mean parameter values calculated from the optimal percentile cut-offs to do a receiver operating characteristic (ROC) analysis based on individual parameters or their combinations. We compared the results with those obtained by averaging data over the entire region of interest (i.e., 100th percentile). We found the optimal percentiles for Dm, 𝛼, and 𝛽 to be 68%, 75%, and 100% for differentiating grade II vs. III and 58%, 19%, and 100% for differentiating grade III vs. IV gliomas, respectively. The optimal percentile cut-offs outperformed the entire-ROI-based analysis in sensitivity (0.761 vs. 0.690), specificity (0.578 vs. 0.526), accuracy (0.704 vs. 0.639), and AUC (0.671 vs. 0.599) for grade II vs. III differentiations and in sensitivity (0.789 vs. 0.578) and AUC (0.637 vs. 0.620) for grade III vs. IV differentiations, respectively. Percentile-based histogram analysis, coupled with the multi-parametric approach enabled by the CTRW diffusion model using high b-values, can improve glioma grading.

The Influence of Inclusive Leadership on Innovative Behavior and Job Performance in Chinese IT Enterprises -Employee Voice Behavior as Mediating Variables (중국 IT기업 포용적 리더십이 직원 혁신행동과 직무성과에 미치는 영향 -직원 발언 행동의 매개효과를 중심으로)

  • Zheng, Jun-Yi;Li, Yan-Nan;Yuan, Hao
    • The Journal of the Korea Contents Association
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    • v.22 no.2
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    • pp.501-513
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    • 2022
  • The COVID-19 crisis has accelerated the Digital Transformation, The ability to innovate is more important than ever for businesses. In particular, competition among IT companies is getting fiercer. The intimacy of inclusive leadership plays an important role in the innovation behavior and performance improvement of employees and contributes to the development and competitiveness of the company. The purpose of this study is to examine how inclusive leadership affects employees' innovative behavior and job performance. In order to confirm the purpose of this study, in this paper, a survey was conducted on employees working in Chinese IT companies. Total of 309 questionnaires were used and the collected data were empirically analyzed using SPSS26.0. The study results are summarized as follows. As a result of the study, 1) Inclusive leadership has a positive effect on innovative behavior and job performance. 2) Employee voice behavior positively affects innovation behavior and job performance. 3) Employee voice behavior showed a positive mediating effect between inclusive leadership and innovation behavior and job performance. This study is considered to be a useful guideline for encouraging innovative behavior and improving the performance of IT employees.

The Analysis and Forecasting Model for Maintenance Costs Considering Elapsed Years of Old Long-Term Public Rental Housing (노후 장기공공임대주택의 경과 연수별 유지관리비 분석 및 예측 모형)

  • Jung, Yong-Chan;Jin, Zheng-Xun;Hyun, Chang-Taek;Lee, Sanghoon
    • Korean Journal of Construction Engineering and Management
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    • v.23 no.3
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    • pp.83-94
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    • 2022
  • The number of public rental housing has increased according to the government's 「Housing Welfare Roadmap (2017)」, and facility maintenance costs for the demand of improvement of performance and residential standards due to the aging of long-term public housing are significantly increasing. Consequently, the financial burden of public housing rental business for maintaining stocked housing is aggravated. However, there is a lack of objective data to analyze the size of the maintenance costs that are executed by the type of repair work, and the elapsed years of the aged long-term public rental housing. This study analyzes the execution status of 33 long-term public rental housing complexes located in Seoul for 14 to 28 years of elapsed years based on the data of maintenance costs. In addition, this study proposes a model to predict the maintenance costs by elapsed years by dividing 'Long-term Repair Plan Work and Government-Funded Project [Y1]', 'Planned Repair Work and General & Unplanned Repair Work [Y2]', and 'Total maintenance costs [Y3]'. It is intended to be used as basic data for the establishment of the maintenance plan at the stage of setting up the budget and the establishment of the sustainable operation plan for public rental housing